Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 9, 2000, Pages 1380-1391

  Lin, Shi Hua ^a   Vincent, Andrea ^a   Shaw, Tatyana ^a   Maynard, Kenneth I ^b   Maiese, Kenneth ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis; Cysteine proteases; DNA fragmentation; Hippocampal neurons; Nicotinamide; Phosphatidylserine

Indexed keywords

CASPASE 3; CYSTEINE PROTEINASE; DNA; DNA FRAGMENT; FREE RADICAL; INTERLEUKIN 1BETA CONVERTING ENZYME; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PHOSPHATIDYLSERINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PH; CLINICAL PATHWAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPAIR; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME REGULATION; HIPPOCAMPUS; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033847695     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200009000-00013     Document Type: Article

References (34)

1. Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats
2. Poly(ADP-ribose) in the cellular response to DNA damage
3. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase
4. Increase of mono(ADP-ribose) protein conjugate levels in rat liver induced by nicotinamide administration
5. Nitric oxide (NO): An effector of apoptosis
6. Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor- induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease
7. Citicoline (CDP-choline): Mechanisms of action and effects in ischemic brain injury
8. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
9. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase
10. Enhancement of brain choline levels by nicotinamide: Mechanism of action
11. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease
12. Effects of the nitricoxide donor sodium nitroprusside on intracellular pH and contraction in hypertrophied myocytes
13. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
14. Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat
15. Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain
16. Metabotropic glutamate receptor subtypes independently modulate neuronal intracellular calcium
17. Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C
18. Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons
19. Membrane asymmetry and DNA degradation: Functionally distinct determinants of neuronal programed cell death
20. Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1 beta
21. Increased surface phosphatidylserine is an early marker of neuronal apoptosis
22. Extended therapeutic window for caspase inhibition and synergy with MK- 801 in the treatment of cerebral histotoxic hypoxia
23. Intracellular inhibition of mono(ADP-ribosylation) by meta- iodobenzylguanidine: Specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis
24. Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers
25. Apoptosis in cerebellar granule neurones: Involvement of interleukin-1 beta convetting enzyme-like proteases
26. DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions
27. Experimental displacement of intracellular pH and the mechanism of its subsequent recovery
28. Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH- SY5Y cells
29. Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes
30. Direct temporal analysis of apoptosis induction in living adherent neurons
31. Nitric oxide induction of neuronal endonuclease activity in programed cell death
32. Metabotropic glutamate receptors prevent programed cell death through the modulation of neuronal endonuclease activity and intracellular pH
33. Neuronal intracellular pH directly mediates nitric oxide-induced programed cell death
34. Traumatic neuroprotection with inhibitors of nitric oxide and ADP- ribosylation