Cytoplasmic PML function in TGF-β signalling

Nature

Volumn 431, Issue 7005, 2004, Pages 205-211

  Lin, Hui Kuan ^a   Bergmann, Stephan ^a   Pandolfi, Pler Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; GENES; PATHOLOGY; PROTEINS; TUMORS;

APOPTOSIS; CELLULAR SENESCENCE; GROWTH FACTORS; LEUKEMIA;

CELLS;

ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; SMAD ANCHOR FOR RECEPTOR ACTIVATION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

BIOLOGY;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOPLASM; ENDOSOME; GROWTH DISORDER; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NULL CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CARRIER PROTEINS; CELL AGING; CELL DIVISION; CELL LINE; CELL LINE, TUMOR; CYTOPLASM; DNA-BINDING PROTEINS; ENDOSOMES; FIBROBLASTS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 4544256756     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02783     Document Type: Article

References (30)

1. Derynck, R., Akhurst, R. J. & Balmain, A. TGF-β signaling in tumor suppression and cancer progression. Nature Genet. 29, 117-129 (2001).
2. Siegel, P. M. & Massague, J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nature Rev. Cancer 3, 807-820 (2003).
3. Attisano, L. & Wrana, J. L. Signal transduction by the TGF-β superfamily. Science 296, 1646-1647 (2002).
4. Kim, S. J. & Letterio, J. Transforming growth factor-β signaling in normal and malignant hematopoiesis. Leukemia 17, 1731-1737 (2003).
5. Jensen, K., Shiels, C. & Freemont, P. S. PML protein isoforms and the RBCC/TRIM motif. Oncogene 20, 7223-7233 (2001).
6. Fagioli, M. et al. Alternative splicing of PW transcripts predicts coexpression of several carboxy-terminally different protein isoforms. Oncogene 7, 1083-1091 (1992).
7. Melnick, A. & Licht, J. D. Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93, 3167-3215 (1999).
8. Salomoni, P. & Pandolfi, P. P. The role of PML in tumor suppression. Cell 108, 165-170 (2002).
9. Kastner, P. et al. Structure, localization and transcriptional properties of two classes of retinoic acid receptor α fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO 11, 629-642 (1992).
10. Ferbeyre, G. et al. PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 14, 2015-2027 (2000).
11. Pearson, M. et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210 (2000).
12. Katakura, Y., Nakata, E., Miura, T. & Shirahata, S. Transforming growth factor β triggers two independent-senescence programs in cancer cells. Biochem. Biophys. Res. Commun. 255, 110-115 (1999).
13. Tsukazaki, T., Chiang, T. A., Davison, A. F., Attisano, L. & Wrana, J. L. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 95, 779-791 (1998).
14. Di Guglielmo, G. M., Le Roy, C., Goodfellow, A. F. & Wrana, J. L. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nature Cell Biol. 5, 410-421 (2003).
15. Panopoulou, E. et al. Early endosomal regulation of Smad-dependent signaling in endothelial cells. J. Biol. Chem. 277, 18046-18052 (2002).
16. Hayes, S., Chawla, A. & Corvera, S. TGF β receptor internalization into EEA1-enriched early endosomes: enclosomes: role in signaling to Smad2. J. Cell. Biol. 158, 1239-1249 (2002).
17. Testa, U. et al. pML/RAR α+U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3. Cancer Res. 54, 4508-4515 (1994).
18. Grignani, E. et al. The acute promyelocytic leukemia-specific PML-RAR α fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74, 423-431 (1993).
19. Testa, U. et al. Transforming growth factor-β potentiates vitamin D3-induced terminal monocytic differentiation of human leukemic cell lines. J. Immunol. 150, 2418-2430 (1993).
20. Zhu, J., Chen, Z., Lallemand-Breitenbach, V. & de The, H. How acute promyelocytic leukaemia revived arsenic. Nature Rev. Cancer 2, 705-713 (2002).
21. Turelli, P. et al. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. Mol. Cell 7, 1245-1254 (2001).
22. Cordenonsi, M. et al. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113, 301-314 (2003).
23. Gurrieri, C. et al. Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J. Natl Cancer Inst. 96, 269-279 (2004).
24. Howe, J. R. et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 280, 1086-1088 (1998).
25. Miyaki, M. et al. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18, 3098-3103 (1999).
26. Wang, Z. G. et al. Role of PML in cell growth and the retinoic acid pathway. Science 279, 1547-1551 (1998).
27. Kang, H. Y. et al. From transforming growth factor-β signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proc. Natl Acad. Sci. USA 98, 3018-3023 (2001).
28. Lin, H. K., Wang, L., Hu, Y. C., Altuwaijri, S. & Chang, C. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21, 4037-4048 (2002).
29. Kurokawa, M. et al. The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3. Nature 394, 92-96 (1998).
30. Escola, J. M., Grivel J. C., Chavrier, P. & Gorvel, J. P. Different endocytic compartments are involved in the tight association of class II molecules with processed hen egg lysozyme and ribonuclease A in B cells. J. Cell Sci. 108, 2337-2345 (1995).