Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Molecular and Cellular Biology

Volumn 24, Issue 6, 2004, Pages 2546-2559

  Frederick, Joshua P ^a   Liberati, Nicole T ^a,d   Waddell, David S ^a   Shi, Yigong ^b   Wang, Xiao Fan ^a,c  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c Dept of Pharmacol and Cancer Biol ^*  (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F4; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING SITE; CELL GROWTH; CONSENSUS SEQUENCE; CYTOSTASIS; DNA RESPONSIVE ELEMENT; GENE REPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPRESSIVE SMAD BINDING ELEMENT; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; TRANSFORMING GROWTH FACTOR BETA INHIBITORY ELEMENT;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CELL LINE; DNA; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F4 TRANSCRIPTION FACTOR; GENES, MYC; HUMANS; MICE; MICE, KNOCKOUT; MUTAGENESIS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; RNA, MESSENGER; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 1542314236     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.6.2546-2559.2004     Document Type: Article

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