Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

Journal of Cell Biology

Volumn 162, Issue 6, 2003, Pages 1089-1098

  Foletta, Victoria C ^a,c   Lim, Mei Ann ^a,d   Soosairaiah, Juliana ^a   Kelly, April P ^a,e   Stanley, Edouard G ^a   Shannon, Mark ^a   He, Wei ^b   Das, Supratik ^b,f   Massagué, Joan ^b   Bernard, Ora ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c DEAKIN UNIVERSITY   (Australia)

^d Mays Cancer Center at UT Health San Antonio   (United States)

^e State Key Laboratory of Plant Physiology and Biochemistry   (United Kingdom)

^f UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

BMPR II; Cofilin; Cytoskeleton; F actin; LIM kinase 1

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CELL PROTEIN; COFILIN; PROTEIN LIMK1; SMAD PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; COS CELLS; CYTOSKELETON; DNA-BINDING PROTEINS; EUKARYOTIC CELLS; HUMANS; HYPERTENSION, PULMONARY; MUTATION; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; UP-REGULATION;

ANIMALIA;

EID: 0141656297     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200212060     Document Type: Article

References (35)

1. Aberle, H., A.P. Haghighi, R.D. Fetter, B.D. McCabe, T.R. Magalhaes, and C.S. Goodman. 2002. Wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron. 33:545-558.
2. Allan, D.W., S.E. Pierre, I. Miguel-Aliaga, and S. Thor. 2003. Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell. 113:73-86.
3. Arber, S., F.A. Barbayannis, H. Hanser, C. Schneider, CA. Stanyon, O. Bernard, and P. Caroni. 1998. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature. 393:805-809.
4. Bernard, O., S. Ganiatsas, G. Kannourakis, and R. Dringen. 1994. Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 5:1159-1171.
5. Birkenfeld, J., H. Betz, and D. Roth. 2003. Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 4. Biochem. J. 369:45-54.
6. Brymora, A., M.A. Cousin, B.D. Roufogalis, and P.J. Robinson. 2001. Enhanced protein recovery and reproducibility from pull-down assays and immuno-precipitations using spin columns. Anal. Biochem. 295:119-122.
7. Chan, A.Y., M. Bailly, N. Zebda, J.E. Segall, and J.S. Condeelis. 2000. Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion. J. Cell. Biol. 148:531-542.
8. Chen, C.R., Y. Kang, P.M. Siegel, and J. Massague. 2002. E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression. Cell. 110:19-32.
9. Condeelis, J. 2001. How is actin polymerization nucleated in vivo? Trends Cell Biol. 11:288-293.
10. Dan, C., A. Kelly, O. Bernard, and A. Minden. 2001. Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J. Biol. Chem. 276:32115-32121.
11. Edwards, D.C., L.C. Sanders, G.M. Bokoch, and G.N. Gill. 1999. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell. Biol. 1:253-259.
12. Eng, C. 2001. To be or not to BMP. Nat. Genet. 28:105-107.
13. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature. 340:245-246.
14. Gohla, A., and G.M. Bokoch. 2002. 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr. Biol. 12:1704-1710.
15. Harlow, E., and P. Lane. 1999. Using Antibodies. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 495 pp.
16. Hogan, B.L. 1996. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10:1580-1594.
17. Huang, D.C., S. Cory, and A. Strasser. 1997. Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene. 14:405-414.
18. Kuroda, S., C. Tokunaga, Y. Kiyohara, O. Higuchi, H. Konishi, K. Mizuno, G.N. Gill, and U. Kikkawa. 1996. Protein-protein interaction of zinc finger LIM domains with protein kinase C. J. Biol. Chem. 271:31029-31032.
19. Lane, K.B., R.D. Machado, M.W. Pauciulo, J.R. Thomson, J.A. Phillips, III, J.E. Loyd, W.C. Nichols, and R.C. Trembath. 2000. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat. Gene. 26:81-84.
20. Larson, R.C., I. Lavenir, T.A. Larson, R. Baer, A.J. Warren, I. Wadman, K. Nottage, and T.H. Rabbitts. 1996. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 15:1021-1027.
21. Liu, F., F. Ventura, J. Doody, and J. Massague. 1995. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol. Cell. Biol. 15:3479-3486.
22. Liu, J.P., and T.M. Jessell. 1998. A role for rhoB in the delamination of neural crest cells from the dorsal neural tube. Development. 125:5055-5067.
23. Machado, R.D., M.W. Pauciulo, J.R. Thomson, K.B. Lane, N.V. Morgan, L. Wheeler, J.A. Phillips, III, J. Newman, D. Williams, N. Galie, et al. 2001. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am. J. Hum. Genet. 68:92-102.
24. Maekawa, M., T. Ishizaki, S. Boku, N. Watanabe, A. Fujita, A. Iwamatsu, T. Obinata, K. Ohashi, K. Mizuno, and S. Narumiya. 1999. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science. 285:895-898.
25. Massague, J., S.W. Blain, and R.S. Lo. 2000. TGFβ signaling in growth control, cancer, and heritable disorders. Cell. 103:295-309.
26. Morrell, N.W., X. Yang, P.D. Upton, K.B. Jourdan, N. Morgan, K.K. Sheares, and R.C. Trembath. 2001. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-β1 and bone morphogenetic proteins. Circulation. 104:790-795.
27. Nishihara, A., T. Watabe, T. Imamura, and K. Miyazono. 2002. Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol. Biol. Cell. 13:3055-3063.
28. O'Reilly, L.A., L. Cullen, K. Moriishi, L. O'Connor, D.C. Huang, and A. Strasser. 1998. Rapid hybridoma screening method for the identification of monodonal antibodies to low-abundance cytoplasmic proteins. Biotechniques. 25:824-830.
29. Shi, Y., and J. Massague. 2003. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell. 113:685-700.
30. Thomson, J.R., R.D. Machado, M.W. Pauciulo, N.V. Morgan, M. Humbert, G.C. Elliott, K. Ward, M. Yacoub, G. Mikhail, P. Rogers, et al. 2000. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family. J. Med. Genet. 37:741-745.
31. Wang, J.Y., K.E. Frenzel, D. Wen, and D.L. Falls. 1998. Transmembrane nettregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition. J. Biol. Chem. 273:20525-20534.
32. Wieser, R., L. Attisano, J.L. Wrana, and J. Massague. 1993. Signaling activity of transforming growth factor β type II receptors lacking specific domains in the cytoplasmic region. Mol. Cell. Biol 13:7239-7247.
33. Yang, N., O. Higuchi, K. Ohashi, K. Nagata, A. Wada, K. Kangawa, E. Nishidi, and K. Mizuno. 1998. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature. 393:809-812.
34. Yoshioka, K., V. Foletta, O. Bernard, and K. Itoh. 2003. A role for LIM kinase in cancer invasion. Proc. Natl. Acad. Sci. USA. 100:7247-7252.
35. Zebda, N., O. Bernard, M. Bailly, S. Welti, D.S. Lawrence, and J.S. Condeelis. 2000. Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension. J. Cell. Biol. 151:1119-1128.