-
1
-
-
0025770622
-
Uptake of bilirubin glucuronides by isolated rat hepatocytes
-
Adachi Y, Kinne R, Roy-Chowdhury J, Roy-Chowdhury N, Theilmann L, Tran T and Arias IM (1991) Uptake of bilirubin glucuronides by isolated rat hepatocytes. Gastroenterol Jpn 26:350-355
-
(1991)
Gastroenterol Jpn
, vol.26
, pp. 350-355
-
-
Adachi, Y.1
Kinne, R.2
Roy-Chowdhury, J.3
Roy-Chowdhury, N.4
Theilmann, L.5
Tran, T.6
Arias, I.M.7
-
2
-
-
0019941549
-
14C)morphine in the isolated perfused rat liver
-
14C)morphine in the isolated perfused rat liver. Drug Metab Dispos 10:344-349.
-
(1982)
Drug Metab Dispos
, vol.10
, pp. 344-349
-
-
Auansakul, A.C.1
Vore, M.2
-
3
-
-
0029122398
-
Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin
-
Bischer A, Iwaki M, Zia-Amirhosseini P and Benet LZ (1995) Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos 23:900-903.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 900-903
-
-
Bischer, A.1
Iwaki, M.2
Zia-Amirhosseini, P.3
Benet, L.Z.4
-
4
-
-
0242288198
-
The fate of gemfibrozil and its metabolites in the rat
-
Curtis CG, Danaher TM, Hibbert EA, Morris CL, Scott AM, Woolcott BA and Powell GM (1985) The fate of gemfibrozil and its metabolites in the rat. Biochem Soc Trans 13:1190-1191.
-
(1985)
Biochem Soc Trans
, vol.13
, pp. 1190-1191
-
-
Curtis, C.G.1
Danaher, T.M.2
Hibbert, E.A.3
Morris, C.L.4
Scott, A.M.5
Woolcott, B.A.6
Powell, G.M.7
-
5
-
-
84886641270
-
Secretion of the organic anion harmol sulfate from liver into blood: Evidence for a carrier-mediated mechanism
-
De Vries MH, Groothuis GMM, Mulder GJ, Nguyen H and Meijer DKF (1985) Secretion of the organic anion harmol sulfate from liver into blood: Evidence for a carrier-mediated mechanism. Biochem Pharmacol 34:2129-2135.
-
(1985)
Biochem Pharmacol
, vol.34
, pp. 2129-2135
-
-
De Vries, M.H.1
Groothuis, G.M.M.2
Mulder, G.J.3
Nguyen, H.4
Meijer, D.K.F.5
-
6
-
-
0016156684
-
Dibromsulphalein (DBSP) estimation of hepatic transport function in man
-
Dhumeaux D, Berthelot P and Javitt NB (1974) Dibromsulphalein (DBSP) estimation of hepatic transport function in man. Eur J Clin Invest 4:181-185.
-
(1974)
Eur J Clin Invest
, vol.4
, pp. 181-185
-
-
Dhumeaux, D.1
Berthelot, P.2
Javitt, N.B.3
-
7
-
-
0022337322
-
Effects of taurocholate infusion on biliary excretion in isolated perfused rat livers: Decreased biliary excretion of dibromosulfophthalein in pregnancy
-
Durham S, Mack R III and Vore M (1985) Effects of taurocholate infusion on biliary excretion in isolated perfused rat livers: Decreased biliary excretion of dibromosulfophthalein in pregnancy. Drug Metab Dispos 13:695-699.
-
(1985)
Drug Metab Dispos
, vol.13
, pp. 695-699
-
-
Durham, S.1
Mack R. III2
Vore, M.3
-
8
-
-
0007937634
-
Effect of probenecid and cimetidine on the disposition of morphine and morphine-3-glucuronide in the rat isolated perfused liver
-
Evans AM, O'Brien J and Nation RL (1995) Effect of probenecid and cimetidine on the disposition of morphine and morphine-3-glucuronide in the rat isolated perfused liver. Proc ASCEPT 2:46.
-
(1995)
Proc ASCEPT
, vol.2
, pp. 46
-
-
Evans, A.M.1
O'Brien, J.2
Nation, R.L.3
-
9
-
-
0029990308
-
Drug traffic in the hepatobiliary system
-
Groothuis GMM and Meijer DKF (1996) Drug traffic in the hepatobiliary system. J Hepatol 24:3-28.
-
(1996)
J Hepatol
, vol.24
, pp. 3-28
-
-
Groothuis, G.M.M.1
Meijer, D.K.F.2
-
11
-
-
0027930364
-
Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac
-
Hargus SJ, Amouzedeh HR, Pumford NR, Myers TG, McCoy SC and Pohl LR (1994) Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Chem Res Toxicol 7:575-582.
-
(1994)
Chem Res Toxicol
, vol.7
, pp. 575-582
-
-
Hargus, S.J.1
Amouzedeh, H.R.2
Pumford, N.R.3
Myers, T.G.4
McCoy, S.C.5
Pohl, L.R.6
-
12
-
-
0026748501
-
Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin
-
Hayball PJ, Nation RL and Bochner F (1992) Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin. Biochem Pharmacol 44:291-299.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 291-299
-
-
Hayball, P.J.1
Nation, R.L.2
Bochner, F.3
-
13
-
-
0027493955
-
Hepatic uptake of intact glutathione S-conjugate, inhibition by organic anions, and sinusoidal catabolism
-
Hinchman CA, Truong AT and Ballatori N (1993) Hepatic uptake of intact glutathione S-conjugate, inhibition by organic anions, and sinusoidal catabolism. Am J Physiol 28:G547-G554.
-
(1993)
Am J Physiol
, vol.28
-
-
Hinchman, C.A.1
Truong, A.T.2
Ballatori, N.3
-
14
-
-
0025095648
-
Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin
-
Iwakawa S, Spahn H, Benet LZ and Lin ET (1990) Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Biochem Pharmacol 39:949-953.
-
(1990)
Biochem Pharmacol
, vol.39
, pp. 949-953
-
-
Iwakawa, S.1
Spahn, H.2
Benet, L.Z.3
Lin, E.T.4
-
16
-
-
0023157406
-
Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary conjugated hyperbilirubinaemia
-
Jansen PLM, Groothuis GMM, Peters WHM and Meijer DFM (1987) Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary conjugated hyperbilirubinaemia. Hepatology 7:71-76.
-
(1987)
Hepatology
, vol.7
, pp. 71-76
-
-
Jansen, P.L.M.1
Groothuis, G.M.M.2
Peters, W.H.M.3
Meijer, D.F.M.4
-
17
-
-
0344733048
-
Phenol 3,6-dibromphthalein disulfonate, a new compound for the study of liver disease
-
Javitt NB (1964) Phenol 3,6-dibromphthalein disulfonate, a new compound for the study of liver disease. Prof Soc Exp Biol Med 117:254-257.
-
(1964)
Prof Soc Exp Biol Med
, vol.117
, pp. 254-257
-
-
Javitt, N.B.1
-
18
-
-
0027935783
-
Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane
-
Jedlitschky G, Leier I, Bohme M, Buchholz U, Bar-Tana J and Keppler D (1994) Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane. Biochem Pharmacol 48:1113-1120.
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 1113-1120
-
-
Jedlitschky, G.1
Leier, I.2
Bohme, M.3
Buchholz, U.4
Bar-Tana, J.5
Keppler, D.6
-
19
-
-
0030638506
-
Hepatic canalicular membrane: Introduction: Transport across the hepatocyte canalicular membrane
-
Keppler D and Arias IM (1997) Hepatic canalicular membrane: Introduction: Transport across the hepatocyte canalicular membrane. FASEB J 11:15-18.
-
(1997)
FASEB J
, vol.11
, pp. 15-18
-
-
Keppler, D.1
Arias, I.M.2
-
20
-
-
0014337431
-
Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein
-
Klaassen CD and Plaa GL (1968) Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein. Am J Physiol 215:971-976.
-
(1968)
Am J Physiol
, vol.215
, pp. 971-976
-
-
Klaassen, C.D.1
Plaa, G.L.2
-
21
-
-
0025348840
-
Gemfibrozil absorption and elimination in kidney and liver disease
-
Knauf H, Kolle EU and Mutschler E (1990) Gemfibrozil absorption and elimination in kidney and liver disease. Klin Worchenschr 68:692-698.
-
(1990)
Klin Worchenschr
, vol.68
, pp. 692-698
-
-
Knauf, H.1
Kolle, E.U.2
Mutschler, E.3
-
22
-
-
0024844257
-
Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinaemia
-
Kuipers F, Radominska A, Zimniak P, Little JM, Havinga R, Vonk RJ and Lester R (1989) Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinaemia. J Lipid Res 30:1835-1845.
-
(1989)
J Lipid Res
, vol.30
, pp. 1835-1845
-
-
Kuipers, F.1
Radominska, A.2
Zimniak, P.3
Little, J.M.4
Havinga, R.5
Vonk, R.J.6
Lester, R.7
-
23
-
-
0021020527
-
A renal mechanism for the clofibric acid-probenecid interaction
-
Meffin PJ, Zilm DM and Veenendaal JR (1983a) A renal mechanism for the clofibric acid-probenecid interaction. J Pharmacol Exp Ther 227:739-742.
-
(1983)
J Pharmacol Exp Ther
, vol.227
, pp. 739-742
-
-
Meffin, P.J.1
Zilm, D.M.2
Veenendaal, J.R.3
-
24
-
-
0021075134
-
Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle
-
Meffin PJ, Zilm DM and Veenendaal JR (1983b) Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle. J Pharmacol Exp Ther 227:732-738.
-
(1983)
J Pharmacol Exp Ther
, vol.227
, pp. 732-738
-
-
Meffin, P.J.1
Zilm, D.M.2
Veenendaal, J.R.3
-
25
-
-
0017669374
-
Hepatic uptake and biliary excretion of dibromosulphthalein: Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of Y and Z protein
-
Meijer DKF, Vonk RJ, Keulemans K and Weitering JG (1977) Hepatic uptake and biliary excretion of dibromosulphthalein: Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of Y and Z protein. J Pharmacol Exp Ther 202:8-21.
-
(1977)
J Pharmacol Exp Ther
, vol.202
, pp. 8-21
-
-
Meijer, D.K.F.1
Vonk, R.J.2
Keulemans, K.3
Weitering, J.G.4
-
27
-
-
0028243524
-
Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro
-
Ojingwa JC, Spahn-Langguth H and Benet LZ (1994a) Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica 24:495-506.
-
(1994)
Xenobiotica
, vol.24
, pp. 495-506
-
-
Ojingwa, J.C.1
Spahn-Langguth, H.2
Benet, L.Z.3
-
28
-
-
0028275849
-
Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma
-
Ojingwa JC, Spahn-Langguth H and Benet LZ (1994b) Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. J Pharmacokinet Biopharm 22:19-39.
-
(1994)
J Pharmacokinet Biopharm
, vol.22
, pp. 19-39
-
-
Ojingwa, J.C.1
Spahn-Langguth, H.2
Benet, L.Z.3
-
29
-
-
0029082150
-
Hepatobiliary secretion of compounds: Molecular mechanisms of membrane transport
-
Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK and Groothuis GMM (1995) Hepatobiliary secretion of compounds: Molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
-
(1995)
Biochim Biophys Acta
, vol.1241
, pp. 215-268
-
-
Oude Elferink, R.P.J.1
Meijer, D.K.F.2
Kuipers, F.3
Jansen, P.L.M.4
Groen, A.K.5
Groothuis, G.M.M.6
-
30
-
-
0028956772
-
Biosynthesis, characterisation and direct high-performance liquid chromatographic analysis of gemfibrozil 1-O-β acylglucuronide
-
Sallustio BC and Fairchild BA (1995) Biosynthesis, characterisation and direct high-performance liquid chromatographic analysis of gemfibrozil 1-O-β acylglucuronide. J Chromatogr 665:345-353.
-
(1995)
J Chromatogr
, vol.665
, pp. 345-353
-
-
Sallustio, B.C.1
Fairchild, B.A.2
-
31
-
-
0031012606
-
Interaction of human serum albumin with the electrophilic metabolite 1-O-gemfibrozil-β-D-glucuronide
-
Sallustio BC, Fairchild BA and Pannall PR (1997a) Interaction of human serum albumin with the electrophilic metabolite 1-O-gemfibrozil-β-D-glucuronide. Drug Metab Dispos 25:55-60.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 55-60
-
-
Sallustio, B.C.1
Fairchild, B.A.2
Pannall, P.R.3
-
32
-
-
0029841891
-
Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver
-
Sallustio BC, Fairchild BA, Shanahan K, Evans AM and Nation RL (1996) Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver. Drug Metab Dispos 24:984-989.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 984-989
-
-
Sallustio, B.C.1
Fairchild, B.A.2
Shanahan, K.3
Evans, A.M.4
Nation, R.L.5
-
33
-
-
0029143748
-
Reactivity of gemfibrozil 1-O-β-acyl glucuronide: Pharmacokinetics of covalently bound gemfibrozil-protein adducts in rats
-
Sallustio BC and Foster DjR (1995) Reactivity of gemfibrozil 1-O-β-acyl glucuronide: Pharmacokinetics of covalently bound gemfibrozil-protein adducts in rats. Drug Metab Dispos 23:892-899.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 892-899
-
-
Sallustio, B.C.1
Foster, D.J.R.2
-
34
-
-
0031422924
-
Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: A novel role for phase II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones
-
Sallustio BC, Harkin LA, Mann MC, Krivickas SJ and Burcham PC (1997b) Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: A novel role for phase II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones. Toxicol Appl Pharmacol 147:459-464.
-
(1997)
Toxicol Appl Pharmacol
, vol.147
, pp. 459-464
-
-
Sallustio, B.C.1
Harkin, L.A.2
Mann, M.C.3
Krivickas, S.J.4
Burcham, P.C.5
-
35
-
-
0028027840
-
Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds
-
Shimamura H, Suzuki H, Hanano M, Suzuki A, Tagaya O, Horie T and Sugiyama Y (1994) Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds. J Pharmacol Exp Ther 271:370-378.
-
(1994)
J Pharmacol Exp Ther
, vol.271
, pp. 370-378
-
-
Shimamura, H.1
Suzuki, H.2
Hanano, M.3
Suzuki, A.4
Tagaya, O.5
Horie, T.6
Sugiyama, Y.7
-
36
-
-
0026532030
-
Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism?
-
Spahn-Langguth H and Benet LZ (1992) Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism? Drug Metab Rev 24:4-48
-
(1992)
Drug Metab Rev
, vol.24
, pp. 4-48
-
-
Spahn-Langguth, H.1
Benet, L.Z.2
-
37
-
-
0030942171
-
Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methyl-amino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: Quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo
-
Takenaka O, Horie T, Suzuki H and Sugiyama Y (1997) Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methyl-amino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: Quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo. J Pharmacol Exp Ther 280:948-958.
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 948-958
-
-
Takenaka, O.1
Horie, T.2
Suzuki, H.3
Sugiyama, Y.4
-
38
-
-
0344695456
-
Regulation of drug conjugate processing by hepatocellular transport systems
-
(Kauffman FC ed) Springer-Verlag, Berlin
-
Vore M (1994) Regulation of drug conjugate processing by hepatocellular transport systems, in Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity (Kauffman FC ed) vol 112, pp 311-338, Springer-Verlag, Berlin.
-
(1994)
Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity
, vol.112
, pp. 311-338
-
-
Vore, M.1
-
39
-
-
0016566218
-
Commentary: A physiological approach to hepatic drug clearance
-
Wilkinson GR and Shand DG (1975) Commentary: A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377-390.
-
(1975)
Clin Pharmacol Ther
, vol.18
, pp. 377-390
-
-
Wilkinson, G.R.1
Shand, D.G.2
-
40
-
-
0029846754
-
Tissue-selective uptake of pravastatin in rats: Contribution of a specific carrier-mediated uptake system
-
Yamazaki M, Tokui T, Ishigami M and Sugiyama Y (1996) Tissue-selective uptake of pravastatin in rats: Contribution of a specific carrier-mediated uptake system. Biopharm Drug Dispos 17:775-789.
-
(1996)
Biopharm Drug Dispos
, vol.17
, pp. 775-789
-
-
Yamazaki, M.1
Tokui, T.2
Ishigami, M.3
Sugiyama, Y.4
|