Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

Genes and Development

Volumn 17, Issue 24, 2003, Pages 3023-3028

  Pera, Edgar M ^a,b   Ikeda, Atsushi ^a   Eivers, Edward ^a   De Robertis, Eddy M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

BMP; Chordin; FGF; IGF; Neural induction; Smad; Xenopus

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; CHORDIN; FIBROBLAST GROWTH FACTOR 8; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SMAD1 PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENETIC TRANSCRIPTION; INHIBITION KINETICS; MOLECULAR MECHANICS; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEINS; DNA-BINDING PROTEINS; EMBRYO, NONMAMMALIAN; EMBRYONIC INDUCTION; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; INSULIN-LIKE GROWTH FACTOR II; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; NERVOUS SYSTEM; NIH 3T3 CELLS; PHOSPHORYLATION; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA; VERTEBRATA;

EID: 0346594337     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1153603     Document Type: Article

References (31)

1. Blume-Jensen, P. and Hunter, T. 2001. Oncogenic kinase signalling. Nature 411: 355-365.
2. Chesnel, F., Bonnec, G., Tardivel, A., and Boujard, D. 1997. Comparative effects of insulin on the activation of the Raf/Mos-dependent MAP kinase cascade in vitellogenic versus postvitellogenic Xenopus oocytes. Dev. Biol. 188: 122-133.
3. Christen, B. and Slack, J.M.W. 1997. FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus. Dev. Biol. 192: 455-466.
4. Collavin, L. and Kirschner, M.W. 2003. The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development 130: 805-816.
5. Cooke, J. and Smith, J.C. 1989. Gastrulation and larval pattern in Xenopus after blastocoelic injection of a Xenopus-derived inducing factor: Experiments testing models for the normal organization of mesoderm. Dev. Biol. 131: 383-400.
6. De Robertis, E.M., Larraín, J., Oelgeschläger, M., and Wessely, O. 2000. The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nat. Rev. Genet. 1: 171-181.
7. Grimm, O.H. and Gurdon, J.B. 2002. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat. Cell Biol. 4: 519-522.
8. Hardcastle, Z., Chalmers, A.D., and Papalopulu, N. 2000. FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos. Curr. Biol. 10: 1511-1514.
9. Harland, R. 2000. Neural induction. Curr. Opin. Genet. Dev. 10: 357-362.
10. Hongo, I., Kengaku, M., and Okamoto, H. 1999. FGF signaling and the anterior neural induction in Xenopus. Dev. Biol. 216: 561-581.
11. Kretzschmar, M., Doody, J., and Massagué, J. 1997. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature 389: 618-622.
12. Kretzschmar, M., Doody, J., Timokhina, I., and Massague, J. 1999. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes & Dev. 13: 804-816.
13. Lamb, T.M. and Harland, R.M. 1995. Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development 121: 3627-3636.
14. Massagué, J. and Chen, Y.-G. 2000. Controlling TGF-β signaling. Genes & Dev. 14: 627-644.
15. Nguyen, V.H., Trout, J., Connors, S.A., Andermann, P., Weinberg, E., and Mullins, M.C. 2000. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development 127: 1209-1220.
16. Niswander, L. and Martin, G.R. 1993. FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361: 68-71.
17. Pera, E.M., Wessely, O., Li, S.-Y., and De Robertis, E.M. 2001. Neural and head induction by insulin-like growth factor signals. Dev. Cell 1: 655-665.
18. Richard-Parpaillon, L., Héligon, C., Chesnel, F., Boujard, D., and Philpott, A. 2002. The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus. Dev. Biol. 244: 407-417.
19. Sater, A.K., El-Hodiri, H.M., Goswami, M., Alexander, T.B., Al-Sheikh, O., Etkin, L.D., and Akif Uzman, J. 2003. Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification. Differentiation 71: 434-444.
20. Schohl, A. and Fagotto, F. 2002. β-catenin, MAPK and Smad signaling during early Xenopus development. Development 129: 37-52.
21. Spemann, H. 1938. Embryonic development and induction. Yale University Press, New Haven, CT.
22. Stern, C.D. 2002. Induction and initial patterning of the nervous system - The chick embryo enters the scene. Curr. Opin. Genet. Dev. 12: 447-451.
23. Streit, A., Stern, C.D., Thery, C., Ireland, G.W., Aparicio, S., Sharpe, M.J., and Gherardi, E. 1995. A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation. Development. 121: 813-824.
24. Streit, A., Sockanathan, S., Perez, L., Rex, M., Scotting, P.J., Sharpe, P.T., Lovell-Badge, R., and Stern, C.D. 1997. Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. Development 124: 1191-1202.
25. Streit, A., Berliner, A.J., Papanayotou, C., Sirulnik, A., and Stern, C.D. 2000. Initiation of neural induction by FGF signalling before gastrulation. Nature 406: 74-78.
26. Thesleff, I. and Mikkola, M. 2002. The role of growth factors in tooth development. Int. Rev. Cytol. 217: 93-135.
27. Warren, S.M., Brunet, L.J., Harland, R.M., Economides, A.N., and Longaker, M.T. 2003. The BMP antagonist noggin regulates cranial suture fusion. Nature 422: 625-629.
28. Weaver, M., Dunn, N.R., and Hogan, B.L.M. 2000. Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development 127: 2695-2704.
29. Weinstein, D.C. and Hemmati-Brivanlou, A. 1999. Neural induction. Annu. Rev. Cell Dev. Biol. 15: 411-433.
30. Wilson, S.I. and Edlund, T. 2001. Neural induction: Toward a unifying mechanism. Nat. Neurosci. 4: 1161-1168.
31. Wilson, S.I., Graziano, E., Harland, R., Jessell, T.M., and Edlund, T. 2000. An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo. Curr. Biol. 10: 421-429.