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Volumn 389, Issue 6651, 1997, Pages 618-622

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR; TRANSCRIPTION FACTOR;

EID: 0030773834     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/39348     Document Type: Article
Times cited : (778)

References (34)
  • 2
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan, B. L. M. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1580-1594
    • Hogan, B.L.M.1
  • 3
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGFβ-regutated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert, K. et al. MADR2 maps to 18q21 and encodes a TGFβ-regutated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543-552 (1996).
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1
  • 4
    • 0029940972 scopus 로고    scopus 로고
    • Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily
    • Graff, J. M., Bansal, A. & Melton, D. A. Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85, 479-487 (1996).
    • (1996) Cell , vol.85 , pp. 479-487
    • Graff, J.M.1    Bansal, A.2    Melton, D.A.3
  • 5
    • 0029892494 scopus 로고    scopus 로고
    • MADR1, a MAD-related protein that functions in BMP2 signalling pathways
    • Hoodless, P. A. et al. MADR1, a MAD-related protein that functions in BMP2 signalling pathways. Cell 85, 489-500 (1996).
    • (1996) Cell , vol.85 , pp. 489-500
    • Hoodless, P.A.1
  • 6
    • 0030911104 scopus 로고    scopus 로고
    • The TGFβ family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar, M., Liu, F., Hata, A., Doody, I. & Massagué, J. The TGFβ family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11, 984-995 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, I.4    Massagué, J.5
  • 7
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna, G., Hata, A., Hemmatí-Brivanlou, A. & Massague, J. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383, 832-836 (1996).
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmatí-Brivanlou, A.3    Massague, J.4
  • 8
  • 9
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGFβ receptor and phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva, M. et al. MADR2 is a substrate of the TGFβ receptor and phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224 (1996).
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1
  • 10
    • 0029833909 scopus 로고    scopus 로고
    • Mammalian Dwarfins are phosphorylated in response to TGF-β and are implicated in control of cell growth
    • Yingling, J. M. et al. Mammalian Dwarfins are phosphorylated in response to TGF-β and are implicated in control of cell growth. Proc. Natl Acad. Sci. USA 93, 8940-8944 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 8940-8944
    • Yingling, J.M.1
  • 11
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, mMadr-2, functions in the activin signal transduction pathway
    • Baker, J. & Harland, R. M. A novel mesoderm inducer, mMadr-2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880-1889 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1880-1889
    • Baker, J.1    Harland, R.M.2
  • 12
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • Lui, F. et al. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620-623 (1996).
    • (1996) Nature , vol.381 , pp. 620-623
    • Lui, F.1
  • 13
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner of MAD proteins in TGF-β signalling
    • Chen, X., Rubock, M. J. & Whitman, M. A transcriptional partner of MAD proteins in TGF-β signalling. Nature 383, 691-696 (1996).
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 14
    • 0027452636 scopus 로고
    • FGF-4 and BMP-2 have opposite effects on limb growth
    • Niswander, L. & Martin, G. R. FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361, 68-71 (1993).
    • (1993) Nature , vol.361 , pp. 68-71
    • Niswander, L.1    Martin, G.R.2
  • 15
    • 0029831470 scopus 로고    scopus 로고
    • Role of TGFβs and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod
    • Ganan, Y., Macias, D., Duterque-Coquillaud, M., Ros, M. A. & Hurle, J. M. Role of TGFβs and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod. Development 122, 2349-2357 (1996).
    • (1996) Development , vol.122 , pp. 2349-2357
    • Ganan, Y.1    Macias, D.2    Duterque-Coquillaud, M.3    Ros, M.A.4    Hurle, J.M.5
  • 16
    • 0026634708 scopus 로고
    • Effect of protein and steroidal osteotropic agents on differentiation and epidermal growth factor-mediated growth of the CFK1 osseous cell line
    • Bernier, S. M & Goltzman, D. Effect of protein and steroidal osteotropic agents on differentiation and epidermal growth factor-mediated growth of the CFK1 osseous cell line. J. Cell Physiol. 152, 317-327 (1992).
    • (1992) J. Cell Physiol. , vol.152 , pp. 317-327
    • Bernier, S.M.1    Goltzman, D.2
  • 17
    • 0038028264 scopus 로고    scopus 로고
    • Antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation
    • Neubüser, A., Peters, H., Balling, R. & Martin, G. R. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90, 247-255 (1997).
    • (1997) Cell , vol.90 , pp. 247-255
    • Neubüser, A.1    Peters, H.2    Balling, R.3    Martin, G.R.4
  • 18
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
    • Hata, A., Lo, R. S., Wotton, D., Lagna, G. & Massagué, J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4, Nature 388, 82-87 (1997).
    • (1997) Nature , vol.388 , pp. 82-87
    • Hata, A.1    Lo, R.S.2    Wotton, D.3    Lagna, G.4    Massagué, J.5
  • 19
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim, J., Johnson, K., Chen, H. J., Carroll, S. & Laughon, A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308 (1997).
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 20
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang, Y., Feng, X.-H, Wu, R.-Y. & Derynck, R. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172 (1996).
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.-H.2    Wu, R.-Y.3    Derynck, R.4
  • 21
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interactions correlate with signalling activity and functional cooperativky of Smad3 and Smad4/DPC4
    • Wu, R.-Y., Zhang, Y., Feng, X.-H. & Derynck, R. Heteromeric and homomeric interactions correlate with signalling activity and functional cooperativky of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17, 2521-2528 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2521-2528
    • Wu, R.-Y.1    Zhang, Y.2    Feng, X.-H.3    Derynck, R.4
  • 22
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn, S.A. et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353 (1996).
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1
  • 23
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • Shi, Y., Hata, A., Lo, R. S., Massague, J. & Pavletich, N. P. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87-93 (1997).
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massague, J.4    Pavletich, N.P.5
  • 24
    • 0031128153 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 as a central mediator of Smad function
    • Zhang, Y., Musci, T. & Derynck, R. The tumor suppressor Smad4/DPC4 as a central mediator of Smad function. Curr. Biol. 7, 270-276 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 270-276
    • Zhang, Y.1    Musci, T.2    Derynck, R.3
  • 25
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • Hill, C. S. & Treisman, R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80, 199-211 (1995).
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 27
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall, C. J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185 (1995).
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 28
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke, T. F., Kaplan, D. R. & Cantley, L. C. PI3K: downstream AKTion blocks apoptosis. Cell 88, 435-437 (1997).
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 29
    • 0031045203 scopus 로고    scopus 로고
    • Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2
    • Besser, D. et al. Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2. Oncogene 14, 705-711 (1997).
    • (1997) Oncogene , vol.14 , pp. 705-711
    • Besser, D.1
  • 30
    • 0027233448 scopus 로고
    • Signal transduction via the MAP kinases: Proceed at your own RSK
    • Blenis, J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl Acad. Sci. USA 90, 5889-5892 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 5889-5892
    • Blenis, J.1
  • 31
    • 0028332818 scopus 로고
    • Identification of type I receptors for Osteogenic Protein-1 and Bone Morphogenetic Protein-4
    • ten Dijke, P. et al. Identification of type I receptors for Osteogenic Protein-1 and Bone Morphogenetic Protein-4. J. Biol. Chem. 269, 16985-16988 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 16985-16988
    • Ten Dijke, P.1
  • 32
    • 0023472472 scopus 로고
    • Tricrne-sodium dodecyt sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
    • Schagger, H. & von Jagow, G. Tricrne-sodium dodecyt sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem. 166, 368-379 (1987).
    • (1987) Anal Biochem. , vol.166 , pp. 368-379
    • Schagger, H.1    Von Jagow, G.2
  • 33
    • 0030996361 scopus 로고    scopus 로고
    • Synergistic activation of transcription by CBP and p53
    • Gu, W., Shi, X.-L. & Roeder, R. G. Synergistic activation of transcription by CBP and p53, Nature 387, 819-823 (1997).
    • (1997) Nature , vol.387 , pp. 819-823
    • Gu, W.1    Shi, X.-L.2    Roeder, R.G.3
  • 34
    • 0030816043 scopus 로고    scopus 로고
    • TGF-β signalling through the Smad pathway
    • Massagué, J., Hata, A. & Liu, F. TGF-β signalling through the Smad pathway. Trends Cell Biol. 7, 187-192 (1997).
    • (1997) Trends Cell Biol. , vol.7 , pp. 187-192
    • Massagué, J.1    Hata, A.2    Liu, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.