Activation of transforming growth factor-β signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

Journal of Biological Chemistry

Volumn 278, Issue 21, 2003, Pages 18714-18719

  Lin, Xia ^a   Liang, Min ^a   Liang, Yao Yun ^a   Brunicardi, F Charles ^a   Melchior, Frauke ^b   Feng, Xin Hua ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; PROTEINS; TUMORS;

PHOSPHORYLATION;

BIOCHEMISTRY;

CARRIER PROTEIN; ENZYME; FAST PROTEIN; LYSINE; PROTEIN; PROTEIN UBC9; RECEPTOR; SMAD PROTEIN; SMAD4 PROTEIN; SUMO 1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HYBRID PROTEIN; LIGASE; LUCIFERASE; SMAD4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME UBC9; UBIQUITIN-CONJUGATING ENZYME UBC9;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; EMBRYO; GENE OVEREXPRESSION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SUMOYLATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL; DNA RESPONSIVE ELEMENT; DRUG EFFECT; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; GENETIC TRANSFECTION; GENETICS; HAMSTER; HELA CELL; KIDNEY; LUNG; METABOLISM; MINK; MOLECULAR GENETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; TUMOR SUPPRESSOR GENE;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; DNA-BINDING PROTEINS; DRUG STABILITY; EMBRYO; GENE DELETION; GENES, TUMOR SUPPRESSOR; HELA CELLS; HUMANS; IMMUNOSORBENT TECHNIQUES; KIDNEY; LIGASES; LUCIFERASES; LUNG; LYSINE; MINK; MOLECULAR SEQUENCE DATA; MUTAGENESIS; RECOMBINANT FUSION PROTEINS; RESPONSE ELEMENTS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; SUMO-1 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-CONJUGATING ENZYMES;

EID: 0037805684     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302243200     Document Type: Article

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