Intramyocardial injection of naked DNA encoding HIF-1α/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat

Cardiovascular Research

Volumn 54, Issue 3, 2002, Pages 576-583

  Shyu, Kou Gi ^a   Wang, Mei Ti ^b   Wang, Bao Wei ^a   Chang, Chih Chuna ^a   Leu, Jyh Gang ^b   Kuan, Peiliang ^a   Chang, Hang ^a  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Collateral circulation; Gene therapy; Infarction

Indexed keywords

HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; NAKED DNA; PLASMID DNA; PROTEIN VP16; UNCLASSIFIED DRUG; VASCULOTROPIN; VIRUS PROTEIN;

ACUTE HEART INFARCTION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DISEASE MODEL; DRUG EFFICACY; DRUG POTENCY; GENE THERAPY; GENETIC CODE; HEART INFARCTION SIZE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HYBRID; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

ANIMALS; CAPILLARIES; COLLATERAL CIRCULATION; DNA; ENDOTHELIAL GROWTH FACTORS; ETOPOSIDE; GENE EXPRESSION; GENE THERAPY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INJECTIONS; LYMPHOKINES; MALE; MODELS, ANIMAL; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036275028     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00259-6     Document Type: Article

References (29)

1. Growth regulation of the vascular system: Evidence for a metabolic hypothesis
2. Rapid induction of vascular endothelial growth factor by transient ischemia in rat heart
3. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
4. Vascular endothelial growth factor is a potent tumor angiogenesis factor in human gliomas in vivo
5. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
6. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
7. Vascular endothelial growth factor, a potent and selective angiogenic agent
8. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
9. Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells
10. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
11. Transactivation and inhibitory domains of hypoxia-inducible factor 1α: Modulation of transcriptional activity by oxygen tension
12. Transcriptional regulation by hypoxia-inducible factor 1: Molecular mechanisms of oxygen homeostasis
13. Oxygen sensing and molecular adaptation to hypoxia
14. A nuclear factor induced by hypoxia de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
15. Characterization of hypoxia-inducible factor 1 and regulaton of DNA binding activity by hypoxia
16. Structural and functional nalysis of hypoxia-inducible factor 1
17. 2 tension
18. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
19. Activation of hypoxia-inducible factor-1; Definition of regulatory domains within the α subunit
20. Hypoxia-inducible factor modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
21. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
22. Targeting gene expression to hypoxic tumor cells
23. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP16 hybrid transcription factor
24. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
25. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
26. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
27. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat - Angiogenesis and angioma formation
28. VEGF gene delivery to muscle: Potential role for vasculogenesis in adults
29. Oxygen(es) and hypoxia-inducible factor-1