The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12064-12069

  Da Costa, Cristine Alves ^a   Mattson, Mark P ^b   Ancolio, Karine ^a   Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; DEGRADATION; DISEASES;

HOLOPROTEINS;

BIOCHEMISTRY;

CASPASE 3 INHIBITOR; CYTOCHROME C; ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PIFITHRIN ALPHA; PRESENILIN 2; PRESENILINASE; PROTEIN BCL 2; PROTEIN INHIBITOR; PROTEIN P53; STAUROSPORINE; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; DRUG DERIVATIVE; ENZYME INHIBITOR; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PIFITHRIN; PSEN2 PROTEIN, HUMAN; THIAZOLE DERIVATIVE; TOLUENE;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; FIBROBLAST; FLOW CYTOMETRY; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; NICK END LABELING; PRIORITY JOURNAL; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DIMERIZATION; DRUG EFFECT; GENE EXPRESSION; GENETICS; KIDNEY; METABOLISM; MOUSE; PHENOTYPE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; APOPTOSIS; BENZOTHIAZOLES; CASPASE 3; CASPASES; CELLS, CULTURED; DIMERIZATION; ENZYME INHIBITORS; FIBROBLASTS; GENE EXPRESSION; HUMANS; KIDNEY; MEMBRANE PROTEINS; MICE; PEPTIDE FRAGMENTS; PHENOTYPE; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY; STAUROSPORINE; THIAZOLES; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037809240     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212379200     Document Type: Article

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