메뉴 건너뛰기




Volumn 288, Issue 2, 1999, Pages 414-420

Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-β-D- glucuronide: Effects of dibromosulfophthalein on membrane transport and aglycone formation

Author keywords

[No Author keywords available]

Indexed keywords

1 O GEMFIBROZIL BETA DEXTRO GLUCURONIDE; ALBUMIN; ANION; DIBROMOSULFOPHTHALEIN; GEMFIBROZIL; GLUCURONIDE; UNCLASSIFIED DRUG;

EID: 0032987802     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (29)

References (40)
  • 2
    • 0019941549 scopus 로고
    • 14C)morphine in the isolated perfused rat liver
    • 14C)morphine in the isolated perfused rat liver. Drug Metab Dispos 10:344-349.
    • (1982) Drug Metab Dispos , vol.10 , pp. 344-349
    • Auansakul, A.C.1    Vore, M.2
  • 3
    • 0029122398 scopus 로고
    • Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin
    • Bischer A, Iwaki M, Zia-Amirhosseini P and Benet LZ (1995) Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos 23:900-903.
    • (1995) Drug Metab Dispos , vol.23 , pp. 900-903
    • Bischer, A.1    Iwaki, M.2    Zia-Amirhosseini, P.3    Benet, L.Z.4
  • 5
    • 84886641270 scopus 로고
    • Secretion of the organic anion harmol sulfate from liver into blood: Evidence for a carrier-mediated mechanism
    • De Vries MH, Groothuis GMM, Mulder GJ, Nguyen H and Meijer DKF (1985) Secretion of the organic anion harmol sulfate from liver into blood: Evidence for a carrier-mediated mechanism. Biochem Pharmacol 34:2129-2135.
    • (1985) Biochem Pharmacol , vol.34 , pp. 2129-2135
    • De Vries, M.H.1    Groothuis, G.M.M.2    Mulder, G.J.3    Nguyen, H.4    Meijer, D.K.F.5
  • 6
    • 0016156684 scopus 로고
    • Dibromsulphalein (DBSP) estimation of hepatic transport function in man
    • Dhumeaux D, Berthelot P and Javitt NB (1974) Dibromsulphalein (DBSP) estimation of hepatic transport function in man. Eur J Clin Invest 4:181-185.
    • (1974) Eur J Clin Invest , vol.4 , pp. 181-185
    • Dhumeaux, D.1    Berthelot, P.2    Javitt, N.B.3
  • 7
    • 0022337322 scopus 로고
    • Effects of taurocholate infusion on biliary excretion in isolated perfused rat livers: Decreased biliary excretion of dibromosulfophthalein in pregnancy
    • Durham S, Mack R III and Vore M (1985) Effects of taurocholate infusion on biliary excretion in isolated perfused rat livers: Decreased biliary excretion of dibromosulfophthalein in pregnancy. Drug Metab Dispos 13:695-699.
    • (1985) Drug Metab Dispos , vol.13 , pp. 695-699
    • Durham, S.1    Mack R. III2    Vore, M.3
  • 8
    • 0007937634 scopus 로고
    • Effect of probenecid and cimetidine on the disposition of morphine and morphine-3-glucuronide in the rat isolated perfused liver
    • Evans AM, O'Brien J and Nation RL (1995) Effect of probenecid and cimetidine on the disposition of morphine and morphine-3-glucuronide in the rat isolated perfused liver. Proc ASCEPT 2:46.
    • (1995) Proc ASCEPT , vol.2 , pp. 46
    • Evans, A.M.1    O'Brien, J.2    Nation, R.L.3
  • 9
    • 0029990308 scopus 로고    scopus 로고
    • Drug traffic in the hepatobiliary system
    • Groothuis GMM and Meijer DKF (1996) Drug traffic in the hepatobiliary system. J Hepatol 24:3-28.
    • (1996) J Hepatol , vol.24 , pp. 3-28
    • Groothuis, G.M.M.1    Meijer, D.K.F.2
  • 11
    • 0027930364 scopus 로고
    • Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac
    • Hargus SJ, Amouzedeh HR, Pumford NR, Myers TG, McCoy SC and Pohl LR (1994) Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Chem Res Toxicol 7:575-582.
    • (1994) Chem Res Toxicol , vol.7 , pp. 575-582
    • Hargus, S.J.1    Amouzedeh, H.R.2    Pumford, N.R.3    Myers, T.G.4    McCoy, S.C.5    Pohl, L.R.6
  • 12
    • 0026748501 scopus 로고
    • Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin
    • Hayball PJ, Nation RL and Bochner F (1992) Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin. Biochem Pharmacol 44:291-299.
    • (1992) Biochem Pharmacol , vol.44 , pp. 291-299
    • Hayball, P.J.1    Nation, R.L.2    Bochner, F.3
  • 13
    • 0027493955 scopus 로고
    • Hepatic uptake of intact glutathione S-conjugate, inhibition by organic anions, and sinusoidal catabolism
    • Hinchman CA, Truong AT and Ballatori N (1993) Hepatic uptake of intact glutathione S-conjugate, inhibition by organic anions, and sinusoidal catabolism. Am J Physiol 28:G547-G554.
    • (1993) Am J Physiol , vol.28
    • Hinchman, C.A.1    Truong, A.T.2    Ballatori, N.3
  • 14
    • 0025095648 scopus 로고
    • Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin
    • Iwakawa S, Spahn H, Benet LZ and Lin ET (1990) Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Biochem Pharmacol 39:949-953.
    • (1990) Biochem Pharmacol , vol.39 , pp. 949-953
    • Iwakawa, S.1    Spahn, H.2    Benet, L.Z.3    Lin, E.T.4
  • 16
    • 0023157406 scopus 로고
    • Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary conjugated hyperbilirubinaemia
    • Jansen PLM, Groothuis GMM, Peters WHM and Meijer DFM (1987) Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary conjugated hyperbilirubinaemia. Hepatology 7:71-76.
    • (1987) Hepatology , vol.7 , pp. 71-76
    • Jansen, P.L.M.1    Groothuis, G.M.M.2    Peters, W.H.M.3    Meijer, D.F.M.4
  • 17
    • 0344733048 scopus 로고
    • Phenol 3,6-dibromphthalein disulfonate, a new compound for the study of liver disease
    • Javitt NB (1964) Phenol 3,6-dibromphthalein disulfonate, a new compound for the study of liver disease. Prof Soc Exp Biol Med 117:254-257.
    • (1964) Prof Soc Exp Biol Med , vol.117 , pp. 254-257
    • Javitt, N.B.1
  • 18
    • 0027935783 scopus 로고
    • Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane
    • Jedlitschky G, Leier I, Bohme M, Buchholz U, Bar-Tana J and Keppler D (1994) Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane. Biochem Pharmacol 48:1113-1120.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1113-1120
    • Jedlitschky, G.1    Leier, I.2    Bohme, M.3    Buchholz, U.4    Bar-Tana, J.5    Keppler, D.6
  • 19
    • 0030638506 scopus 로고    scopus 로고
    • Hepatic canalicular membrane: Introduction: Transport across the hepatocyte canalicular membrane
    • Keppler D and Arias IM (1997) Hepatic canalicular membrane: Introduction: Transport across the hepatocyte canalicular membrane. FASEB J 11:15-18.
    • (1997) FASEB J , vol.11 , pp. 15-18
    • Keppler, D.1    Arias, I.M.2
  • 20
    • 0014337431 scopus 로고
    • Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein
    • Klaassen CD and Plaa GL (1968) Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein. Am J Physiol 215:971-976.
    • (1968) Am J Physiol , vol.215 , pp. 971-976
    • Klaassen, C.D.1    Plaa, G.L.2
  • 21
    • 0025348840 scopus 로고
    • Gemfibrozil absorption and elimination in kidney and liver disease
    • Knauf H, Kolle EU and Mutschler E (1990) Gemfibrozil absorption and elimination in kidney and liver disease. Klin Worchenschr 68:692-698.
    • (1990) Klin Worchenschr , vol.68 , pp. 692-698
    • Knauf, H.1    Kolle, E.U.2    Mutschler, E.3
  • 22
    • 0024844257 scopus 로고
    • Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinaemia
    • Kuipers F, Radominska A, Zimniak P, Little JM, Havinga R, Vonk RJ and Lester R (1989) Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinaemia. J Lipid Res 30:1835-1845.
    • (1989) J Lipid Res , vol.30 , pp. 1835-1845
    • Kuipers, F.1    Radominska, A.2    Zimniak, P.3    Little, J.M.4    Havinga, R.5    Vonk, R.J.6    Lester, R.7
  • 23
    • 0021020527 scopus 로고
    • A renal mechanism for the clofibric acid-probenecid interaction
    • Meffin PJ, Zilm DM and Veenendaal JR (1983a) A renal mechanism for the clofibric acid-probenecid interaction. J Pharmacol Exp Ther 227:739-742.
    • (1983) J Pharmacol Exp Ther , vol.227 , pp. 739-742
    • Meffin, P.J.1    Zilm, D.M.2    Veenendaal, J.R.3
  • 24
    • 0021075134 scopus 로고
    • Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle
    • Meffin PJ, Zilm DM and Veenendaal JR (1983b) Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle. J Pharmacol Exp Ther 227:732-738.
    • (1983) J Pharmacol Exp Ther , vol.227 , pp. 732-738
    • Meffin, P.J.1    Zilm, D.M.2    Veenendaal, J.R.3
  • 25
    • 0017669374 scopus 로고
    • Hepatic uptake and biliary excretion of dibromosulphthalein: Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of Y and Z protein
    • Meijer DKF, Vonk RJ, Keulemans K and Weitering JG (1977) Hepatic uptake and biliary excretion of dibromosulphthalein: Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of Y and Z protein. J Pharmacol Exp Ther 202:8-21.
    • (1977) J Pharmacol Exp Ther , vol.202 , pp. 8-21
    • Meijer, D.K.F.1    Vonk, R.J.2    Keulemans, K.3    Weitering, J.G.4
  • 27
    • 0028243524 scopus 로고
    • Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro
    • Ojingwa JC, Spahn-Langguth H and Benet LZ (1994a) Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica 24:495-506.
    • (1994) Xenobiotica , vol.24 , pp. 495-506
    • Ojingwa, J.C.1    Spahn-Langguth, H.2    Benet, L.Z.3
  • 28
    • 0028275849 scopus 로고
    • Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma
    • Ojingwa JC, Spahn-Langguth H and Benet LZ (1994b) Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. J Pharmacokinet Biopharm 22:19-39.
    • (1994) J Pharmacokinet Biopharm , vol.22 , pp. 19-39
    • Ojingwa, J.C.1    Spahn-Langguth, H.2    Benet, L.Z.3
  • 30
    • 0028956772 scopus 로고
    • Biosynthesis, characterisation and direct high-performance liquid chromatographic analysis of gemfibrozil 1-O-β acylglucuronide
    • Sallustio BC and Fairchild BA (1995) Biosynthesis, characterisation and direct high-performance liquid chromatographic analysis of gemfibrozil 1-O-β acylglucuronide. J Chromatogr 665:345-353.
    • (1995) J Chromatogr , vol.665 , pp. 345-353
    • Sallustio, B.C.1    Fairchild, B.A.2
  • 31
    • 0031012606 scopus 로고    scopus 로고
    • Interaction of human serum albumin with the electrophilic metabolite 1-O-gemfibrozil-β-D-glucuronide
    • Sallustio BC, Fairchild BA and Pannall PR (1997a) Interaction of human serum albumin with the electrophilic metabolite 1-O-gemfibrozil-β-D-glucuronide. Drug Metab Dispos 25:55-60.
    • (1997) Drug Metab Dispos , vol.25 , pp. 55-60
    • Sallustio, B.C.1    Fairchild, B.A.2    Pannall, P.R.3
  • 32
    • 0029841891 scopus 로고    scopus 로고
    • Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver
    • Sallustio BC, Fairchild BA, Shanahan K, Evans AM and Nation RL (1996) Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver. Drug Metab Dispos 24:984-989.
    • (1996) Drug Metab Dispos , vol.24 , pp. 984-989
    • Sallustio, B.C.1    Fairchild, B.A.2    Shanahan, K.3    Evans, A.M.4    Nation, R.L.5
  • 33
    • 0029143748 scopus 로고
    • Reactivity of gemfibrozil 1-O-β-acyl glucuronide: Pharmacokinetics of covalently bound gemfibrozil-protein adducts in rats
    • Sallustio BC and Foster DjR (1995) Reactivity of gemfibrozil 1-O-β-acyl glucuronide: Pharmacokinetics of covalently bound gemfibrozil-protein adducts in rats. Drug Metab Dispos 23:892-899.
    • (1995) Drug Metab Dispos , vol.23 , pp. 892-899
    • Sallustio, B.C.1    Foster, D.J.R.2
  • 34
    • 0031422924 scopus 로고    scopus 로고
    • Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: A novel role for phase II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones
    • Sallustio BC, Harkin LA, Mann MC, Krivickas SJ and Burcham PC (1997b) Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: A novel role for phase II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones. Toxicol Appl Pharmacol 147:459-464.
    • (1997) Toxicol Appl Pharmacol , vol.147 , pp. 459-464
    • Sallustio, B.C.1    Harkin, L.A.2    Mann, M.C.3    Krivickas, S.J.4    Burcham, P.C.5
  • 35
    • 0028027840 scopus 로고
    • Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds
    • Shimamura H, Suzuki H, Hanano M, Suzuki A, Tagaya O, Horie T and Sugiyama Y (1994) Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds. J Pharmacol Exp Ther 271:370-378.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 370-378
    • Shimamura, H.1    Suzuki, H.2    Hanano, M.3    Suzuki, A.4    Tagaya, O.5    Horie, T.6    Sugiyama, Y.7
  • 36
    • 0026532030 scopus 로고
    • Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism?
    • Spahn-Langguth H and Benet LZ (1992) Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism? Drug Metab Rev 24:4-48
    • (1992) Drug Metab Rev , vol.24 , pp. 4-48
    • Spahn-Langguth, H.1    Benet, L.Z.2
  • 37
    • 0030942171 scopus 로고    scopus 로고
    • Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methyl-amino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: Quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo
    • Takenaka O, Horie T, Suzuki H and Sugiyama Y (1997) Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methyl-amino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: Quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo. J Pharmacol Exp Ther 280:948-958.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 948-958
    • Takenaka, O.1    Horie, T.2    Suzuki, H.3    Sugiyama, Y.4
  • 38
    • 0344695456 scopus 로고
    • Regulation of drug conjugate processing by hepatocellular transport systems
    • (Kauffman FC ed) Springer-Verlag, Berlin
    • Vore M (1994) Regulation of drug conjugate processing by hepatocellular transport systems, in Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity (Kauffman FC ed) vol 112, pp 311-338, Springer-Verlag, Berlin.
    • (1994) Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity , vol.112 , pp. 311-338
    • Vore, M.1
  • 39
    • 0016566218 scopus 로고
    • Commentary: A physiological approach to hepatic drug clearance
    • Wilkinson GR and Shand DG (1975) Commentary: A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377-390.
    • (1975) Clin Pharmacol Ther , vol.18 , pp. 377-390
    • Wilkinson, G.R.1    Shand, D.G.2
  • 40
    • 0029846754 scopus 로고    scopus 로고
    • Tissue-selective uptake of pravastatin in rats: Contribution of a specific carrier-mediated uptake system
    • Yamazaki M, Tokui T, Ishigami M and Sugiyama Y (1996) Tissue-selective uptake of pravastatin in rats: Contribution of a specific carrier-mediated uptake system. Biopharm Drug Dispos 17:775-789.
    • (1996) Biopharm Drug Dispos , vol.17 , pp. 775-789
    • Yamazaki, M.1    Tokui, T.2    Ishigami, M.3    Sugiyama, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.