TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

Nature Cell Biology

Volumn 3, Issue 6, 2001, Pages 587-595

  Bonni, Shirin ^a   Wang, Hong Rui ^a   Causing, Carrie G ^a   Kavsak, Peter ^a,b   Stroschein, Shannon L ^c   Luo, Kunxin ^c   Wrana, Jeffrey L ^a,b,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; NUCLEAR PROTEIN; PROLINE; PROTEASOME; SMAD PROTEIN; SMAD PROTEIN 2; SMAD PROTEIN 3; SMURF 2 PROTEIN; SNON PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID MOTIFS; ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGASES; MINK; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; SMAD2 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

ANIMALIA; MAMMALIA;

EID: 0034976149     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35078562     Document Type: Article

References (39)

1. Signal transduction by members of the transforming growth factor-β superfamily
2. TGF-β signalling from cell membrane to nucleus through SMAD proteins
3. TGF-β signal transduction
4. Smads: Transcriptional activators of TGF-β responses
5. Controlling TGF-β signalling
6. TGF-β signalling by Smad proteins
7. Regulation of Smad activity
8. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signalling
9. The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
10. TβRI phosphorylation of Smad2 on Ser 465 and 467 is required for Smad2/Smad4 complex formation and signalling
11. 467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for Transforming Growth Factor-β signalling
12. Smads as transcriptional co-modulators
13. A Smad transcriptional co-repressor
14. The Ski oncoprotein interacts with the Smad proteins to repress TGF-β signalling
15. c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signalling through interaction with Smads
16. Negative feedback regulation of TGF-β signalling by the SnoN oncoprotein
17. Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signalling
18. SnoN and Ski proto-oncogene proteins are rapidly degraded in response to transforming growth factor-β signalling
19. Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor
20. The MAD-related protein Smad7 associates with the TGF-β receptor and functions as an antagonist of TGF-β signalling
21. Identification of Smad7, a TGF-β inducible antagonist of TGF-β signalling
22. Smad6 inhibits signalling by the TGF-β superfamily
23. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
24. The ubiquitin system
25. SCF and cullin/ring H2-based ubiquitin ligases
26. The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
27. The importance of being proline: The interaction of proline-rich motifs in signalling proteins with their cognate domains
28. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
29. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming Growth Factor-β signalling
30. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
31. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets TGF-β receptor for degradation
32. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
33. Ubiquitin-dependent degradation of TGF-β-activated Smad2
34. Identification of the receptor component of the IκBα ubiquitin ligase
35. β-TRCP ubiquitin ligase complex associates specifically with phophorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
36. Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
37. The human F-box protein β-TrCP associates with the Cul1/Skp1 complex and regulates the stability of β-catenin
38. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell