-
1
-
-
0042342564
-
The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer
-
George DJ, Kaelin WG Jr. The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. N Engl J Med 2003;349:419-21.
-
(2003)
N Engl J Med
, vol.349
, pp. 419-421
-
-
George, D.J.1
Kaelin Jr., W.G.2
-
4
-
-
0242608613
-
The genetic basis of cancer of the kidney
-
Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol 2003;170:2163-72.
-
(2003)
J Urol
, vol.170
, pp. 2163-2172
-
-
Linehan, W.M.1
Walther, M.M.2
Zbar, B.3
-
5
-
-
0001397111
-
Von Hippel-Lindau disease and capillary hemangiobla!stoma
-
Kleihues P, Cawenee W, editors. World Health Organization classification of tumors. Lyon: IARC Press
-
Böhling T, Hatva E, Plate K, Haltia M, Alitalo K. Von Hippel-Lindau disease and capillary hemangiobla!stoma. In: Kleihues P, Cawenee W, editors. Pathology and genetics: tumors of the nervous system. World Health Organization classification of tumors. Lyon: IARC Press; 1997. p.179-81.
-
(1997)
Pathology and Genetics: Tumors of the Nervous System
, pp. 179-181
-
-
Böhling, T.1
Hatva, E.2
Plate, K.3
Haltia, M.4
Alitalo, K.5
-
6
-
-
0031837459
-
Haemangioblastoma of the central nervous system in von Hippel-Lindau disease
-
Richard S, Campello C, Taillandier L, Parker F, Resche F. Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. J Intern Med 1998;243:547-53.
-
(1998)
J Intern Med
, vol.243
, pp. 547-553
-
-
Richard, S.1
Campello, C.2
Taillandier, L.3
Parker, F.4
Resche, F.5
-
7
-
-
0034213146
-
Expression of hypoxia-inducible factor 1α in brain tumors: Association with angiogenesis, invasion, and progression
-
Zagzag D, Zhong H, Scalzitti JM, et al. Expression of hypoxia-inducible factor 1α in brain tumors: association with angiogenesis, invasion, and progression. Cancer 2000;88:2606-18.
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
-
8
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999;59:5830-5.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
9
-
-
0037093238
-
Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation
-
Turner KJ, Moore JW, Jones A, et al. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 2002;62:2957-61.
-
(2002)
Cancer Res
, vol.62
, pp. 2957-2961
-
-
Turner, K.J.1
Moore, J.W.2
Jones, A.3
-
10
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
11
-
-
0033587146
-
The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, et al. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
13
-
-
18844474899
-
Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas
-
Lee JY, Dong SM, Park WS, et al. Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas. Cancer Res 1998;58:504-8.
-
(1998)
Cancer Res
, vol.58
, pp. 504-508
-
-
Lee, J.Y.1
Dong, S.M.2
Park, W.S.3
-
14
-
-
0029775576
-
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
-
Bleul CC, Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382:829-33.
-
(1996)
Nature
, vol.382
, pp. 829-833
-
-
Bleul, C.C.1
Farzan, M.2
Choe, H.3
-
15
-
-
0032508033
-
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
-
Tachibana K, Hirota S, Iizasa H, et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 1998;393:591-4.
-
(1998)
Nature
, vol.393
, pp. 591-594
-
-
Tachibana, K.1
Hirota, S.2
Iizasa, H.3
-
16
-
-
2642710893
-
The chemokine receptor CXCR4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell derived factor-1
-
Mohle R, Bautz F, Rafii S, et al. The chemokine receptor CXCR4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell derived factor-1. Blood 1998;91:4523-30.
-
(1998)
Blood
, vol.91
, pp. 4523-4530
-
-
Mohle, R.1
Bautz, F.2
Rafii, S.3
-
17
-
-
0033959917
-
Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma
-
Rempel SA, Dudas S, Ge S, Gutierrez JA. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 2000;6:102-11.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 102-111
-
-
Rempel, S.A.1
Dudas, S.2
Ge, S.3
Gutierrez, J.A.4
-
19
-
-
19944431949
-
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers
-
Kryczek I, Lange A, Mottram P, et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res 2005;65:465-72.
-
(2005)
Cancer Res
, vol.65
, pp. 465-472
-
-
Kryczek, I.1
Lange, A.2
Mottram, P.3
-
20
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller P, Sulitkova J, Lisztwan J, et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003;425:307-11.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
-
21
-
-
17644397285
-
Pathology and genetics: Tumors of the urinary system and male genital organs
-
Elbe JN, Sauter G, Epstein JI, Sesterhenn IA, editors. Lyon: IARC Press
-
Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and genetics: tumors of the urinary system and male genital organs. In: Elbe JN, Sauter G, Epstein JI, Sesterhenn IA, editors. WHO classification of tumors. Lyon: IARC Press: 2004. p. 10.
-
(2004)
WHO Classification of Tumors
, pp. 10
-
-
Eble, J.N.1
Sauter, G.2
Epstein, J.I.3
Sesterhenn, I.A.4
-
22
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos O, Levy AP, Jiang C, Kaelin WG Jr, Goldberg MA. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A 1996;93:10595-9.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
Kaelin Jr., W.G.4
Goldberg, M.A.5
-
23
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
-
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 2003;23:9361-74.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
24
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2
-
Feldser D, Agani F, Iyer NV, et al. Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2. Cancer Res 1999;59:3915-8.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
-
25
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995;270:1230-7.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
26
-
-
0020376310
-
Prognostic significance of morphologic parameters in renal cell carcinoma
-
Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655-63.
-
(1982)
Am J Surg Pathol
, vol.6
, pp. 655-663
-
-
Fuhrman, S.A.1
Lasky, L.C.2
Limas, C.3
-
27
-
-
0344823964
-
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
-
Rubin JB, Kung AL, Klein RS, et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 2003;100:13513-8.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13513-13518
-
-
Rubin, J.B.1
Kung, A.L.2
Klein, R.S.3
-
28
-
-
0019451604
-
Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems
-
Wood GS, Warnke R. Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems. J Histochem Cytochem 1981;29:1196-204.
-
(1981)
J Histochem Cytochem
, vol.29
, pp. 1196-1204
-
-
Wood, G.S.1
Warnke, R.2
-
29
-
-
0033013480
-
Detection of endogenous biotin in various tissues: Novel functions in the hippocampus and implications for its use in avidin-biotin technology
-
Wang H, Pevsner J. Detection of endogenous biotin in various tissues: novel functions in the hippocampus and implications for its use in avidin-biotin technology. Cell Tissue Res 1999;296:511-6.
-
(1999)
Cell Tissue Res
, vol.296
, pp. 511-516
-
-
Wang, H.1
Pevsner, J.2
-
30
-
-
0038206771
-
The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
-
Phillips RJ, Burdick MD, Lutz M, et al. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 2003;167:1676-86.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 1676-1686
-
-
Phillips, R.J.1
Burdick, M.D.2
Lutz, M.3
-
31
-
-
18544373080
-
CXCR4/ CXCL12 expression and signalling in kidney cancer
-
Schrader AJ, Lechner O, Templin M, et al. CXCR4/ CXCL12 expression and signalling in kidney cancer. Br J Cancer 2002;86:1250-6.
-
(2002)
Br J Cancer
, vol.86
, pp. 1250-1256
-
-
Schrader, A.J.1
Lechner, O.2
Templin, M.3
-
32
-
-
10744219598
-
Regulation of the chemokine receptor CXCR4 by hypoxia
-
Schioppa T, Uranchimeg B, Saccani A, et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 2003;198:1391-402.
-
(2003)
J Exp Med
, vol.198
, pp. 1391-1402
-
-
Schioppa, T.1
Uranchimeg, B.2
Saccani, A.3
-
33
-
-
0036822541
-
Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts
-
Hitchon C, Wong K, Ma G, et al. Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum 2002;46:2587-97.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2587-2597
-
-
Hitchon, C.1
Wong, K.2
Ma, G.3
-
34
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004;10:858-64.
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
-
35
-
-
0030614893
-
2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
-
2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997;3:177-82.
-
(1997)
Nat Med
, vol.3
, pp. 177-82
-
-
Helmlinger, G.1
Yuan, F.2
Dellian, M.3
Jain, R.K.4
-
36
-
-
0035394516
-
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1α in clear cell renal carcinomas
-
Wiesener MS, Munchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1α in clear cell renal carcinomas. Cancer Res 2001;61:5215-22.
-
(2001)
Cancer Res
, vol.61
, pp. 5215-5222
-
-
Wiesener, M.S.1
Munchenhagen, P.M.2
Berger, I.3
-
37
-
-
0032211161
-
Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M, Marti HH, Plate KH. Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function. Blood 1998;92:3388-93.
-
(1998)
Blood
, vol.92
, pp. 3388-3393
-
-
Krieg, M.1
Marti, H.H.2
Plate, K.H.3
-
38
-
-
0038507194
-
Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1α expression in renal cell carcinomas
-
Na X, Wu G, Ryan CK, et al. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1α expression in renal cell carcinomas. J Urol 2003;170:588-92.
-
(2003)
J Urol
, vol.170
, pp. 588-592
-
-
Na, X.1
Wu, G.2
Ryan, C.K.3
-
39
-
-
0037089405
-
Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1
-
Salvucci O, Yao L, Villalba S, et al. Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood 2002;99:2703-11.
-
(2002)
Blood
, vol.99
, pp. 2703-2711
-
-
Salvucci, O.1
Yao, L.2
Villalba, S.3
-
40
-
-
0036051818
-
Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation
-
Shibuta K, Mori M, Shimoda K, Inoue H, Mitra F, Barnard GF. Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation. Jpn J Cancer Res 2002;93:789-97.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 789-797
-
-
Shibuta, K.1
Mori, M.2
Shimoda, K.3
Inoue, H.4
Mitra, F.5
Barnard, G.F.6
-
41
-
-
0141685979
-
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
-
Kato M, Kitayama J, Kazama S, Nagawa H. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 2003;5:144-50.
-
(2003)
Breast Cancer Res
, vol.5
, pp. 144-150
-
-
Kato, M.1
Kitayama, J.2
Kazama, S.3
Nagawa, H.4
-
42
-
-
2342432307
-
Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: Pattern of expression and correlation with outcome
-
Spano JP, Andre F, Morat L, et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol 2004;15:613-7.
-
(2004)
Ann Oncol
, vol.15
, pp. 613-617
-
-
Spano, J.P.1
Andre, F.2
Morat, L.3
-
43
-
-
0038360798
-
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
-
Sun YX, Wang J, Shelburne CE, et al. Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. J Cell Biochem 2003;89:462-73.
-
(2003)
J Cell Biochem
, vol.89
, pp. 462-473
-
-
Sun, Y.X.1
Wang, J.2
Shelburne, C.E.3
-
44
-
-
13744255245
-
CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
-
Tavor S, Petit I, Porozov S, et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res 2004;64:2817-24.
-
(2004)
Cancer Res
, vol.64
, pp. 2817-2824
-
-
Tavor, S.1
Petit, I.2
Porozov, S.3
-
45
-
-
4143136640
-
Vascular endothelial growth factor: Basic science and clinical progress
-
Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25:581-611.
-
(2004)
Endocr Rev
, vol.25
, pp. 581-611
-
-
Ferrara, N.1
-
46
-
-
0029785838
-
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
-
Gnarra JR, Zhou S, Merrill MJ, et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A 1996;93:10589-94.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10589-10594
-
-
Gnarra, J.R.1
Zhou, S.2
Merrill, M.J.3
-
48
-
-
0034666724
-
SDF-1 activity on microvascular endothelial cells: Consequences on angiogenesis in in vitro and in vivo models
-
Mirshahi F, Pourtau J, Li H, et al. SDF-1 activity on microvascular endothelial cells: consequences on angiogenesis in in vitro and in vivo models. Thromb Res 2000;99:587-94.
-
(2000)
Thromb Res
, vol.99
, pp. 587-594
-
-
Mirshahi, F.1
Pourtau, J.2
Li, H.3
-
49
-
-
0242289607
-
The use of suppression subtractive hybridization for the study of SDF-1α induced gene-expression in human endothelial cells
-
Neuhaus T, Lutz C, Stier S, et al. The use of suppression subtractive hybridization for the study of SDF-1α induced gene-expression in human endothelial cells. Mol Cell Probes 2003;17:245-52.
-
(2003)
Mol Cell Probes
, vol.17
, pp. 245-252
-
-
Neuhaus, T.1
Lutz, C.2
Stier, S.3
-
50
-
-
0034210253
-
Up-regulation of vascular endothelial growth factor receptor Fit-1 after endothelial denudation: Role of transcription factor Egr-1
-
Vidal F, Aragones J, Alfranca A, de Landazuri MO. Up-regulation of vascular endothelial growth factor receptor Fit-1 after endothelial denudation: role of transcription factor Egr-1. Blood 2000;95:3387-95.
-
(2000)
Blood
, vol.95
, pp. 3387-3395
-
-
Vidal, F.1
Aragones, J.2
Alfranca, A.3
De Landazuri, M.O.4
|