Levels of hypoxia-inducible factor-1α during breast carcinogenesis

Journal of the National Cancer Institute

Volumn 93, Issue 4, 2001, Pages 309-314

  Bos, Reinhard ^a   Zhong, Hua ^b   Hanrahan, Colleen F ^c   Mommers, Ellen C M ^a   Semenza, Gregg L ^c   Pinedo, Herbert M ^a   Abeloff, Martin D ^c   Simons, Jonathan W ^b   Van Diest, Paul J ^a   Van Der Wall, Elsken ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; PARAFFIN; PROTEIN P53; TRANSCRIPTION FACTOR; TUMOR MARKER; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BREAST; BREAST CARCINOGENESIS; BREAST HYPERPLASIA; CANCER CELL; CANCER STAGING; CARCINOMA IN SITU; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; METASTASIS; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR VASCULARIZATION;

EID: 0035925072     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.4.309     Document Type: Article

References (54)

1. Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases
2. 2 homeostasis by hypoxia-inducible factor 1
3. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
4. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
5. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
6. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
7. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
8. 2 homeostasis by hypoxia-inducible factor 1 alpha
9. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
10. HIF-1 alpha is required for solid tumor formation and embryonic vascularization
11. Activation of hypoxia-inducible transcription factor depends primarily upon redoxsensitive stabilization of its alpha subunit
12. 2 tension
13. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
14. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
15. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
16. Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
17. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
18. 2 tension measurements
19. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
20. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
21. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
22. Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
23. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
24. Induction of angiogenesis during the transition from hyperplasia to neoplasia
25. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast
26. Ductal carcinoma in situ: A proposal for a new classification
27. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
28. Microvessel density and distribution in ductal carcinoma in situ of the breast
29. Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
30. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma
31. Hot spot microvessel density and the mitotic activity index are strong additional prognostic indicators in invasive breast cancer
32. Quality control in immunocytochemistry: Experiences with the oestrogen receptor assay
33. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
34. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
35. Different genetic pathways in the evolution of invasive breast cancer are associated with distinct morphological subtypes
36. Ductal carcinoma in situ in breast carcinogenesis
37. Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor
38. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
39. Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer
40. Early expression of angiogenesis factors in acute myocardial ischemia and infarction
41. ERK activation upon hypoxia: Involvement in HIF-1 activation
42. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
43. Loss of PTEN facilitates HIF-1-mediated gene expression
44. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
45. Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells
46. Evidence for transcriptional activation of ERalpha by IL-1beta in breast cancer cells
47. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
48. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
49. Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops
50. Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis
51. Malignancy-associated changes in breast tissue detected by image cytometry
52. Loss of heterozygosity in normal tissue adjacent to breast carcinomas
53. UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response
54. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes