Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA

Molecular and Cellular Biology

Volumn 20, Issue 24, 2000, Pages 9346-9355

  Miura, S ^a   Takeshita, T ^a   Asao, H ^a   Kimura, Y ^a   Murata, K ^a   Sasaki, Y ^a   Hanai, J I ^a   Beppu, H ^a   Tsukazaki, T ^a   Wrana, J L ^a   Miyazono, K ^a   Sugamura, K ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; PROTEIN DERIVATIVE; PROTEIN HGS; SMAD ANCHOR FOR RECEPTOR ACTIVATION; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MUTANT; CONTROLLED STUDY; EMBRYO; GENE DELETION; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS; ACTIVINS; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; CHIMERA; DNA-BINDING PROTEINS; EMBRYO; GENE TARGETING; GENES, REPORTER; INHIBINS; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0034462833     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.24.9346-9355.2000     Document Type: Article

References (32)

1. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth
2. Mads and Smads in TGF-β signaling
3. Activation of signalling by the activin receptor complex
4. Hrs-2 is an ATPase implicated in calcium-regulated secretion
5. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to ring FYVE finger domains
6. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
7. TGF-β signaling
8. FYVE fingers bind PtdIns(3)P
9. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
10. Formation and function of Spemann's organizer
11. The MAD-related protein Smad7 associates with the TGF-β receptor and functions as an antagonist of TGF-β signaling
12. TGF-β signaling from cell membrane to nucleus through SMAD proteins
13. Insertional mutation of a gene involved in growth regulation of the early mouse embryo
14. Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
15. Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain
16. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes
17. Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis
18. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling
19. TGF-beta signal transduction
20. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
21. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
22. A functional PtdIns(3)P-binding motif
23. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae
24. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
25. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
26. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction
27. Signalling through the lipid products of phosphoinositide-3-OH kinase
28. SARA, a FYVE domain protein that recruits Smad2 to the TGF-β receptor
29. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
30. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor Smad2
31. Formation and activation by phosphorylation of activin receptor complexes
32. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice