Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

Nature

Volumn 397, Issue 6721, 1999, Pages 710-713

  Ulloa, Luis ^a   Doody, Jacqueline ^a   Massagué, Joan ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL CULTURE; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; JANUS KINASE 1; LUCIFERASES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD7 PROTEIN; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033602101     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/17826     Document Type: Article

References (30)

1. Letterio, J. L. & Roberts, A. B. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16, 137-161 (1998).
2. Czarnieki, C. W., Chiu, H. H., Wong, C. H., McCabe, S. M. & Palladino, M. A. Transforming growth factor-β1 modulates the expression of class II histocompatibility antigens on human cells. J. Immunol. 140, 4217-4223 (1988).
3. Bauvois, B., Rouillard, D., Sanceau, J. & Wietzerbin, J, IFN-γ and transforming growth factor-β1 differently regulate fibronectin and laminin receptors of human differentiating monocytic cells. J. Immunol. 148, 3912-3919 (1992).
4. + T cells requires the coordinate action of interleukin-12 and Interferon-γ and is inhibited by transforming growth factor-β. Eur. J. Immunol. 24, 793-798 (1994).
5. Xiao, B. G., Zhang, G. X., Ma, C. G. & Link, H. Transforming growth factor-β1 (TGF-β1)- mediated inhibition of glial cell proliferation and down-regulation of intercellular adhesion molecule-1 (ICAM-1) are interrupted by interferon-γ (IFN-γ). Clin. Exp. Immunol 103, 475-481 (1996).
6. Stark, G. R., Kerr, I. M., Williams, B. R., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264 (1998).
7. Massague, J. TGFβ signal transduction. Annu. Rev. Biochem. 67, 753-791 (1998).
8. Heldin, C.-H., Miyazono, K. & ten Dijke, P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471 (1997).
9. Schindler, C. & Darnell, J. F. Transcriptional responses to polypeptide ligands: the Jak-Stat pathway. Annu. Rev. Biochem. 64, 621-651 (1995).
10. Ihle, J. N. Cytokine receptor signalling. Nature 377, 591-594 (1995).
11. Hayashi, H. et al. The MAD-related protein Smad7 associated with the TGFβ receptor and functions as an antagonist of TGFβ signalling. Cell 89, 1165-1173 (1997).
12. Sakao, A. et al. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389, 631-635 (1997).
13. Muller, M. et al. The protein tyrosine kinase Jak1 complements defects in inferferon-α/β and -γ signal transduction. Nature 366, 129-135 (1993).
14. Cácamo, J. et al. Type I receptors specify growth inhibitory and transcriptional responses to TGF-β and activin. Mol. Cell Biol. 14, 3810-3821 (1994).
15. Chen, X., Rubock, M. J. & Whitman, M. A transcriptional partner of MAD proteins in TGF-β signalling. Nature 383, 691-696 (1996).
16. Liu, F., Pouponnot, C. & Massague, J. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional responses. Genes Dev. 11, 3157-3167 (1997).
17. Kretzschmar, M., Doody, J. & Massagué, J. Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1. Nature 389, 618-622 (1997).
18. Sakatsume, M. et al. Interferon γ activation of Raf-1 is Jak1 -dependent and p21ras-independent. J. Biol. Chem. 273, 3021-3026 (1998).
19. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. & Saltiel, A. R. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl Acad. Sci. USA 92, 7686-7689 (1995).
20. Muller, M. et al. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of the ISGF3 in the interferon-α and -γ signal transduction pathways. EMBO J. 12, 4221-4228 (1993).
21. Spittler, A. et al. Effects of 1 α,25-dihydroxyvitamin D3 and cytokines on the expression of MHC antigens, complement receptors and other antigens on human blood monocytes and U937 cells: role in cells differentiation, activation and phagocytosis. Immunology 90, 286-293 (1997).
22. Lee, K., Tanaka, M., Hatanaka, M. & Kuze, F. Reciprocal effects of epidermal growth factor and transforming growth factor and transforming growth factor β on the anchorage-dependent and -independent growth of A431 epidermoid carcinoma cells. Exp. Cell Res. 173, 156-162 (1987).
23. Kumar, R. & Mendelsohn, J. Growth regulation of A431 cells. Modulation of expression of transforming growth factor-α mRNA and 2′,5′ -oligoadenylate synthetase activity. J. Biol. Chem. 265, 4578-4582 (1990).
24. Souchelnytskyi, S. et al. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors. J. Biol. Chem. 273, 25364-25370 (1998).
25. Ohta, M., Greenberger, J. S., Anklesaria, P., Bassols, A. & Massagué, J. Two forms of transforming growth factor-β distinguished by multipotential hematopoietic progenitor cells. Nature 329, 539-541 (1987).
26. Zhang, Y., Feng, X.-H., Wu, R.-Y. & Derynck, R. Receptor-associated Mad homologues synergize as efectors of the TGFβ response. Nature 383, 168-172 (1996).
27. Lagna, G., Hata, A., Hemmati-Brivanlou, A. & Massagué, J. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383, 832-836 (1996).
28. Tu, G. C., Cao, Q.-N., Zhou, F. & Israel, Y. Tetranucleotide GGGA motif in primary RNA transcripts. Novel target for antisense design. J. Biol. Chem. 273, 25125-25131 (1998).
29. Hata, A., Lagna, G., Massagué, J. & Hemmati-Brivanlou, A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12, 186-197 (1998).
30. Massagué, J. Identification of receptors of type β transforming growth factor. Methods Enzymol. 146, 174-195 (1987).