Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: Identification of a functional hypoxia-responsive element

Biochemical Journal

Volumn 387, Issue 3, 2005, Pages 711-717

  Metzen, Eric ^a   Stiehl, Daniel P ^a   Doege, Kathrin ^a   Marxsen, Jan H ^a   Hellwig Bürgel, Thomas ^a   Jelkmann, Wolfgang ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Egg laying deficiency protein nine like protein (EGLN); Hydroxylation; Hypoxia; Hypoxia inducible factor (HIF); Oxygen; Prolyl hydroxylase domain (PHD)

Indexed keywords

CELLS; CHEMICAL SENSORS; ELECTROPHORESIS; GENES; OXYGEN; RNA;

HYPOXIC SIGNALING; MOBILITY-SHIFT ASSAY; PROLYL HYDROXYLASE DOMAIN (PHD); SEQUENCE ANALYSIS;

PROTEINS;

CIS ACTING ELEMENT; EGG LAYING DEFICIENCY PROTEIN NINE LIKE PROTEIN; GENE PRODUCT; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN PROTEIN 1; PROLYL HYDROXYLASE DOMAIN PROTEIN 2; PROLYL HYDROXYLASE DOMAIN PROTEIN 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CPG ISLAND; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE ISOLATION; GENE VECTOR; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; START CODON;

BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CPG ISLANDS; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; MOLECULAR SEQUENCE DATA; PROCOLLAGEN-PROLINE DIOXYGENASE; PROMOTER REGIONS (GENETICS); SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION INITIATION SITE;

MURINAE;

EID: 18844408840     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041736     Document Type: Article

References (41)

1. Hopfl, G., Ogunshola, O. and Gassmann, M. (2004) HIFs and tumors - causes and consequences. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R608-R623
2. Wetzen, E. and Ratcliffe, P. J. (2004) HIF hydroxylation and cellular oxygen sensing. Biol. Chem. 385, 223-230
3. Hewitson, K. S. and Schofield, C. J. (2004) The HIF pathway as a therapeutic target. Drug Discov. Today 9, 704-711
4. 2-regulated gene expression. FASEB J. 16, 1151-1162
5. Beck, I., Weinmann, R. and Caro, J. (1993) Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells. Blood 82, 704-711
6. 2 tension. Proc. Natl. Acad. Sci. U.S.A. 92, 5510-5514
7. 2 sensing. Science 292, 464-468
8. 2-regulated prolyl hydroxylation. Science 292, 468-472
9. Massen, N., Willam, C., Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J. (2001) Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206
10. Salceda, S. and Caro, J. (1997) Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272, 22642-22647
11. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. U.S.A. 95, 7987-7992
12. Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y. M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M. et al. (2002) Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 26351-26355
13. Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L. and Bruick, R. K. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471
14. Mahon, P. C., Hirota, K. and Semenza, G. L. (2001) FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev, 15, 2675-2686
15. Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherii, M., Metzen, E., Wilson, M. I., Dhanda, A. et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell (Cambridge, Mass.) 107, 43-54
16. Bruick, R. K. and McKnight, S. L. (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340
17. Yu, F., White, S. B., Zhao, Q. and Lee, F. S. (2001) HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. U.S.A. 98, 9630-9635
18. Taylor, M. S. (2001) Characterization and comparative analysis of the EGLN gene family Gene 275, 125-132
19. Oehme, F., Ellinghaus, P., Kolkhof, P., Smith, T. J., Ramakrishnan, S., Hütter, J., Schramm, M. and Flamme, I. (2002) Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Biochem. Biophys. Res. Commun. 296, 343-349
20. Lieb, M. E., Menzies, K., Moschella, M. C., Ni, R. and Taubman, M. B. (2002) Mammalian EGLN genes have distinct patterns of mRNA expression and regulation Biochem. Cell Biol. 80, 421-426
21. Lavista-Llanos, S., Centanin, L., Irisarri, M., Russo, D. M., Gleadle, J. M., Bocca, S. N., Muzzopappa, M., Ratcliffe, P. J. and Wappner, P. (2002) Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Mol. Cell Biol. 22, 6842-6853
22. Wax, S. D., Rosenfield, C. L. and Taubman, M. B. (1994) Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. J. Biol. Chem. 269, 13041-13047
23. Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D. and Pouysségur, J. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22, 4082-4090
24. D'Angelo, G., Duplan, E., Boyer, N., Vigne, P. and Frelin, C. (2003) Hypoxia up regulates prolyl hydroxylase. A feedback mechanism that limits HIF-1 responses during reoxygenation. J. Biol. Chem. 278, 38183-38187
25. del Peso, L., Castellanos, M. C., Temes, E., Martin-Puig, S., Cuevas, Y., Olmos, G. and Landazuri, M. O. (2003) The von Hippel Lindau/hypoxia inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 278, 48690-48695
26. Marxsen, J. H., Stengel, P., Doege, K., Heikkinen, P., Jokilehto, T., Wagner, T., Jelkmann, W., Jaakkola, P. and Metzen, E. (2004) Hypoxia-inducible factor-1 promotes its degradation by induction of HIF-1α-prolyl-4- hydroxylases. Biochem. J. 381, 761-767
27. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F. and Higgins, D. G. (1997) The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25, 4876-4882
28. Takai, D. and Jones, P. A. (2002) Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc. Natl. Acad. Sci. U.S.A. 99, 3740-3745
29. Hellwig-Burgel, T., Rutkowski, K., Metzen, E., Fandrey, J. and Jelkmann, W. (1999) Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 94, 1561-1567
30. Rolfs, A., Kvietikova, I., Gassmann, M. and Wenger, R. H. (1997) Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J. Biol. Chem. 272, 20055-20062
31. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
32. Wenger, R. H., Rolfs, A., Marti, H. H., Bauer, C. and Gassmann, M. (1995) Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line. J. Biol. Chem. 270, 27865-27870
33. Dupuy, D., Aubert, I., Dupérat, V. G., Petit, J., Taine, L., Stef, M., Bloch, B. and Arveiler, B. (2000) Mapping, characterization, and expression analysis of the SM-20 human homologue, C1orf12, and identification of a novel related gene, SCAND2. Genomics 69, 348-354
34. Ryan, H. E., Lo, J. and Johnson, R. S. (1998) HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005-3015
35. Vengellur, A., Woods, B. G., Ryan, H. E., Johnson, R. S. and LaPres, J. J. (2003) Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr. 11, 181-197
36. Dalgard, C. L., Lu, H., Mohyeldin, A. and Verma, A. (2004) Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem. J, 380, 419-424
37. Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Buergel, T., Jelkmann, W. et al. (2003) Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing, J. Cell Sci. 116, 1319-1326
38. Hofer, T., Wenger, R. H., Kramer, M. F., Ferreira, G. C. and Gassmann, M. (2003) Hypoxic up-regulation of erythroid 5-aminolevulinate synthase. Blood 101, 348-350
39. Antequera, F. and Bird, A. (1999) CpG islands as genomic tootprints of promoters that are associated with replication origins. Curr. Biol. 9, R661-R667
40. Pedersen, A. G., Baldi, P., Chauvin, Y. and Brunak, S. (1999) The biology of eukaryotic promoter prediction-a review. Comput. Chem. 23, 191-207
41. Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K. I. and Myllyharju, J. (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278, 30772-30780