메뉴 건너뛰기




Volumn 19, Issue 8, 2000, Pages 1745-1754

Transcriptional control by the TGF-β/Smad signaling system

Author keywords

Receptors; Signal transduction; SMAD; TGF ; Transcription

Indexed keywords

CELL RECEPTOR; PROTEIN TYROSINE KINASE; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034678908     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1801)

References (90)
  • 1
    • 0033521032 scopus 로고    scopus 로고
    • c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with smads
    • Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K. and Kawabata, M. (1999) c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with smads. J. Biol. Chem., 274, 35269-35277.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35269-35277
    • Akiyoshi, S.1    Inoue, H.2    Hanai, J.3    Kusanagi, K.4    Nemoto, N.5    Miyazono, K.6    Kawabata, M.7
  • 2
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • Ashcroft, G.S. et al. (1999) Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nature Cell Biol., 1, 260-266.
    • (1999) Nature Cell Biol. , vol.1 , pp. 260-266
    • Ashcroft, G.S.1
  • 3
    • 0025061096 scopus 로고
    • TFE3: A helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif
    • Beckmann, H., Su, L.K. and Kadesch, T. (1990) TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif. Genes Dev., 4, 167-179.
    • (1990) Genes Dev. , vol.4 , pp. 167-179
    • Beckmann, H.1    Su, L.K.2    Kadesch, T.3
  • 4
    • 0029558541 scopus 로고
    • A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif
    • Bertolino, E., Reimund, B., Wildt-Perinic, D. and Clerc, R. (1995) A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. J. Biol. Chem., 270, 31178-31188.
    • (1995) J. Biol. Chem. , vol.270 , pp. 31178-31188
    • Bertolino, E.1    Reimund, B.2    Wildt-Perinic, D.3    Clerc, R.4
  • 5
    • 0033605704 scopus 로고    scopus 로고
    • Requirement of type III TGF-β receptor for endocardial cell transformation in the heart
    • Brown, C.B., Boyer, A.S., Runyan, R.B. and Barnett, J.V. (1999) Requirement of type III TGF-β receptor for endocardial cell transformation in the heart. Science, 283, 2080-2082.
    • (1999) Science , vol.283 , pp. 2080-2082
    • Brown, C.B.1    Boyer, A.S.2    Runyan, R.B.3    Barnett, J.V.4
  • 6
    • 0033582646 scopus 로고    scopus 로고
    • Transducing the Dpp morphogen gradient in the wing of Drosophila: Regulation of Dpp targets by brinker
    • Campbell, G. and Tomlinson, A. (1999) Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker. Cell, 96, 553-562.
    • (1999) Cell , vol.96 , pp. 553-562
    • Campbell, G.1    Tomlinson, A.2
  • 7
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner of MAD proteins in TGF-β signalling
    • Chen, X., Rubock, M.J. and Whitman, M. (1996) A transcriptional partner of MAD proteins in TGF-β signalling. Nature, 383, 691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 9
    • 0033524945 scopus 로고    scopus 로고
    • Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors
    • Chen, Y.G. and Massagué, J. (1999) Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors. J. Biol. Chem., 274, 3672-3677.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3672-3677
    • Chen, Y.G.1    Massagué, J.2
  • 12
    • 0030897846 scopus 로고    scopus 로고
    • A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction
    • Eresh, S., Riese, J., Jackson, D.B., Bohman, D. and Bienz, M. (1997) A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J., 16, 2014-2022.
    • (1997) EMBO J. , vol.16 , pp. 2014-2022
    • Eresh, S.1    Riese, J.2    Jackson, D.B.3    Bohman, D.4    Bienz, M.5
  • 13
    • 0030926005 scopus 로고    scopus 로고
    • A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling activity
    • Feng, X.H. and Derynck, R. (1997) A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling activity. EMBO J., 16, 3912-3922.
    • (1997) EMBO J. , vol.16 , pp. 3912-3922
    • Feng, X.H.1    Derynck, R.2
  • 14
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
    • Feng, X.-H., Zhang, Y., Wu, R.-Y. and Derynck, R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes Dev., 12, 2153-2163.
    • (1998) Genes Dev. , vol.12 , pp. 2153-2163
    • Feng, X.-H.1    Zhang, Y.2    Wu, R.-Y.3    Derynck, R.4
  • 15
    • 0034007925 scopus 로고    scopus 로고
    • Homeo-domain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
    • Germain, S., Howell, M., Esslemont, G.M. and Hill, C. (2000) Homeo-domain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev., 14, 435-451.
    • (2000) Genes Dev. , vol.14 , pp. 435-451
    • Germain, S.1    Howell, M.2    Esslemont, G.M.3    Hill, C.4
  • 16
    • 0033578721 scopus 로고    scopus 로고
    • Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression
    • Hanafusa, H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuya, H., Matsumoto, K. and Nishida, E. (1999) Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression. J. Biol. Chem., 274, 27161-27167.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27161-27167
    • Hanafusa, H.1    Ninomiya-Tsuji, J.2    Masuyama, N.3    Nishita, M.4    Fujisawa, J.5    Shibuya, H.6    Matsumoto, K.7    Nishida, E.8
  • 17
    • 0039844411 scopus 로고    scopus 로고
    • Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter
    • Hanai, J. et al. (1999) Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter. J. Biol. Chem., 274, 31577-31582.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31577-31582
    • Hanai, J.1
  • 18
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate the tumour suppressors Smad2 and Smad4
    • Hata, A., Lo, R., Wotton, D., Lagna, M. and Massagué, J. (1997) Mutations increasing autoinhibition inactivate the tumour suppressors Smad2 and Smad4. Nature, 388, 82-86.
    • (1997) Nature , vol.388 , pp. 82-86
    • Hata, A.1    Lo, R.2    Wotton, D.3    Lagna, M.4    Massagué, J.5
  • 19
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata, A., Lagna, G., Massagué, J. and Hemmati-Brivanlou, A. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev., 12, 186-197.
    • (1998) Genes Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massagué, J.3    Hemmati-Brivanlou, A.4
  • 20
    • 0034695506 scopus 로고    scopus 로고
    • OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways
    • Hata, A., Seoane, J., Lagna, G., Montalvo, E., Hemmati-Brivanlou, A. and Massagué, J. (2000) OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell, 100, 229-240.
    • (2000) Cell , vol.100 , pp. 229-240
    • Hata, A.1    Seoane, J.2    Lagna, G.3    Montalvo, E.4    Hemmati-Brivanlou, A.5    Massagué, J.6
  • 21
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
    • Hayashi, H. et al. (1997) The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell, 89, 1165-1173.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1
  • 22
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.-H., Miyazono, K. and ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature, 390, 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 23
    • 0033104505 scopus 로고    scopus 로고
    • TGF-β induces ribronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
    • Hocevar, B.A., Brown, T.L. and Howe, P.H. (1999) TGF-β induces ribronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J., 18, 1345-1356.
    • (1999) EMBO J. , vol.18 , pp. 1345-1356
    • Hocevar, B.A.1    Brown, T.L.2    Howe, P.H.3
  • 24
    • 0033568923 scopus 로고    scopus 로고
    • Xenopus Smad4β is the Co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes
    • Howell, M., Itoh, F., Pierreux, C.E., Valgeirsdottir, S., Itoh, S., ten Dijke, P. and Hill, C.S. (1999) Xenopus Smad4β is the Co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes. Dev. Biol., 214, 354-369.
    • (1999) Dev. Biol. , vol.214 , pp. 354-369
    • Howell, M.1    Itoh, F.2    Pierreux, C.E.3    Valgeirsdottir, S.4    Itoh, S.5    Ten Dijke, P.6    Hill, C.S.7
  • 25
    • 0033539612 scopus 로고    scopus 로고
    • Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3 and Smad proteins
    • Hua, X., Miller, Z.A., Wu, G., Shi, Y. and Lodish, H.F. (1999) Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor μE3 and Smad proteins. Proc. Natl Acad. Sci. USA, 96, 13130-13135.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 13130-13135
    • Hua, X.1    Miller, Z.A.2    Wu, G.3    Shi, Y.4    Lodish, H.F.5
  • 26
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the type 1 TGF β receptor in complex with FKBP12
    • Huse, M., Chen, Y.G., Massagué, J. and Kuriyan, J. (1999) Crystal structure of the cytoplasmic domain of the type 1 TGF β receptor in complex with FKBP12. Cell, 96, 425-436.
    • (1999) Cell , vol.96 , pp. 425-436
    • Huse, M.1    Chen, Y.G.2    Massagué, J.3    Kuriyan, J.4
  • 27
    • 0032527756 scopus 로고    scopus 로고
    • TGF-β-stipulated cooperation of Smad proteins with the coactivators CBP/p300
    • Janknecht, R., Wells, N.J. and Hunter, T. (1998) TGF-β-stipulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev., 12, 2114-2119.
    • (1998) Genes Dev. , vol.12 , pp. 2114-2119
    • Janknecht, R.1    Wells, N.J.2    Hunter, T.3
  • 28
    • 0033582753 scopus 로고    scopus 로고
    • The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation
    • Jazwinska, A., Kirov, N., Wieschaus, E., Roth, S. and Rushlow, C. (1999) The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell, 96, 563-573.
    • (1999) Cell , vol.96 , pp. 563-573
    • Jazwinska, A.1    Kirov, N.2    Wieschaus, E.3    Roth, S.4    Rushlow, C.5
  • 30
    • 0032516862 scopus 로고    scopus 로고
    • Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin and bone morphogenetic protein-inducible enhancer
    • Jonk, L.J., Itoh, S., Heldin, C.H., ten Dijke, P. and Kruijer, W. (1998) Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin and bone morphogenetic protein-inducible enhancer. J. Biol. Chem., 273, 21145-21152.
    • (1998) J. Biol. Chem. , vol.273 , pp. 21145-21152
    • Jonk, L.J.1    Itoh, S.2    Heldin, C.H.3    Ten Dijke, P.4    Kruijer, W.5
  • 31
    • 0032528041 scopus 로고    scopus 로고
    • Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
    • Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. and Miyazono, K. (1998) Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J., 17, 4056-4065.
    • (1998) EMBO J. , vol.17 , pp. 4056-4065
    • Kawabata, M.1    Inoue, H.2    Hanyu, A.3    Imamura, T.4    Miyazono, K.5
  • 32
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim, J., Johnson, K., Chen, H.J., Carroll, S. and Laughon, A. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature, 388, 304-308.
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 33
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFb/Smad signaling by ongenic ras
    • Kretzschmar, M., Doody, J., Timokhina, I. and Massagué, J. (1999) A mechanism of repression of TGFb/Smad signaling by ongenic ras. Genes Dev., 13, 804-816.
    • (1999) Genes Dev. , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massagué, J.4
  • 35
    • 0032110463 scopus 로고    scopus 로고
    • Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2
    • Labbé, E., Silvestri, C., Hoodless, P.A., Wrana, J.L. and Attisano, L. (1998) Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell, 2, 109-120.
    • (1998) Mol. Cell , vol.2 , pp. 109-120
    • Labbé, E.1    Silvestri, C.2    Hoodless, P.A.3    Wrana, J.L.4    Attisano, L.5
  • 36
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways
    • Lagna, G., Hata, A., Hemmati-Brivanlou, A. and Massagué, J. (1996) Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways. Nature, 383, 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massagué, J.4
  • 38
    • 0026649466 scopus 로고
    • Regulation of transcription of the germ-line Ig α constant region gene by an ATF element and by novel transforming growth factor-β1-responsive elements
    • Lin, Y.C. and Stavnezer, J. (1992) Regulation of transcription of the germ-line Ig α constant region gene by an ATF element and by novel transforming growth factor-β1-responsive elements. J. Immunol., 149, 2914-2925.
    • (1992) J. Immunol. , vol.149 , pp. 2914-2925
    • Lin, Y.C.1    Stavnezer, J.2
  • 39
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • Liu, F., Hata, A., Baker, J., Doody, J., Cárcamo, J., Harland, R. and Massagué, J. (1996) A human Mad protein acting as a BMP-regulated transcriptional activator. Nature, 381, 620-623.
    • (1996) Nature , vol.381 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.3    Doody, J.4    Cárcamo, J.5    Harland, R.6    Massagué, J.7
  • 40
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional responses
    • Liu, F., Pouponnot, C. and Massagué, J. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional responses. Genes Dev., 11, 3157-3167.
    • (1997) Genes Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massagué, J.3
  • 41
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-β-activated Smad2
    • Lo, R.S. and Massagué, J. (1999) Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nature Cell Biol., 1, 472-478.
    • (1999) Nature Cell Biol. , vol.1 , pp. 472-478
    • Lo, R.S.1    Massagué, J.2
  • 42
    • 0032481351 scopus 로고    scopus 로고
    • The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors
    • Lo, R.S., Chen, Y.G., Shi, Y.G., Pavletich, N. and Massagué, J. (1998) The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO J., 17, 996-1005.
    • (1998) EMBO J. , vol.17 , pp. 996-1005
    • Lo, R.S.1    Chen, Y.G.2    Shi, Y.G.3    Pavletich, N.4    Massagué, J.5
  • 43
    • 0033200361 scopus 로고    scopus 로고
    • The ski oncoprotein interacts with the smad proteins to repress TGFβ signaling
    • Luo, K., Stroschein, S.L., Wang, W., Chen, D., Martens, E., Zhou, S. and Zhou, Q. (1999) The ski oncoprotein interacts with the smad proteins to repress TGFβ signaling. Genes Dev., 13, 2196-2206.
    • (1999) Genes Dev. , vol.13 , pp. 2196-2206
    • Luo, K.1    Stroschein, S.L.2    Wang, W.3    Chen, D.4    Martens, E.5    Zhou, S.6    Zhou, Q.7
  • 44
    • 0031685620 scopus 로고    scopus 로고
    • TGFβ signal transduction
    • Massagué, J. (1998) TGFβ signal transduction. Annu. Rev. Biochem., 67, 753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massagué, J.1
  • 45
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGFβ signaling
    • Massagué, J. and Chen, Y.G. (2000) Controlling TGFβ signaling. Genes Dev., 14, 627-644.
    • (2000) Genes Dev. , vol.14 , pp. 627-644
    • Massagué, J.1    Chen, Y.G.2
  • 46
    • 0033597107 scopus 로고    scopus 로고
    • Identification of two Smad4 proteins in Xenopus. Their common and distinct properties
    • Masuyama, N., Hanafusa, H., Kusakabe, M., Shibuya, H. and Nishida, E. (1999) Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. J. Biol. Chem., 274, 12163-12170.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12163-12170
    • Masuyama, N.1    Hanafusa, H.2    Kusakabe, M.3    Shibuya, H.4    Nishida, E.5
  • 47
    • 0033580437 scopus 로고    scopus 로고
    • brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes
    • Minami, M., Kinoshita, N., Kamoshida, Y., Tanimoto, H. and Tabata, T. (1999) brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes. Nature, 398, 242-246.
    • (1999) Nature , vol.398 , pp. 242-246
    • Minami, M.1    Kinoshita, N.2    Kamoshida, Y.3    Tanimoto, H.4    Tabata, T.5
  • 48
    • 0033584854 scopus 로고    scopus 로고
    • Regulation of Smad7 promoter by direct association with Smad3 and Smad4
    • Nagarajan, R.P., Zhang, J., Li, W. and Chen, Y. (1999) Regulation of Smad7 promoter by direct association with Smad3 and Smad4. J. Biol. Chem., 274, 33412-33418.
    • (1999) J. Biol. Chem. , vol.274 , pp. 33412-33418
    • Nagarajan, R.P.1    Zhang, J.2    Li, W.3    Chen, Y.4
  • 49
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling
    • Nakao, A. et al. (1997) Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling. Nature, 389, 631-635.
    • (1997) Nature , vol.389 , pp. 631-635
    • Nakao, A.1
  • 51
    • 0029662049 scopus 로고    scopus 로고
    • TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H. and Reichmann, E. (1996) TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev., 10, 2462-2477.
    • (1996) Genes Dev. , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 53
    • 0027403003 scopus 로고
    • Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo
    • Padgett, R.W., Wozney, J.M. and Gelbart, W.M. (1993) Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc. Natl Acad. Sci. USA, 90, 2905-2909.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2905-2909
    • Padgett, R.W.1    Wozney, J.M.2    Gelbart, W.M.3
  • 55
    • 0032483493 scopus 로고    scopus 로고
    • Physical and functional interactions of Smads and p300/CBP
    • Pouponnot, C., Jayaraman, L. and Massagué, J. (1998) Physical and functional interactions of Smads and p300/CBP. J. Biol. Chem., 273, 22865-22868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22865-22868
    • Pouponnot, C.1    Jayaraman, L.2    Massagué, J.3
  • 56
    • 0033568198 scopus 로고    scopus 로고
    • New mode of DNA binding of multi-zinc finger transcription factors: δEF1 family members bind with two hands to two target sites
    • Remacle, J.E., Kraft, H., Lerchner, W., Wuytens, G., Collart, C., Verschueren, K., Smith, J.C. and Huylebroeck, D. (1999) New mode of DNA binding of multi-zinc finger transcription factors: δEF1 family members bind with two hands to two target sites. EMBO J., 18, 5073-5084.
    • (1999) EMBO J. , vol.18 , pp. 5073-5084
    • Remacle, J.E.1    Kraft, H.2    Lerchner, W.3    Wuytens, G.4    Collart, C.5    Verschueren, K.6    Smith, J.C.7    Huylebroeck, D.8
  • 57
    • 0033969935 scopus 로고    scopus 로고
    • Left-right assymetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
    • Saijoh, Y. et al. (2000) Left-right assymetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol. Cell, 5, 35-47.
    • (2000) Mol. Cell , vol.5 , pp. 35-47
    • Saijoh, Y.1
  • 58
    • 0027161383 scopus 로고
    • Drosophila transforming growth factor β superfamily proteins induce endochondral bone formation in mammals
    • Sampath, T.K., Rashka, K.E., Doctor, J.S., Tucker, R.F. and Hoffman, F.M. (1993) Drosophila transforming growth factor β superfamily proteins induce endochondral bone formation in mammals. Proc. Natl Acad. Sci. USA, 90, 6004-6008.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6004-6008
    • Sampath, T.K.1    Rashka, K.E.2    Doctor, J.S.3    Tucker, R.F.4    Hoffman, F.M.5
  • 59
    • 0033605562 scopus 로고    scopus 로고
    • ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β signaling
    • Sano, Y., Harada, J., Tashiro, S., Gotoh-Mandeville, R., Maekawa, T. and Ishii, S. (1999) ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β signaling. J. Biol. Chem., 274, 8949-8957.
    • (1999) J. Biol. Chem. , vol.274 , pp. 8949-8957
    • Sano, Y.1    Harada, J.2    Tashiro, S.3    Gotoh-Mandeville, R.4    Maekawa, T.5    Ishii, S.6
  • 60
    • 0031773264 scopus 로고    scopus 로고
    • TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
    • Shen, X., Hu, P.P., Liberati, N.T., Datto, M.B., Frederick, J.P. and Wang, X.F. (1998) TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol. Biol. Cell, 9, 3309-3319.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 3309-3319
    • Shen, X.1    Hu, P.P.2    Liberati, N.T.3    Datto, M.B.4    Frederick, J.P.5    Wang, X.F.6
  • 61
    • 0033532057 scopus 로고    scopus 로고
    • Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
    • Shi, X., Yang, X., Chen, D., Chang, Z. and Cao, X. (1999) Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J. Biol. Chem., 274, 13711-13717.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13711-13717
    • Shi, X.1    Yang, X.2    Chen, D.3    Chang, Z.4    Cao, X.5
  • 62
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • Shi, Y., Hata, A., Lo, R.S., Massagué, J. and Pavletich, N.P. (1997) A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature, 388, 87-93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massagué, J.4    Pavletich, N.P.5
  • 63
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA-binding in TGF-β signaling
    • Shi, Y., Wang, Y.-F., Jayaraman, L., Yang, H., Massagué, J. and Pavletich, N. (1998) Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA-binding in TGF-β signaling. Cell, 94, 585-594.
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.-F.2    Jayaraman, L.3    Yang, H.4    Massagué, J.5    Pavletich, N.6
  • 65
    • 0033014867 scopus 로고    scopus 로고
    • MDSI/EVII enhances TGF-β1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/ MDSI/EVII, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1
    • Sood, R., Talwar-Trikha, A., Chakrabarti, S.R. and Nucifora, G. (1999) MDSI/EVII enhances TGF-β1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/ MDSI/EVII, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1. Leukemia, 13, 348-357.
    • (1999) Leukemia , vol.13 , pp. 348-357
    • Sood, R.1    Talwar-Trikha, A.2    Chakrabarti, S.R.3    Nucifora, G.4
  • 66
    • 0033515587 scopus 로고    scopus 로고
    • Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor β-induced smad-dependent transcriptional activation
    • Stroschein, S.L., Wang, W. and Luo, K. (1999a) Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor β-induced smad-dependent transcriptional activation. J. Biol. Chem., 274, 9431-9441.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9431-9441
    • Stroschein, S.L.1    Wang, W.2    Luo, K.3
  • 67
    • 0033595704 scopus 로고    scopus 로고
    • Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
    • Stroschein, S.L., Wang, W., Zhou, S., Zhou, Q. and Luo, K. (1999b) Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science, 286, 771-774.
    • (1999) Science , vol.286 , pp. 771-774
    • Stroschein, S.L.1    Wang, W.2    Zhou, S.3    Zhou, Q.4    Luo, K.5
  • 68
    • 0033213606 scopus 로고    scopus 로고
    • Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling
    • Sun, Y., Liu, X., Eaton, E.N., Lane, W.S., Lodish, H.F. and Weinberg, R.A. (1999a) Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling. Mol. Cell, 4, 499-509.
    • (1999) Mol. Cell , vol.4 , pp. 499-509
    • Sun, Y.1    Liu, X.2    Eaton, E.N.3    Lane, W.S.4    Lodish, H.F.5    Weinberg, R.A.6
  • 69
    • 0033607240 scopus 로고    scopus 로고
    • SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling
    • Sun, Y., Liu, X., Ng-Eaton, E., Lodish, H.F. and Weinberg, R.A. (1999b) SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling. Proc. Natl Acad. Sci. USA, 96, 12442-12447.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 12442-12447
    • Sun, Y.1    Liu, X.2    Ng-Eaton, E.3    Lodish, H.F.4    Weinberg, R.A.5
  • 70
    • 0032915872 scopus 로고    scopus 로고
    • Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins
    • Tian, G., Erman, B., Ishii, H., Gangopadhyay, S.S. and Sen, R. (1999) Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins. Mol. Cell. Biol., 19, 2946-2957.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2946-2957
    • Tian, G.1    Erman, B.2    Ishii, H.3    Gangopadhyay, S.S.4    Sen, R.5
  • 71
    • 0031741736 scopus 로고    scopus 로고
    • Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz
    • Tsai, R.Y. and Reed, R.R. (1998) Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz. Mol. Cell. Biol., 18, 6447-6456.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6447-6456
    • Tsai, R.Y.1    Reed, R.R.2
  • 72
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein thai recruits Smad2 to the TGFβ receptor
    • Tsukazaki, T., Chiang, T.A., Davison, A.F., Attisano, L. and Wrana, J.L. (1998) SARA, a FYVE domain protein thai recruits Smad2 to the TGFβ receptor. Cell, 95, 779-791.
    • (1998) Cell , vol.95 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 73
    • 0033575194 scopus 로고    scopus 로고
    • SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes
    • Verschueren, K. et al. (1999) SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes. J. Biol. Chem., 274, 20489-20498.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20489-20498
    • Verschueren, K.1
  • 74
    • 0032557674 scopus 로고    scopus 로고
    • Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-β
    • Vindevoghel, L, Kon, A., Lechleider, R.J., Uitto, J., Roberts, A.B. and Mauviel, A. (1998) Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-β. J. Biol. Chem., 273, 13053-13057.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13053-13057
    • Vindevoghel, L.1    Kon, A.2    Lechleider, R.J.3    Uitto, J.4    Roberts, A.B.5    Mauviel, A.6
  • 75
    • 0033387743 scopus 로고    scopus 로고
    • FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo
    • Watanabe, M. and Whitman, M. (1999) FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. Development, 126, 5621-5634.
    • (1999) Development , vol.126 , pp. 5621-5634
    • Watanabe, M.1    Whitman, M.2
  • 76
    • 0032709507 scopus 로고    scopus 로고
    • Runt domains take the lead in hematopoiesis and osteogenesis
    • Werner, M.H., Shigesada, K. and Ito, Y. (1999) Runt domains take the lead in hematopoiesis and osteogenesis. Nature Med., 5, 1356-1357.
    • (1999) Nature Med. , vol.5 , pp. 1356-1357
    • Werner, M.H.1    Shigesada, K.2    Ito, Y.3
  • 77
    • 0032979988 scopus 로고    scopus 로고
    • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β
    • Wong, C., Rougier-Chapman, E.M., Frederick, J.P., Datto, M.B., Liberati, N.T., Li, J.M. and Wang, X.F. (1999) Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β. Mol. Cell. Biol., 19, 1821-1830.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1821-1830
    • Wong, C.1    Rougier-Chapman, E.M.2    Frederick, J.P.3    Datto, M.B.4    Liberati, N.T.5    Li, J.M.6    Wang, X.F.7
  • 78
  • 79
    • 0033515620 scopus 로고    scopus 로고
    • A Smad transcriptional corepressor
    • Wotton, D., Lo, R.S., Lee, S. and Massagué, J. (1999a) A Smad transcriptional corepressor. Cell, 97, 29-39.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3    Massagué, J.4
  • 80
    • 0033601272 scopus 로고    scopus 로고
    • Multiple modes of repression by the smad transcriptional corepressor TGIF
    • Wotton, D., Lo, R.S., Swaby, L.A. and Massagué, J. (1999b) Multiple modes of repression by the smad transcriptional corepressor TGIF. J. Biol. Chem., 274, 37105-37110.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37105-37110
    • Wotton, D.1    Lo, R.S.2    Swaby, L.A.3    Massagué, J.4
  • 82
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interactions correlate with signaling activity and functional cooperatively of Smad3 and Smad4/DPC4
    • Wu, R.-Y., Zhang, Y., Feng, X.-H. and Derynck, R. (1997) Heteromeric and homomeric interactions correlate with signaling activity and functional cooperatively of Smad3 and Smad4/DPC4. Mol. Cell. Biol., 17, 2521-2528.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2521-2528
    • Wu, R.-Y.1    Zhang, Y.2    Feng, X.-H.3    Derynck, R.4
  • 83
    • 0032145411 scopus 로고    scopus 로고
    • Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to ihe Drosophila mesoderm
    • Xu, X., Yin, Z., Hudson, J.B., Ferguson, E.L. and Frasch, M. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to ihe Drosophila mesoderm. Genes Dev., 12, 2354-2370.
    • (1998) Genes Dev. , vol.12 , pp. 2354-2370
    • Xu, X.1    Yin, Z.2    Hudson, J.B.3    Ferguson, E.L.4    Frasch, M.5
  • 84
    • 0033531921 scopus 로고    scopus 로고
    • Positive and negative modulation of vitamin D receptor function by transforming growth factor-β signaling through smad proteins
    • Yanagi, Y., Suzawa, M., Kawabata, M., Miyazono, K., Yanagisawa, J. and Kato, S. (1999) Positive and negative modulation of vitamin D receptor function by transforming growth factor-β signaling through smad proteins. J. Biol. Chem., 274, 12971-12974.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12971-12974
    • Yanagi, Y.1    Suzawa, M.2    Kawabata, M.3    Miyazono, K.4    Yanagisawa, J.5    Kato, S.6
  • 85
    • 0033543741 scopus 로고    scopus 로고
    • The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis
    • Yeo, C.Y., Chen, X. and Whitman, M. (1999) The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis. J. Biol. Chem., 274, 26584-26590.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26584-26590
    • Yeo, C.Y.1    Chen, X.2    Whitman, M.3
  • 87
    • 0033168915 scopus 로고    scopus 로고
    • Regulation of Smad signaling by protein associations and signaling crosstalk
    • Zhang, Y. and Derynck, R. (1999) Regulation of Smad signaling by protein associations and signaling crosstalk. Trends Cell Biol., 9, 274-279.
    • (1999) Trends Cell Biol. , vol.9 , pp. 274-279
    • Zhang, Y.1    Derynck, R.2
  • 88
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    • Zhang, Y., Feng, X.H. and Derynck, R. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature, 394, 909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3
  • 89
    • 0032110707 scopus 로고    scopus 로고
    • Characterization of human FAST-1, a TGFβ and activin signal transducer
    • Zhou, S., Zawel, L., Lengauer, C., Kinzler, K.W. and Vogelstein, B. (1998) Characterization of human FAST-1, a TGFβ and activin signal transducer. Mol. Cell, 2, 121-127.
    • (1998) Mol. Cell , vol.2 , pp. 121-127
    • Zhou, S.1    Zawel, L.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 90
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L. and Thomsen, G.H. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature, 400, 687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.