Progress Toward a High-Affinity Allosteric Enhancer at Muscarinic M 1 Receptors

Journal of Molecular Neuroscience

Volumn 20, Issue 3, 2003, Pages 363-367

  Lazareno, Sebastian ^a   Popham, Angela ^a   Birdsall, Nigel J M ^b  

^a Centre for Therapeutics Discovery   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Acetylcholine; Allosteric; Alzheimer's disease; Muscarinic; Receptor

Indexed keywords

17ALPHA ETHYNYL 17BETA HYDROXY 5ALPHA ANDROSTANO[3,2 B]PYRIMIDO[1,2 A]BENZIMIDAZOLE; DONEPEZIL; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; WIN 62577; ACETYLCHOLINE; ANDROSTANE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE;

ALLOSTERISM; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CHEMICAL MODIFICATION; CHOLINERGIC TRANSMISSION; COGNITION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; HIPPOCAMPUS; MEMORY; NONHUMAN; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DESIGN; DRUG POTENTIATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

ANIMALIA;

ACETYLCHOLINE; ALLOSTERIC SITE; ALZHEIMER DISEASE; ANDROSTENES; BENZIMIDAZOLES; BINDING, COMPETITIVE; CEREBRAL CORTEX; DRUG DESIGN; HIPPOCAMPUS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCARINIC AGONISTS; RECEPTOR, MUSCARINIC M1; SYNAPTIC TRANSMISSION;

EID: 0642370864     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:20:3:363     Document Type: Article

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