Transgenic analysis of the Smad family of TGF-β signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members

Genetics

Volumn 157, Issue 4, 2001, Pages 1639-1648

  Marquez, R M ^a   Singer, M A ^a   Takaesu, N T ^a   Waldrip, W R ^a   Kraytsberg, Y ^a   Newfeld, S J ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENETIC ANALYSIS; IMAGINAL DISC; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FUNGAL PROTEINS; HUMANS; INSECT PROTEINS; PHENOTYPE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 0035053298     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Programmed cell death during Drosophila embryogenesis
2. Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wings
3. Compartment boundaries and the control of Drosophila limb pattern by Hedgehog protein
4. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
5. The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development
6. Localized cell death caused by mutations in the Drosophila gene coding for a TGF-β homolog
7. Dpp receptors are autonomously required for cell proliferation in the entire developing wing
8. Visualization of gene expression in living adult Drosophila
9. Targeted expression of the signaling molecule Dpp induces pattern duplications and growth alterations in Drosophila wings
10. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
11. Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity, during the formation of the cross veins in Drosophila
12. A short amino acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
13. Nomenclature: Vertebrate mediators of TGF-β family signals
14. MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma
15. The decapentaplegic gene: A TGF-β homolog controlling pattern formation in Drosophila
16. Synergystic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila
17. DPC-4: A candidate tumor suppressor gene at human chromosome 18q21
18. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
19. CLUSTAL V: Improved software for multiple sequence alignment
20. MADR1, a Mad-related protein that functions in BMP2 signaling pathways
21. Mutations in the Smad4 gene in juvenile polyposis
22. Drosophila Medea is required downstream of dpp and encodes a functional homolog of human Smad4
23. PKA and Hedgehog signaling in Drosophila limb development
24. Smad2 and Smad3 positively and negatively regulate TGF-β dependent transcription through the forkhead DNA-binding protein FAST2
25. Partnership between DPC4 and Smads in TGF-β signaling pathways
26. Controlling TGF-β signaling
27. Pattern-specific expression of Drosophila dpp in imaginal disks is regulated by 3′ elements
28. Developmental parameters of cell death in the wing disc of Drosophila
29. Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: A model for LMO oncogene function
30. Structural basis for the functional difference between Smad2 and Smad3 in FAST-2 mediated transcription
31. Direct and long-range action of a DPP gradient
32. Mad encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
33. Molecular evolution of a developmental pathway: Pphylogenetic analyses of TGF-β family ligands, receptors and Smad signal transducers
34. Human BMP sequences confer normal dorsal-ventral patterning in the Drosophila embryo
35. Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes
36. TGF-β family signal transduction in Drosophila development: From Mad to Smads
37. Mad-related genes in the human
38. Frequency of Smad gene mutations in human cancers
39. Drosophila TGF-β superfamily proteins induce endochondrial bone formation in mammals
40. Genetic characterization and cloning of Mad, a gene required for dpp function in Drosophila
41. Crystal structure of a Smad MH1 domain: DNA binding in TGF-β signaling
42. Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing
43. The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: Control of cell proliferation
44. Cell death during the development of the imaginal disks of Calliphora
45. Specificity of BMP-related factors: Cell fate and gene expression changes in Drosophila embryos induced by Dpp but not 60A
46. Analysis of the genetic hierarchy guiding wing vein development in Drosophila
47. Creating a Drosophila wing de novo, the role of engrailed and the compartment border hypothesis
48. Intestinal tumorigenesis in compound mutant mice of both Smad4 and Apc genes
49. Developmental territories created by mutual antagonism between Wingless and Decapentaplegic
50. Vascular Mads: Two novel Mad-related genes selectively inducible by flow in human vascular endothelium
51. Mad acts downstream of DPP receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
52. Dual functions of wingless in the Drosophila leg imaginal disc
53. Regulation of Smad activity
54. Smad proteins act in combination with synergystic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
55. Alternatively spliced variant of Smad2 lacking exon 3: Comparison with wild-type Smad2 and Smad3
56. Induction of apoptosis by Smad3 and down regulation of Smad3 expression in response to TGF-β in human normal lung epithelial cells
57. Smad3 mutant mice develop metastatic colorectal cancer