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Volumn 49, Issue 1, 2005, Pages 1-21

Stress in the brain: Novel cellular mechanisms of injury linked to Alzheimer's disease

Author keywords

Amyloid; Akt; Cysteine proteases; Erythropoietin; Metabotropic; Wnt

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID PRECURSOR PROTEIN; ANTISENSE OLIGONUCLEOTIDE; AUTACOID; BRAIN DERIVED NEUROTROPHIC FACTOR; CALPAIN; CASPASE; CHOLINESTERASE INHIBITOR; CHROMOGRANIN A; COMPLEMENTARY DNA; DEFEROXAMINE MESYLATE; DONEPEZIL; ERYTHROPOIETIN; ESTROGEN; FREE RADICAL; GALANTAMINE; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; MEMANTINE; METABOTROPIC RECEPTOR; NEUTRALIZING ANTIBODY; NICOTINAMIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHATIDYLSERINE; PRESENILIN 1; PRESENILIN 2; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P35; PYRAZINAMIDASE NICOTINAMIDASE 1; REACTIVE OXYGEN METABOLITE; RIVASTIGMINE; SOMATOMEDIN; SONIC HEDGEHOG PROTEIN; SUPEROXIDE DISMUTASE; TAU PROTEIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 20444399515     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2004.11.005     Document Type: Review
Times cited : (130)

References (256)
  • 1
    • 0036934648 scopus 로고    scopus 로고
    • Calpain activation in neurodegenerative diseases: Confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2
    • E. Adamec, P. Mohan, J.P. Vonsattel, and R.A. Nixon Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2 Acta Neuropathol. (Berl) 104 2002 92 104
    • (2002) Acta Neuropathol. (Berl) , vol.104 , pp. 92-104
    • Adamec, E.1    Mohan, P.2    Vonsattel, J.P.3    Nixon, R.A.4
  • 5
    • 0035298135 scopus 로고    scopus 로고
    • A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons
    • A. Alvarez, J.P. Munoz, and R.B. Maccioni A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons Exp. Cell Res. 264 2001 266 274
    • (2001) Exp. Cell Res. , vol.264 , pp. 266-274
    • Alvarez, A.1    Munoz, J.P.2    MacCioni, R.B.3
  • 6
    • 0037809240 scopus 로고    scopus 로고
    • The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart
    • C. Alves da Costa, M.P. Mattson, K. Ancolio, and F. Checler The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart J. Biol. Chem. 278 2003 12064 12069
    • (2003) J. Biol. Chem. , vol.278 , pp. 12064-12069
    • Alves Da Costa, C.1    Mattson, M.P.2    Ancolio, K.3    Checler, F.4
  • 7
    • 0038329323 scopus 로고    scopus 로고
    • Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
    • R.M. Anderson, K.J. Bitterman, J.G. Wood, O. Medvedik, and D.A. Sinclair Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae Nature 423 2003 181 185
    • (2003) Nature , vol.423 , pp. 181-185
    • Anderson, R.M.1    Bitterman, K.J.2    Wood, J.G.3    Medvedik, O.4    Sinclair, D.A.5
  • 10
    • 0030887531 scopus 로고    scopus 로고
    • Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells
    • A.E. Aplin, J.S. Jacobsen, B.H. Anderton, and J.M. Gallo Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells NeuroReport 8 1997 639 643
    • (1997) NeuroReport , vol.8 , pp. 639-643
    • Aplin, A.E.1    Jacobsen, J.S.2    Anderton, B.H.3    Gallo, J.M.4
  • 11
    • 0034531580 scopus 로고    scopus 로고
    • Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death
    • T. Arendt, M. Holzer, A. Stobe, U. Gartner, H.J. Luth, M.K. Bruckner, and U. Ueberham Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death Ann. N. Y. Acad. Sci. 920 2000 249 255
    • (2000) Ann. N. Y. Acad. Sci. , vol.920 , pp. 249-255
    • Arendt, T.1    Holzer, M.2    Stobe, A.3    Gartner, U.4    Luth, H.J.5    Bruckner, M.K.6    Ueberham, U.7
  • 13
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • A. Ashkenazi, and V.M. Dixit Death receptors: signaling and modulation Science 281 1998 1305 1308
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 14
    • 0030729804 scopus 로고    scopus 로고
    • Role of calpain and its inhibitors in tissue degeneration and neuroprotection in spinal cord injury
    • N.L. Banik, D. Matzelle, G. Gantt-Wilford, and E.L. Hogan Role of calpain and its inhibitors in tissue degeneration and neuroprotection in spinal cord injury Ann. N. Y. Acad. Sci. 825 1997 120 127
    • (1997) Ann. N. Y. Acad. Sci. , vol.825 , pp. 120-127
    • Banik, N.L.1    Matzelle, D.2    Gantt-Wilford, G.3    Hogan, E.L.4
  • 16
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • A. Bellacosa, J.R. Testa, S.P. Staal, and P.N. Tsichlis A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region Science 254 1991 274 277
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 20
    • 0034718421 scopus 로고    scopus 로고
    • Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration
    • R.V. Bhat, J. Shanley, M.P. Correll, W.E. Fieles, R.A. Keith, C.W. Scott, and C.M. Lee Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration Proc. Natl. Acad. Sci. U. S. A. 97 2000 11074 11079
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11074-11079
    • Bhat, R.V.1    Shanley, J.2    Correll, M.P.3    Fieles, W.E.4    Keith, R.A.5    Scott, C.W.6    Lee, C.M.7
  • 21
    • 0030053864 scopus 로고    scopus 로고
    • Coenzyme nicotinamide adenine dinucleotide: New therapeutic approach for improving dementia of the Alzheimer type
    • J.G. Birkmayer Coenzyme nicotinamide adenine dinucleotide: new therapeutic approach for improving dementia of the Alzheimer type Ann. Clin. Lab. Sci. 26 1996 1 9
    • (1996) Ann. Clin. Lab. Sci. , vol.26 , pp. 1-9
    • Birkmayer, J.G.1
  • 22
    • 0037160097 scopus 로고    scopus 로고
    • Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    • K.J. Bitterman, R.M. Anderson, H.Y. Cohen, M. Latorre-Esteves, and D.A. Sinclair Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 J. Biol. Chem. 277 2002 45099 45107
    • (2002) J. Biol. Chem. , vol.277 , pp. 45099-45107
    • Bitterman, K.J.1    Anderson, R.M.2    Cohen, H.Y.3    Latorre-Esteves, M.4    Sinclair, D.A.5
  • 23
    • 0035971091 scopus 로고    scopus 로고
    • Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: A mechanism of "pathological apoptosis"?
    • K. Blomgren, C. Zhu, X. Wang, J.O. Karlsson, A.L. Leverin, B.A. Bahr, C. Mallard, and H. Hagberg Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"? J. Biol. Chem. 276 2001 10191 10198
    • (2001) J. Biol. Chem. , vol.276 , pp. 10191-10198
    • Blomgren, K.1    Zhu, C.2    Wang, X.3    Karlsson, J.O.4    Leverin, A.L.5    Bahr, B.A.6    Mallard, C.7    Hagberg, H.8
  • 25
    • 0030707519 scopus 로고    scopus 로고
    • Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin
    • C. Brancolini, D. Lazarevic, J. Rodriguez, and C. Schneider Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin J. Cell Biol. 139 1997 759 771
    • (1997) J. Cell Biol. , vol.139 , pp. 759-771
    • Brancolini, C.1    Lazarevic, D.2    Rodriguez, J.3    Schneider, C.4
  • 26
    • 0037405248 scopus 로고    scopus 로고
    • Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis
    • N. Bresgen, G. Karlhuber, I. Krizbai, H. Bauer, H.C. Bauer, and P.M. Eckl Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis J. Neurosci. Res. 72 2003 327 333
    • (2003) J. Neurosci. Res. , vol.72 , pp. 327-333
    • Bresgen, N.1    Karlhuber, G.2    Krizbai, I.3    Bauer, H.4    Bauer, H.C.5    Eckl, P.M.6
  • 28
    • 0035206424 scopus 로고    scopus 로고
    • Severity of oxidative stress generates different mechanisms of endothelial cell death
    • A. Burlacu, V. Jinga, A.V. Gafencu, and M. Simionescu Severity of oxidative stress generates different mechanisms of endothelial cell death Cell Tissue Res. 306 2001 409 416
    • (2001) Cell Tissue Res. , vol.306 , pp. 409-416
    • Burlacu, A.1    Jinga, V.2    Gafencu, A.V.3    Simionescu, M.4
  • 29
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • J. Busser, D.S. Geldmacher, and K. Herrup Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain J. Neurosci. 18 1998 2801 2807
    • (1998) J. Neurosci. , vol.18 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 30
    • 0036753272 scopus 로고    scopus 로고
    • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
    • D.A. Butterfield, A. Castegna, C.M. Lauderback, and J. Drake Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death Neurobiol. Aging 23 2002 655 664
    • (2002) Neurobiol. Aging , vol.23 , pp. 655-664
    • Butterfield, D.A.1    Castegna, A.2    Lauderback, C.M.3    Drake, J.4
  • 33
    • 0036452908 scopus 로고    scopus 로고
    • Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12
    • S.L. Chan, C. Culmsee, N. Haughey, W. Klapper, and M.P. Mattson Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12 Neurobiol. Dis. 11 2002 2 19
    • (2002) Neurobiol. Dis. , vol.11 , pp. 2-19
    • Chan, S.L.1    Culmsee, C.2    Haughey, N.3    Klapper, W.4    Mattson, M.P.5
  • 35
    • 0142042435 scopus 로고    scopus 로고
    • Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: Potential strategies for neuroprotection
    • G.J. Chen, J. Xu, S.A. Lahousse, N.L. Caggiano, and S.M. de la Monte Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection J. Alzheimer's Dis. 5 2003 209 228
    • (2003) J. Alzheimer's Dis. , vol.5 , pp. 209-228
    • Chen, G.J.1    Xu, J.2    Lahousse, S.A.3    Caggiano, N.L.4    De La Monte, S.M.5
  • 38
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases Circulation 106 2002 2973 2979
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 39
    • 0036254579 scopus 로고    scopus 로고
    • Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury
    • Z.Z. Chong, S.H. Lin, and K. Maiese Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury J. Vasc. Res. 39 2002 131 147
    • (2002) J. Vasc. Res. , vol.39 , pp. 131-147
    • Chong, Z.Z.1    Lin, S.H.2    Maiese, K.3
  • 41
    • 0037338625 scopus 로고    scopus 로고
    • Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin J. Cereb. Blood Flow Metab. 23 2003 320 330
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 320-330
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 42
    • 0037365196 scopus 로고    scopus 로고
    • Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways Br. J. Pharmacol. 138 2003 1107 1118
    • (2003) Br. J. Pharmacol. , vol.138 , pp. 1107-1118
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 43
    • 0037216130 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathways
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathways Histol. Histopathol. 18 2003 173 189
    • (2003) Histol. Histopathol. , vol.18 , pp. 173-189
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 44
    • 0038522400 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival
    • Z.Z. Chong, S.-H. Lin, J. Kang, and K. Maiese The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival Cell Mol. Neurobiol. 23 4-5 2003 561 578
    • (2003) Cell Mol. Neurobiol. , vol.23 , Issue.4-5 , pp. 561-578
    • Chong, Z.Z.1    Lin, S.-H.2    Kang, J.3    Maiese, K.4
  • 45
    • 2442461973 scopus 로고    scopus 로고
    • Akt1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-x(L) and caspase 1, 3, and 9
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Akt1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-x(L) and caspase 1, 3, and 9 Exp. Cell Res. 296 2004 196 207
    • (2004) Exp. Cell Res. , vol.296 , pp. 196-207
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 46
    • 1542409923 scopus 로고    scopus 로고
    • Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system
    • Z.Z. Chong, J.Q. Kang, and K. Maiese Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system Antioxid. Redox Signal. 6 2004 277 287
    • (2004) Antioxid. Redox Signal. , vol.6 , pp. 277-287
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 47
    • 3042730681 scopus 로고    scopus 로고
    • The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential.
    • Z.Z. Chong, S.-H. Lin, and K. Maiese The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J. Cereb. Blood Flow. Metab. 24 2004 728 743
    • (2004) J. Cereb. Blood Flow. Metab. , vol.24 , pp. 728-743
    • Chong, Z.Z.1    Lin, S.-H.2    Maiese, K.3
  • 48
    • 11144308859 scopus 로고    scopus 로고
    • Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury
    • Z.Z. Chong, F. Li, and K. Maiese Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury Histol. Histopathol. 20 2005 299 315
    • (2005) Histol. Histopathol. , vol.20 , pp. 299-315
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 49
    • 0001110114 scopus 로고    scopus 로고
    • Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
    • B.T. Chua, K. Guo, and P. Li Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases J. Biol. Chem. 275 2000 5131 5135
    • (2000) J. Biol. Chem. , vol.275 , pp. 5131-5135
    • Chua, B.T.1    Guo, K.2    Li, P.3
  • 52
    • 0041846404 scopus 로고    scopus 로고
    • Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease
    • G.J. Colurso, J.E. Nilson, and L.G. Vervoort Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease Life Sci. 73 2003 1795 1803
    • (2003) Life Sci. , vol.73 , pp. 1795-1803
    • Colurso, G.J.1    Nilson, J.E.2    Vervoort, L.G.3
  • 53
    • 0035866060 scopus 로고    scopus 로고
    • Beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • C.K. Combs, J.C. Karlo, S.C. Kao, and G.E. Landreth beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis J. Neurosci. 21 2001 1179 1188
    • (2001) J. Neurosci. , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3    Landreth, G.E.4
  • 55
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M.E. Greenberg Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 1997 231 241
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 56
    • 0034603525 scopus 로고    scopus 로고
    • Aberrant expression of nitric oxide synthase III in Alzheimer's disease: Relevance to cerebral vasculopathy and neurodegeneration
    • S.M. de la Monte, B.X. Lu, Y.K. Sohn, D. Etienne, J. Kraft, N. Ganju, and J.R. Wands Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration Neurobiol. Aging 21 2000 309 319
    • (2000) Neurobiol. Aging , vol.21 , pp. 309-319
    • De La Monte, S.M.1    Lu, B.X.2    Sohn, Y.K.3    Etienne, D.4    Kraft, J.5    Ganju, N.6    Wands, J.R.7
  • 57
    • 0037329921 scopus 로고    scopus 로고
    • Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: Relevance to Alzheimer's-type neurodegeneration
    • S.M. de la Monte, J. Chiche, A. von dem Bussche, S. Sanyal, S.A. Lahousse, S.P. Janssens, and K.D. Bloch Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration Lab. Invest. 83 2003 287 298
    • (2003) Lab. Invest. , vol.83 , pp. 287-298
    • De La Monte, S.M.1    Chiche, J.2    Von Dem Bussche, A.3    Sanyal, S.4    Lahousse, S.A.5    Janssens, S.P.6    Bloch, K.D.7
  • 58
    • 0025785213 scopus 로고
    • Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: An autoradiographic study of the hippocampus
    • D. Dewar, D.T. Chalmers, D.I. Graham, and J. McCulloch Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus Brain Res. 553 1991 58 64
    • (1991) Brain Res. , vol.553 , pp. 58-64
    • Dewar, D.1    Chalmers, D.T.2    Graham, D.I.3    McCulloch, J.4
  • 59
    • 0035951823 scopus 로고    scopus 로고
    • Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart
    • F. Di Lisa, R. Menabo, M. Canton, M. Barile, and P. Bernardi Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart J. Biol. Chem. 276 2001 2571 2575
    • (2001) J. Biol. Chem. , vol.276 , pp. 2571-2575
    • Di Lisa, F.1    Menabo, R.2    Canton, M.3    Barile, M.4    Bernardi, P.5
  • 60
    • 0037017396 scopus 로고    scopus 로고
    • FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity
    • P.F. Dijkers, K.U. Birkenkamp, E.W. Lam, N.S. Thomas, J.W. Lammers, L. Koenderman, and P.J. Coffer FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity J. Cell Biol. 156 2002 531 542
    • (2002) J. Cell Biol. , vol.156 , pp. 531-542
    • Dijkers, P.F.1    Birkenkamp, K.U.2    Lam, E.W.3    Thomas, N.S.4    Lammers, J.W.5    Koenderman, L.6    Coffer, P.J.7
  • 61
    • 0033856205 scopus 로고    scopus 로고
    • Phosphatidylserine expression on cell surfaces promotes antibody-dependent aggregation and thrombosis in beta2-glycoprotein I-immune mice
    • D. Dombroski, K. Balasubramanian, and A.J. Schroit Phosphatidylserine expression on cell surfaces promotes antibody-dependent aggregation and thrombosis in beta2-glycoprotein I-immune mice J. Autoimmun. 14 2000 221 229
    • (2000) J. Autoimmun. , vol.14 , pp. 221-229
    • Dombroski, D.1    Balasubramanian, K.2    Schroit, A.J.3
  • 62
    • 0041921105 scopus 로고    scopus 로고
    • Current treatments for Alzheimer's disease: Cholinesterase inhibitors
    • R.S. Doody Current treatments for Alzheimer's disease: cholinesterase inhibitors J. Clin. Psychiatry 64 Suppl 9 2003 11 17
    • (2003) J. Clin. Psychiatry , vol.64 , Issue.9 SUPPL. , pp. 11-17
    • Doody, R.S.1
  • 63
    • 0030902595 scopus 로고    scopus 로고
    • Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity
    • S. Dore, S. Kar, and R. Quirion Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity Proc. Natl. Acad. Sci. U. S. A. 94 1997 4772 4777
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 4772-4777
    • Dore, S.1    Kar, S.2    Quirion, R.3
  • 66
    • 0032885388 scopus 로고    scopus 로고
    • Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
    • W.C. Earnshaw, L.M. Martins, and S.H. Kaufmann Mammalian caspases: structure, activation, substrates, and functions during apoptosis Annu. Rev. Biochem. 68 1999 383 424
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 383-424
    • Earnshaw, W.C.1    Martins, L.M.2    Kaufmann, S.H.3
  • 67
    • 20444426695 scopus 로고    scopus 로고
    • Apoptosis: A key in neurodegenerative disorders?
    • O. Ekshyyan, and T.Y. Aw Apoptosis: a key in neurodegenerative disorders? Curr. Neurovasc. Res. 1 2004 355 371
    • (2004) Curr. Neurovasc. Res. , vol.1 , pp. 355-371
    • Ekshyyan, O.1    Aw, T.Y.2
  • 68
    • 0037224933 scopus 로고    scopus 로고
    • Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta
    • B.F. El-Khodor, T. Frances Oo, N. Kholodilov, and R.E. Burke Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta Exp. Neurol. 179 2003 17 27
    • (2003) Exp. Neurol. , vol.179 , pp. 17-27
    • El-Khodor, B.F.1    Frances Oo, T.2    Kholodilov, N.3    Burke, R.E.4
  • 70
    • 0035846941 scopus 로고    scopus 로고
    • Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts
    • V.A. Fadok, A. de Cathelineau, D.L. Daleke, P.M. Henson, and D.L. Bratton Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts J. Biol. Chem. 276 2001 1071 1077
    • (2001) J. Biol. Chem. , vol.276 , pp. 1071-1077
    • Fadok, V.A.1    De Cathelineau, A.2    Daleke, D.L.3    Henson, P.M.4    Bratton, D.L.5
  • 72
    • 0034329543 scopus 로고    scopus 로고
    • Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants
    • D.B. Flaherty, J.P. Soria, H.G. Tomasiewicz, and J.G. Wood Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants J. Neurosci. Res. 62 2000 463 472
    • (2000) J. Neurosci. Res. , vol.62 , pp. 463-472
    • Flaherty, D.B.1    Soria, J.P.2    Tomasiewicz, H.G.3    Wood, J.G.4
  • 73
    • 0028006155 scopus 로고
    • The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1
    • T.F. Franke, K.D. Tartof, and P.N. Tsichlis The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1 Oncogene 9 1994 141 148
    • (1994) Oncogene , vol.9 , pp. 141-148
    • Franke, T.F.1    Tartof, K.D.2    Tsichlis, P.N.3
  • 74
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • R.A. Frye Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins Biochem. Biophys. Res. Commun. 273 2000 793 798
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 793-798
    • Frye, R.A.1
  • 75
    • 1642580758 scopus 로고    scopus 로고
    • Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity
    • C.M. Gallo, D.L. Smith Jr., and J.S. Smith Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity Mol. Cell. Biol. 24 2004 1301 1312
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1301-1312
    • Gallo, C.M.1    Smith Jr., D.L.2    Smith, J.S.3
  • 77
    • 0033758751 scopus 로고    scopus 로고
    • N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death
    • G. Gao, and Q.P. Dou N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death J. Cell. Biochem. 80 2000 53 72
    • (2000) J. Cell. Biochem. , vol.80 , pp. 53-72
    • Gao, G.1    Dou, Q.P.2
  • 78
    • 0036884291 scopus 로고    scopus 로고
    • Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway
    • J.L. Garrido, J.A. Godoy, A. Alvarez, M. Bronfman, and N.C. Inestrosa Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway FASEB J. 16 2002 1982 1984
    • (2002) FASEB J. , vol.16 , pp. 1982-1984
    • Garrido, J.L.1    Godoy, J.A.2    Alvarez, A.3    Bronfman, M.4    Inestrosa, N.C.5
  • 79
    • 0042837889 scopus 로고    scopus 로고
    • Caspase activation in the limbic cortex of subjects with early Alzheimer's disease
    • M.C. Gastard, J.C. Troncoso, and V.E. Koliatsos Caspase activation in the limbic cortex of subjects with early Alzheimer's disease Ann. Neurol. 54 2003 393 398
    • (2003) Ann. Neurol. , vol.54 , pp. 393-398
    • Gastard, M.C.1    Troncoso, J.C.2    Koliatsos, V.E.3
  • 80
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • J. Gilley, P.J. Coffer, and J. Ham FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons J. Cell Biol. 162 2003 613 622
    • (2003) J. Cell Biol. , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 81
    • 0033516567 scopus 로고    scopus 로고
    • Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death
    • A. Giovanni, F. Wirtz-Brugger, E. Keramaris, R. Slack, and D.S. Park Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death J. Biol. Chem. 274 1999 19011 19016
    • (1999) J. Biol. Chem. , vol.274 , pp. 19011-19016
    • Giovanni, A.1    Wirtz-Brugger, F.2    Keramaris, E.3    Slack, R.4    Park, D.S.5
  • 82
    • 0035824526 scopus 로고    scopus 로고
    • Neuregulin rescues PC12-ErbB4 cells from cell death induced by H(2)O(2). Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase
    • Y. Goldshmit, S. Erlich, and R. Pinkas-Kramarski Neuregulin rescues PC12-ErbB4 cells from cell death induced by H(2)O(2). Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase J. Biol. Chem. 276 2001 46379 46385
    • (2001) J. Biol. Chem. , vol.276 , pp. 46379-46385
    • Goldshmit, Y.1    Erlich, S.2    Pinkas-Kramarski, R.3
  • 84
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • R. Hanayama, M. Tanaka, K. Miyasaka, K. Aozasa, M. Koike, Y. Uchiyama, and S. Nagata Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice Science 304 2004 1147 1150
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3    Aozasa, K.4    Koike, M.5    Uchiyama, Y.6    Nagata, S.7
  • 86
    • 0036682239 scopus 로고    scopus 로고
    • Fractalkine and fractalkine receptors in human neurons and glial cells
    • K. Hatori, A. Nagai, R. Heisel, J.K. Ryu, and S.U. Kim Fractalkine and fractalkine receptors in human neurons and glial cells J. Neurosci. Res. 69 2002 418 426
    • (2002) J. Neurosci. Res. , vol.69 , pp. 418-426
    • Hatori, K.1    Nagai, A.2    Heisel, R.3    Ryu, J.K.4    Kim, S.U.5
  • 87
    • 1242341933 scopus 로고    scopus 로고
    • Hormone therapy and Alzheimer's disease: Benefit or harm?
    • V.W. Henderson Hormone therapy and Alzheimer's disease: benefit or harm? Expert Opin. Pharmacother. 5 2004 389 406
    • (2004) Expert Opin. Pharmacother. , vol.5 , pp. 389-406
    • Henderson, V.W.1
  • 88
    • 0030954209 scopus 로고    scopus 로고
    • The CARD domain: A new apoptotic signalling motif
    • K. Hofmann, P. Bucher, and J. Tschopp The CARD domain: a new apoptotic signalling motif Trends Biochem. Sci. 22 1997 155 156
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 155-156
    • Hofmann, K.1    Bucher, P.2    Tschopp, J.3
  • 90
    • 0030868557 scopus 로고    scopus 로고
    • Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
    • M. Hong, D.C. Chen, P.S. Klein, and V.M. Lee Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3 J. Biol. Chem. 272 1997 25326 25332
    • (1997) J. Biol. Chem. , vol.272 , pp. 25326-25332
    • Hong, M.1    Chen, D.C.2    Klein, P.S.3    Lee, V.M.4
  • 91
    • 0344348821 scopus 로고    scopus 로고
    • Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
    • Y. Hu, M.A. Benedict, L. Ding, and G. Nunez Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis EMBO J. 18 1999 3586 3595
    • (1999) EMBO J. , vol.18 , pp. 3586-3595
    • Hu, Y.1    Benedict, M.A.2    Ding, L.3    Nunez, G.4
  • 93
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    • S. Ikeda, S. Kishida, H. Yamamoto, H. Murai, S. Koyama, and A. Kikuchi Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin EMBO J. 17 1998 1371 1384
    • (1998) EMBO J. , vol.17 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 94
    • 0035882278 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo
    • H. Ino, and T. Chiba Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo J. Neurosci. 21 2001 6086 6094
    • (2001) J. Neurosci. , vol.21 , pp. 6086-6094
    • Ino, H.1    Chiba, T.2
  • 95
    • 0033984684 scopus 로고    scopus 로고
    • Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line
    • I. Ishihara, Y. Minami, T. Nishizaki, T. Matsuoka, and H. Yamamura Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line Neurosci. Lett. 279 2000 97 100
    • (2000) Neurosci. Lett. , vol.279 , pp. 97-100
    • Ishihara, I.1    Minami, Y.2    Nishizaki, T.3    Matsuoka, T.4    Yamamura, H.5
  • 96
    • 0037313260 scopus 로고    scopus 로고
    • Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling
    • T. Ishitani, J. Ninomiya-Tsuji, and K. Matsumoto Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling Mol. Cell. Biol. 23 2003 1379 1389
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1379-1389
    • Ishitani, T.1    Ninomiya-Tsuji, J.2    Matsumoto, K.3
  • 97
    • 0346435109 scopus 로고    scopus 로고
    • Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases
    • M.D. Jackson, M.T. Schmidt, N.J. Oppenheimer, and J.M. Denu Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases J. Biol. Chem. 278 2003 50985 50998
    • (2003) J. Biol. Chem. , vol.278 , pp. 50985-50998
    • Jackson, M.D.1    Schmidt, M.T.2    Oppenheimer, N.J.3    Denu, J.M.4
  • 98
  • 99
    • 0032577677 scopus 로고    scopus 로고
    • Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons
    • C. Jolly-Tornetta, Z.Y. Gao, V.M. Lee, and B.A. Wolf Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons J. Biol. Chem. 273 1998 14015 14021
    • (1998) J. Biol. Chem. , vol.273 , pp. 14015-14021
    • Jolly-Tornetta, C.1    Gao, Z.Y.2    Lee, V.M.3    Wolf, B.A.4
  • 100
    • 0034526359 scopus 로고    scopus 로고
    • Modulated expression of secreted frizzled-related proteins in human retinal degeneration
    • S.E. Jones, C. Jomary, J. Grist, H.J. Stewart, and M.J. Neal Modulated expression of secreted frizzled-related proteins in human retinal degeneration NeuroReport 11 2000 3963 3967
    • (2000) NeuroReport , vol.11 , pp. 3963-3967
    • Jones, S.E.1    Jomary, C.2    Grist, J.3    Stewart, H.J.4    Neal, M.J.5
  • 101
    • 0030893610 scopus 로고    scopus 로고
    • Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture
    • J. Jordan, M.F. Galindo, and R.J. Miller Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture J. Neurochem. 68 1997 1612 1621
    • (1997) J. Neurochem. , vol.68 , pp. 1612-1621
    • Jordan, J.1    Galindo, M.F.2    Miller, R.J.3
  • 102
    • 0032505127 scopus 로고    scopus 로고
    • Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
    • P. Juo, C.J. Kuo, J. Yuan, and J. Blenis Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade Curr. Biol. 8 1998 1001 1008
    • (1998) Curr. Biol. , vol.8 , pp. 1001-1008
    • Juo, P.1    Kuo, C.J.2    Yuan, J.3    Blenis, J.4
  • 103
    • 0141646358 scopus 로고    scopus 로고
    • Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity
    • J.Q. Kang, Z.Z. Chong, and K. Maiese Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity J. Neurosci. Res. 74 2003 37 51
    • (2003) J. Neurosci. Res. , vol.74 , pp. 37-51
    • Kang, J.Q.1    Chong, Z.Z.2    Maiese, K.3
  • 104
    • 0042355359 scopus 로고    scopus 로고
    • Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
    • J.Q. Kang, Z.Z. Chong, and K. Maiese Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation Mol. Pharmacol. 64 2003 557 569
    • (2003) Mol. Pharmacol. , vol.64 , pp. 557-569
    • Kang, J.Q.1    Chong, Z.Z.2    Maiese, K.3
  • 108
    • 0037335443 scopus 로고    scopus 로고
    • The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons
    • Y. Konishi, and A. Bonni The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons J. Neurosci. 23 2003 1649 1658
    • (2003) J. Neurosci. , vol.23 , pp. 1649-1658
    • Konishi, Y.1    Bonni, A.2
  • 109
    • 0037419533 scopus 로고    scopus 로고
    • Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons
    • Y. Koriyama, K. Chiba, and T. Mohri Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons Eur. J. Pharmacol. 458 2003 235 241
    • (2003) Eur. J. Pharmacol. , vol.458 , pp. 235-241
    • Koriyama, Y.1    Chiba, K.2    Mohri, T.3
  • 111
    • 0037112117 scopus 로고    scopus 로고
    • Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein
    • K. Kuwako, I. Nishimura, T. Uetsuki, T.C. Saido, and K. Yoshikawa Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein Brain Res. Mol. Brain Res. 107 2002 166 175
    • (2002) Brain Res. Mol. Brain Res. , vol.107 , pp. 166-175
    • Kuwako, K.1    Nishimura, I.2    Uetsuki, T.3    Saido, T.C.4    Yoshikawa, K.5
  • 114
    • 0642370864 scopus 로고    scopus 로고
    • Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors
    • S. Lazareno, A. Popham, and N.J. Birdsall Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors J. Mol. Neurosci. 20 2003 363 367
    • (2003) J. Mol. Neurosci. , vol.20 , pp. 363-367
    • Lazareno, S.1    Popham, A.2    Birdsall, N.J.3
  • 115
    • 0029935359 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats
    • R.K. Lee, J. Jimenez, A.J. Cox, and R.J. Wurtman Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats Ann. N. Y. Acad. Sci. 777 1996 338 343
    • (1996) Ann. N. Y. Acad. Sci. , vol.777 , pp. 338-343
    • Lee, R.K.1    Jimenez, J.2    Cox, A.J.3    Wurtman, R.J.4
  • 116
    • 0037102626 scopus 로고    scopus 로고
    • Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG → TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells
    • D.H. Lee, T.R. O'Connor, and G.P. Pfeifer Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG → TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells Nucleic Acids Res. 30 2002 3566 3573
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3566-3573
    • Lee, D.H.1    O'Connor, T.R.2    Pfeifer, G.P.3
  • 117
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 118
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • H. Li, H. Zhu, C.J. Xu, and J. Yuan Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 1998 491 501
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 120
    • 11144287874 scopus 로고    scopus 로고
    • Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide
    • F. Li, Z.Z. Chong, and K. Maiese Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide Front. Biosci. 9 2004 2500 2520
    • (2004) Front. Biosci. , vol.9 , pp. 2500-2520
    • Li, F.1    Chong, Z.Z.2    Maiese, K.3
  • 121
    • 11344254385 scopus 로고    scopus 로고
    • Erythropoietin on a tightrope: Balancing neuronal and vascular protection between intrinsic and extrinsic pathways
    • F. Li, Z.Z. Chong, and K. Maiese Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways NeuroSignals 13 2004 265 289
    • (2004) NeuroSignals , vol.13 , pp. 265-289
    • Li, F.1    Chong, Z.Z.2    Maiese, K.3
  • 122
    • 0033847695 scopus 로고    scopus 로고
    • Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death
    • S.H. Lin, A. Vincent, T. Shaw, K.I. Maynard, and K. Maiese Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death J. Cereb. Blood Flow Metab. 20 2000 1380 1391
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 1380-1391
    • Lin, S.H.1    Vincent, A.2    Shaw, T.3    Maynard, K.I.4    Maiese, K.5
  • 123
    • 0035860478 scopus 로고    scopus 로고
    • Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat
    • S. Lin, Z.Z. Chong, and K. Maiese Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat Neurosci. Lett. 310 2001 173 177
    • (2001) Neurosci. Lett. , vol.310 , pp. 173-177
    • Lin, S.1    Chong, Z.Z.2    Maiese, K.3
  • 124
    • 0035092461 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells
    • S.H. Lin, and K. Maiese The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells J. Cereb. Blood Flow Metab. 21 2001 262 275
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 262-275
    • Lin, S.H.1    Maiese, K.2
  • 125
    • 0036286499 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor system: G-protein mediated pathways that modulate neuronal and vascular cellular injury.
    • S.-H. Lin, Z.Z. Chong, and K. Maiese The metabotropic glutamate receptor system: G-protein mediated pathways that modulate neuronal and vascular cellular injury. Curr. Med. Chem. -Central Nervous System Agents 2 2002 17 28
    • (2002) Curr. Med. Chem. -Central Nervous System Agents , vol.2 , pp. 17-28
    • Lin, S.-H.1    Chong, Z.Z.2    Maiese, K.3
  • 126
    • 0037376665 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
    • S.J. Lin, and L. Guarente Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease Curr. Opin. Cell Biol. 15 2003 241 246
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 241-246
    • Lin, S.J.1    Guarente, L.2
  • 127
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • X. Liu, C.N. Kim, J. Yang, R. Jemmerson, and X. Wang Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c Cell 86 1996 147 157
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 128
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
    • B. Liu, and J.S. Hong Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention J. Pharmacol. Exp. Ther. 304 2003 1 7
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 130
    • 0032901904 scopus 로고    scopus 로고
    • Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
    • S. Love, R. Barber, and G.K. Wilcock Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease Brain 122 Pt 2 1999 247 253
    • (1999) Brain , vol.122 , Issue.2 PART , pp. 247-253
    • Love, S.1    Barber, R.2    Wilcock, G.K.3
  • 131
    • 0032933750 scopus 로고    scopus 로고
    • Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF
    • M.A. Lovell, S.P. Gabbita, and W.R. Markesbery Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF J. Neurochem. 72 1999 771 776
    • (1999) J. Neurochem. , vol.72 , pp. 771-776
    • Lovell, M.A.1    Gabbita, S.P.2    Markesbery, W.R.3
  • 133
  • 134
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • J.J. Lucas, F. Hernandez, P. Gomez-Ramos, M.A. Moran, R. Hen, and J. Avila Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice EMBO J. 20 2001 27 39
    • (2001) EMBO J. , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 135
    • 0029992872 scopus 로고    scopus 로고
    • Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients
    • L.F. Lue, L. Brachova, D.G. Walker, and J. Rogers Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients Neurobiol. Aging 17 1996 421 429
    • (1996) Neurobiol. Aging , vol.17 , pp. 421-429
    • Lue, L.F.1    Brachova, L.2    Walker, D.G.3    Rogers, J.4
  • 136
    • 0037778008 scopus 로고    scopus 로고
    • The Wnt signaling pathway and its role in tumor development
    • B. Lustig, and J. Behrens The Wnt signaling pathway and its role in tumor development J. Cancer Res. Clin. Oncol. 129 2003 199 221
    • (2003) J. Cancer Res. Clin. Oncol. , vol.129 , pp. 199-221
    • Lustig, B.1    Behrens, J.2
  • 137
    • 0029822118 scopus 로고    scopus 로고
    • Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells
    • M.P. Madaio, M. Fabbi, M. Tiso, A. Daga, and A. Puccetti Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells Eur. J. Immunol. 26 1996 3035 3041
    • (1996) Eur. J. Immunol. , vol.26 , pp. 3035-3041
    • Madaio, M.P.1    Fabbi, M.2    Tiso, M.3    Daga, A.4    Puccetti, A.5
  • 138
    • 0035066009 scopus 로고    scopus 로고
    • The dynamics of cellular injury: Transformation into neuronal and vascular protection
    • K. Maiese The dynamics of cellular injury: transformation into neuronal and vascular protection Histol. Histopathol. 16 2001 633 644
    • (2001) Histol. Histopathol. , vol.16 , pp. 633-644
    • Maiese, K.1
  • 139
    • 0034652027 scopus 로고    scopus 로고
    • Membrane asymmetry and DNA degradation: Functionally distinct determinants of neuronal programmed cell death
    • K. Maiese, and A.M. Vincent Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death J. Neurosci. Res. 59 2000 568 580
    • (2000) J. Neurosci. Res. , vol.59 , pp. 568-580
    • Maiese, K.1    Vincent, A.M.2
  • 140
    • 0038061606 scopus 로고    scopus 로고
    • Nicotinamide: Necessary nutrient emerges as a novel cytoprotectant for the brain
    • K. Maiese, and Z.Z. Chong Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain Trends Pharmacol. Sci. 24 2003 228 232
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 228-232
    • Maiese, K.1    Chong, Z.Z.2
  • 141
    • 3042819409 scopus 로고    scopus 로고
    • Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease
    • K. Maiese, and Z.Z. Chong Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease Restor. Neurol. Neurosci. 22 2004 87 104
    • (2004) Restor. Neurol. Neurosci. , vol.22 , pp. 87-104
    • Maiese, K.1    Chong, Z.Z.2
  • 142
    • 26444459724 scopus 로고    scopus 로고
    • Impacting neuronal and vascular cellular signal transduction through the metabotropic glutamate receptor system
    • (in press).
    • K. Maiese, Z.Z. Chong, Impacting neuronal and vascular cellular signal transduction through the metabotropic glutamate receptor system, Medicinal Chemistry Reviews (in press).
    • Medicinal Chemistry Reviews
    • Maiese, K.1    Chong, Z.Z.2
  • 143
    • 0029980906 scopus 로고    scopus 로고
    • Cellular mechanisms of protection by metabotropic glutamate receptors during anoxia and nitric oxide toxicity
    • K. Maiese, M. Swiriduk, and M. TenBroeke Cellular mechanisms of protection by metabotropic glutamate receptors during anoxia and nitric oxide toxicity J. Neurochem. 66 1996 2419 2428
    • (1996) J. Neurochem. , vol.66 , pp. 2419-2428
    • Maiese, K.1    Swiriduk, M.2    Tenbroeke, M.3
  • 144
    • 0000448993 scopus 로고    scopus 로고
    • Elucidating neuronal and vascular injury through the cytoprotective agent nicotinamide
    • K. Maiese, S. Lin, and Z.Z. Chong Elucidating neuronal and vascular injury through the cytoprotective agent nicotinamide Curr. Med. Chem.-Imm., Endocr. Metab. Agents 1 2001 257 267
    • (2001) Curr. Med. Chem.-Imm., Endocr. Metab. Agents , vol.1 , pp. 257-267
    • Maiese, K.1    Lin, S.2    Chong, Z.Z.3
  • 145
    • 5644245234 scopus 로고    scopus 로고
    • Erythropoietin in the brain: Can the promise to protect be fulfilled?
    • K. Maiese, L. Faqi, and Z.Z. Chong Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol. Sci. 25 2004 577 583
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 577-583
    • Maiese, K.1    Faqi, L.2    Chong, Z.Z.3
  • 146
    • 0034145658 scopus 로고    scopus 로고
    • Molecular interactions between presenilin and calpain: Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain
    • K. Maruyama, M. Usami, F. Kametani, T. Tomita, T. Iwatsubo, T.C. Saido, H. Mori, and S. Ishiura Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain Int. J. Mol. Med. 5 2000 269 273
    • (2000) Int. J. Mol. Med. , vol.5 , pp. 269-273
    • Maruyama, K.1    Usami, M.2    Kametani, F.3    Tomita, T.4    Iwatsubo, T.5    Saido, T.C.6    Mori, H.7    Ishiura, S.8
  • 148
    • 0032742675 scopus 로고    scopus 로고
    • Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons
    • H. Matsuzaki, M. Tamatani, N. Mitsuda, K. Namikawa, H. Kiyama, S. Miyake, and M. Tohyama Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons J. Neurochem. 73 1999 2037 2046
    • (1999) J. Neurochem. , vol.73 , pp. 2037-2046
    • Matsuzaki, H.1    Tamatani, M.2    Mitsuda, N.3    Namikawa, K.4    Kiyama, H.5    Miyake, S.6    Tohyama, M.7
  • 149
    • 0034801808 scopus 로고    scopus 로고
    • Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life
    • W.C. McCormick, J. Hardy, W.A. Kukull, J.D. Bowen, L. Teri, S. Zitzer, and E.B. Larson Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life J. Am. Geriatr. Soc. 49 2001 1156 1160
    • (2001) J. Am. Geriatr. Soc. , vol.49 , pp. 1156-1160
    • McCormick, W.C.1    Hardy, J.2    Kukull, W.A.3    Bowen, J.D.4    Teri, L.5    Zitzer, S.6    Larson, E.B.7
  • 150
    • 0043135185 scopus 로고    scopus 로고
    • DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    • D.L. McPhie, R. Coopersmith, A. Hines-Peralta, Y. Chen, K.J. Ivins, S.P. Manly, M.R. Kozlowski, K.A. Neve, and R.L. Neve DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3 J. Neurosci. 23 2003 6914 6927
    • (2003) J. Neurosci. , vol.23 , pp. 6914-6927
    • McPhie, D.L.1    Coopersmith, R.2    Hines-Peralta, A.3    Chen, Y.4    Ivins, K.J.5    Manly, S.P.6    Kozlowski, M.R.7    Neve, K.A.8    Neve, R.L.9
  • 151
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • A. McShea, P.L. Harris, K.R. Webster, A.F. Wahl, and M.A. Smith Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease Am. J. Pathol. 150 1997 1933 1939
    • (1997) Am. J. Pathol. , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 152
    • 0034237388 scopus 로고    scopus 로고
    • Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology
    • G. Mehlhorn, M. Hollborn, and R. Schliebs Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology Int. J. Dev. Neurosci. 18 2000 423 431
    • (2000) Int. J. Dev. Neurosci. , vol.18 , pp. 423-431
    • Mehlhorn, G.1    Hollborn, M.2    Schliebs, R.3
  • 153
    • 0035949733 scopus 로고    scopus 로고
    • Models of progression in AD: Predicting disability and costs
    • M.S. Mendiondo, R.J. Kryscio, and F.A. Schmitt Models of progression in AD: predicting disability and costs Neurology 57 2001 943 944
    • (2001) Neurology , vol.57 , pp. 943-944
    • Mendiondo, M.S.1    Kryscio, R.J.2    Schmitt, F.A.3
  • 154
    • 0037451044 scopus 로고    scopus 로고
    • Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease
    • B. Michalski, and M. Fahnestock Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease Brain Res. Mol. Brain Res. 111 2003 148 154
    • (2003) Brain Res. Mol. Brain Res. , vol.111 , pp. 148-154
    • Michalski, B.1    Fahnestock, M.2
  • 155
    • 0033609561 scopus 로고    scopus 로고
    • Increased expression of Wnt-1 in schizophrenic brains
    • T. Miyaoka, H. Seno, and H. Ishino Increased expression of Wnt-1 in schizophrenic brains Schizophr. Res. 38 1999 1 6
    • (1999) Schizophr. Res. , vol.38 , pp. 1-6
    • Miyaoka, T.1    Seno, H.2    Ishino, H.3
  • 157
    • 0034973708 scopus 로고    scopus 로고
    • The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides
    • A. Monji, H. Utsumi, T. Ueda, T. Imoto, I. Yoshida, S. Hashioka, K. Tashiro, and N. Tashiro The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides J. Neurochem. 77 2001 1425 1432
    • (2001) J. Neurochem. , vol.77 , pp. 1425-1432
    • Monji, A.1    Utsumi, H.2    Ueda, T.3    Imoto, T.4    Yoshida, I.5    Hashioka, S.6    Tashiro, K.7    Tashiro, N.8
  • 158
    • 0030972976 scopus 로고    scopus 로고
    • Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis
    • J.W. Montague, F. Hughes Jr., and J.A. Cidlowski Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis J. Biol. Chem. 272 1997 6677 6684
    • (1997) J. Biol. Chem. , vol.272 , pp. 6677-6684
    • Montague, J.W.1    Hughes Jr., F.2    Cidlowski, J.A.3
  • 160
    • 2942625603 scopus 로고    scopus 로고
    • Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    • P.K. Mukherjee, V.L. Marcheselli, C.N. Serhan, and N.G. Bazan Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress Proc. Natl. Acad. Sci. U. S. A. 101 2004 8491 8496
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 8491-8496
    • Mukherjee, P.K.1    Marcheselli, V.L.2    Serhan, C.N.3    Bazan, N.G.4
  • 161
    • 0031567583 scopus 로고    scopus 로고
    • Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons
    • J.R. Munoz-Montano, F.J. Moreno, J. Avila, and J. Diaz-Nido Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons FEBS Lett. 411 1997 183 188
    • (1997) FEBS Lett. , vol.411 , pp. 183-188
    • Munoz-Montano, J.R.1    Moreno, F.J.2    Avila, J.3    Diaz-Nido, J.4
  • 163
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, and J. Yuan Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta Nature 403 2000 98 103
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 165
    • 0036166263 scopus 로고    scopus 로고
    • Cell death induced by a caspase-cleaved transmembrane fragment of the Alzheimer amyloid precursor protein
    • I. Nishimura, T. Uetsuki, K. Kuwako, T. Hara, T. Kawakami, S. Aimoto, and K. Yoshikawa Cell death induced by a caspase-cleaved transmembrane fragment of the Alzheimer amyloid precursor protein Cell Death Differ. 9 2002 199 208
    • (2002) Cell Death Differ. , vol.9 , pp. 199-208
    • Nishimura, I.1    Uetsuki, T.2    Kuwako, K.3    Hara, T.4    Kawakami, T.5    Aimoto, S.6    Yoshikawa, K.7
  • 166
    • 0028973512 scopus 로고
    • Distribution of mu-calpain proenzyme in the brain and other neural tissues in the rat
    • K. Onizuka, M. Kunimatsu, Y. Ozaki, K. Muramatsu, M. Sasaki, and H. Nishino Distribution of mu-calpain proenzyme in the brain and other neural tissues in the rat Brain Res. 697 1995 179 186
    • (1995) Brain Res. , vol.697 , pp. 179-186
    • Onizuka, K.1    Kunimatsu, M.2    Ozaki, Y.3    Muramatsu, K.4    Sasaki, M.5    Nishino, H.6
  • 167
    • 0031196773 scopus 로고    scopus 로고
    • Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve
    • Y. Owada, A. Utsunomiya, T. Yoshimoto, and H. Kondo Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve J. Mol. Neurosci. 9 1997 27 33
    • (1997) J. Mol. Neurosci. , vol.9 , pp. 27-33
    • Owada, Y.1    Utsunomiya, A.2    Yoshimoto, T.3    Kondo, H.4
  • 168
    • 20444371194 scopus 로고    scopus 로고
    • Abnormalities of peptide metabolism in Alzheimer disease
    • M. Panchal, M. Rholam, and N. Brakch Abnormalities of peptide metabolism in Alzheimer disease Curr. Neurovasc. Res. 1 2004 317 323
    • (2004) Curr. Neurovasc. Res. , vol.1 , pp. 317-323
    • Panchal, M.1    Rholam, M.2    Brakch, N.3
  • 169
    • 0031046748 scopus 로고    scopus 로고
    • Identification of a novel 97 kDa endonuclease capable of internucleosomal DNA cleavage
    • S. Pandey, P.R. Walker, and M. Sikorska Identification of a novel 97 kDa endonuclease capable of internucleosomal DNA cleavage Biochemistry 36 1997 711 720
    • (1997) Biochemistry , vol.36 , pp. 711-720
    • Pandey, S.1    Walker, P.R.2    Sikorska, M.3
  • 170
    • 0032577899 scopus 로고    scopus 로고
    • WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells
    • J. Papkoff, and M. Aikawa WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells Biochem. Biophys. Res. Commun. 247 1998 851 858
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 851-858
    • Papkoff, J.1    Aikawa, M.2
  • 171
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons
    • E. Paradis, H. Douillard, M. Koutroumanis, C. Goodyer, and A. LeBlanc Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons J. Neurosci. 16 1996 7533 7539
    • (1996) J. Neurosci. , vol.16 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    Leblanc, A.5
  • 172
    • 0029947673 scopus 로고    scopus 로고
    • Calcium influx is a determining factor of calpain activation and microparticle formation in platelets
    • J.M. Pasquet, J. Dachary-Prigent, and A.T. Nurden Calcium influx is a determining factor of calpain activation and microparticle formation in platelets Eur. J. Biochem. 239 1996 647 654
    • (1996) Eur. J. Biochem. , vol.239 , pp. 647-654
    • Pasquet, J.M.1    Dachary-Prigent, J.2    Nurden, A.T.3
  • 173
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • G.N. Patrick, L. Zukerberg, M. Nikolic, S. de la Monte, P. Dikkes, and L.H. Tsai Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 1999 615 622
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    De La Monte, S.4    Dikkes, P.5    Tsai, L.H.6
  • 174
    • 0032578024 scopus 로고    scopus 로고
    • Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
    • J.J. Pei, I. Grundke-Iqbal, K. Iqbal, N. Bogdanovic, B. Winblad, and R.F. Cowburn Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration Brain Res. 797 1998 267 277
    • (1998) Brain Res. , vol.797 , pp. 267-277
    • Pei, J.J.1    Grundke-Iqbal, I.2    Iqbal, K.3    Bogdanovic, N.4    Winblad, B.5    Cowburn, R.F.6
  • 175
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes
    • J.J. Pei, E. Braak, H. Braak, I. Grundke-Iqbal, K. Iqbal, B. Winblad, and R.F. Cowburn Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes J. Neuropathol. Exp. Neurol. 58 1999 1010 1019
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1010-1019
    • Pei, J.J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 179
    • 0033198217 scopus 로고    scopus 로고
    • BAX translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, BCL-2, and caspases
    • G.V. Putcha, M. Deshmukh, and E.M. Johnson Jr. BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases J. Neurosci. 19 1999 7476 7485
    • (1999) J. Neurosci. , vol.19 , pp. 7476-7485
    • Putcha, G.V.1    Deshmukh, M.2    Johnson Jr., E.M.3
  • 180
    • 0034661784 scopus 로고    scopus 로고
    • Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease
    • A.K. Raina, X. Zhu, C.A. Rottkamp, M. Monteiro, A. Takeda, and M.A. Smith Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease J. Neurosci. Res. 61 2000 128 133
    • (2000) J. Neurosci. Res. , vol.61 , pp. 128-133
    • Raina, A.K.1    Zhu, X.2    Rottkamp, C.A.3    Monteiro, M.4    Takeda, A.5    Smith, M.A.6
  • 181
    • 0242289451 scopus 로고    scopus 로고
    • Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury
    • S.K. Ray, D.D. Matzelle, E.A. Sribnick, M.K. Guyton, J.M. Wingrave, and N.L. Banik Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury J. Chem. Neuroanat. 26 2003 119 124
    • (2003) J. Chem. Neuroanat. , vol.26 , pp. 119-124
    • Ray, S.K.1    Matzelle, D.D.2    Sribnick, E.A.3    Guyton, M.K.4    Wingrave, J.M.5    Banik, N.L.6
  • 184
    • 0345095292 scopus 로고    scopus 로고
    • Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms
    • D. Religa, and B. Winblad Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms Acta Neurobiol. Exp. (Wars) 63 2003 393 396
    • (2003) Acta Neurobiol. Exp. (Wars) , vol.63 , pp. 393-396
    • Religa, D.1    Winblad, B.2
  • 185
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • G. Rena, S. Guo, S.C. Cichy, T.G. Unterman, and P. Cohen Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B J. Biol. Chem. 274 1999 17179 17183
    • (1999) J. Biol. Chem. , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohen, P.5
  • 186
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • C.S. Rhee, M. Sen, D. Lu, C. Wu, L. Leoni, J. Rubin, M. Corr, and D.A. Carson Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas Oncogene 21 2002 6598 6605
    • (2002) Oncogene , vol.21 , pp. 6598-6605
    • Rhee, C.S.1    Sen, M.2    Lu, D.3    Wu, C.4    Leoni, L.5    Rubin, J.6    Corr, M.7    Carson, D.A.8
  • 187
    • 0037442820 scopus 로고    scopus 로고
    • Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition
    • H.J. Rideout, Q. Wang, D.S. Park, and L. Stefanis Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition J. Neurosci. 23 2003 1237 1245
    • (2003) J. Neurosci. , vol.23 , pp. 1237-1245
    • Rideout, H.J.1    Wang, Q.2    Park, D.S.3    Stefanis, L.4
  • 188
    • 0030273482 scopus 로고    scopus 로고
    • Blockade of metabotropic glutamate receptors protects hippocampal neurons from hypoxia-induced cell death in rat in vivo
    • G. Riedel, T. Opitz, and K.G. Reymann Blockade of metabotropic glutamate receptors protects hippocampal neurons from hypoxia-induced cell death in rat in vivo Prog. Neuro-psychopharmacol. Biol. Psychiatry 20 1996 1253 1263
    • (1996) Prog. Neuro-psychopharmacol. Biol. Psychiatry , vol.20 , pp. 1253-1263
    • Riedel, G.1    Opitz, T.2    Reymann, K.G.3
  • 189
    • 0034814056 scopus 로고    scopus 로고
    • Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    • J. Rogers, and L.F. Lue Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease Neurochem. Int. 39 2001 333 340
    • (2001) Neurochem. Int. , vol.39 , pp. 333-340
    • Rogers, J.1    Lue, L.F.2
  • 190
    • 0035141757 scopus 로고    scopus 로고
    • Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease
    • T.T. Rohn, E. Head, J.H. Su, A.J. Anderson, B.A. Bahr, C.W. Cotman, and D.H. Cribbs Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease Am. J. Pathol. 158 2001 189 198
    • (2001) Am. J. Pathol. , vol.158 , pp. 189-198
    • Rohn, T.T.1    Head, E.2    Su, J.H.3    Anderson, A.J.4    Bahr, B.A.5    Cotman, C.W.6    Cribbs, D.H.7
  • 191
    • 0033568430 scopus 로고    scopus 로고
    • Implication of calpain in caspase activation during B cell clonal deletion
    • A. Ruiz-Vela, G. Gonzalez de Buitrago, and A.C. Martinez Implication of calpain in caspase activation during B cell clonal deletion EMBO J. 18 1999 4988 4998
    • (1999) EMBO J. , vol.18 , pp. 4988-4998
    • Ruiz-Vela, A.1    Gonzalez De Buitrago, G.2    Martinez, A.C.3
  • 192
    • 0032171182 scopus 로고    scopus 로고
    • The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress
    • Y. Sagara, and D. Schubert The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress J. Neurosci. 18 1998 6662 6671
    • (1998) J. Neurosci. , vol.18 , pp. 6662-6671
    • Sagara, Y.1    Schubert, D.2
  • 193
    • 11244266064 scopus 로고    scopus 로고
    • Regulation of endothelial cell death and its role in angiogenesis and vascular regression
    • K. Sakamaki Regulation of endothelial cell death and its role in angiogenesis and vascular regression Curr. Neurovasc. Res. 1 2004 305 315
    • (2004) Curr. Neurovasc. Res. , vol.1 , pp. 305-315
    • Sakamaki, K.1
  • 194
    • 0038529681 scopus 로고    scopus 로고
    • Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner
    • M. Salinas, R. Diaz, N.G. Abraham, C.M. Ruiz de Galarreta, and A. Cuadrado Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner J. Biol. Chem. 278 2003 13898 13904
    • (2003) J. Biol. Chem. , vol.278 , pp. 13898-13904
    • Salinas, M.1    Diaz, R.2    Abraham, N.G.3    Ruiz De Galarreta, C.M.4    Cuadrado, A.5
  • 195
    • 0032524692 scopus 로고    scopus 로고
    • Measurement and characterization of superoxide generation in microglial cells: Evidence for an NADPH oxidase-dependent pathway
    • S. Sankarapandi, J.L. Zweier, G. Mukherjee, M.T. Quinn, and D.L. Huso Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway Arch. Biochem. Biophys. 353 1998 312 321
    • (1998) Arch. Biochem. Biophys. , vol.353 , pp. 312-321
    • Sankarapandi, S.1    Zweier, J.L.2    Mukherjee, G.3    Quinn, M.T.4    Huso, D.L.5
  • 196
    • 0026507413 scopus 로고
    • Role of poly(ADP-ribose) formation in DNA repair
    • M.S. Satoh, and T. Lindahl Role of poly(ADP-ribose) formation in DNA repair Nature 356 1992 356 358
    • (1992) Nature , vol.356 , pp. 356-358
    • Satoh, M.S.1    Lindahl, T.2
  • 199
    • 0038575498 scopus 로고    scopus 로고
    • Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons
    • S.K. Sharma, and M. Ebadi Metallothionein attenuates 3- morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons Antioxid. Redox Signal. 5 2003 251 264
    • (2003) Antioxid. Redox Signal. , vol.5 , pp. 251-264
    • Sharma, S.K.1    Ebadi, M.2
  • 200
    • 0030612795 scopus 로고    scopus 로고
    • Restriction of microM-calcium-requiring calpain activation to the plasma membrane in human neuroblastoma cells: Evidence for regionalized influence of a calpain activator protein
    • T.B. Shea Restriction of microM-calcium-requiring calpain activation to the plasma membrane in human neuroblastoma cells: evidence for regionalized influence of a calpain activator protein J. Neurosci. Res. 48 1997 543 550
    • (1997) J. Neurosci. Res. , vol.48 , pp. 543-550
    • Shea, T.B.1
  • 201
    • 0030757323 scopus 로고    scopus 로고
    • Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms
    • J.G. Sheng, R.E. Mrak, and W.S. Griffin Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms Acta Neuropathol. (Berl) 94 1997 1 5
    • (1997) Acta Neuropathol. (Berl) , vol.94 , pp. 1-5
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.3
  • 202
    • 0033549526 scopus 로고    scopus 로고
    • IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity
    • H. Shiraha, A. Glading, K. Gupta, and A. Wells IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity J. Cell Biol. 146 1999 243 254
    • (1999) J. Cell Biol. , vol.146 , pp. 243-254
    • Shiraha, H.1    Glading, A.2    Gupta, K.3    Wells, A.4
  • 203
    • 0029794641 scopus 로고    scopus 로고
    • Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2
    • M. Silva, D. Grillot, A. Benito, C. Richard, G. Nunez, and J.L. Fernandez-Luna Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 Blood 88 1996 1576 1582
    • (1996) Blood , vol.88 , pp. 1576-1582
    • Silva, M.1    Grillot, D.2    Benito, A.3    Richard, C.4    Nunez, G.5    Fernandez-Luna, J.L.6
  • 204
    • 0036833572 scopus 로고    scopus 로고
    • Nitric oxide and hydroxyl radical-induced retinal lipid peroxidation in vitro
    • A.W. Siu, and C.H. To Nitric oxide and hydroxyl radical-induced retinal lipid peroxidation in vitro Clin. Exp. Optom. 85 2002 378 382
    • (2002) Clin. Exp. Optom. , vol.85 , pp. 378-382
    • Siu, A.W.1    To, C.H.2
  • 205
    • 0031456672 scopus 로고    scopus 로고
    • Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
    • D.C. Slusarski, V.G. Corces, and R.T. Moon Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling Nature 390 1997 410 413
    • (1997) Nature , vol.390 , pp. 410-413
    • Slusarski, D.C.1    Corces, V.G.2    Moon, R.T.3
  • 207
    • 0035911156 scopus 로고    scopus 로고
    • Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing
    • S. Soriano, D.E. Kang, M. Fu, R. Pestell, N. Chevallier, H. Zheng, and E.H. Koo Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing J. Cell Biol. 152 2001 785 794
    • (2001) J. Cell Biol. , vol.152 , pp. 785-794
    • Soriano, S.1    Kang, D.E.2    Fu, M.3    Pestell, R.4    Chevallier, N.5    Zheng, H.6    Koo, E.H.7
  • 209
    • 0031741578 scopus 로고    scopus 로고
    • The free radical antioxidant vitamin e protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: Relevance to the free radical hypothesis of Alzheimer's disease
    • R. Subramaniam, T. Koppal, M. Green, S. Yatin, B. Jordan, J. Drake, and D.A. Butterfield The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease Neurochem. Res. 23 1998 1403 1410
    • (1998) Neurochem. Res. , vol.23 , pp. 1403-1410
    • Subramaniam, R.1    Koppal, T.2    Green, M.3    Yatin, S.4    Jordan, B.5    Drake, J.6    Butterfield, D.A.7
  • 210
    • 0028175797 scopus 로고
    • Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis
    • X.M. Sun, and G.M. Cohen Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis J. Biol. Chem. 269 1994 14857 14860
    • (1994) J. Biol. Chem. , vol.269 , pp. 14857-14860
    • Sun, X.M.1    Cohen, G.M.2
  • 211
    • 0034130385 scopus 로고    scopus 로고
    • Xwnt11 is a target of Xenopus Brachyury: Regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway
    • M. Tada, and J.C. Smith Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway Development 127 2000 2227 2238
    • (2000) Development , vol.127 , pp. 2227-2238
    • Tada, M.1    Smith, J.C.2
  • 212
    • 0033563738 scopus 로고    scopus 로고
    • Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: Sequential activation of caspases 8, 3, and 1 in the apoptotic process
    • H. Takahashi, S. Nakamura, K. Asano, M. Kinouchi, A. Ishida-Yamamoto, and H. Iizuka Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: sequential activation of caspases 8, 3, and 1 in the apoptotic process Exp. Cell Res. 249 1999 291 298
    • (1999) Exp. Cell Res. , vol.249 , pp. 291-298
    • Takahashi, H.1    Nakamura, S.2    Asano, K.3    Kinouchi, M.4    Ishida-Yamamoto, A.5    Iizuka, H.6
  • 214
    • 0031695652 scopus 로고    scopus 로고
    • Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
    • A. Takashima, T. Honda, K. Yasutake, G. Michel, O. Murayama, M. Murayama, K. Ishiguro, and H. Yamaguchi Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons Neurosci. Res. 31 1998 317 323
    • (1998) Neurosci. Res. , vol.31 , pp. 317-323
    • Takashima, A.1    Honda, T.2    Yasutake, K.3    Michel, G.4    Murayama, O.5    Murayama, M.6    Ishiguro, K.7    Yamaguchi, H.8
  • 215
    • 0028232888 scopus 로고
    • Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death
    • M. Tanaka, A. Sotomatsu, T. Yoshida, S. Hirai, and A. Nishida Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death J. Neurochem. 63 1994 266 270
    • (1994) J. Neurochem. , vol.63 , pp. 266-270
    • Tanaka, M.1    Sotomatsu, A.2    Yoshida, T.3    Hirai, S.4    Nishida, A.5
  • 218
    • 0037444442 scopus 로고    scopus 로고
    • Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity
    • D.L. Taylor, L.T. Diemel, and J.M. Pocock Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity J. Neurosci. 23 2003 2150 2160
    • (2003) J. Neurosci. , vol.23 , pp. 2150-2160
    • Taylor, D.L.1    Diemel, L.T.2    Pocock, J.M.3
  • 219
    • 18844396519 scopus 로고    scopus 로고
    • Caspase activation increases Abeta generation independently of caspase cleavage of APP
    • G. Tesco, Y.H. Koh, and R.E. Tanzi Caspase activation increases Abeta generation independently of caspase cleavage of APP J. Biol. Chem. 5 2003 5
    • (2003) J. Biol. Chem. , vol.5 , pp. 5
    • Tesco, G.1    Koh, Y.H.2    Tanzi, R.E.3
  • 220
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • O. Tetsu, and F. McCormick Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 221
    • 0032921489 scopus 로고    scopus 로고
    • Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: A modulator of in vivo programmed cell death?
    • S. Timsit, S. Rivera, P. Ouaghi, F. Guischard, E. Tremblay, Y. Ben-Ari, and M. Khrestchatisky Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death? Eur. J. Neurosci. 11 1999 263 278
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 263-278
    • Timsit, S.1    Rivera, S.2    Ouaghi, P.3    Guischard, F.4    Tremblay, E.5    Ben-Ari, Y.6    Khrestchatisky, M.7
  • 223
    • 0030611725 scopus 로고    scopus 로고
    • On the use of Zn2+ to discriminate endonucleases activated during apoptosis
    • A. Torriglia, E. Chaudun, Y. Courtois, and M.F. Counis On the use of Zn2+ to discriminate endonucleases activated during apoptosis Biochimie 79 1997 435 438
    • (1997) Biochimie , vol.79 , pp. 435-438
    • Torriglia, A.1    Chaudun, E.2    Courtois, Y.3    Counis, M.F.4
  • 228
    • 0030974065 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices
    • I.H. Ulus, and R.J. Wurtman Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices J. Pharmacol. Exp. Ther. 281 1997 149 154
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 149-154
    • Ulus, I.H.1    Wurtman, R.J.2
  • 233
    • 0032964018 scopus 로고    scopus 로고
    • Direct temporal analysis of apoptosis induction in living adherent neurons
    • A.M. Vincent, and K. Maiese Direct temporal analysis of apoptosis induction in living adherent neurons J. Histochem. Cytochem. 47 1999 661 672
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 661-672
    • Vincent, A.M.1    Maiese, K.2
  • 234
    • 0033080459 scopus 로고    scopus 로고
    • Nitric oxide induction of neuronal endonuclease activity in programmed cell death
    • A.M. Vincent, and K. Maiese Nitric oxide induction of neuronal endonuclease activity in programmed cell death Exp. Cell Res. 246 1999 290 300
    • (1999) Exp. Cell Res. , vol.246 , pp. 290-300
    • Vincent, A.M.1    Maiese, K.2
  • 235
    • 0033756673 scopus 로고    scopus 로고
    • The metabotropic glutamate system promotes neuronal survival through distinct pathways of programmed cell death
    • A.M. Vincent, and K. Maiese The metabotropic glutamate system promotes neuronal survival through distinct pathways of programmed cell death Exp. Neurol. 166 2000 65 82
    • (2000) Exp. Neurol. , vol.166 , pp. 65-82
    • Vincent, A.M.1    Maiese, K.2
  • 236
    • 0030690931 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors prevent nitric oxide induced programmed cell death
    • A.M. Vincent, Y. Mohammad, I. Ahmad, R. Greenberg, and K. Maiese Metabotropic glutamate receptors prevent nitric oxide induced programmed cell death J. Neurosci. Res. 50 1997 549 564
    • (1997) J. Neurosci. Res. , vol.50 , pp. 549-564
    • Vincent, A.M.1    Mohammad, Y.2    Ahmad, I.3    Greenberg, R.4    Maiese, K.5
  • 237
    • 0033011288 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH
    • A.M. Vincent, M. TenBroeke, and K. Maiese Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH Exp. Neurol. 155 1999 79 94
    • (1999) Exp. Neurol. , vol.155 , pp. 79-94
    • Vincent, A.M.1    Tenbroeke, M.2    Maiese, K.3
  • 238
    • 0035807940 scopus 로고    scopus 로고
    • Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis
    • C. Volbracht, E. Fava, M. Leist, and P. Nicotera Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis NeuroReport 12 2001 3645 3648
    • (2001) NeuroReport , vol.12 , pp. 3645-3648
    • Volbracht, C.1    Fava, E.2    Leist, M.3    Nicotera, P.4
  • 239
    • 0031567596 scopus 로고    scopus 로고
    • Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells
    • U. Wagner, J. Brownlees, N.G. Irving, F.R. Lucas, P.C. Salinas, and C.C. Miller Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells FEBS Lett. 411 1997 369 372
    • (1997) FEBS Lett. , vol.411 , pp. 369-372
    • Wagner, U.1    Brownlees, J.2    Irving, N.G.3    Lucas, F.R.4    Salinas, P.C.5    Miller, C.C.6
  • 240
    • 0035876056 scopus 로고    scopus 로고
    • Huperzine a attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat
    • R. Wang, H.Y. Zhang, and X.C. Tang Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat Eur. J. Pharmacol. 421 2001 149 156
    • (2001) Eur. J. Pharmacol. , vol.421 , pp. 149-156
    • Wang, R.1    Zhang, H.Y.2    Tang, X.C.3
  • 241
    • 0242516020 scopus 로고    scopus 로고
    • Oxidative neurotoxicity in rat cerebral cortex neurons: Synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3
    • J.Y. Wang, A.Y. Shum, and Y.J. Ho Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3 J. Neurosci. Res. 72 2003 508 519
    • (2003) J. Neurosci. Res. , vol.72 , pp. 508-519
    • Wang, J.Y.1    Shum, A.Y.2    Ho, Y.J.3
  • 242
    • 12344275932 scopus 로고    scopus 로고
    • Calcium homeostasis following traumatic neuronal injury
    • J. Weber Calcium homeostasis following traumatic neuronal injury Curr. Neurovasc. Res. 1 2004 151 171
    • (2004) Curr. Neurovasc. Res. , vol.1 , pp. 151-171
    • Weber, J.1
  • 243
    • 0034295217 scopus 로고    scopus 로고
    • Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation
    • J. Wegiel, K.C. Wang, M. Tarnawski, and B. Lach Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation Acta Neuropathol. (Berl) 100 2000 356 364
    • (2000) Acta Neuropathol. (Berl) , vol.100 , pp. 356-364
    • Wegiel, J.1    Wang, K.C.2    Tarnawski, M.3    Lach, B.4
  • 245
    • 0034704141 scopus 로고    scopus 로고
    • Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1
    • M.J. Wick, L.Q. Dong, R.A. Riojas, F.J. Ramos, and F. Liu Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1 J. Biol. Chem. 275 2000 40400 40406
    • (2000) J. Biol. Chem. , vol.275 , pp. 40400-40406
    • Wick, M.J.1    Dong, L.Q.2    Riojas, R.A.3    Ramos, F.J.4    Liu, F.5
  • 246
    • 0036703627 scopus 로고    scopus 로고
    • Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt
    • A. Wick, W. Wick, J. Waltenberger, M. Weller, J. Dichgans, and J.B. Schulz Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt J. Neurosci. 22 2002 6401 6407
    • (2002) J. Neurosci. , vol.22 , pp. 6401-6407
    • Wick, A.1    Wick, W.2    Waltenberger, J.3    Weller, M.4    Dichgans, J.5    Schulz, J.B.6
  • 247
    • 0033836217 scopus 로고    scopus 로고
    • Phagocytic clearance of apoptotic neurons by Microglia/Brain macrophages in vitro: Involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition
    • A. Witting, P. Muller, A. Herrmann, H. Kettenmann, and C. Nolte Phagocytic clearance of apoptotic neurons by Microglia/Brain macrophages in vitro: involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition J. Neurochem. 75 2000 1060 1070
    • (2000) J. Neurochem. , vol.75 , pp. 1060-1070
    • Witting, A.1    Muller, P.2    Herrmann, A.3    Kettenmann, H.4    Nolte, C.5
  • 250
    • 0036169830 scopus 로고    scopus 로고
    • Selective nitration of mitochondrial complex I by peroxynitrite: Involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells
    • T. Yamamoto, W. Maruyama, Y. Kato, H. Yi, M. Shamoto-Nagai, M. Tanaka, Y. Sato, and M. Naoi Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells J. Neural Transm. 109 2002 1 13
    • (2002) J. Neural Transm. , vol.109 , pp. 1-13
    • Yamamoto, T.1    Maruyama, W.2    Kato, Y.3    Yi, H.4    Shamoto-Nagai, M.5    Tanaka, M.6    Sato, Y.7    Naoi, M.8
  • 251
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • Y. Yang, E.J. Mufson, and K. Herrup Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease J. Neurosci. 23 2003 2557 2563
    • (2003) J. Neurosci. , vol.23 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.J.2    Herrup, K.3
  • 252
    • 0036830353 scopus 로고    scopus 로고
    • Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia
    • X.M. Yin, Y. Luo, G. Cao, L. Bai, W. Pei, D.K. Kuharsky, and J. Chen Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia J. Biol. Chem. 277 2002 42074 42081
    • (2002) J. Biol. Chem. , vol.277 , pp. 42074-42081
    • Yin, X.M.1    Luo, Y.2    Cao, G.3    Bai, L.4    Pei, W.5    Kuharsky, D.K.6    Chen, J.7
  • 254
    • 0037446980 scopus 로고    scopus 로고
    • The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
    • C. Yu, M. Rahmani, Y. Dai, D. Conrad, G. Krystal, P. Dent, and S. Grant The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt- dependent process Cancer Res. 63 2003 1822 1833
    • (2003) Cancer Res. , vol.63 , pp. 1822-1833
    • Yu, C.1    Rahmani, M.2    Dai, Y.3    Conrad, D.4    Krystal, G.5    Dent, P.6    Grant, S.7
  • 255
    • 0037017399 scopus 로고    scopus 로고
    • Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
    • Y. Zhang, R. McLaughlin, C. Goodyer, and A. LeBlanc Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons J. Cell Biol. 156 2002 519 529
    • (2002) J. Cell Biol. , vol.156 , pp. 519-529
    • Zhang, Y.1    McLaughlin, R.2    Goodyer, C.3    Leblanc, A.4
  • 256
    • 0032521599 scopus 로고    scopus 로고
    • Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase a at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation
    • Q. Zheng-Fischhofer, J. Biernat, E.M. Mandelkow, S. Illenberger, R. Godemann, and E. Mandelkow Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical- filament-like conformation Eur. J. Biochem. 252 1998 542 552
    • (1998) Eur. J. Biochem. , vol.252 , pp. 542-552
    • Zheng-Fischhofer, Q.1    Biernat, J.2    Mandelkow, E.M.3    Illenberger, S.4    Godemann, R.5    Mandelkow, E.6


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