Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1

Journal of Biological Chemistry

Volumn 277, Issue 47, 2002, Pages 45099-45107

  Bitterman, Kevin J ^a   Anderson, Rozalyn M ^a   Cohen, Haim Y ^a   Latorre Esteves, Magda ^a   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GENES; HYDROLYSIS; PROTEINS; TUMORS; YEAST;

ACCELERATED AGING;

BIOCHEMISTRY;

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE ACETATE; FUNGAL PROTEIN; GENE PRODUCT; HISTONE DEACETYLASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN P53; PROTEIN SIRT1; RIBOSOME DNA; SILENT INFORMATION REGULATOR PROTEIN 2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACCELERATION; AGING; ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DEACETYLATION; DNA RECOMBINATION; GENE ACTIVITY; GENE CONTROL; GENE SEQUENCE; GENE SILENCING; GENETIC STABILITY; HORMONE ACTION; HUMAN; IC 50; IN VITRO STUDY; MITOSIS INHIBITION; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN MODIFICATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; YEAST;

AGING; DNA, RIBOSOMAL; GENE SILENCING; GENES, FUNGAL; GREEN FLUORESCENT PROTEINS; HISTONE DEACETYLASES; HUMANS; LIFE EXPECTANCY; LUMINESCENT PROTEINS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NIACINAMIDE; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TELOMERE;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037160097     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205670200     Document Type: Article

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