Oxidative neurotoxicity in rat cerebral cortex neurons: Synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3

Journal of Neuroscience Research

Volumn 72, Issue 4, 2003, Pages 508-519

  Wang, Jiz Yuh ^a   Shum, Andrew Y C ^b   Ho, Yi Jung ^a   Wang, Jia Yi ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase 3; H2O2; NO; p38 MAPK

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PEROXYNITRITE; SUPEROXIDE; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MICROGLIA; NERVE CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; OXIDATION KINETICS; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; EXTRACELLULAR SPACE; FETUS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NITRIC OXIDE; NITRIC OXIDE DONORS; OXIDANTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXYNITROUS ACID; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; S-NITROSO-N-ACETYLPENICILLAMINE;

EID: 0242516020     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10597     Document Type: Article

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