Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

Journal of Biological Chemistry

Volumn 278, Issue 51, 2003, Pages 50985-50998

  Jackson, Michael D ^a   Schmidt, Manning T ^a   Oppenheimer, Norman J ^b   Denu, John M ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; CATALYSIS; ENZYME INHIBITION; GENES; METABOLISM;

DEACETYLATION;

ENZYMES;

ADENOSINE DIPHOSPHATE RIBOSE; HISTONE DEACETYLASE; LYSINE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SILENT INFORMATION REGULATOR PROTEIN 2;

ACETYLATION; ANIMAL CELL; ARTICLE; CATALYSIS; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME METABOLISM; GENE CONTROL; GENE SILENCING; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN TARGETING; TARGET CELL;

AMINO ACID SUBSTITUTION; CATALYSIS; GLYCOSYLATION; HISTONE DEACETYLASES; HUMANS; KINETICS; MODELS, CHEMICAL; NAD; NIACINAMIDE; PYRIDINES; RIBOSE; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS;

ANIMALIA;

EID: 0346435109     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306552200     Document Type: Article

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