Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling

Cell

Volumn 94, Issue 5, 1998, Pages 585-594

  Shi, Yigong ^a   Wang, Yan Fel ^a   Jayaraman, Lata ^b   Yang, Haijuan ^b   Massagué, Joan ^b   Pavletich, Nikola P ^b  

^a PRINCETON UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CRYSTAL STRUCTURE; DNA SEQUENCE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

EID: 0032483544     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81600-1     Document Type: Article

References (42)

1. Baker, J.C., and Harland, R.M. (1996). A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880-1889.
2. Brunger, A.T. (1991). X-PLOR, a System for Crystallography and NMR, Version 3.0 Manual Edition (New Haven, CT: Yale University Press).
3. Chen, X., Rubock, M.J., and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383, 691-696.
4. Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. (1997a). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-89.
5. Chen, Y., Bhushan, A., and Vale, W. (1997b). Smad8 mediates the signaling of the receptor serine kinase. Proc. Natl. Acad. Sci. USA 94, 12938-12943.
6. Collaborative Computational Project. (1994). The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760-763.
7. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J.-M. (1998). Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100.
8. Derynck, R. (1994). TGF-β-receptor-mediated signaling. Trends Biochem. Sci. 19, 548-553.
9. Eppert, K., Scherer, S.W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L-C., Bapat, B., Gallinger, S., Andrulis, I.L., et al. (1996). MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543-552.
10. Glover, J.N., and Harrison, S.C. (1995). Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373, 257-261.
11. Hata, A., Lo, R.A., Wotton, D., and Massagué, J. (1997). Mutations increasing auto-inhibition inactivate the tumour suppressors Smad2 and Smad4. Nature 388, 82-87.
12. Heldin, C.-H., Miyazomo, K., and ten Dijke, P. (1997). TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
13. Hicks, G.R., and Raikhel, N. (1995). Protein import into the nucleus: an integrated view. Annu. Rev. Cell Dev. Biol. 11, 155-188.
14. Hogan, B.L.M. (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594.
15. Holm, L., and Sander, C. (1994). The FSSP database of structurally aligned protein fold families. Nucleic Acids Res. 22, 3600-3609.
16. Hoodless, P.A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M.B., Attisano, L., and Wrana, J.L. (1996). MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85, 489-500.
17. Jones, T.A., Zou, J.-Y., Cowan, S.W., and Kjeldgaard, M. (1991). Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119.
18. Kim, J., Johnson, K., Chen, H.J., Carroll, S., and Laughon, A. (1997). Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308.
19. Klaulis, P.J. (1991). Molscript: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950.
20. Kretzschmar, M., and Massagué, J. (1998). SMADS: mediators and regulators of TGF-β signaling. Curr. Opin. Genet. Dev. 8, 103-111.
21. Lagna, G., Hata, A., Hemmati-Brivanlou, A., and Massagué, J. (1996). Partnership between DPC4 and SMAD proteins in TGF-β signaling pathways. Nature 383, 832-836.
22. Lechleider, R.J., de Caestecker, M.P., Dehejia, A., Polymeropoulos, M.H., and Roberts, A.B. (1996). Serine phosphorylation, chromosomal localization, and transforming growth factor-β signal transduction by human bsp-1. J. Biol. Chem. 271, 17617-17620.
23. Liu, F., Hata, A., Baker, J.C., Doody, J., Carcamo, J., Harland, R.M., and Massagué, J. (1996). A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623.
24. Liu, F., Pouponnot, C., and Massagué, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11, 3157-3167.
25. MacGrogan, D., Pegram, M., Slamon, D., and Bookstein, R. (1997). Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas. Oncogene 15, 1111-1114.
26. Massagué, J., and Weis-Garcia, F. (1996). Serine/threonine kinase receptors: mediators of transforming growth factor β signals. Cancer Surv. 27, 41-64.
27. Merrit, E.A., and Murphy, M.E. (1994). Raster3D Version 2.0: a program for photorealistic molecular graphics. Acta Crystallogr. D 50, 869-873.
28. Pabo, C.O., and Sauer, R.T. (1992). Transcription factors: structural families and principles of DNA recognition. Annu. Rev. Biochem. 61, 1053-1095.
29. Puglisi, J.D., Chen, L., Blanchard, S., and Frankel, A.D. (1995). Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science 270, 1200-1203.
30. Raumann, B.E., Rould, M.A., Pabo, C.O., and Sauer, R.T. (1994). DNA recognition by β-sheets in the Arc repressor-operator crystal structure. Nature 367, 754-757.
31. Roberts, A.B., and Sporn, M.B. (1990). Peptide Growth Factors and Their Receptors, M.B. Sporn and A.B. Roberts, eds. (Heidelberg: Springer-Verlag), pp. 419-472.
32. Saenger, W. (1984). Principles of Nucleic Acid Structure (New York: Springer-Verlag).
33. Schutte, M., Hruban, R.H., Hedrick, L., Cho, K.R., Nadasdy, G.M., Weinstein, C.L., Bova, G.S., Isaacs, W.B., Cairns, P., Nawroz, H., et al. (1996). DPC4 gene in various tumor types. Cancer Res. 56, 2527-2530.
34. Shi, Y., Hata, A., Lo, R.S., Massagué, J., and Pavletich, N.P. (1997). A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87-93.
35. Somers, W.S., and Philips, S.E.V. (1992). Crystal structure of the met repressor-operator complex at 2.8 Å resolution reveals DNA recognition by β-strands. Nature 359, 387-393.
36. Thiagalingam, S., Lengauer, C., Leach, F.S., Schutte, M., Hahn, S.A., Overhauser, J., Willson, J.K.V., Markowitz, S., Hamilton, S.R., Kern, S.E., et al. (1996). Evaluation of candidate tumour suppressor genes on the chromosome 18 in colorectal cancers. Nat. Genet. 13, 343-346.
37. Ye, X., Kumar, R.A., and Patel, D.J. (1995). Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex. Chem. Biol. 2, 827-840.
38. Yingling, J.M., Das, P., Savage, C., Zhang, M., Padgett, R.W., and Wang, X.-F. (1996). Mammalian dwarfins are phosphorylated in response to transforming growth factor β and are implicated in control of cell growth. Proc. Natl. Acad. Sci. USA 93, 8940-8944.
39. Yingling, J.M., Datto, M.B., Wong, C., Frederick, J.P., Liberati, N.T., and Wang, X.-F. (1997). Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol. 17, 7019-7028.
40. Zawel, L., Dai, J.L., Buckhaults, P., Zhou, S., Kinzler, K.W., Vogelstein, B., and Kern, S.E. (1998). Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1, 611-617.
41. Zhang, K.Y.J. (1993). SQUASH-combining constraints for macromolecular phase refinement and extension. Acta Crystallogr. D 49, 213-222.
42. Zhang, Y., Feng, X.-H., Wu, R.-Y., and Derynck, R. (1996). Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172.