Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain

Journal of Neuroscience

Volumn 18, Issue 8, 1998, Pages 2801-2807

  Busser, Jonathan ^a   Geldmacher, David S ^a   Herrup, Karl ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Cdk4; Cell death; Cyclin B1; Cyclin D; PCNA

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN B; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LOCUS CERULEUS; MALE; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; SUBICULUM;

EID: 0032522911     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-08-02801.1998     Document Type: Article

References (31)

1. al-Ubaidi MR, Hollyfield JG, Overbeek PA, Baehr W (1992) Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc Natl Acad Sci USA 89:1194-1198.
2. Alzheimer A (1907) Über eine eigenartige Erkangkung der Hirnrinde. Allg. Z Psychiatrie Psych-Gerichtliche Med 64:146-148.
3. Blessed G, Tomlinson B, Roth M (1968) The association between quantitative measures of dementia and of senile dementia in the cerebral gray matter of elderly subjects. Br J Psychiatry 114:797-811.
4. Bondareff W, Mountjoy C, Roth M (1982) Loss of neurons of origin in the adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia. Neurology 32:164-168.
5. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239-259.
6. Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-284.
7. Bravo R, MacDonald-Bravo H (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 105:1549-1554.
8. Clarke A, Maandag E, van Roon M, van der Lugt N, van der Valk M, Hooper M, Berns A, te Riele H (1992) Requirement for a functional Rb-1 gene in murine development. Nature 359:328-330.
9. Doree M (1990) Control of M-phase by maturation promoting factor. Curr Opin Cell Biol 2:269-273.
10. Evans D, Funkenstein H, Albert M, Scherr P, Cook N, Chown M, Hebert L, Hennekens C, Taylor J (1989) Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported. JAMA 262:2551-2556.
11. Feddersen RM, Ehlenfeldt R, Yunis WS, Clark HB, Orr HT (1992) Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron 9:955-966.
12. Freeman R, Estus S, Johnson E (1994) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12:343-355.
13. Greenberg S, Davies P, Schein J, Binder L (1992) Hydrofluoric acid-treated tPHF proteins display the same biochemical properties as normal tPHF. J Biol Chem 267:564-569.
14. Heintz N (1993) Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem Sci 18:157-159.
15. Herrup K, Busser JC (1995) The induction of multiple cell cycle events precedes target-related neuronal death. Development 121:2385-2395.
16. Jacks T, Fazeli A, Schmitt E, Bronson R, Goodell M, Weinberg R (1992) Effects of an Rb mutation in the mouse. Nature 359:295-300.
17. Jost B, Grossberg G (1995) The natural history of Alzheimer's disease: a brain bank study. J Am Geriatr Soc 43:1248-1255.
18. Lee EY-HP, Chang C-Y, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee W-H, Bradley A (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359:288-294.
19. Lee EY-HP, Hu N, Yuan S-SF, Cox LA, Bradley A, Lee W-H, Herrup K (1994) Dual roles of the RB protein in cell cycle regulation and neuron differentiation. Genes Dev 8:2008-2021.
20. Liu W-K, Williams R, Hall F, Dickson D, Yen S-H (1995) Detection of a cdc2-related kinase associated with Alzheimer paired helical filaments. Am J Pathol 146:228-238.
21. Maller J (1991) Mitotic control. Curr Opin Cell Biol 3:269-275.
22. Nurse P (1990) Universal control mechanism regulating onset of M-phase. Nature 344:503-508.
23. Pines J (1993) Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem Sci 18:195-197.
24. Pines J (1994) The cell cycle kinases. Semin Cancer Biol 5:305-313.
25. Pines J (1995) Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J 308:697-711.
26. Pope W, Lambert M, Leypole B, Seupaul R, Sletten L, Krafft G, Klein W (1994) Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Exp Neurol 126:185-194.
27. Vincent I, Rosado M, Davies P (1996) Mitotic mechanisms in Alzheimer's disease? J Cell Biol 132:413-425.
28. Vincent I, Jicha G, Rosado M, Dickson D (1997) Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 17:3588-3598.
29. Waseem N, Lane D (1990) Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA): structural conservation and the detection of a nucleolar form. J Cell Sci 69:121-129.
30. Whitehouse P, Price D, Struble R, Clark A, Coyle J, DeLong M (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-1239.
31. Zweig R, Ross C, Hedreen J, Steele C, Cardillo J, Whitehouse P, Folstein M, Price D (1988) The neuropathology of aminergic nuclei in Alzheimer's disease. Ann Neurol 24:233-242.