Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease

American Journal of Pathology

Volumn 150, Issue 6, 1997, Pages 1933-1939

  McShea, Andrew ^a   Harris, Peggy L R ^b   Webster, Kevin R ^c   Wahl, Alan F ^a   Smith, Mark A ^b,c  

^a BRISTOL MYERS SQUIBB   (United States)

^b Pharmaceutical Research Institute   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN P16; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL;

ALZHEIMER DISEASE; BRAIN; CARRIER PROTEINS; CELL CYCLE; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; IMMUNOHISTOCHEMISTRY; NEUROFIBRILLARY TANGLES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS;

EID: 0030921323     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Elledge SJ, Winston J, Harper JW: A question of balance: the role of cyclin kinase inhibitors in development and tumorigenesis. Trends Cell Biol 1996, 6:388-392
2. Sherr CJ: D-type cyclins. Trends Biochem Sci 1995, 20:187-190
3. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4, Nature 1993, 366:704-707
4. Berry DE, Lu Y, Schmidt B, Fallon PG, O'Connell C, Hu SX, Xu HJ, Blanck G: Retinoblastoma protein inhibits IFN-γ induced apoptosis. Oncogene 1996, 12:1809-1819
5. Donaldson KL, Goolsby GL, Kiener PA, Wahl AF: Activation of p34cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ 1994, 5:1041-1050
6. Schang LM, Hossain A, Jones C: The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression. J Virol 1996, 70:3807-3814
7. Kranenburg O, van der Eb AJ, Zantema A: Cyclin D1 is an essential mediator of apoptotic neuronal cell death, EMBO J 1996, 15:46-54
8. Freeman RS, Estus S, Johnson EM Jr: Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 1994, 12:343-355
9. Pope W, Enam SA, Bawa N, Miller BE, Ghanbari HA, Klein WL: Phosphorylated tau epitopes of Alzheimer's disease is coupled to axon development in the avian central nervous system. Exp Neurol 1993, 120:106-113
10. Brion JP, Passarier H, Nunez J, Flament-Durand J: Immunologic determinants of tau protein are present in neurofibrillary tangles of Alzheimer's disease. Arch Biol 1985, 95:229-235
11. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI: Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology, Proc Natl Acad Sci USA 1986, 83:4913-4917
12. Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A: Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci USA 1988, 85:4051-4055
13. Kanemaru K, Takio K, Miura R, Tiani K, Ihara Y: Fetal-type phosphorylation of the tau in paired helical filaments. J Neurochem 1992, 58:1667-1675
14. 396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule bindings, Neuron 1993, 10:1089-1099
15. 202 in Alzheimer's disease recapitulates phosphorylation during development. Proc Natl Acad Sci USA 1993, 90:5066-5070
16. Lee JH, Goedert M, Hill WD, Lee VMY, Trojanowski JQ: Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer's patients and developmentally regulated in fetal spinal cord. Exp Neurol 1993, 121:93-105
17. Brion JP, Octave JN, Couck AM: Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons. Neuroscience 1994, 63:895-909
18. Pope WB, Lambert MP, Leypofd B, Seupaul R, Sletten L, Krafft G, Klein WL: Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Exp Neurol 1994, 126:185-194
19. Preuss U, Doring F, Illenberger S, Mandelkow EM: Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells. Mol Biol Cell 1995, 6:1397-1410
20. Liu WK, Williams RT, Hall FL, Dickson DW, Yen SH: Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments. Am J Pathol 1995, 146:228-238
21. Ledesma MD, Correas I, Avila J, Diaz-Nido J: Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease. FEBS Lett 1992, 308:218-224
22. Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E: Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett 1993, 336:417-424
23. Khachaturian ZS: Diagnosis of Alzheimer's disease, Arch Neurol 1985, 42:1097-1105
24. Sternberger LA: Immunocytochemistry, ed 3. New York, Wiley, 1986
25. Perry G, Siedlak SL, Richey P, Kawai M, Cras P, Kalaria RN, Galloway PG, Miriam Scardina J, Cordell B, Greenberg BD, Ledbetter SR, Gambetti P: Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J Neurosci 1991, 11:3679-3683
26. Kranenburg O, de Groot RP, Van der Eb AJ, Zantema A: Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile, Oncogene 1995, 10:87-95
27. Kiess M, Gill RM, Hamel PA: Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubules, Oncogene 1995, 10:159-166
28. Terada Y, Tatsuka M, Jinno S, Okayama H: Requirement for tyrosine phosphorylation of CDK4 in G1 arrest induced by ultraviolet irradiation, Nature 1995, 376:358-362
29. Spana C, O'Rourke EC, Bolen JB, Fargnoli J: Analysis of the tyrosine protein kinase p561ck expressed as a glutathione S-transferase fusion protein in Spodoptera frugiperda cells, Protein Exp Purif 1993, 4:390-397
30. Smith MA, Kutty RK, Richey PL, Yan S-D, Stern D, Chader GJ, Wiggert B, Petersen RB, Perry G: Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol 1994, 145:42-47
31. Premkumar DRD, Smith MA, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, Kalaria RN: Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. J Neurochem 1995, 65:1399-1402
32. Smith MA, Sayre LM, Monnier VM, Perry G: Radical AGEing in Alzheimer's disease. Trends Neurosci 1995, 18:172-176
33. Curcio F, Ceriello A: Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell Dev Biol 1992, 28A787-790
34. Stewart BW: Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 1994, 86:1286-1296
35. Ferrari G, Van CY, Greene LA: N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 1995, 15:2857-2866
36. Sugano T, Nitta M, Ohmori H, Yamaizumi M: Nuclear accumulation of p53 in normal human fibroblasts is induced by various cellular stresses which evoke the heat shock response, independently of the cell cycle. Jpn J Cancer Res 1995, 86:415-418
37. Lee PJ, Alam J, Wiegand GW, Choi AMK: Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci USA 1996, 93:10393-10398
38. Gómez-Pinilla F, Cummings BJ, Cotman CW: Induction of basic fibroblast growth factor in Alzheimer's disease pathology. Neuroreport 1990, 1:211-214
39. Stoppa EG, Gonzalez A-M, Chorsky R, Corona RJ, Alvarez J, Bird ED, Baird A: Basic fibroblast growth factor in Alzheimer's disease. Biochem Biophys Res Commun 1990, 171:690-696
40. Crutcher KA, Scott SA, Liang S, Everson WV, Weingartner J: Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J Neurosci 1993, 13:2540-2550
41. Van Der Wal E, Gómez F, Cotman CW: Transforming growth factor-β1 is in plaques in Alzheimer's and Down's pathologies. Neuroreport 1993, 4:69-72
42. Dobashi Y, Kudoh T, Toyoshima K, Akiyama T: Persistent activation of CDK4 during neuronal differentiation of rat pheochromocytoma PC 12 cells. Biochem Biophys Res Commun 1996, 221:351-355
43. '43. Van GZ, Ziff EB: NGF regulates the PC12 cell cycle machinery through specific inhibition of the CDK kinases and induction of cyclin D1. J Neurosci 1995, 15:6200-6212
44. Olson L: NGF and the treatment of Alzheimer's disease. Exp Neurol 1993, 124:5-15
45. Williams ME, Swerdlow SH: Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangements. Ann Oncol 1994, 5:71-73
46. Wilhide CC, Van Dang C, Dipersio J, Kenedy AA, Bray PF: Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest, Blood 1995, 86:294-304
47. Vincent I, Rosado M, Davies P: Mitotic mechanisms in Alzheimer's disease? J Cell Biol 1996, 132:413-425
48. Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, Wang JH: A brain-specific activator of cyclin-dependent kinase 5. Nature 1994, 371:423-426
49. Khleif SN, DeGregori J, Yee CL, Otterson GA, Kaye FJ, Nevins JR, Howley PM: Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci USA 1996, 93:4350-4354
50. Masliah E, Mallory M, Alford M, Hansen LA, Saitoh T: Immunoreactivity of the nuclear antigen p105 is associated with plaques and tangles in Alzheimer's disease. Lab Invest 1993, 69:562-569
51. Smith TW, Lippa CF: Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol 1995, 54:297-303
52. Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P: Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J 1994, 13:1114-1122