The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH 2-terminal kinase-mediated neurotoxic signal via dimerization

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 3, 2003, Pages 889-902

  Hashimoto, Yuichi ^a   Niikura, Takako ^a   Chiba, Tomohiro ^a   Tsukamoto, Emi ^a   Kadowaki, Hisae ^b   Nishitoh, Hideki ^b   Yamagishi, Yohichi ^a   Ishizaka, Miho ^a   Yamada, Marina ^a   Nawa, Mikiro ^a   Terashita, Kenzo ^a   Aiso, Sadakazu ^a   Ichijo, Hidenori ^b   Nishimoto, Ikuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLASPARTYLGLUTAMYLVALYLASPARTALDEHYDE; ALDEHYDE; ALPHA SYNUCLEIN; AMYLOID PRECURSOR PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIBODY; APOPTOSIS SIGNAL REGULATING KINASE 1; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTATHIONE ETHYL ESTER; HUMANIN; PERTUSSIS TOXIN; PROTEIN; PROTEIN KINASE; PYRAZOLONE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTHRACENES; CARRIER PROTEINS; DIMERIZATION; EPIDERMAL GROWTH FACTOR; FLAVONOIDS; HUMANS; HYBRID CELLS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; OLIGOPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PYRIDINES; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 0042934160     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.051383     Document Type: Article

References (50)

1. o heterotrimeric protein within a cell compartment specialized in signal transduction. J Neurosci 19:1717-1727.
2. Caricasole A, Bruno V, Cappuccio I, Melchiorri D, Copani A, and Nicoletti F (2002) A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. FASEB J 16:1331-1333.
3. Coso OA, Teramoto H, Simonds WF, and Gutkind JS (1996) Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem 271:3963-3966.
4. Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, and Davis RJ (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science (Wash DC) 277:693-696.
5. o. J Neurochem 74:151-158.
6. Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, and Nishimoto I (1997) G protein βγ complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J 16:4897-4907.
7. Hagiwara A, Hashimoto Y, Niikura T, Ito Y, Terashita K, Kita Y, Nishimoto I, and Umezawa K (2000) Neuronal cell apoptosis by a receptor-binding domain peptide of ApoE4, not through low-density lipoprotein receptor-related protein. Biochem Biophys Res Commun 278:633-639.
8. Hart BA and Simons JM (1992) Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drug. Biotechnol Ther 3:119-135.
9. Hashimoto Y, Ito Y, Arakawa E, Kita Y, Terashita K, Niikura T, and Nishimoto I (2002a) Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase a novel pertussis toxin target. J Neurochem 80:426-437.
10. Hashimoto Y, Ito Y, Niikura T, Shao Z, Hata M, Oyama F, and Nishimoto I (2001a) Mechanisms of neuroprotection by a novel rescue factor Humanin from Swedish mutant amyloid precursor protein. Biochem Biophys Res Commun 283:460-468.
11. Hashimoto Y, Jiang H, Niikura T, Ito Y, Hagiwara A, Umezawa K, Abe Y, Murayama Y, and Nishimoto I (2000a) Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. J Neurosci 20:8401-8409.
12. Hashimoto Y, Niikura T, Ito Y, Kita Y, Terashita K, and Nishimoto I (2002b) Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin2. J Pharmacol Exp Ther 300:736-745.
13. Hashimoto Y, Niikura T, Ito Y, and Nishimoto I (2000b) Multiple mechanisms underlie neurotoxicity by different type Alzheimer's disease mutations of amyloid precursor protein. J Biol Chem 275:34541-34551.
14. Hashimoto Y, Niikura T, Ito Y, Sudo H, Hata M, Arakawa E, Abe Y, Kita Y, and Nishimoto I (2001b) Detailed characterization of neuroprotection by a rescue factor Humanin against various Alzheimer's disease-relevant insults. J Neurosci 21:9235-9245.
15. Hashimoto Y, Niikura T, Tajima H, Yasukawa Y, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, et al. (2001c) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Ap. Proc Natl Acad Sci USA 98:6336-6341.
16. Hashimoto Y, Tsuji O, Niikura T, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Tsukamoto E, et al. (2003) Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. J Neurochem 84:864-877.
17. Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, et al. (2000) Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci 20:7951-7963.
18. Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, and Herzog V (1999) Binding and selective detection of the secretory N-terminal domain of the Alzheimer amyloid precursor protein on cell surfaces. J Histochem Cytochem 47:373-382.
19. Huang P, Miao S, Fan H, Sheng Q, Yan Y, Wang L, and Koide SS (2000) Expression and characterization of the human YWK-II gene, encoding a sperm membrane protein related to the Alzheimer βA4-amyloid precursor protein. Mol Hum Reprod 6:1069-1078.
20. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, and Gotoh Y (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (Wash DC) 275:90-94.
21. Jung SS and Van Nostrand WE (2003) Humanin rescues human cerebrovascular smooth muscle cells from Aβ-induced toxicity. J Neurochem 84:266-272.
22. Kanamoto T, Mota M, Takeda K, Rubin LL, Miyazono K, Ichijo H, and Bazenet CE (2000) Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Mol Cell Biol 20:196-204.
23. Kang J, Lemaire H-G, Unterback A, Salbaum JM, Masters CL, Grezeschik KH, Multhaup G, Beyreuther K, and Müller-Hill B (1987) The precursor of Alzheimer disease amyloid A4 protein resembles a cell-surface receptor. Nature (Lond) 325:733-736.
24. Kariya S, Takahashi N, Ooba N, Kawahara M, Nakayama H, and Ueno S (2002) Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport 13:903-907.
25. Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, Ishizaka M, Tajima H, Niikura T, and Nishimoto I (2002) Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein relevant insults. NeuroSignals 11:236-250.
26. Matsuda S, Yasukawa T, Homma Y, Shao Z, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, et al. (2001) c-Jun N-terminal kinase (JNK) -interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci 21:6597-6607.
27. Mbebi C, See V, Mercken L, Pradier L, Muller U, and Loeffler JP (2002) Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. J Biol Chem 277:20979-20990.
28. Müller U, Cristina N, Li Z-W, Wolfer DP, Lipp H-P, Rülicke T, Brandner S, Aguzzi A, and Weissmann C (1994) Behavioral and anatomical deficits in mice homozygous for a modified β-amyloid precursor protein gene. Cell 79:755-765.
29. Nakahara S, Yone K, Sakou T, Wada S, Nagamine T, Niiyama T, and Ichijo H (1999) Induction of apoptosis signal regulating kinase 1 (ASK1) spinal cord injury in rats: possible involvement ofASK1-JNK and -p38 pathways in neuronal apoptosis. J Neuropathol Exp Neurol 58:442-450.
30. Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, et al. (2001) Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. J Neurosci 21:1902-1910.
31. Niikura T, Hashimoto Y, Tajima H, and Nishimoto I (2002) Death and survival of neuronal cells exposed to Alzheimer's insults. J Neurosci Res 70:380-391.
32. Niikura T, Murayama N, Hashimoto Y, Ito Y, Yamagishi Y, Matsuoka M, Takeuchi Y, Aiso S, and Nishimoto I (2000) V642I APP-inducible neuronal cells: a model system for investigating Alzheimer's disorders. Biochem Biophys Res Commun 274:445-454.
33. Nishimoto I, Hata Y, Ogata E, and Kojima I (1987) Insulin-like growth factor-II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. J Biol Chem 262:12120-12126.
34. 0. Nature (Lond) 362:75-79.
35. Platika D, Boulos MH, Baizer L, and Fishman MC (1985) Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc Natl Acad Sci USA 82:3499-3503.
36. Rohn TT, Ivins KJ, Bahr BA, Cotman CW, and Cribbs DH (2000) A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J Neurochem 74:2331-2342.
37. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, and Ichijo H (1998) Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17:2596-2606.
38. Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, and D'Adamio L (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's β-amyloid precursor protein (APP). J Biol Chem 277:3767-3775.
39. Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, and Multhaup G (2001) Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem 276:33923-33929.
40. Storms SD and Rutishauser U (1998) A role for polysialic acid in neural cell adhesion molecule heterophilic binding to proteoglycans. J Biol Chem 273:27124-27129.
41. Sudo H, Hashimoto Y, Niikura T, Shao Z, Yasukawa T, Ito Y, Yamada M, Hata M, Hiraki T, Kawasumi M, et al. (2001) Secreted Ap does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein. Biochem Biophys Res Commun 282:548-556.
42. Sudo H, Jiang H, Yasukawa T, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, et al. (2000) Antibody-regulated neurotoxic function of cell surface β-amyloid precursor protein. Mol Cell Neurosci 16:708-723.
43. Tian XY, Sha YS, Zhang SM, Chen YB, Miao SY, Wang LF, and Koide SS (2001) Extracellular domain of YWK-II, a human sperm transmembrane protein, interacts with rat Muellerian-inhibiting substance. Reproduction 121:873-880.
44. Tobiume K, Saitoh M, and Ichijo H (2002) Activation of ASK1 by the stress-induced activating phosphorylation of pre-formed oligomer. J Cell Physiol 191:95-104.
45. Torroja L, Packard M, Gorczyca M, White K, and Budnik V (1999) The Drosophila β-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J Neurosci 19:7793-7803.
46. von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, and Sisodia SS (1997) Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging 18:661-669.
47. Yamatsuji T, Okamoto T, Takeda S, Fukumoto H, Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, Kinane TB, and Nishimoto I (1996a) G-protein-mediated neuronal DNA fragmentation by familial Alzheimer's disease-associated V642 mutants of APP. Science (Wash DC) 272:1349-1352.
48. Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, and Nishimoto I (1996b) Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype. EMBO J 15:498-509.
49. Yamauchi J, Kawano T, Nagao M, Kaziro Y, and Itoh H (2000) Gi-dependent activation of c-Jun N-terminal kinase in human embryonal kidney 293 cells. J Biol Chem 275:7633-7640.
50. Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJS, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, et al. (1995) β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-531.