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Volumn 12, Issue 2, 1998, Pages 186-197

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

Author keywords

Antagonist; BMP receptors; Mammalian cells; Smad proteins; TGF ; Xenopus

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CELL PROTEIN; SMAD1; SMAD4; SMAD6; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 0031964859     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.2.186     Document Type: Article
Times cited : (605)

References (54)
  • 3
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, mMadr-2, functions in the activin signal transduction pathway
    • Baker, J. and R.M. Harland. 1996. A novel mesoderm inducer, mMadr-2, functions in the activin signal transduction pathway. Genes & Dev. 10: 1880-1889.
    • (1996) Genes & Dev. , vol.10 , pp. 1880-1889
    • Baker, J.1    Harland, R.M.2
  • 4
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner of MAD proteins in TGF-β signalling
    • Chen, X., M.J. Rubock, and M. Whitman. 1996. A transcriptional partner of MAD proteins in TGF-β signalling. Nature 383: 691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 6
    • 0030969573 scopus 로고    scopus 로고
    • Embryonic patterning: To BMP or not to BMP, that is the question
    • Graff, J.M. 1997. Embryonic patterning: to BMP or not to BMP, that is the question. Cell 89: 171-174.
    • (1997) Cell , vol.89 , pp. 171-174
    • Graff, J.M.1
  • 7
    • 0028170038 scopus 로고
    • Studies with a Xenopus BMP Receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
    • Graff, J.M., R.S. Thies, J.J. Song, A.J. Celeste, and D.A. Melton. 1994. Studies with a Xenopus BMP Receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79: 169-179.
    • (1994) Cell , vol.79 , pp. 169-179
    • Graff, J.M.1    Thies, R.S.2    Song, J.J.3    Celeste, A.J.4    Melton, D.A.5
  • 8
    • 0029940972 scopus 로고    scopus 로고
    • Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily
    • Graff, J.M., A. Bansal, and D.A. Melton. 1996. Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85: 479-487.
    • (1996) Cell , vol.85 , pp. 479-487
    • Graff, J.M.1    Bansal, A.2    Melton, D.A.3
  • 10
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
    • Hata, A., R.S. Lo, D. Wotton, G. Lagna, and J. Massagué. 1997. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388: 82-87.
    • (1997) Nature , vol.388 , pp. 82-87
    • Hata, A.1    Lo, R.S.2    Wotton, D.3    Lagna, G.4    Massagué, J.5
  • 12
    • 0026660438 scopus 로고
    • A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
    • Hemmati-Brivanlou, A. and D.A. Melton. 1992. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359: 609-614.
    • (1992) Nature , vol.359 , pp. 609-614
    • Hemmati-Brivanlou, A.1    Melton, D.A.2
  • 13
  • 14
    • 0028270311 scopus 로고
    • Follistatin, an antagonist of activin is expressed in the Spemann organizer and displays direct neuralizing activity
    • Hemmati-Brivanlou, A., O.G. Kelly and D.A. Melton. 1994. Follistatin, an antagonist of activin is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 77: 283-295.
    • (1994) Cell , vol.77 , pp. 283-295
    • Hemmati-Brivanlou, A.1    Kelly, O.G.2    Melton, D.A.3
  • 15
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan, B.L.M. 1996. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes &. Dev. 10: 1580-1594.
    • (1996) Genes &. Dev. , vol.10 , pp. 1580-1594
    • Hogan, B.L.M.1
  • 18
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar, M., F. Liu, A. Hata, J. Doody, and J. Massagué. 1997. The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes & Dev. 11: 984-995.
    • (1997) Genes & Dev. , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, J.4    Massagué, J.5
  • 19
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways
    • Lagna, G., A. Hata, A. Hemmati-Brivanlou, and J. Massagué. 1996. Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways. Nature 383: 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massagué, J.4
  • 21
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • Liu, F., A. Hata, J. Baker, J. Doody, J. Cárcamo, R. Harland, and J. Massagué. 1996. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381: 620-623.
    • (1996) Nature , vol.381 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.3    Doody, J.4    Cárcamo, J.5    Harland, R.6    Massagué, J.7
  • 22
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
    • Liu, F., C. Puponnot, and J. Massagué. 1997. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes & Dev. 11: 3157-3167.
    • (1997) Genes & Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Puponnot, C.2    Massagué, J.3
  • 23
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGFβ receptor and phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva, M., S. Abdollah, P.A. Hoodless, R. Pirone, L. Attisano, and J.L. Wrana. 1996. MADR2 is a substrate of the TGFβ receptor and phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 24
    • 0030816043 scopus 로고    scopus 로고
    • TGF-β signalling through the Smad pathway
    • Massagué, J., A. Hata, and F. Liu. 1997. TGF-β signalling through the Smad pathway. Trends Cell Biol. 7: 187-192.
    • (1997) Trends Cell Biol. , vol.7 , pp. 187-192
    • Massagué, J.1    Hata, A.2    Liu, F.3
  • 25
    • 0029904671 scopus 로고    scopus 로고
    • Serine/threonine kinase receptors: Mediators of TGF-β family signals
    • (ed. T. Pawson and P. Parker), Imperial Cancer Research Fund, London, UK
    • Massagué, J. and F. Weis-Garcia. 1996. Serine/threonine kinase receptors: Mediators of TGF-β family signals. In Cancer Surveys (ed. T. Pawson and P. Parker), pp. 41-64. Imperial Cancer Research Fund, London, UK.
    • (1996) Cancer Surveys , pp. 41-64
    • Massagué, J.1    Weis-Garcia, F.2
  • 27
    • 0030018425 scopus 로고    scopus 로고
    • Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGFβ responsive cells
    • Newfeld, S.J., E.H. Chartoff, J.M. Graff, D.M. Melton, and W.M. Gelbart. 1996. Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGFβ responsive cells. Development 122: 2099-2108.
    • (1996) Development , vol.122 , pp. 2099-2108
    • Newfeld, S.J.1    Chartoff, E.H.2    Graff, J.M.3    Melton, D.M.4    Gelbart, W.M.5
  • 29
    • 0027967380 scopus 로고
    • Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
    • Sasai, Y., B. Lu, H. Steinbeisser, D. Geissert, L.K. Gont, and E.M. De Robertis. 1994. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79: 779-790.
    • (1994) Cell , vol.79 , pp. 779-790
    • Sasai, Y.1    Lu, B.2    Steinbeisser, H.3    Geissert, D.4    Gont, L.K.5    De Robertis, E.M.6
  • 30
    • 0029009530 scopus 로고
    • Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
    • Sasai, Y., B. Lu, H. Steinbeisser, and E.M. De Robertis. 1995. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376: 333-336.
    • (1995) Nature , vol.376 , pp. 333-336
    • Sasai, Y.1    Lu, B.2    Steinbeisser, H.3    De Robertis, E.M.4
  • 31
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • Shi, Y., A. Hata, R.S. Lo, J. Massagué, and N.P. Pavletich. 1997. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388: 87-93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massagué, J.4    Pavletich, N.P.5
  • 32
    • 0025932959 scopus 로고
    • Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center
    • Smith, W.C. and R.M. Harland. 1991. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell 67: 753-765.
    • (1991) Cell , vol.67 , pp. 753-765
    • Smith, W.C.1    Harland, R.M.2
  • 33
    • 0026646326 scopus 로고
    • Expression cloning of noggin, a new dorsalizing factor localized to the Spemann Organizer in Xenopus embryos
    • _. 1992. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann Organizer in Xenopus embryos. Cell 70: 829-840.
    • (1992) Cell , vol.70 , pp. 829-840
  • 34
    • 0025324104 scopus 로고
    • Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
    • Smith, J.C., B.M.J. Price, K. Van Nimmen, and D. Huylebroeck. 1990. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 345: 729-731.
    • (1990) Nature , vol.345 , pp. 729-731
    • Smith, J.C.1    Price, B.M.J.2    Van Nimmen, K.3    Huylebroeck, D.4
  • 35
    • 0028091791 scopus 로고
    • A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
    • Suzuki, A., R.S. Thies, N. Yamaji, J.J. Song, J.M. Wozney, K. Murakami, and N. Ueno. 1994. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc. Natl. Acad. Sci. 91: 10255-10259.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 10255-10259
    • Suzuki, A.1    Thies, R.S.2    Yamaji, N.3    Song, J.J.4    Wozney, J.M.5    Murakami, K.6    Ueno, N.7
  • 37
    • 0029944441 scopus 로고    scopus 로고
    • Signaling via hetero-oligomeric complexes of type I and type II serine/ threonine kinase receptors
    • ten Dijke, P., K. Miyazono, and C.H. Heldin. 1996. Signaling via hetero-oligomeric complexes of type I and type II serine/ threonine kinase receptors. Curr. Opin. Cell Biol. 8: 139-145.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 139-145
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.H.3
  • 38
    • 0029834231 scopus 로고    scopus 로고
    • Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
    • Thomsen, G. 1996. Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development 122: 2359-2366.
    • (1996) Development , vol.122 , pp. 2359-2366
    • Thomsen, G.1
  • 39
    • 0025016517 scopus 로고
    • Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
    • Thomsen, G., T. Woolf, M. Whitman, S. Sokol, J. Vaughan, W. Vale, and D.A. Melton. 1990. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63: 485-493.
    • (1990) Cell , vol.63 , pp. 485-493
    • Thomsen, G.1    Woolf, T.2    Whitman, M.3    Sokol, S.4    Vaughan, J.5    Vale, W.6    Melton, D.A.7
  • 41
    • 0030863365 scopus 로고    scopus 로고
    • Daughters against dpp modulates dpp organizing activity in drosophila wing development
    • Tsuneizumi, K., T. Nakayama, Y. Kamoshida, T.B. Kornberg, J.L. Christian, and T. Tabata. 1997. Daughters against dpp modulates dpp organizing activity in drosophila wing development. Nature 389: 627-631.
    • (1997) Nature , vol.389 , pp. 627-631
    • Tsuneizumi, K.1    Nakayama, T.2    Kamoshida, Y.3    Kornberg, T.B.4    Christian, J.L.5    Tabata, T.6
  • 42
    • 0028306459 scopus 로고
    • Expression of achaetescute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
    • Turner, D.L. and H. Weintraub. 1994. Expression of achaetescute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes &. Dev. 8: 1434-1447.
    • (1994) Genes &. Dev. , vol.8 , pp. 1434-1447
    • Turner, D.L.1    Weintraub, H.2
  • 45
    • 0029022221 scopus 로고
    • GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex
    • Wieser, R., J.L. Wrana, and J. Massagué. 1995. GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14: 2199-2208.
    • (1995) EMBO J. , vol.14 , pp. 2199-2208
    • Wieser, R.1    Wrana, J.L.2    Massagué, J.3
  • 46
    • 0029059425 scopus 로고
    • Induction of epidermis and inhibition of neural fate by Bmp-4
    • Wilson, P.A. and A. Hemmati-Brivanlou. 1995. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376: 331-333.
    • (1995) Nature , vol.376 , pp. 331-333
    • Wilson, P.A.1    Hemmati-Brivanlou, A.2
  • 47
    • 0030956930 scopus 로고    scopus 로고
    • Vertebrate neural induction: Inducers, inhibitors, and a new synthesis
    • _. 1997. Vertebrate neural induction: Inducers, inhibitors, and a new synthesis. Neuron 18: 699-710.
    • (1997) Neuron , vol.18 , pp. 699-710
  • 48
    • 0030886059 scopus 로고    scopus 로고
    • Concentration-dependent patterning of the Xenopus extoderm by BMP4 and its signal transducer Smad1
    • Wilson, P.A., G. Lagna, A. Suzuki, and A. Hemmati-Brivanlou. 1997. Concentration-dependent patterning of the Xenopus extoderm by BMP4 and its signal transducer Smad1. Development 124: 3177-3184.
    • (1997) Development , vol.124 , pp. 3177-3184
    • Wilson, P.A.1    Lagna, G.2    Suzuki, A.3    Hemmati-Brivanlou, A.4
  • 49
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interacions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/ DPC4
    • Wu, R.-Y., Y. Zhang, X.-H. Feng, and R. Derynck. 1997. Heteromeric and homomeric interacions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/ DPC4. Mol. Cell. Biol. 17: 2521-2528.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2521-2528
    • Wu, R.-Y.1    Zhang, Y.2    Feng, X.-H.3    Derynck, R.4
  • 50
    • 0029086983 scopus 로고
    • A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm
    • Xu, R.H., J. Kim, M. Taira, S. Zhan, D. Sredni, and H.F. Kung. 1995. A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. Biochem. Biophys. Res. Commun. 212: 212-219.
    • (1995) Biochem. Biophys. Res. Commun. , vol.212 , pp. 212-219
    • Xu, R.H.1    Kim, J.2    Taira, M.3    Zhan, S.4    Sredni, D.5    Kung, H.F.6
  • 51
    • 0029833909 scopus 로고    scopus 로고
    • Mammalian Dwarfins are phosphorylated in response to TGF-β and are implicated in control of cell growth
    • Yingling, J.M., P. Das, C. Savage, C. Zhang, R.W. Padgett, and X.-F. Wang. 1996. Mammalian Dwarfins are phosphorylated in response to TGF-β and are implicated in control of cell growth. Proc. Natl. Acad. Sci. 93: 8940-8944.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 8940-8944
    • Yingling, J.M.1    Das, P.2    Savage, C.3    Zhang, C.4    Padgett, R.W.5    Wang, X.-F.6
  • 52
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGFβ response
    • Zhang, Y., X.-H. Feng, R.-Y. Wu, and R. Derynck. 1996. Receptor-associated Mad homologues synergize as effectors of the TGFβ response. Nature 383: 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.-H.2    Wu, R.-Y.3    Derynck, R.4
  • 53
    • 0031128153 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 as a central mediator of Smad function
    • Zhang, Y., T. Musci, and R. Derynck. 1997. The tumor suppressor Smad4/DPC4 as a central mediator of Smad function. Curr. Biol. 7: 270-276.
    • (1997) Curr. Biol. , vol.7 , pp. 270-276
    • Zhang, Y.1    Musci, T.2    Derynck, R.3
  • 54
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman, L., J. De Jesus-Escobar, and R. Harland. 1996. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86: 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.1    De Jesus-Escobar, J.2    Harland, R.3


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