Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

Journal of Neuroscience

Volumn 18, Issue 18, 1998, Pages 7061-7074

  Canu, Nadia ^a,b   Dus, Laura ^b   Barbato, Christian ^a   Ciotti, Maria T ^b   Brancolini, Claudio ^c   Rinaldi, Anna M ^a   Novak, Michal ^d,e   Cattaneo, Antonino ^d   Bradbury, Andrew ^d   Calissano, Pietro ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CNR   (Italy)

^c AREA Science Park   (Italy)

^d SISSA   (Italy)

^e INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Alzheimer's disease; Apoptosis; Calpain; Caspase; Cerebellar granule neurons; Tau

Indexed keywords

CALPAIN; PROTEINASE; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; GRANULE CELL; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION;

EID: 17344365975     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07061.1998     Document Type: Article

References (17)

1. Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E (1993) Phosphorylation at Ser 262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11:153-163.
2. Bonfoco E, Ceccatelli S, Manzo L, Nicotera L (1995) Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res 218:189-200.
3. Brancolini C, Lazarevic D, Rodriguez J, Schneider C (1997) Dismantling cell-cell contacts during apoptosis is coupled to caspase-dependent proteolytic cleavage of β-catenin. J Cell Biol 139:759-771.
4. Brandt R, Leger J, Lee G (1995) Interaction of tau with the neural plasma membrana by tau's amino-terminal projection domain. J Cell Biol 131:1327-1340.
5. Brion JP, Hanger DP, Bruce MT, Couck AM, Flament-Durand J, Anderton BH (1991) Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site. Biochem J 273:127-133.
6. Burack MA, Halpain S (1996) Site-specific regulation of Alzheimer-Iike tau phosphorylation in living neurons. Neuroscience 72:167-184.
7. Carlier MF, Simon C, Cassoly R, Pradel LA (1984) Interaction between microtubule-associated protein tau and spectrin. Biochimie 66:305-311.
8. Cohen GM (1997) Caspase: the executioners of apoptosis. Biochem J 326:1-16.
9. Cohen JJ (1993) Apoptosis. Immunol Today 14:126-130.
10. Correas I, Padilla R, Avila J (1990) The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP2, is also involved in actin binding. Biochem J 269:61-64.
11. Cryns V, Bergeron L, Zhu H, Li H, Yuan J (1996) Specific cleavage of a-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1β-converting enzyme/ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. J Biol Chem 271:31277-31282.
12. De la Monte SM, Sohn YK, Wands JR (1997) Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. Neurol Sci 152:73-83.
13. D'Mello SR, Galli, C, Ciotti MT, Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of cell death by insulin-growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
14. Drechsel DN, Hyman AA, Cobb MH, Kirschner MW (1992) Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell 3:1141-1154.
15. Drubin DG, Kirschner MW (1986) Tau protein function in living cells. J Cell Biol 103:1583-1591.
16. Fasulo L, Visintin M, Novak M, Cattaneo A (1998) Tau truncation in Alzheimer's disease: expression of a fragment encompassing PHF core tau induces apoptosis in COS cells. Alzheimer's Rep 1:1-7.
17. Galli C, Meucci O, Scorziello A, Werge T, Calissano P, Schettini G (1995) Apoptosis in cerebellar granule cells is blocked by high KC1, forskolin, and IGF-1 through distinct mechanism of action: the involvement of intracellular calcium and RNA synthesis. J Neurosci 15:1172-1179.