Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads

Cell

Volumn 113, Issue 3, 2003, Pages 301-314

  Cordenonsi, Michelangelo ^a   Dupont, Sirio ^a   Maretto, Silvia ^a   Insinga, Alessandra ^b   Imbriano, Carol ^c   Piccolo, Stefano ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; PROTEIN P53; SMAD PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; EMBRYO; EMBRYO (ANATOMY); EMBRYO DEVELOPMENT; GENE; GENE ACTIVATION; MAMMAL CELL; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TGF BETA GENE; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; VERTEBRATE; XENOPUS;

ANIMALIA; MAMMALIA; VERTEBRATA;

EID: 0038274163     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)00308-8     Document Type: Article

References (32)

1. Baker J.C., Harland R.M. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 10:1996;1880-1889.
2. Candia A.F., Watabe T., Hawley S.H., Onichtchouk D., Zhang Y., Derynck R., Niehrs C., Cho K.W. Cellular interpretation of multiple TGF-beta signals. intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads Development. 124:1997;4467-4480.
3. Chen X., Rubock M.J., Whitman M. A transcriptional partner for MAD proteins in TGF-beta signalling. Nature. 383:1996;691-696.
4. Cox L.S., Midgley C.A., Lane D.P. Xenopus p53 is biochemically similar to the human tumour suppressor protein p53 and is induced upon DNA damage in somatic cells. Oncogene. 9:1994;2951-2959.
5. Datto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., Wang X.F. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA. 92:1995;5545-5549.
6. Deng C., Zhang P., Harper J.W., Elledge S.J., Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:1995;675-684.
7. Dennler S., Itoh S., Vivien D., ten Dijke P., Huet S., Gauthier J.M. Direct binding of Smad3 and Smad4 to critical TGF-beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17:1998;3091-3100.
8. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A. Jr., Butel J.S., Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 356:1992;215-221.
9. Flores E.R., Tsai K.Y., Crowley D., Sengupta S., Yang A., McKeon F., Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. 416:2002;560-564.
10. Fortunel N.O., Hatzfeld A., Hatzfeld J.A. Transforming growth factor-beta. pleiotropic role in the regulation of hematopoiesis Blood. 96:2000;2022-2036.
11. Gaiddon C., Lokshin M., Ahn J., Zhang T., Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol. Cell. Biol. 21:2001;1874-1887.
12. Gurdon J.B., Bourillot P.Y. Morphogen gradient interpretation. Nature. 413:2001;797-803.
13. Hall P.A., Campbell S.J., O'Neill M., Royston D.J., Nylander K., Carey F.A., Kernohan N.M. Expression of the p53 homologue p63alpha and deltaNp63alpha in normal and neoplastic cells. Carcinogenesis. 21:2000;153-160.
14. Harland R., Gerhart J. Formation and function of Spemann's organizer. Annu. Rev. Cell Dev. Biol. 13:1997;611-667.
15. Huang H.C., Murtaugh L.C., Vize P.D., Whitman M. Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo. EMBO J. 14:1995;5965-5973.
16. Kern S.E., Pietenpol J.A., Thiagalingam S., Seymour A., Kinzler K.W., Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science. 256:1992;827-830.
17. Lehmann K., Janda E., Pierreux C.E., Rytomaa M., Schulze A., McMahon M., Hill C.S., Beug H., Downward J. Raf induces TGF-beta production while blocking its apoptotic but not invasive responses. a mechanism leading to increased malignancy in epithelial cells Genes Dev. 14:2000;2610-2622.
18. Liu B., Sun Y., Jiang F., Zhang S., Wu Y., Lan Y., Yang X., Mao N. Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. Blood. 101:2003;124-133.
19. Lu P., Barad M., Vize P.D. Xenopus p63 expression in early ectoderm and neurectoderm. Mech. Dev. 102:2001;275-278.
20. Macleod K.F., Sherry N., Hannon G., Beach D., Tokino T., Kinzler K., Vogelstein B., Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9:1995;935-944.
21. Massagué J. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1:2000;169-178.
22. Minucci S., Monestiroli S., Giavara S., Ronzoni S., Marchesi F., Insinga A., Diverio D., Gasparini P., Capillo M., Colombo E.et al. PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors. Blood. 100:2002;2989-2995.
23. Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., De Robertis E.M. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature. 397:1999;707-710.
24. Prunier C., Ferrand N., Frottier B., Pessah M., Atfi A. Mechanism for mutational inactivation of the tumor suppressor Smad2. Mol. Cell. Biol. 21:2001;3302-3313.
25. Qian H., Wang T., Naumovski L., Lopez C.D., Brachmann R.K. Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene. 21:2002;7901-7911.
26. Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R., DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L. derriere. a TGF-beta family member required for posterior development in Xenopus Development. 126:1999;1467-1482.
27. Vairapandi M., Balliet A.G., Fornace A.J. Jr., Hoffman B., Liebermann D.A. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene. 12:1996;2579-2594.
28. Vogelstein B., Lane D., Levine A.J. Surfing the p53 network. Nature. 408:2000;307-310.
29. Wakefield L.M., Roberts A.B. TGF-beta signaling. positive and negative effects on tumorigenesis Curr. Opin. Genet. Dev. 12:2002;22-29.
30. Whitman M. Nodal signaling in early vertebrate embryos. themes and variations Dev. Cell. 1:2001;605-617.
31. Wolkowicz R., Peled A., Elkind N.B., Rotter V. Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form. Proc. Natl. Acad. Sci. USA. 92:1995;6842-6846.
32. Yang A., McKeon F. P63 and P73. P53 mimics, menaces and more Nat. Rev. Mol. Cell Biol. 1:2000;199-207.