Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice

Science

Volumn 299, Issue 5606, 2003, Pages 574-577

  Tang, Yi ^a   Katuri, Varalakshmi ^a   Dillner, Allan ^a   Mishra, Bibhuti ^a   Deng, Chu Xia ^b   Mishra, Lopa ^a,c,d  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTIONS; DEFECTS; SIGNALING;

PHOSPHORYLATION;

PROTEINS;

ADAPTOR PROTEIN; FODRIN; SMAD PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SPECTRIN; TRANSFORMING GROWTH FACTOR BETA;

GROWTH; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONGENITAL HEART MALFORMATION; DEATH; DISEASE ASSOCIATION; GASTROINTESTINAL DISEASE; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GESTATION PERIOD; HUMAN; HUMAN CELL; LIVER DISEASE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ABNORMALITIES, MULTIPLE; ANIMALS; CARRIER PROTEINS; CELL MEMBRANE; CELL NUCLEUS; CONTRACTILE PROTEINS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; GENE TARGETING; GENES, FOS; LIVER; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MICROSCOPY, CONFOCAL; MUTATION; PHENOTYPE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SPECTRIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0037462502     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1075994     Document Type: Article

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25. We thank C. Li for invaluable assistance with generating mutant elf mice and mouse blastocyte injection; S. J. Kim, A. Roberts, J. Wrana, L. Attisano, J. Massague, and A. Hata for the kind gift of Smad expression vectors; S. Danovitch, E. P. Reddy, and M. Zasloff for their constructive criticism during the evolution of this manuscript; and R. Redman, E. Fiores, A. Lorman, and E. Mishra for assistance with immunohistochemistry. Supported by NIH R01 DK56111 (L.M.), NIH R01 DK58637 (B.M.), a Veterans Administration merit award (L.M.), NIH R03 DK53861 (L.M.), the Betty and Harry Myerberg Foundation, and the Elisabeth and John Cox Foundation. This manuscript is dedicated to J.B.