Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN

Genes and Development

Volumn 15, Issue 21, 2001, Pages 2822-2836

  Stroschein, Shannon L ^a   Bonni, Shirin ^b   Wrana, Jeffrey L ^b   Luo, Kunxin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Anaphase promoting complex; Degradation; Smad proteins; SnoN; TGF ; Ubiquitin

Indexed keywords

LYSINE; PROTEIN SNON; REGULATOR PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE MUTATION; GENE TARGETING; GENETIC STABILITY; GROWTH REGULATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN INTERACTION; REPRESSOR GENE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE DELETION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LYSINE; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RETROVIRIDAE; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TIME FACTORS; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN;

EID: 0035498980     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads
2. E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins
3. TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
4. Sequence and biological activity of chicken snoN cDNA clones
5. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
6. The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization
7. A transcriptional partner for MAD proteins in TGF-β signalling
8. Smad4 and FAST-1 in the assembly of activin-responsive factor
9. The ski oncogene induces muscle differentiation in quail embryo cells
10. Activation of the c-ski oncogene by overexpression
11. Structure and functions of the 20S and 26S proteasomes
12. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
13. Expression of the c-ski proto-oncogene in human melanoma cell lines
14. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
15. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
16. Cyclin is degraded by the ubiquitin pathway
17. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
18. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IκBα
19. TGF-β signalling from cell membrane to nucleus through SMAD proteins
20. The ubiquitin system
21. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
22. Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway
23. Identification of a family of closely related human ubiquitin conjugating enzymes
24. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation
25. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction
26. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
27. Mitotic regulation of the APC activator proteins CDC20 and CDH1
28. Smad2 and Smad3 positively and negatively regulate TGF-β-dependent transcription through the forkhead DNA-binding protein FAST2
29. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing
30. The APC11 RING-H2 finger mediates E2-dependent ubiquitination
31. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
32. Dual role of the Smad4/DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes
33. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
34. Ubiquitin-dependent degradation of TGF-β-activated smad2
35. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
36. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts
37. Signaling by chimeric erythropoietin-TGF-β receptors: Homodimerization of the cytoplasmic domain of the type I TGF-β receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction
38. The Ski oncoprotein interacts with the Smad proteins to repress TGF-β signaling
39. Transcriptional control by the TGF-β/Smad signaling system
40. TGF-β signaling in growth control, cancer, and heritable disorders
41. Isolation of human cDNA clones of ski and the ski-related gene, sno
42. SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno
43. Subunits and substrates of the anaphase-promoting complex
44. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1
45. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
46. More than one way to skin a catenin
47. Reconstitution of p53-ubiquitinylation reactions from purified components: The role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)
48. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex
49. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
50. Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53
51. The sno gene, which encodes a component of the histone deacetylation complex, acts as a tumor suppressor in mice
52. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
53. Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor β-induced Smad-dependent transcriptional activation
54. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
55. Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling
56. SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling
57. Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
58. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
59. The ubiquitin system
60. A Smad transcriptional corepressor
61. Formation of a stable hetero-dimer between Smad2 and Smad4
62. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
63. Whose end is destruction: Cell division and the anaphase-promoting complex
64. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
65. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
66. Transcription elongation factor P-TEFβ mediates Tat activation of HIV-1 transcription at multiple stages
67. Characterization of human FAST-1, a TGF-β and activin signal transducer
68. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation