Transport between the cell nucleus and the cytoplasm

Annual Review of Cell and Developmental Biology

Volumn 15, Issue , 1999, Pages 607-660

  Gorlich D ^a   Kutay, U ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Exportins; Importins; Nuclear pore complex; RNA export

Indexed keywords

KARYOPHERIN; MESSENGER RNA; NUCLEAR PROTEIN; TRANSFER RNA;

CELL COMPARTMENTALIZATION; CELL NUCLEUS; CELL TRANSPORT; CYTOPLASM; ENDOPLASMIC RETICULUM; EUKARYOTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR INTRINSIC ACTIVITY; REVIEW; RIBOSOME; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CYTOPLASM; HUMANS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0033279841     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.15.1.607     Document Type: Review

References (341)

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42. Regulation by HIV Rev depends upon recognition of splice sites
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50. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p
51. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
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57. A look at messenger RNP moving through the nuclear pore
58. Intranuclear location of the tRNA splicing enzymes
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60. The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export
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66. From nucleoporins to nuclear pore complexes
67. A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution
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69. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line
70. Translocation of RNA-coated gold particles through the nuclear pores of oocytes
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73. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA
74. Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif
75. Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking
76. Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin
77. The nuclear annuli as pathways for nucleocytoplasmic exchanges
78. Movement of karyophilic protein through the nuclear pores of oocytes
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84. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis
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86. Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA
87. 3G cap
88. The nuclear transport factor karyopherin β binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein
89. Disassembly of RanGTP-karyopherin beta complex, an intermediate in nuclear protein import
90. Crm 1 is an export receptor for leucine rich nuclear export signals
91. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
92. Defects in mRNA 3′-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: Possible coupling of mRNA processing and chromatin structure
93. Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex
94. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
95. Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta
96. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
97. Nuclear envelope and nuclear pore assembly: Analysis of assembly intermediates by electron microscopy
98. Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p
99. A novel class of RanGTP binding proteins
100. A 41 amino acid motif in importin alpha confers binding to importin beta and hence transit into the nucleus
101. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
102. Importin provides a link between nuclear protein import and U snRNA export
103. Identification of different roles for RanGDP and RanGTP in nuclear protein import
104. Isolation of a protein that is essential for the first step of nuclear protein import
105. Distinct functions for the two importin subunits in nuclear protein import
106. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP 159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes
107. Isolation of cDNA coding for the placental protein 15 (PP15)
108. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
109. MPF localization is controlled by nuclear export
110. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization
111. Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation
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113. The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal
114. Monomethylated cap structures facilitate RNA export from the nucleus
115. A Ran-binding motif in nuclear pore proteins
116. Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene
117. Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA
118. Interactions between HIV Rev and nuclear import and export factors: The Rev nuclear localisation signal mediates specific binding to human importin-beta
119. Determination of the functional domain organization of the importin alpha nuclear import factor
120. A monoclonal antibody to the COOH-terminal acidic portion of ran inhibits both the recycling of ran and nuclear protein import in living cells
121. Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae
122. A yeast mutant which accumulates precursor tRNAs
123. Processing of intervening sequences: A new yeast mutant which fails to excise intervening sequences from precursor tRNAs
124. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
125. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins
126. 3G-cap-specific nuclear import receptor with a novel domain structure
127. Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing
128. A novel in vivo assay reveals inhibition of ribosomal nuclear export in Ran-cycle and nucleoporin mutants
129. The nuclear pore targeting complex binds to nuclear pores after association with a karyophile
130. In vivo evidence for involvement of a 58 kDa component of nuclear pore targeting complex in nuclear protein import
131. The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor
132. A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p
133. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
134. A cap-binding protein complex mediating U sn-RNA export
135. A nuclear cap binding protein complex involved in pre-mRNA splicing
136. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
137. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
138. Nuclear export of different classes of RNA is mediated by specific factors
139. Characterization of HIV-1 vpr nuclear import: Analysis of signals and pathways
140. Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPa but not importin alpha
141. Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants
142. Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily
143. A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm
144. Regulation of nuclear localization: A key to a door
145. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
146. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121
147. Sequence requirements for nuclear location of Simian Virus 40 large T antigen
148. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
149. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
150. Transportin-SR, a nuclear import receptor for SR proteins
151. Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT in vitro
152. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export
153. Nucleocytoplasmic transport of ribosomes in a eukaryotic system: Is there a facilitated transport process?
154. Active nuclear pore complexes in Chironomus: Visualization of transporter configurations related to mRNP export
155. The kinetic mechanism of Rannucleotide exchange catalyzed by RCC1
156. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha
157. Dynamic localization of the nuclear import receptor and its interactions with transport factors
158. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importinalpha protein family
159. Evidence for distinct substrate specificities of importin αfamily members in nuclear protein import
160. Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex
161. Beta-subunit of nuclear pore-targeting complex (importin-beta) can be exported from the nucleus in a ranindependent manner
162. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm
163. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm
164. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate
165. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
166. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
167. Crm1 (XpoI) dependent nuclear export of the budding yeast transcription factor yAP-1 is sensitive to oxidative stress
168. Cselp functions as the nuclear export receptor for importin alpha in yeast
169. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
170. Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex
171. Identification of a tRNA-specific nuclear export receptor
172. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha
173. Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen
174. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
175. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
176. Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes
177. Coordination of tRNA nuclear export with processing of tRNA
178. NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex
179. Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (Ran-GAP) inhibition by karyopherin beta
180. Structure of spliceosomal snRNPs and their role in pre-mRNA splicing
181. Proofreading and aminoacylation of tRNAs before export from the nucleus
182. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
183. Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids
184. Functional dissection of the HIV-1 Rev trans-activator - Derivation of a transdominant repressor of Rev function
185. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency
186. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain
187. Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p
188. Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding
189. Ribonucleoprotein assembly: Clues from spinal muscular atrophy
190. Nucleocytoplasmic transport: The soluble phase
191. Association of individual hnRNP proteins and snRNPs with nascent transcripts
192. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
193. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
194. Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor
195. A functional homologue of the RNA 1 gene product in Schizosaccharomyces pombe: Purification, biochemical characterization, and identification of a leucine-rich repeat motif
196. Order and intracellular location of the events involved in the maturation of a spliced tRNA
197. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway
198. The K nuclear shuttling domain: A novel signal for nuclear import and nuclear export in the hnRNP K protein
199. The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors
200. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
201. Purification of a Ran-interacting protein that is required for protein import into the nucleus
202. Multiple DNA and protein sequence alignment based on segment-to-segment comparison
203. Mammalian karyopherin α 1 β and α2β heterodimers: 1 or α2 subunit binds nuclear localization sequence and β subunit interacts with peptide repeat containing nucleoporins
204. Human RanBP3, a group of nuclear RanGTP binding proteins
205. GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function
206. An RNA-export mediator with an essential nuclear export signal
207. Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor
208. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals
209. Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis
210. RNA transport
211. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain
212. Role of the nuclear transport factor p10 in nuclear import
213. The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
214. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
215. Nuclear import can be separated into distinct steps in vitro, nuclear pore binding and translocation
216. Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation
217. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
218. Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein
219. Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1
220. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation
221. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA
222. A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue
223. Evidence for a role of CRM1 in signal-mediated nuclear protein export
224. Leptomycin B inhibits equine infectious anemia virus Rev and feline immuno-deficiency virus rev function but not the function of the hepatitis B virus posttranscriptional regulatory element
225. Nuclear protein accumulation by facilitated transport and intranuclear binding
226. Nuclear envelope permeability
227. Nuclear import of U snRNPs requires importin beta
228. Importin beta can mediate the nuclear import of an argininerich nuclear localization signal in the absence of importin alpha
229. Molecular dissection of the nuclear pore complex
230. Interactions and three-dimensional localization of a group of nuclear pore complex proteins
231. CRM1-mediated recycling of snurportin 1 to the cytoplasm
232. Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97
233. High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2
234. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore protein p62
235. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway
236. Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease
237. A repeating amino acid motif shared by proteins with diverse cellular roles
238. A distinct and parallel pathway for the nuclear import of an mRNA-binding protein
239. Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting
240. Disruption of the nucleoporin gene NUP133 results in clustering of nuclear pore complexes
241. Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import
242. Yeast mutant, rna1, affects the entry into polysomes of ribosomal RNA as well as messenger RNA
243. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
244. 3G cap hypermethylation of U1 small nuclear ribonucleoprotein (snRNP) in vitro: Evidence that the U1 small nuclear RNA-(guanosine-N2)-methyltransferase is a non-snRNP cytoplasmic protein that requires a binding site on the Sm core domain
245. Nuclear export pathways of tRNA and 40 S ribosomes include both common and specific intermediates
246. The HIV-1 Rev protein
247. A novel receptor-mediated nuclear protein import pathway
248. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex
249. The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways
250. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like Nup98 motif at the nuclear pore complex through multiple domains
251. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
252. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
253. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components
254. Ran/TC4: A small nuclear GTP-binding protein that regulates DNA synthesis
255. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
256. The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy
257. NTF2 mediates nuclear import of Ran
258. Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export
259. A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1
260. The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1
261. Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores
262. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
263. A nuclear import pathway for a protein involved in tRNA maturation
264. Nuclear import and the evolution of a multifunctional RNA-binding protein
265. Isolation of the yeast nuclear pore complex
266. A distinct nuclear import pathway used by ribosomal proteins
267. The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export
268. RanBP2 associates with Ubc9p and a modified form of RanGAP 1
269. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
270. tRNA nuclear export in Saccharomyces cerevisiae: In situ hybridization analysis
271. Identification and functional analysis of the nuclear localization signals of ribosomal protein L25 from Saccharomyces cerevisiae
272. The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm
273. Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
274. Mutants in a yeast Ran binding protein are defective in nuclear transport
275. Dbp5, a DEAD box-protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
276. Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran
277. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
278. Importin/karyopherin protein family members required for mRNA export from the nucleus
279. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(a)+ RNA and nuclear pores
280. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: Discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL
281. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1
282. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Np13p
283. Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominantnegative inhibitors
284. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr
285. A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases
286. The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl and glutamyl tRNA synthesases
287. Nuclear pore proteins are involved in the biogenesis of functional tRNA
288. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores
289. A nuclear localization domain in the hnRNP A1 protein
290. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins
291. Nuclear import of ran is mediated by the transport factor NTF2
292. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
293. Cse1p is involved in export of yeast importin alpha from the nucleus
294. Exportin 1 (Crm1p) is an essential nuclear export factor
295. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran
296. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
297. The yeast nucleoporin rip 1 p contributes to multiple export pathways with no essential role for its FG-repeat region
298. Nuclear RNA export
299. A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm
300. The hrp23 protein in the Balbiani ring pre-mRNP particles is released just before or at the binding of the particles to the nuclear pore complex
301. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export
302. Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue
303. Two functionally distinct domains generated by in vivo cleavage of Nup145p: A novel biogenesis pathway for nucleoporins
304. tRNA nuclear transport: Defining the critical regions of human transfer I-met by point mutagenesis
305. Trans-acting factors in ribosome synthesis
306. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint
307. The argininerich domains present in human immunodeficiency virus type 1 tat and rev function as direct importin beta-dependent nuclear localization signals
308. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
309. Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression
310. The nucleoporin nup153 plays a critical role in multiple types of nuclear export
311. Structural view of the Ran-Importin β interaction at 2.3 Å resolution
312. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: Implications for nuclear transport
313. A premRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes
314. A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export
315. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection
316. Nuclear export of actin: A novel mechanism regulating the subcellular localization of a major cytoskeletal protein
317. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export
318. Nucleocytoplasmic distribution of human hnRNP proteins: A search for the targeting domains in hnRNP A1
319. Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities
320. Identification of hSRP1a as a functional receptor for nuclear localization sequences
321. The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import
322. Identification of a signal for rapid export of proteins from the nucleus
323. A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic
324. NUP145 encodes a novel yeast glycine-leucine-phenylalanineglycine (GLFG) nucleoporin required for nuclear envelope structure
325. Nuclear import and export of viruses and virus genomes
326. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
327. The trials and travels of tRNA
328. Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport
329. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin, a homologous domain, and a leucine-rich region
330. Identification of two RNA-binding proteins in Balbiani ring premessenger ribonucleoprotein granules and presence of these proteins in specific subsets of heterogeneous nuclear ribonucleoprotein particles
331. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae
332. Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor
333. Control of cyclin B 1 localization through regulated binding of the nuclear export factor CRM 1
334. Three-dimensional architecture of the isolated yeast nuclear pore complex: Functional and evolutionary implications
335. Cloning and characterization of human karyopherin beta3
336. Beta-catenin can be transported into the nucleus in a Ran-unassisted manner
337. A giant nucleopore protein that binds Ran/TC4
338. tRNA transport from the nucleus in a eukaryotic cell: Carrier-mediated translocation process
339. Met
340. Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1
341. Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes