Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation

Molecular Pharmacology

Volumn 64, Issue 3, 2003, Pages 557-569

  Kang, Jing Qiong ^a   Chong, Zhao Zhong ^a   Maiese, Kenneth ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CELL NUCLEUS DNA; CYSTEINE PROTEINASE; CYTOCHROME C; PHOSPHATIDYLSERINE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DRUG ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROGLIA; PHAGOCYTE; PLASMID; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; HUMANS; MICROGLIA; NITRIC OXIDE; PHOSPHATIDYLSERINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TUMOR CELLS, CULTURED;

EID: 0042355359     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.3.557     Document Type: Article

References (37)

1. Anderson I, Adinolfi C, Doctrow S, Huffman K, Joy KA, Malfroy B, Soden P, Rupniak HT, and Barnes JC (2001) Oxidative signalling and inflammatory pathways in Alzheimer's disease. Biochem Soc Symp 67:141-149.
2. Andree HA, Reutelingsperger CP, Hauptmann R, Hemker HC, Hermens WT, and Willems GM (1990) Binding of vascular anticoagulant α (VAC α) to planar phospholipid bilayers. J Biol Chem 265:4923-4928.
3. Bal-Price A and Brown GC (2000) Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem 75:1455-1464.
4. Chong ZZ, Kang JQ, and Maiese K (2002a) Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab 22:503-514.
5. Chong ZZ, Lin SH, and Maiese K (2002b) Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury. J Vasc Res 39:131-147.
6. Dombroski D, Balasubramanian K, and Schroit AJ (2000) Phosphatidylserine expression on cell surfaces promotes antibody-dependent aggregation and thrombosis in beta2-glycoprotein I-immune mice. J Autoimmun 14:221-229.
7. Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Janicke RU, Porter AG, Belka C, et al. (2000) Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 19:4563-4573.
8. Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, and Morrison RS (2000) p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol 150:335-347.
9. Giulian D and Baker TJ (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
10. Hoffmann PR, deCathelineau AM, Ogden CA, Leverrier Y, Bratton DL, Daleke DL, Ridley AJ, Fadok VA, and Henson PM (2001) Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J Cell Biol 155:649-659.
11. Jessel R, Haertel S, Socaciu C, Tykhonova S, and Diehl HA (2002) Kinetics of apoptotic markers in exogenously induced apoptosis of EL4 cells. J Cell Mol Med 6:82-92.
12. Kennedy SG, Kandel ES, Cross TK and Hay N (1999) Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 19:5800-5810.
13. Keramaris E, Stefanis L, MacLaurin J, Harada N, Takaku K, Ishikawa T, Taketo MM, Robertson GS, Nicholson DW, Slack RS, et al. (2000) Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage. Mol Cell Neurosci 15:368-379.
14. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, and Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489.
15. Lin SH and Maiese K (2001) The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells. J Cereb Blood Flow Metab 21:262-275.
16. Maiese K and Vincent AM (2000) Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death. J Neurosci Res 59:568-580.
17. Mandal D, Moitra PK, Saha S, and Basu J (2002) Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes. FEBS Lett 513:184-188.
18. Martin LJ and Liu Z (2002) DNA damage profiling in motor neurons: a single-cell analysis by comet assay. Neurochem Res 27:1093-1104.
19. Martinez-Contreras A, Huerta M, Lopez-Perez S, Garcia-Estrada J, Luquin S, and Beas Zarate C (2002) Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. J Neurosci Res 67:200-210.
20. Matsuzaki H, Tamatani M, Mitsuda N, Namikawa K, Kiyama H, Miyake S, and Tohyama M (1999) Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. J Neurochem 73:2037-2046.
21. Murashov AK, Ul Haq I, Hill C, Park E, Smith M, Wang X, Goldberg DJ, and Wolgemuth DJ (2001) Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury. Brain Res Mol Brain Res 93:199-208.
22. Namikawa K, Honma M, Abe K, Takeda M, Mansur K, Obata T, Miwa A, Okado H, and Kiyama H (2000) Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J Neurosci 20:2875-2886.
23. Oka M, Hirouchi M, Itoh Y, and Ukai Y (2000) Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices. Neuropharmacology 39:1319-1330.
24. Rucker-Martin C, Henaff M, Hatem SN, Delpy E, and Mercadier JJ (1999) Early redistribution of plasma membrane phosphatidylserine during apoptosis of adult rat ventricular myocytes in vitro. Basic Res Cardiol 94:171-179.
25. Sakurai M, Hayashi T, Abe K, Itoyuama Y, and Tabayashi K (2001) Induction of phosphatidylinositol 3-kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia. Neurosci Lett 302:17-20.
26. Schutte B, Nuydens R, Geerts H, and Ramaekers F (1998) Annexin V binding assay as a tool to measure apoptosis in differentiated neuronal cells. J Neurosci Methods 86:63-69.
27. Scott BA, Avidan MS, and Crowder CM (2002) Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science (Wash DC) 296:2388-2391.
28. Simak J, Holada K, and Vostal JG (2002) Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin. BMC Cell Biol 3:11.
29. Stegh AH, Barnhart BC, Volkland J, Algeciras-Schimnich A, Ke N, Reed JC, and Peter ME (2002) Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. J Biol Chem 277:4351-4360.
30. Takahashi H, Nakamura S, Asano K, Kinouchi M, Ishida-Yamamoto A, and Iizuka H (1999) Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: sequential activation of caspases 8, 3 and 1 in the apoptotic process. Exp Cell Res 249:291-298.
31. Vanags DM, Porn-Ares MI, Coppola S, Burgess DH, and Orrenius S (1996) Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J Biol Chem 271:31075-31085.
32. Vincent AM and Maiese K (1999a) Direct temporal analysis of apoptosis induction in living adherent neurons. J Histochem Cytochem 47:661-672.
33. Vincent AM and Maiese K (1999b) Nitric oxide induction of neuronal endonuclease activity in programmed cell death. Exp Cell Res 246:290-300.
34. Vincent AM, TenBroeke M, and Maiese K (1999) Neuronal intracellular pH directly mediates nitric oxide-induced programmed cell death. J Neurobiol 40:171-184.
35. Wick MJ, Dong LQ, Riojas RA, Ramos FJ, and Liu F (2000) Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1. J Biol Chem 275:40400-40406.
36. Williams K, Schwartz A, Corey S, Orandle M, Kennedy W, Thompson B, Alvarez X, Brown C, Gartner S, and Lackner A (2002) Proliferating cellular nuclear antigen expression as a marker of perivascular macrophages in simian immunodeficiency virus encephalitis. Am J Pathol 161:575-585.
37. Yabuki M, Tsutsui K, Horton AA, Yoshioka T, and Utsumi K (2000) Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor. Free Radic Res 32:507-514.