-
1
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I. A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco-2) cells
-
Artursson P (1990) Epithelial transport of drugs in cell culture. I. A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco-2) cells. J Pharm Sci 79:476-482.
-
(1990)
J Pharm Sci
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
2
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson P and Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 175:880-885.
-
(1991)
Biochem Biophys Res Commun
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
3
-
-
0027730961
-
Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport
-
Augustijns PF, Bradshaw TP, Gan L-SL, Hendren RW and Thakker DR (1993) Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport. Biochem Biophys Res Commun 197:360-365.
-
(1993)
Biochem Biophys Res Commun
, vol.197
, pp. 360-365
-
-
Augustijns, P.F.1
Bradshaw, T.P.2
Gan, L.-S.L.3
Hendren, R.W.4
Thakker, D.R.5
-
4
-
-
0029997940
-
Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells
-
Cavet ME, West M and Simmons NL (1996) Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells. Br J Pharmacol 118:1389-1396.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1389-1396
-
-
Cavet, M.E.1
West, M.2
Simmons, N.L.3
-
5
-
-
0029120525
-
Sparfloxacin secretion across Caco-2 cells involves a multidrug resistance-like mechanism
-
Cormet E, Barlier AM, Huneau JF, Rubinstein E, Carbon C, Farinotti R and Tomé D (1995) Sparfloxacin secretion across Caco-2 cells involves a multidrug resistance-like mechanism. Drugs 49(Suppl 2):307-309.
-
(1995)
Drugs
, vol.49
, Issue.2 SUPPL.
, pp. 307-309
-
-
Cormet, E.1
Barlier, A.M.2
Huneau, J.F.3
Rubinstein, E.4
Carbon, C.5
Farinotti, R.6
Tomé, D.7
-
6
-
-
0027954464
-
Taxol metabolism by human liver microsomes: Identification of cytochrome P450 isozymes involved in its biotransformation
-
Cresteil T, Monsarrat B, Alvinerie P, Treluyer JM, Vieira I and Wright M (1994) Taxol metabolism by human liver microsomes: Identification of cytochrome P450 isozymes involved in its biotransformation. Cancer Res 54:386-392.
-
(1994)
Cancer Res
, vol.54
, pp. 386-392
-
-
Cresteil, T.1
Monsarrat, B.2
Alvinerie, P.3
Treluyer, J.M.4
Vieira, I.5
Wright, M.6
-
7
-
-
0028023306
-
1 mice
-
1 mice. Cancer Chemother Pharmacol 34:465-471.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 465-471
-
-
Eiseman, J.L.1
Eddington, N.D.2
Leslie, J.3
MacAuley, C.4
Sentz, D.L.5
Zuhowski, M.6
Kujawa, J.M.7
Young, D.8
Egorin, M.J.9
-
8
-
-
0029986277
-
Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation
-
Fricker G, Drewe J, Huwyler J, Gutmann H and Beglinger C (1996) Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation. Br J Pharmacol 118:1841-1847.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1841-1847
-
-
Fricker, G.1
Drewe, J.2
Huwyler, J.3
Gutmann, H.4
Beglinger, C.5
-
9
-
-
9044252313
-
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells: Interaction between the two biochemical barriers to intestinal transport
-
Gan L-SL, Moseley MA, Khosla B, Augustijns PF, Bradshaw TP, Hendren RW and Thakker DR (1996) CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells: Interaction between the two biochemical barriers to intestinal transport. Drug Metab Dispos 24:344-349.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 344-349
-
-
Gan, L.-S.L.1
Moseley, M.A.2
Khosla, B.3
Augustijns, P.F.4
Bradshaw, T.P.5
Hendren, R.W.6
Thakker, D.R.7
-
10
-
-
0028590127
-
Biochemistry and molecular biology of the human CYP2C subfamily
-
Goldstein JA and de Morais SMF (1994) Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 4:285-299.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 285-299
-
-
Goldstein, J.A.1
De Morais, S.M.F.2
-
11
-
-
0021868158
-
Cross-resistance of vinblastine- and taxol-resistant mutants of Chinese hamster ovary cells to other anticancer drugs
-
Gupta RS (1985) Cross-resistance of vinblastine-and taxol-resistant mutants of Chinese hamster ovary cells to other anticancer drugs. Cancer Treat Rep 69:515-521.
-
(1985)
Cancer Treat Rep
, vol.69
, pp. 515-521
-
-
Gupta, R.S.1
-
12
-
-
0027957132
-
Metabolism of taxol by human hepatic microsomes and liver slices: Participation of cytochrome P450 3A4 and an unknown P450 enzyme
-
Harris JW, Rahman A, Kim B-R, Guengerich FP and Collins JM (1994) Metabolism of taxol by human hepatic microsomes and liver slices: Participation of cytochrome P450 3A4 and an unknown P450 enzyme. Cancer Res 54:4026-4035.
-
(1994)
Cancer Res
, vol.54
, pp. 4026-4035
-
-
Harris, J.W.1
Rahman, A.2
Kim, B.-R.3
Guengerich, F.P.4
Collins, J.M.5
-
13
-
-
0022557227
-
Taxol: Mechanisms of action and resistance
-
Horwitz SB, Lothstein L, Manfredi JJ, Mellado W, Parness J, Roy SN, Schiff PB, Sorbara L and Zeheb R (1986) Taxol: Mechanisms of action and resistance. Ann NY Acad Sci 466:733-744.
-
(1986)
Ann NY Acad Sci
, vol.466
, pp. 733-744
-
-
Horwitz, S.B.1
Lothstein, L.2
Manfredi, J.J.3
Mellado, W.4
Parness, J.5
Roy, S.N.6
Schiff, P.B.7
Sorbara, L.8
Zeheb, R.9
-
14
-
-
0029896241
-
Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers
-
Hosoya KI, Kim KJ and Lee VH (1996) Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm Res 13:885-890
-
(1996)
Pharm Res
, vol.13
, pp. 885-890
-
-
Hosoya, K.I.1
Kim, K.J.2
Lee, V.H.3
-
15
-
-
0027180795
-
Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
-
Hunter J, Hirst BH and Simmons NL (1993a) Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm Res 10:743-749.
-
(1993)
Pharm Res
, vol.10
, pp. 743-749
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
16
-
-
0027181852
-
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells: Kinetics of vinblastine secretion and interaction with modulators
-
Hunter J, Jepson MA, Tsuruo T, Simmons NL and Hirst BH (1993b) Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells: Kinetics of vinblastine secretion and interaction with modulators. J Biol Chem 268:14991-14997.
-
(1993)
J Biol Chem
, vol.268
, pp. 14991-14997
-
-
Hunter, J.1
Jepson, M.A.2
Tsuruo, T.3
Simmons, N.L.4
Hirst, B.H.5
-
17
-
-
0026464616
-
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes
-
Kolars JC, Schmiedlin-Ren P, Schuetz JD, Fang C and Watkins PB (1992) Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J Clin Invest 90:1871-1878.
-
(1992)
J Clin Invest
, vol.90
, pp. 1871-1878
-
-
Kolars, J.C.1
Schmiedlin-Ren, P.2
Schuetz, J.D.3
Fang, C.4
Watkins, P.B.5
-
18
-
-
0028786481
-
The human intestinal epithelial cell line Caco-2: Pharmacological and pharmacokinetic applications
-
Meunier V, Bourrié M, Berger Y and Fabre G (1995) The human intestinal epithelial cell line Caco-2: Pharmacological and pharmacokinetic applications. Cell Biol Toxicol 11:187-194.
-
(1995)
Cell Biol Toxicol
, vol.11
, pp. 187-194
-
-
Meunier, V.1
Bourrié, M.2
Berger, Y.3
Fabre, G.4
-
19
-
-
0022560656
-
2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells
-
2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells. Cancer Treat Rep 70:275-278.
-
(1986)
Cancer Treat Rep
, vol.70
, pp. 275-278
-
-
Racker, E.1
Wu, L.-T.2
Westcott, D.3
-
20
-
-
0028036727
-
Selective biotransformation of taxol to 6α-hydroxytaxol by human cytochrome P450 2C8
-
Rahman A, Korzekwa KR, Grogan J, Gonzalez FJ and Harris JW (1994) Selective biotransformation of taxol to 6α-hydroxytaxol by human cytochrome P450 2C8. Cancer Res 54:5543-5546.
-
(1994)
Cancer Res
, vol.54
, pp. 5543-5546
-
-
Rahman, A.1
Korzekwa, K.R.2
Grogan, J.3
Gonzalez, F.J.4
Harris, J.W.5
-
22
-
-
0026723301
-
Taxol: The first of the taxanes, an important new class of antitumor agents
-
Rowinsky EK, Onetto N, Canetta RM and Arbuck SG (1992) Taxol: The first of the taxanes, an important new class of antitumor agents. Semin Oncol 19:646-662.
-
(1992)
Semin Oncol
, vol.19
, pp. 646-662
-
-
Rowinsky, E.K.1
Onetto, N.2
Canetta, R.M.3
Arbuck, S.G.4
-
23
-
-
0030945754
-
Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1α,25-dihydroxyvitamin D3
-
Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF, Lown KS and Watkins PB (1997) Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1α,25-dihydroxyvitamin D3. Mol Pharmacol 51:741-754.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 741-754
-
-
Schmiedlin-Ren, P.1
Thummel, K.E.2
Fisher, J.M.3
Paine, M.F.4
Lown, K.S.5
Watkins, P.B.6
-
25
-
-
0029764332
-
Assays of CYP2C8- and CYP3A4-mediated metabolism of taxol in vivo and in vitro
-
Walle T (1996) Assays of CYP2C8-and CYP3A4-mediated metabolism of taxol in vivo and in vitro. Methods Enzymol 272:145-151.
-
(1996)
Methods Enzymol
, vol.272
, pp. 145-151
-
-
Walle, T.1
-
27
-
-
0023588109
-
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
-
Watkins PB, Wrighton SA, Schuetz EG, Molowa DT and Guzelian PS (1987) Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 80:1029-1036.
-
(1987)
J Clin Invest
, vol.80
, pp. 1029-1036
-
-
Watkins, P.B.1
Wrighton, S.A.2
Schuetz, E.G.3
Molowa, D.T.4
Guzelian, P.S.5
-
28
-
-
0029986922
-
Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: Concentration- and dose-dependent absorption in vitro and in vivo
-
Wetterich U, Spahn-Langguth H, Mutschler E, Terhaag B, Rösch W and Langguth P (1996) Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: Concentration-and dose-dependent absorption in vitro and in vivo. Pharm Res 13:514-522.
-
(1996)
Pharm Res
, vol.13
, pp. 514-522
-
-
Wetterich, U.1
Spahn-Langguth, H.2
Mutschler, E.3
Terhaag, B.4
Rösch, W.5
Langguth, P.6
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