The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of β-lactam antibiotics in the rat small intestine

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 8, 1997, Pages 796-801

  Tamai, Ikumi ^a   Nakanishi, Takeo ^a   Hayashi, Kiyomi ^a   Terao, Toshimitsu ^a   Sai, Yoshimichi ^a   Shiraga, Toshiyuki ^b   Miyamoto, Ken Ichi ^b   Takeda, Eiji ^b   Higashida, Haruhiro ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTISENSE OLIGONUCLEOTIDE; BETA LACTAM ANTIBIOTIC; CARBON 14; CARRIER PROTEIN; CEFADROXIL; CEFALEXIN; CEFAZOLIN; CEFIXIME; CEFRADINE; CEFTIBUTEN; COMPLEMENTARY RNA; DIPEPTIDE; GLYCYLSARCOSINE; MESSENGER RNA; OLIGOPEPTIDE; PENTAPEPTIDE; TETRAPEPTIDE; TRIPEPTIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG TRANSPORT; DRUG UPTAKE; EXPRESSION VECTOR; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; MALE; NONHUMAN; OOCYTE; PROTEIN ANALYSIS; RAT; SMALL INTESTINE; XENOPUS LAEVIS;

EID: 15144346706     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06115.x     Document Type: Article

References (37)

1. Addison, J. M., Burston, D., Dalrymple, J. A., Matthews, J. M., Payne, J. W., Sleisenger, M. H., Wilkinson, S. (1975) A common mechanism for transport of di- and tri-peptides by hamster jejunum in vitro. Clin. Sci. Mol. Med. 49: 313-322
2. Boll, M., Markovich, D., Weber, W.-M., Korte, H., Daniel, H., Murer, H. (1994) Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, β-lactam antibiotics, and ACE-inhibitors. Pflügers Arch. 429: 146-149
3. Boll, M., Herget, M., Wagner, M., Weber, W. M., Markovich, D., Biber, J., Claiss, W., Murer, H., Daniel, H. (1996) Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc. Natl Acad. Sci. USA 93: 284-289
4. Dantzig, A. H., Duckworth, D. C., Tabas, L. B. (1994a) Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axecil into human intestinal Caco-2 cells. Biochim. Biophys. Acta 1191: 7-13
5. Dantzig, A. H., Hoskins, J., Tabas, L. B., Bright, S., Shepard, R. L., Jenkins, I. L., Duckworth, D. C., Sportsman, J. R., Mackensen, D., Rosteck, P. R., Skatrud, P. L. (1994b) Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science 264: 430-433
6. Fei, Y.-J., Kanai, Y., Nussberger, S., Ganapathy, V., Leibach, F. H., Romero, M. F., Singh, S. K., Boron, W. F., Hediger, M. A. (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368: 563-566
7. Gochoco, C. H., Ryan, F. M., Miller, J., Smith, P. L., Hidalgo, I. J. (1994) Uptake and transepithelial transport of the orally absorbed cephalosporin cephalexin, in the human intestinal cell line, Caco-2. Int. J. Pharm. 104: 187-202
8. Hu, M., Chen, J., Zhu, Y., Dantzig, A. H., Stratford, R. E., Kuhfeld, M. T. (1994) Mechanism and kinetics of transcellular transport of a new β-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2). Pharm. Res. 11: 1405-1413
9. +-Coupled transport of p.o. cephalosporins via dipeptide carriers in rabbit intestinal brush-border membranes: difference of transport characteristics between cefixime and cephradine. J. Pharmacol. Exp. Ther. 247: 235-241
10. Inui, K., Yamamoto, M., Saito, H. (1992) Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 261: 195-201
11. Kimura, T., Yamamoto, T., Ishizuka, R., Sezaki, H. (1985) Transport of cefadroxil, an aminocephalosporin antibiotic, across the small intestinal brush-border membrane. Biochem. Pharmacol. 34: 81-84
12. 3H]benzylpenicillin. Biochem. Pharmacol. 37: 2427-2435
13. Kramer, W., Gutjahr, U., Kowalewski, S., Girbig, F. (1993) Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and α-amino-β-lactam antibiotics in rabbit small intestine. Biochem. Pharmacol. 46: 542-546
14. +/peptide cotransporter family, from human kidney. Biochim. Biophys. Acta 1235: 461-466
15. Matthews, D. M. (1991) Protein Absorption, Wiley-Liss, New York
16. Miyamoto, Y., Thompson, Y. G., Howard, E. F., Ganapathy, V., Leibach, F. H. (1991) Functional expression of the intestinal peptide-proton co-transporter in Xenopus laevis oocytes. J. Biol. Chem. 266: 4742-4745
17. Miyamoto , K., Shiraga, T., Yamamoto, H., Haga, H., Taketani, Y., Tamai, I., Sai, Y., Tsuji, A., Takeda, E. (1996) Sequence and tissue distribution of rat intestinal oligopeptide transporter. Biochim. Biophys. Acta 1305: 34-38
18. Muranushi, N., Yoshikawa, T., Yoshida, M., Oguma, T., Hirano, K., Yamada, H. (1989) Transport characteristics of ceftibuten, a new oral cephem, in rat intestinal brush-border membrane vesicles: relationship to oligopeptide and amino-β-lactam transport. Pharm. Res. 6: 308-312
19. Muranushi, N., Horie, K., Masuda, K., Hirano, K. (1994) Characteristics of ceftibuten uptake into Caco-2 cells. Pharm. Res. 11: 1761-1765
20. Nakashima, E., Tsuji, A., Mizuo, H., Yamana, T. (1984) Kinetics and mechanism of in vitro uptake of amino-β-lactam antibiotics by rat small intestine and relation to the intact-peptide transport system. Biochem. Pharmacol. 33: 3345-3352
21. +-Coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes. J. Biol. Chem. 261: 14130-14134
22. Sai, Y., Tamai, I., Sumikawa, H., Hayashi, K., Nakanishi, T., Amano, O., Numata, M., Iseki, S., Tsuji, A. (1996) Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β-lactam antibiotics. FEBS Lett. 392: 25-29
23. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney. J. Pharmacol. Exp. Ther. 275: 1631-1637
24. Saito, H., Terada, T., Okuda, M., Saxaki, S., Inui, K. (1996) Molecular cloning and tissue distribution of rat peptide transporter PepT2. Biochim. Biophys. Acta 1280: 173-177
25. Sinko, P. J., Amidon, G. L. (1989) Characterization of the oral absorption of β-lactam antibiotics II: competitive absorption and peptide carrier specificity. J. Pharm. Sci. 78: 723-727
26. Sugawara, M., Saitoh, H., Iseki, K., Miyazaki, K., Arita, T. (1990) Contribution of passive transport mechanisms to the intestinal absorption of β-lactam antibiotics. J. Pharm. Pharmacol. 42: 314-318
27. Sugawara, M., Toda, T., Iseki, K., Miyazaki, K., Shiroto, H., Kondo, Y., Uchino, J. I. (1992) Transport characteristics of cephalosporin antibiotics across the intestinal brush-border membrane in man, rat and rabbit. J. Pharm. Pharmacol. 44: 968-972
28. Tamai, I., Ling, H.-Y., Simanjuntak, M. T., Nishikido, J., Tsuji, A. (1988) Stereospecific absorption and degradation of cephalexin. J. Pharm. Pharmacol. 40: 320-324
29. Tamai, I., Tomizawa, N., Kadowaki, A., Terasaki, T., Nakayama, K., Higashida, H., Tsuji, A. (1994) Functional expression of intestinal dipeptide/β-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem. Pharmacol. 48: 881-888
30. Tamai, I., Tomizawa, N., Takeuchi, T., Nakayama, K., Higashida, H., Tsuji, A. (1995) Functional expression of transporter for β-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestine. J. Pharmacol. Exp. Ther. 273: 26-31
31. + dependent undine transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes. Biol. Pharm. Bull. 16: 493-496
32. Tsuji, A., Nakashima, E., Asano, T., Nakashima, R., Yamana, T. (1979) Saturable absorption of amino-cephalosporins by the rat intestine. J. Pharm. Pharmacol. 31: 718-720
33. Tsuji, A., Tamai, I., Nakanishi, M., Terasaki, T., Hamano, S. (1993) Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits. J. Pharm. Pharmacol. 45: 996-998
34. Tsuji, A., Tamai, I., Hirooka, H., Terasaki, T. (1987a) β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane. Biochem. Pharmacol. 36: 565-567
35. + Gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. J. Pharmacol. Exp. Ther. 241: 594-600
36. Wenzel, U., Gebert, I., Weintraut, H., Weber, W., Clauss, W., Daniel, H. (1996) Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J. Pharmacol. Exp. Ther. 277: 831-839
37. Yoshikawa, T., Muranushi, N., Yoshida, M., Oguma, T., Hirano, K., Yamada, H. (1989) Transport characteristics of ceftibuten (7432-S), a new oral cephem, in rat intestinal brush-border membrane vesicles: proton-coupled and stereoselective transport of ceftibuten. Pharm. Res. 6: 302-307