The relationship between the aggregational state of the amyloid-β peptides and free radical generation by the peptides

Journal of Neurochemistry

Volumn 77, Issue 6, 2001, Pages 1425-1432

  Monji, Akira ^a   Utsumi, Hideo ^b   Ueda, Tadashi ^b   Imoto, Taiji ^b   Yoshida, Ichiro ^a   Hashioka, Sadayuki ^a   Tashiro, Ken Ichiro ^c   Tashiro, Nobutada ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Aggregation; Alzheimer's disease; Beta amyloid; Cytotoxicity; Electron spin resonance; Free radical

Indexed keywords

AMYLOID BETA PROTEIN; FREE RADICAL;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CYTOTOXICITY; ELECTRON SPIN RESONANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELL SURVIVAL; CIRCULAR DICHROISM; ELECTRON SPIN RESONANCE SPECTROSCOPY; FLUORESCENT DYES; FREE RADICALS; HUMANS; PC12 CELLS; RATS; THIAZOLES;

ANIMALIA;

EID: 0034973708     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00392.x     Document Type: Article

References (41)

1. Glutamate synthetase-induced enhancement of β-amyloid peptide Aβ(1-40) neurotoxicity accompanied by abrogation of fibril formation and Aβ fragmentation
2. α-1-antichymotrypsin interaction with Aβ(1-42) does not inhibit fibril formation but attenuates the peptide toxicity
3. α-1-antichymotrypsin interaction with Aβ(1-40) inhibits fibril formation but does not affect the peptide toxicity
4. 2+ increase
5. Promotion of transition metal-induced reactive oxygen species formation by β-amyloid
6. Spin trapping: ESR parameters of spin adducts
7. Oxidative stress and Alzheimer disease
8. Amyloid β peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides
9. Amyloidogenicity of βA4 and βA4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation
10. Oligomerization and toxicity of β-amyloid-42 implicated in Alzheimer's disease
11. Amidation of β-amyloid peptide strongly reduced the amyloidogenic activity without alteration of neurotoxicity
12. A strategy for designing inhibitors of β-amyloid toxicity
13. Models of amyloid seeding in Alzheimer's disease and scrapie: Mechanistic truths and consequence of the time-dependent solubility of amyloid proteins
14. Assembly of amyloid protofibrils: An in vitro model for a possibly early event in Alzheimer's disease
15. β-Amyloid peptide derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: Implication for Alzheimer's disease
16. Protofibrillar intermediates of amyloid β-protein induce acute eletrophsyiological changes of progressive neurotoxicity on cortical neurons
17. A new model for β-amyloid aggregation and neurotoxicity based on free radical generating capacity of the peptide
18. The Aβ peptide of Alzheimer's disease directly produce hydrogen peroxide through metal ion reduction
19. Spontaneous free-radical formation in the reactions of m-chloroperbenzoic acid with C-phenyl-N-tert butylnitrone (PBN) and 3- or 4-substituted PBN's
20. Mechanochemical mechanism for peptidyl free radical generation by amyloid fibrils
21. Diffusible nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
22. Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution
23. Intramuscular desferrri-oxamine in patients with Alzheimer's disease
24. Laminin inhibits Aβ40 and Aβ42 fibril formation but does not affect Aβ40 and Aβ42-induced cytotoxicity in PC12 cells
25. Alzheimer's disease: A re-examination of the amyloid hypothesis
26. Clusterin (ApoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and slowly sedimenting Aβ complexes that cause oxidative stress
27. Immunohistochemical evidence of antioxidant stress in Alzheimer's disease
28. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
29. Nicotine inhibits amyloid formation by the β-peptide
30. Mechanism of neurotoxicity associated with amyloid β deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: A critical appraisal
31. The role of iron in beta amyloid toxicity
32. Inhibition of PC12 cell redox activity is a specific, eary indicator of the mechanism of β-amyloid-mediated cell death
33. Inhibition of amyloid β protein aggregation by rifampicin. Its possible function as a free radical scavenger
34. Alzheimer's disease and the amyloid β protein: What is the role of amyloid?
35. Iron accumulation in Alzheimer's disease is a source of redox-generated free radicals
36. β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implication for Alzheimer's therapy
37. The molecular chaperone αB-crystallin enhances amyloid β neurotoxicity
38. Methionine residue 35 is important in amyloid β-petide-associated free radical oxidative stress
39. Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity
40. Amyloid β-protein fibrillogenesis, structure and biological activity of protofibrillar intermediates
41. Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of β-amyloid peptide