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Volumn 23, Issue 4, 2003, Pages 1237-1245

Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition

Author keywords

Apoptosis; Cell cycle; Flavopiridol; Proteasome; Retinoblastoma; Ubiquitin

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; ENZYME INHIBITOR; FLAVOPIRIDOL; LACTACYSTIN; MUTANT PROTEIN; PROTEASOME; PROTEIN P16; PROTEIN P27; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; UBIQUITIN;

EID: 0037442820     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-04-01237.2003     Document Type: Article
Times cited : (104)

References (48)
  • 2
    • 0033005133 scopus 로고    scopus 로고
    • Depolarization regulates cyclin D1 degradation and neuronal apoptosis: A hypothesis about the role of the ubiquitin/proteasome signaling pathway
    • Boutillier A-L, Kienlen-Campard P, Loeffler J-P (1999) Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signaling pathway. Eur J Neurosci 11:441-448.
    • (1999) Eur J Neurosci , vol.11 , pp. 441-448
    • Boutillier, A.-L.1    Kienlen-Campard, P.2    Loeffler, J.-P.3
  • 3
    • 0032931991 scopus 로고    scopus 로고
    • Cumulative effect of phosphorylation of pRB on regulation of E2F activity
    • Brown VD, Phillips RA, Gallie BL (1999) Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol Cell Biol 19:3246-3256.
    • (1999) Mol Cell Biol , vol.19 , pp. 3246-3256
    • Brown, V.D.1    Phillips, R.A.2    Gallie, B.L.3
  • 4
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser J, Geldmacher DS, Herrup K (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 18:2801-2807.
    • (1998) J Neurosci , vol.18 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 5
    • 2942618660 scopus 로고    scopus 로고
    • The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
    • Chung KK, Dawson VL, Dawson TM (2001) The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci 24:S7-S14.
    • (2001) Trends Neurosci , vol.24
    • Chung, K.K.1    Dawson, V.L.2    Dawson, T.M.3
  • 6
    • 0032192529 scopus 로고    scopus 로고
    • Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome c
    • Deshmukh M, Johnson Jr EM (1998) Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c. Neuron 21:695-705.
    • (1998) Neuron , vol.21 , pp. 695-705
    • Deshmukh, M.1    Johnson E.M., Jr.2
  • 7
    • 0031034160 scopus 로고    scopus 로고
    • Activation of the cell death program by inhibition of proteasome function
    • Drexler H (1997) Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci USA 94:855-860.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 855-860
    • Drexler, H.1
  • 8
    • 0032502719 scopus 로고    scopus 로고
    • Lactacystin, proteasome function, and cell fate
    • Fenteany G, Schreiber S (1998) Lactacystin, proteasome function, and cell fate. J Biol Chem 273:8545-8548.
    • (1998) J Biol Chem , vol.273 , pp. 8545-8548
    • Fenteany, G.1    Schreiber, S.2
  • 9
    • 0029033981 scopus 로고
    • Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
    • Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726-731.
    • (1995) Science , vol.268 , pp. 726-731
    • Fenteany, G.1    Standaert, R.F.2    Lane, W.S.3    Choi, S.4    Corey, E.J.5    Schreiber, S.L.6
  • 10
    • 0028136875 scopus 로고
    • A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S Proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell
    • Figueiredo-Pereira M, Berg K, Wilk S (1994) A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S Proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell. J Neurochem 63:1578-1581.
    • (1994) J Neurochem , vol.63 , pp. 1578-1581
    • Figueiredo-Pereira, M.1    Berg, K.2    Wilk, S.3
  • 11
    • 0033516567 scopus 로고    scopus 로고
    • Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in β-amyloid-induced neuronal death
    • Giovanni A, Wirtz-Brugger F, Keramaris E, Slack R, Park DS (1999) Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in β-amyloid-induced neuronal death. J Biol Chem 274:19011-19016.
    • (1999) J Biol Chem , vol.274 , pp. 19011-19016
    • Giovanni, A.1    Wirtz-Brugger, F.2    Keramaris, E.3    Slack, R.4    Park, D.S.5
  • 12
    • 0034941949 scopus 로고    scopus 로고
    • Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: Effect of R-apomorphine
    • Grunblatt E, Mandel S, Maor G, Youdim MB (2001) Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine. J Neurochem 78:1-12.
    • (2001) J Neurochem , vol.78 , pp. 1-12
    • Grunblatt, E.1    Mandel, S.2    Maor, G.3    Youdim, M.B.4
  • 13
    • 0034306996 scopus 로고    scopus 로고
    • The Rb/E2F pathway: Expanding roles and emerging paradigms
    • Harbour JW, Dean DC (2000) The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14:2393-2409.
    • (2000) Genes Dev , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2
  • 15
    • 0034667633 scopus 로고    scopus 로고
    • Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase
    • Hsieh FF, Barnett LA, Green WF, Freedman K, Matushansky I, Skoultchi AI, Kelley LL (2000) Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase. Blood 96:2746-2754.
    • (2000) Blood , vol.96 , pp. 2746-2754
    • Hsieh, F.F.1    Barnett, L.A.2    Green, W.F.3    Freedman, K.4    Matushansky, I.5    Skoultchi, A.I.6    Kelley, L.L.7
  • 16
    • 0029866793 scopus 로고    scopus 로고
    • Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease
    • Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM (1996) Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am J Pathol 148:1517-1529.
    • (1996) Am J Pathol , vol.148 , pp. 1517-1529
    • Iwatsubo, T.1    Yamaguchi, H.2    Fujimuro, M.3    Yokosawa, H.4    Ihara, Y.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 20
    • 0035829650 scopus 로고    scopus 로고
    • Regulation of neuronal survival and death by E2F-dependent gene repression and derepression
    • Liu DX, Greene LA (2001) Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 32:425-438.
    • (2001) Neuron , vol.32 , pp. 425-438
    • Liu, D.X.1    Greene, L.A.2
  • 22
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg LS, Weinberg RA (1998) Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 18:753-761.
    • (1998) Mol Cell Biol , vol.18 , pp. 753-761
    • Lundberg, L.S.1    Weinberg, R.A.2
  • 24
    • 0029880622 scopus 로고    scopus 로고
    • Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases
    • Meikrantz W, Schlegel R (1996) Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J Biol Chem 271:10205-10209.
    • (1996) J Biol Chem , vol.271 , pp. 10205-10209
    • Meikrantz, W.1    Schlegel, R.2
  • 25
    • 0033621047 scopus 로고    scopus 로고
    • Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
    • Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM (1999) Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci USA 96:10403-10408.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10403-10408
    • Meng, L.1    Mohan, R.2    Kwok, B.H.3    Elofsson, M.4    Sin, N.5    Crews, C.M.6
  • 26
    • 0035879071 scopus 로고    scopus 로고
    • Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage
    • Morris EJ, Keramaris E, Rideout HJ, Slack RS, Dyson NJ, Stefanis L, Park DS (2001) Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage. J Neurosci 21:5017-5026.
    • (2001) J Neurosci , vol.21 , pp. 5017-5026
    • Morris, E.J.1    Keramaris, E.2    Rideout, H.J.3    Slack, R.S.4    Dyson, N.J.5    Stefanis, L.6    Park, D.S.7
  • 27
    • 0031661968 scopus 로고    scopus 로고
    • The cell division cycle and the pathophysiology of Alzheimer's disease
    • Nagy Z, Esiri MM, Smith AD (1998) The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience 87:731-739.
    • (1998) Neuroscience , vol.87 , pp. 731-739
    • Nagy, Z.1    Esiri, M.M.2    Smith, A.D.3
  • 28
    • 0032555934 scopus 로고    scopus 로고
    • Blocking cytochrome c activity within intact neurons inhibits apoptosis
    • Neame SJ, Rubin LL, Philpott KL (1998) Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol 142:1583-1593.
    • (1998) J Cell Biol , vol.142 , pp. 1583-1593
    • Neame, S.J.1    Rubin, L.L.2    Philpott, K.L.3
  • 29
    • 0033597133 scopus 로고    scopus 로고
    • Neurite outgrowth in PC12 cells. Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis
    • Obin M, Mesco E, Gong X, Haas AL, Joseph J, Taylor A (1999) Neurite outgrowth in PC12 cells. Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis. J Biol Chem 274:11789-11795.
    • (1999) J Biol Chem , vol.274 , pp. 11789-11795
    • Obin, M.1    Mesco, E.2    Gong, X.3    Haas, A.L.4    Joseph, J.5    Taylor, A.6
  • 30
    • 0033570320 scopus 로고    scopus 로고
    • Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
    • Padmanabhan J, Park DS, Greene LA,Shelanski ML (1999) Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J Neurosci 19:8747-8756.
    • (1999) J Neurosci , vol.19 , pp. 8747-8756
    • Padmanabhan, J.1    Park, D.S.2    Greene, L.A.3    Shelanski, M.L.4
  • 31
    • 0030727466 scopus 로고    scopus 로고
    • Cell cycle regulation by the ubiquitin pathway
    • Pagano M (1997) Cell cycle regulation by the ubiquitin pathway. FASEB J 11:1067-1075.
    • (1997) FASEB J , vol.11 , pp. 1067-1075
    • Pagano, M.1
  • 33
    • 0029913242 scopus 로고    scopus 로고
    • Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
    • Park DS, Farinelli SE, Greene LA (1996) Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem 271:8161-8169.
    • (1996) J Biol Chem , vol.271 , pp. 8161-8169
    • Park, D.S.1    Farinelli, S.E.2    Greene, L.A.3
  • 34
    • 0030694346 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors and dominant negative cyclin-dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
    • Park DS, Levine B, Ferrari G, Greene LA (1997) Cyclin-dependent kinase inhibitors and dominant negative cyclin-dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J Neurosci 17:8975-8983.
    • (1997) J Neurosci , vol.17 , pp. 8975-8983
    • Park, D.S.1    Levine, B.2    Ferrari, G.3    Greene, L.A.4
  • 37
    • 0000991680 scopus 로고    scopus 로고
    • Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons
    • Qiu JH, Asai A, Chi S, Saito N, Hamada H, Kirino T (2000) Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons. J Neurosci 20:259-265.
    • (2000) J Neurosci , vol.20 , pp. 259-265
    • Qiu, J.H.1    Asai, A.2    Chi, S.3    Saito, N.4    Hamada, H.5    Kirino, T.6
  • 38
    • 0034888540 scopus 로고    scopus 로고
    • Caspase inhibition: A potential therapeutic strategy in neurological diseases
    • Rideout HJ, Stefanis L (2001) Caspase inhibition: a potential therapeutic strategy in neurological diseases. Histol Histopathol 16:895-908.
    • (2001) Histol Histopathol , vol.16 , pp. 895-908
    • Rideout, H.J.1    Stefanis, L.2
  • 39
    • 0036432029 scopus 로고    scopus 로고
    • Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination
    • Rideout HJ, Stefanis L (2002) Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination. Mol Cell Neurosci 21:223-238.
    • (2002) Mol Cell Neurosci , vol.21 , pp. 223-238
    • Rideout, H.J.1    Stefanis, L.2
  • 40
    • 0034884622 scopus 로고    scopus 로고
    • Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells
    • Rideout HJ, Larsen KE, Sulzer D, Stefanis L (2001a) Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells. J Neurochem 78:899-908.
    • (2001) J Neurochem , vol.78 , pp. 899-908
    • Rideout, H.J.1    Larsen, K.E.2    Sulzer, D.3    Stefanis, L.4
  • 41
    • 0035900612 scopus 로고    scopus 로고
    • Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction
    • Rideout HJ, Zang E, Yeasmin M, Gordon R, Jabado O, Park DS, Stefanis L (2001b) Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction. Neuroscience 107:339-352.
    • (2001) Neuroscience , vol.107 , pp. 339-352
    • Rideout, H.J.1    Zang, E.2    Yeasmin, M.3    Gordon, R.4    Jabado, O.5    Park, D.S.6    Stefanis, L.7
  • 42
    • 0034656419 scopus 로고    scopus 로고
    • p16INK4A mediates cyclin-dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells
    • Sandhu C, Peehl DM, Slingerland J (2000) p16INK4A mediates cyclin-dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells. Cancer Res 60:2616-2622.
    • (2000) Cancer Res , vol.60 , pp. 2616-2622
    • Sandhu, C.1    Peehl, D.M.2    Slingerland, J.3
  • 43
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou F, Finbeiner S, Devy D, Greenberg M (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95:55-66.
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finbeiner, S.2    Devy, D.3    Greenberg, M.4
  • 45
    • 0033178444 scopus 로고    scopus 로고
    • Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons
    • Stefanis L, Park DS, Friedman WJ, Greene LA (1999) Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons. J Neurosci 19:6235-6247.
    • (1999) J Neurosci , vol.19 , pp. 6235-6247
    • Stefanis, L.1    Park, D.S.2    Friedman, W.J.3    Greene, L.A.4
  • 46
    • 0035894855 scopus 로고    scopus 로고
    • Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
    • Stefanis L, Larsen KE, Rideout HJ, Sulzer D, Greene LA (2001) Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci 21:9549-9560.
    • (2001) J Neurosci , vol.21 , pp. 9549-9560
    • Stefanis, L.1    Larsen, K.E.2    Rideout, H.J.3    Sulzer, D.4    Greene, L.A.5
  • 48
    • 0034754875 scopus 로고    scopus 로고
    • Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
    • Waelter S, Boeddrich A, Lurz R, Scherzinger E, Lueder G, Lerach H, Wanker EE (2001) Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol Biol Cell 12:1393-1407.
    • (2001) Mol Biol Cell , vol.12 , pp. 1393-1407
    • Waelter, S.1    Boeddrich, A.2    Lurz, R.3    Scherzinger, E.4    Lueder, G.5    Lerach, H.6    Wanker, E.E.7


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