Schnurri mediates Dpp-dependent repression of brinker transcription

Nature Cell Biology

Volumn 2, Issue 10, 2000, Pages 745-749

  Marty, Thomas ^a   Müller, Bruno ^b   Basler, Konrad ^b   Affolter, Markus ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE ACTIVATION; GENE MUTATION; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; XENOPUS;

ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT PROTEINS; MODELS, GENETIC; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0242620396     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35036383     Document Type: Article

References (27)

1. Raftery, L. A. & Sutherland, D. J. TGF-β family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210, 251-268 (1999).
2. Massagué, J. TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791 (1998).
3. Massagué, J. & Wotton, D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19, 1745-1754 (2000).
4. Campbell, G. & Tomlinson, A. Transducing the Dpp morphogen gradient in the wing of Drosophila: Regulation of Dpp targets by brinker. Cell 96, 553-562 (1999).
5. Jaźwińska, A., Kirov, N., Wieschaus, E., Roth, S. & Rushlow, C. The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell 96, 563-573 (1999).
6. Minami, M., Kinoshita, N., Kamoshida, Y., Tanimoto, H. & Tabata, T. brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes. Nature 398, 242-246 (1999).
7. Jaźwińska, A., Rushlow, C. & Roth, S. The role of brinker in mediating the graded response to Dpp in early Drosophila embryos. Development 126, 3323-3334 (1999).
8. Arora, K. et al. The Drosophila schnurri gene acts in the Dpp/TGFβ signalling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81, 781-790 (1995).
9. Grieder, N. C., Nellen, D., Burke, R., Basler, K. & Affolter, M. schnurri is required for Drosophila Dpp signalling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BFI. Cell 81, 791-800 (1995).
10. Staehling-Hampton, K., Laughon, A.S. & Hoffmann, F.M. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signalling. Development 121, 3393-3403 (1995).
11. Burke, R. & Basler, K. Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269 (1996).
12. Bienz, M. Induction of the endoderm in Drosophila. Sem. Cell Dev. Biol. 7, 113-119 (1996).
13. Tsuneizumi, K. et al. Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389, 627-631 (1997).
14. Nellen, D., Burke, R., Struhl, G. & Basler, K. Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368 (1996).
15. Lecuit, T. et al. Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing. Nature 381, 387-393 (1996).
16. 16. Kim, J. et al. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigal gene. Nature 382, 133-138.
17. Kim, J., Hohnson, K., Chen, H. J., Carroll, S & Laughon, A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308.
18. Udagawa, Y. et al. Schnurri interacts with Mad in a Dpp-dependent manner. Genes to Cell 5, 359-370 (2000).
19. Certel, K., Hudson, A., Carroll, S. B. & Johnson, W. A. Restricted patterning of vestigal expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the Drifter POU domain transcription factor. Development 127, 3173-3183 (2000).
20. Fan, C. M.& Maniatis, T. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev. 4, 29-42 (1990).
21. Mitchelmore, C., Traboni, C. & Cortese, R. Isolation of two cDNAs encoding zinc finger proteins which bind to the al-antitrypsin promoter and to the major histocompatibility complex class I enhancer. Nucleic Acids Res. 19, 141-147 (1990).
22. Baldwin, A. S. Jr, LeClair, K. P., Singh, H. & Sharp, P. A. A large protein containing zinc finger domains bind to related sequence elements in the enhancer of the class I major histocompatibility complex and kappa immunoglobulin genes. Mol. Cell Biol. 10, 1406-1414 (1990).
23. Brand, A. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415 (1993).
24. Grieder, N. C. Involvement of the zinc finger protein encoded by the schnurri gene of Drosophila melanogaster in the signal transduction pathway of Dpp. PhD Thesis, Univ. Basel, Switzerland (1997).
25. Ruberte, E., Marty, T., Nellen, D., Affolter, M. & Basler, K. An absolute requirement for both the type II and type I receptors, Punt and thick veins, for Dpp signaling in vivo. Cell 80, 890-898 (1995).
26. Martin-Bermudo, M. D., Dunin-Borkowski, O. M. & Brown, N. H. Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain. EMBO J. 16, 4184-4193 (1997).
27. Tautz, D. & Pfeifle, C. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals a translational control of the segmentation gene hunchback. Chromosoma 98, 81-85 (1989).