-
1
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
-
Berra E., Benizri E., Ginouves A., Volmat V., Roux D., Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22:2003;4082-4090
-
(2003)
EMBO J.
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
2
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 294:2001;1337-1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
3
-
-
0037131271
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α
-
Chan D.A., Sutphin P.D., Denko N.C., Giaccia A.J. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α J. Biol. Chem. 277:2002;40112-40117
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
4
-
-
0141643358
-
Hypoxia up-regulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxygenation
-
D'Angelo G., Duplan E., Boyer N., Vigne P., Frelin C. Hypoxia up-regulates prolyl hydroxylase activity. a feedback mechanism that limits HIF-1 responses during reoxygenation J. Biol. Chem. 278:2003;38183-38187
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38183-38187
-
-
D'Angelo, G.1
Duplan, E.2
Boyer, N.3
Vigne, P.4
Frelin, C.5
-
5
-
-
0037180452
-
Structure of factor inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
-
Dann C.E. III, Bruick R.K., Deisenhofer J. Structure of factor inhibiting hypoxia-inducible factor 1. an asparaginyl hydroxylase involved in the hypoxic response pathway Proc. Natl. Acad. Sci. USA. 99:2002;15351-15356
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 15351-15356
-
-
Dann III, C.E.1
Bruick, R.K.2
Deisenhofer, J.3
-
6
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107:2001;43-54
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
7
-
-
0037144427
-
YOS9, the putative yeast homologue of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins
-
Friedmann E., Salzburg Y., Weinberger A., Shaltiel S., Gerst J.E. YOS9, the putative yeast homologue of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J. Biol. Chem. 277:2002;35274-35281
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35274-35281
-
-
Friedmann, E.1
Salzburg, Y.2
Weinberger, A.3
Shaltiel, S.4
Gerst, J.E.5
-
9
-
-
18544386401
-
Hypoxia-inducible factor asparaginyl hydroxylase is identical to factor inhibiting HIF-1 (FIH-1) and is related to the cupin structural family
-
Hewitson K.S., McNeill L.A., Riordan M.V., Tian Y.M., Bullock A.N., Welford R.W., Elkins J.M., Oldham N.J., Bhattacharya S., Gleadle J.M., et al. Hypoxia-inducible factor asparaginyl hydroxylase is identical to factor inhibiting HIF-1 (FIH-1) and is related to the cupin structural family. J. Biol. Chem. 277:2002;26351-26355
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
-
10
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M., Koivunen P., Gunzler V., Kivirikko K.I., Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278:2003;30772-30780
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
11
-
-
0023481280
-
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli
-
Hoffman C.S., Winston F. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene. 57:1987;267-272
-
(1987)
Gene
, vol.57
, pp. 267-272
-
-
Hoffman, C.S.1
Winston, F.2
-
13
-
-
0037131159
-
Sequence determinants in hypoxia-inducible factor-1a for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
-
Huang J., Zhao Q., Mooney S.M., Lee F.S. Sequence determinants in hypoxia-inducible factor-1a for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J. Biol. Chem. 277:2002;39792-39800
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
14
-
-
0035917313
-
2 sensing
-
2 sensing Science. 292:2001;464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
15
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan M., Haberberger T., Gervasi D.C., Michelson K.S., Gunzler V., Kondo K., Yang H., Sorokina I., Conaway R.C., Conaway J.W., Kaelin W.G. Jr. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc. Natl. Acad. Sci. USA. 99:2002;13459-13464
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Michelson, K.S.4
Gunzler, V.5
Kondo, K.6
Yang, H.7
Sorokina, I.8
Conaway, R.C.9
Conaway, J.W.10
Kaelin Jr., W.G.11
-
16
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science. 292:2001;468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
V., K.A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
18
-
-
0037098081
-
How oxygen makes its presence felt
-
Kaelin W.G. Jr. How oxygen makes its presence felt. Genes Dev. 16:2002;1441-1445
-
(2002)
Genes Dev.
, vol.16
, pp. 1441-1445
-
-
Kaelin Jr., W.G.1
-
19
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
-
Kallio P.J., Wilson W.J., O'Brien S., Makino Y., Poellinger L. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J. Biol. Chem. 274:1999;6519-6525
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
20
-
-
0034641615
-
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
-
Kamura T., Sato S., Iwai K., Czyzyk-Krzeska M., Conaway R.C., Conaway J.W. Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA. 97:2000;10430-10435
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
Czyzyk-Krzeska, M.4
Conaway, R.C.5
Conaway, J.W.6
-
21
-
-
0031474116
-
Genomic organization of the OS-9 gene amplified in human sarcomas
-
Kimura Y., Nakazawa M., Tsuchiya N., Asakawa S., Yamada M. Genomic organization of the OS-9 gene amplified in human sarcomas. J. Biochem. (Tokyo). 122:1997;1190-1195
-
(1997)
J. Biochem. (Tokyo)
, vol.122
, pp. 1190-1195
-
-
Kimura, Y.1
Nakazawa, M.2
Tsuchiya, N.3
Asakawa, S.4
Yamada, M.5
-
22
-
-
0031970586
-
Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines
-
Kimura Y., Nakazawa M., Yamada M. Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. J. Biochem. (Tokyo). 123:1998;876-882
-
(1998)
J. Biochem. (Tokyo)
, vol.123
, pp. 876-882
-
-
Kimura, Y.1
Nakazawa, M.2
Yamada, M.3
-
23
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
a
-
Lando D., Peet D.J., Gorman J.J., Whelan D.A., Whitelaw M.L., Bruick R.K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16:2002;1466-1471. a
-
(2002)
Genes Dev.
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
24
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
b
-
Lando D., Peet D.J., Whelan D.A., Gorman J.J., Whitelaw M.L. Asparagine hydroxylation of the HIF transactivation domain. a hypoxic switch Science. 295:2002;858-861. b
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
25
-
-
0037072881
-
A selective interaction between OS-9 and the carboxyl-terminal tail of meprin β
-
Litovchick L., Friedmann E., Shaltiel S. A selective interaction between OS-9 and the carboxyl-terminal tail of meprin β J. Biol. Chem. 277:2002;34413-34423
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 34413-34423
-
-
Litovchick, L.1
Friedmann, E.2
Shaltiel, S.3
-
26
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and vhl to mediate repression of HIF-1 transcriptional activity
-
Mahon P.C., Hirota K., Semenza G.L. FIH-1. a novel protein that interacts with HIF-1alpha and vhl to mediate repression of HIF-1 transcriptional activity Genes Dev. 15:2001;2675-2686
-
(2001)
Genes Dev.
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
27
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
28
-
-
0036846033
-
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyzes hydroxylation at the β-carbon of asparagine-803
-
McNeill L.A., Hewitson K.A., Claridge T.D., Seibel J.F., Horsfall L.E., Schofield C.J. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyzes hydroxylation at the β-carbon of asparagine-803. Biochem. J. 367:2002;571-575
-
(2002)
Biochem. J.
, vol.367
, pp. 571-575
-
-
McNeill, L.A.1
Hewitson, K.A.2
Claridge, T.D.3
Seibel, J.F.4
Horsfall, L.E.5
Schofield, C.J.6
-
29
-
-
0037386143
-
Intracellular localisation of human HIF-1α hydroxylases: Implications for oxygen sensing
-
Metzen E., Berchner-Pfannschmidt U., Stengel P., Marxsen J.H., Stolze I., Klinger M., Huang W.Q., Wotzlaw C., Hellwig-Burgel T., Jelkmann W., et al. Intracellular localisation of human HIF-1α hydroxylases. implications for oxygen sensing J. Cell Sci. 116:2003;1319-1326
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
Klinger, M.6
Huang, W.Q.7
Wotzlaw, C.8
Hellwig-Burgel, T.9
Jelkmann, W.10
-
30
-
-
0032587825
-
Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma
-
Nakayama T., Yaoi T., Kuwajima G., Yoshie O., Sakata T. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. FEBS Lett. 18:1999;77-80
-
(1999)
FEBS Lett.
, vol.18
, pp. 77-80
-
-
Nakayama, T.1
Yaoi, T.2
Kuwajima, G.3
Yoshie, O.4
Sakata, T.5
-
31
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIF-1α abundance, and modulates physiological responses to hypoxia
-
Nakayama K., Frew I.J., Hagensen M., Skals M., Habelhah H., Bhoumik A., Kadoya T., Erdjument-Bromage H., Tempst P., Frappell P.B., et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF-1α abundance, and modulates physiological responses to hypoxia. Cell. 117:2004;941-952
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, K.1
Frew, I.J.2
Hagensen, M.3
Skals, M.4
Habelhah, H.5
Bhoumik, A.6
Kadoya, T.7
Erdjument-Bromage, H.8
Tempst, P.9
Frappell, P.B.10
-
32
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh C.W., Ratcliffe P.J. Regulation of angiogenesis by hypoxia. role of the HIF system Nat. Med. 9:2003;677-684
-
(2003)
Nat. Med.
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
33
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S., Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272:1997;22642-22647
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
34
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer. 3:2003;721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
35
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza G.L., Jiang B.-H., Leung S.W., Passantino R., Concordet J.P., Maire P., Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271:1996;32529-32537
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.-H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
Giallongo, A.7
-
36
-
-
15844379850
-
Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas
-
Su Y.A., Hutter C.M., Trent J.M., Meltzer P.S. Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. Mol. Carcinog. 15:1996;270-275
-
(1996)
Mol. Carcinog.
, vol.15
, pp. 270-275
-
-
Su, Y.A.1
Hutter, C.M.2
Trent, J.M.3
Meltzer, P.S.4
-
37
-
-
85044704835
-
Identification of a new peptide recognized by cytolytic T lymphocytes on a human melanoma
-
Vigneron N., Ooms A., Morel S., Degiovanni G., Van den Eynde B.J. Identification of a new peptide recognized by cytolytic T lymphocytes on a human melanoma. Cancer Immun. 2:2002;9
-
(2002)
Cancer Immun.
, vol.2
, pp. 9
-
-
Vigneron, N.1
Ooms, A.2
Morel, S.3
Degiovanni, G.4
Van Den Eynde, B.J.5
-
39
-
-
0035859692
-
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F., White S.B., Zhao Q., Lee F.S. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA. 98:2001;9630-9635
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
40
-
-
0034213146
-
Expression of hypoxia-inducible factor 1α in human brain tumors: Association with angiogenesis, invasion, and progression
-
Zagzag D., Zhong H., Scalzitti J.M., Laughner E., Simons J.W., Semenza G.L. Expression of hypoxia-inducible factor 1α in human brain tumors. association with angiogenesis, invasion, and progression Cancer. 88:2000;2606-2618
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
41
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G.L., Simons J.W. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
|