Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein

Science

Volumn 286, Issue 5440, 1999, Pages 771-774

  Stroschein, Shannon L ^a   Wang, Wei ^a   Zhou, Sharleen ^a   Zhou, Qiang ^a   Luo, Kunxin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GROWTH REGULATION; HUMAN; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

CELL DIVISION; CELL LINE; CELL NUCLEUS; DNA; DNA-BINDING PROTEINS; FEEDBACK; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0033595704     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5440.771     Document Type: Article

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57. We thank S. Pearson-White for providing the c-snoN cDNA, P. Kaufman for the human CAC1 probe, and H. Nolla for help with the FACS analysis. Supported by U.S. Department of Energy (DOE)-LBNL grant DE-AC03-76SF00098, DOE/OBER grant DE-AC03-76SF00099, Wendy Will Case Cancer Fund, California breast cancer research program award, and March of Dimes research grant to K.L S.L.S. was supported by a predoctoral fellowship from the National Science Foundation.