Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2

Cancer Research

Volumn 59, Issue 11, 1999, Pages 2532-2535

  Hooijberg, Jan Hendrik ^b   Broxterman, Henk J ^b   Kool, Marcel ^c   Assaraf, Yehuda G ^d   Peters, Godefridus J ^b   Noordhuis, Paul ^b   Scheper, Rik J ^b   Borst, Piet ^c   Pinedo, Herbert M ^b   Jansen, Gerrit ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID ANTAGONIST; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; POLYGLUTAMIC ACID; RALTITREXED;

ANION TRANSPORT; ARTICLE; DRUG ACCUMULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPOPHILICITY; MEMBRANE VESICLE; MULTIDRUG RESISTANCE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURINE SYNTHESIS;

ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; FOLIC ACID ANTAGONISTS; GLUTAMATES; HUMANS; INDOLES; METHOTREXATE; OVARIAN NEOPLASMS; P-GLYCOPROTEIN; P-GLYCOPROTEINS; QUINAZOLINES; THIOPHENES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033152212     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Cole, S. P., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M., and Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Washington DC), 258: 1650-1654, 1992.
2. Versantvoort, C. H. M., Broxterman, H. J., Pinedo, H. M., Feller, N., Kuiper, C. M., and Lankelma, J. Energy-dependent processes involved in reduced drug accumulation in multidrug resistant human lung cancer cell lines without P-glycoprotein expression. Cancer Res., 52: 17-23, 1992.
3. Zaman, G. J. R., Flens, M. J., van Leusden, M. R., de Haas, M., Mülder, H. S., Lankelma, J., Pinedo, H. M., Scheper, R. J., Baas, F., Broxterman, H. J., and Borst, P. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc. Natl. Acad. Sci. USA, 91: 8822-8826, 1994.
4. Higgins, C. F. ABC Transporters: from micro-organisms to man. Annu. Rev. Cell Biol., 8: 67-113, 1992.
5. Müller, M., Meijer, C., Zaman, G. J. R., Borst, P., Scheper, R. J., Mulder, N. H., de Vries, E. G. E., and Jansen, P. L. M. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA, 91: 13033-13037, 1994.
6. Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., van Eijk, M. J. T., Juijn, J. A., Baas, F., and Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res., 57: 3537-3547, 1997.
7. Kool, M., Van der Linden, M., de Haas, M., Baas, F., and Borst, P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRPI, in tissues and cancer cells. Cancer Res., 59: 175-182, 1999.
8. Bertino, J. R. Ode to methotrexate. J Clin. Oncol., 11: 5-14, 1993.
9. Jansen, G., and Pieters, R. The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates. Drug Resistance Updates, 1: 211-218, 1998.
10. Gorlick, R., Goker, E., Tripett, T., Waltham, M., Banerjee, D., and Bertino, J. R. Intrinsic and acquired resistance to methotrexate in acute leukemia. N. Engl. J. Med., 335: 1041-1048, 1996.
11. Jackman, A. L., Taylor, G. A., Gibson, W., Kimbell, R., Brown, M., Calvert, A. H., Judson, I. R., and Hughes, L. R. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cells growth in vitro and in vivo: a new agent for clinical studies. Cancer Res., 51: 5579-5586, 1991.
12. Duch, D. S., Banks, S., Dev, I. K., Dickerson, S. H., Ferone, R., Health, L. S., Humphreys, J., Knick, V., Pendergast, W., Singer, S., Smith, G. K., Waters, K., and Wilson, H. R. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res., 53: 810-818, 1993.
13. Westerhof, G. R., Schomagel, J. H., Kathmann, I., Jackman, A. L., Rosowsky, A., Forsch, R. A., Hynes, J. B., Boyle, F. T., Peters, G. J., Pinedo, H. M., and Jansen, G. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular structure and biological activity. Mol. Pharmacol., 48: 459-471, 1995.
14. Masuda, M., I'izuka, Y., Yamazaki, M., Nishigaki, R., Kato, Y., Ni'inuma, K., Suzuki, H., and Sugiyama, Y. Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer Res., 57: 3506-3510, 1997.
15. Westerhof, G. R., Rijnboutt, S., Schornagel, J. H., Pinedo, H. M., Peters, G. J., and Jansen, G. Functional activity of the reduced folate carrier in KB, MAI04, and IGROV-I cells expressing folate-binding protein. Cancer Res., 55: 3795-3802, 1995.
16. Nooter, K., Westerman, M. A., Flens, M. J., Zaman, G. J. R., Scheper, R. J., van Wingerden, K. E., Burger, H., Oostrum, R., Boersma, T., Sonneveld, P., Gratema, J. W., Kok, T., Eggermont, A. M. M., Bosman, F. T., and Stoter, G. Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin. Cancer Res., 1: 1301-1310, 1995.
17. Paulusma, C. C., Bosma, P. J., Zaman, G. J. R., Bakker, C. T. M., Otter, M., Scheffer, G. L., Scheper, R. J., Borst, P., and Oude-Elferink, R. P. J. O. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Washington DC), 271: 1126-1128, 1996.
18. Flens, M. J., Izquierdo, M. A., Scheffer, G. L., Fritz, J. M., Meijer, C. J. L. M., Scheper, R. J., and Zaman, G. J. R. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug resistant tumor cells by monoclonal antibodies. Cancer Res., 54: 4557-4563, 1994.
19. Heijn, M., Hooijberg, J. H., Scheffer, G. L., Szabó, G., Westerhoff, H. V., and Lankelma, J. Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim. Biophys. Acta, 1326: 12-22, 1997.
20. Hooijberg, J. H., Broxterman, H. J., Scheffer, G. L., Heijn, M., De Jong, M., Scheper, R. J., Lankelma, J., and Pinedo, H. M. Potent intereaction of flavopiridol with the multidrug resistance protein 1. Br. J. Cancer, in press, 1999.
21. Feller, N., Broxterman, H. J., Wahrer, D. C. R., and Pinedo, H. M. ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular gluthatione depletion. FEBS Lett., 368: 385-388, 1995.
22. Henderson, G. B., Tsjui, J. M., and Kumar, H. P. Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells. Cancer Res., 46: 1633-1638, 1986.
23. Sirotnak, F. M., and O'Leary, D. F. The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors. Cancer Res., 57: 1412-1417, 1991.
24. Saxena, M., and Henderson, G. B. Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 cells. Biochem. Pharmacol., 51: 975-982, 1996.
25. Cocconi, G., Cunningham, D., van Cutsem, E., Francois, E., Gustavsson, B., van Hazel, G., Kerr, D., Possinger, K., and Hietschold, S. M. Open, randomized multi-center trial of raltitrexed versus fluorouracil plus high dose leucovorin in patients with advanced colorectal cancer. J. Clin. Oncol., 16: 2943-2952, 1998.
26. Van Triest, B., Pinedo, H. M., Telleman, F., Van der Wilt, C. L., Jansen, G., and Peters, G. J. Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression. Biochem. Pharmacol., 53: 1855-1866, 1997.
27. Assaraf, Y. G., and Goldman, I. D. Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells. J. Biol. Chem., 272: 17460-17466, 1997.
28. Jansen, G., Barr, H. M., Kathmann, I., Bunni, M. A., Priest, D. G., Noordhuis, P., Peters, G. J., and Assaraf, Y. G. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools and intralysosomal drug sequestration. Mol. Pharmacol., 55: 761-769, 1999.
29. Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathmann, I., Bunni, M., Priest, D. G., Noordhuis, P., Schomagel, J. H., Pinedo, H. M., Peters, G. J., and Assaraf, Y. G. A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J. Biol. Chem., 273: 30189-30198, 1998.
30. Kool, M., Van der Linden, M., De Haas, M., Scheffer, G. L., De Vree, M. L., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N., Scheper, R. J., Oudde Elferink, R. P. V., Baas, F., and Borst, P. MRP3, a new organic anion transporter able to transport anti-cancer drugs. Proc. Natl. Acad. Sci. USA, in press, 1999.