메뉴 건너뛰기




Volumn 88, Issue 3, 1999, Pages 347-350

CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETA LACTAM ANTIBIOTIC; CARRIER PROTEIN; CEFACLOR; CEFALEXIN; CEFRADINE; ENALAPRIL; GLYCYLSARCOSINE; LEVODOPA; METHYLDOPA;

EID: 0344572686     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980132e     Document Type: Article
Times cited : (38)

References (28)
  • 1
    • 0030581089 scopus 로고    scopus 로고
    • The intestinal peptide carrier: A potential transport system for small peptide derived drugs
    • Walter, E.; Kissel, T.; Amidon, G. L. The intestinal peptide carrier: A potential transport system for small peptide derived drugs. Adv. Drug Del. Rev. 1996, 20, 33-58.
    • (1996) Adv. Drug Del. Rev. , vol.20 , pp. 33-58
    • Walter, E.1    Kissel, T.2    Amidon, G.L.3
  • 2
    • 0042557986 scopus 로고
    • Gastrointestinal transport of peptide and protein drugs and prodrugs
    • Bai, J. P. F.; Stewart, B. H.; Amidon, G. L. Gastrointestinal Transport of Peptide and Protein Drugs and Prodrugs, Handbk. Exp. Pharmacol. 1994, 110, 189-206.
    • (1994) Handbk. Exp. Pharmacol. , vol.110 , pp. 189-206
    • Bai, J.P.F.1    Stewart, B.H.2    Amidon, G.L.3
  • 3
    • 0025102678 scopus 로고
    • The use of cultured epithelial and endothelial cells for drug transport and metabolism studies
    • Audus, K. L.; Bartel, R. L.; Hidalgo, I. J.; Borchardt, R. T. The use of cultured epithelial and endothelial cells for drug transport and metabolism studies. Pharm. Res. 1990, 7, 435-449.
    • (1990) Pharm. Res. , vol.7 , pp. 435-449
    • Audus, K.L.1    Bartel, R.L.2    Hidalgo, I.J.3    Borchardt, R.T.4
  • 4
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line(Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo, I. J.; Raub, T. J.; Borchardt, R. T. Characterization of the Human Colon Carcinoma Cell Line(Caco-2) as a Model System for Intestinal Epithelial Permeability. Gastroenterology 1989, 96, 736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 7
    • 0029939330 scopus 로고    scopus 로고
    • In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system
    • Chong, S.; Dando, S. A.; Soucek, K. M.; Morrison, R. A. In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system. Pharm. Res. 1996, 13, 120-123.
    • (1996) Pharm. Res. , vol.13 , pp. 120-123
    • Chong, S.1    Dando, S.A.2    Soucek, K.M.3    Morrison, R.A.4
  • 12
    • 0030922582 scopus 로고    scopus 로고
    • Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: Localizaion of PEPT1 and transport of beta-lactam antibiotics
    • Terada, T.; Saito, H.; Mukai, M.; Inui, K. Characterization of stably transfected kidney epithelial cell line expressing rat H+/Peptide cotransporter PEPT1: localizaion of PEPT1 and transport of beta-lactam antibiotics. J. Pharmacol. Exp. Ther. 1997, 281, 1415-1421.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 1415-1421
    • Terada, T.1    Saito, H.2    Mukai, M.3    Inui, K.4
  • 13
    • 0028826927 scopus 로고
    • Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2
    • Ganapathy, M. E.; Brandsch, M.; Prasad, P. D.; Ganapathy, V.; Leibach, F. H. Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J. Biol. Chem. 1995, 270, 25672-25677.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25672-25677
    • Ganapathy, M.E.1    Brandsch, M.2    Prasad, P.D.3    Ganapathy, V.4    Leibach, F.H.5
  • 14
    • 0030464177 scopus 로고    scopus 로고
    • Human dipeptide transporter, hPEPT1, stably transfected into chinese hamster ovary cells
    • Covitz, K. Y., Amidon, G. L. Sadee, W. Human dipeptide transporter, hPEPT1, stably transfected into chinese hamster ovary cells., Pharm. Res. 1996, 13, 1631-1634.
    • (1996) Pharm. Res. , vol.13 , pp. 1631-1634
    • Covitz, K.Y.1    Amidon, G.L.2    Sadee, W.3
  • 16
    • 0029836840 scopus 로고    scopus 로고
    • HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: In vitro-in vivo correlation with permeability data from rats and humans
    • Walter, E.; Janich, S.; Roessler, B. J.; Hilfinger, J. M.; Amidon, G. L.; HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans. J. Pharm. Sci. 1996, 85, 1070-1076.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1070-1076
    • Walter, E.1    Janich, S.2    Roessler, B.J.3    Hilfinger, J.M.4    Amidon, G.L.5
  • 17
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoidgand assay and physiological dose - Response curves
    • De Lean, A.; Munson, P. J.; Rodbard, D. Simultaneous analysis of families of sigmoidgand assay and physiological dose - response curves. Am. J. Physiol. 1978, 235, E97-102.
    • (1978) Am. J. Physiol. , vol.235
    • De Lean, A.1    Munson, P.J.2    Rodbard, D.3
  • 18
    • 0025106137 scopus 로고
    • Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics
    • Kramer, W.; Girbig, F.; Gutjaha, U.; Kleemann, H.-W.; Leipe, I.; Urbach, H.; Wagner, A. Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics. Biochim. Biophys. Acta 1990, 1027, 25-30.
    • (1990) Biochim. Biophys. Acta , vol.1027 , pp. 25-30
    • Kramer, W.1    Girbig, F.2    Gutjaha, U.3    Kleemann, H.-W.4    Leipe, I.5    Urbach, H.6    Wagner, A.7
  • 19
    • 0024505073 scopus 로고
    • Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: Carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa
    • Hu, M.; Subramanian, P.; Mosberg, H. I.; Amidon, G. L. Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa. Pharm. Res. 1989, 6, 66-70.
    • (1989) Pharm. Res. , vol.6 , pp. 66-70
    • Hu, M.1    Subramanian, P.2    Mosberg, H.I.3    Amidon, G.L.4
  • 20
    • 0025046860 scopus 로고
    • Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2
    • Dantzig, A. H.; Bergin, L. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim. Biophays. Acta, 1990, 1027, 211-217.
    • (1990) Biochim. Biophays. Acta , vol.1027 , pp. 211-217
    • Dantzig, A.H.1    Bergin, L.2
  • 21
    • 0031662109 scopus 로고    scopus 로고
    • 5′-Amino acid esters of antiviral nucleosides, acyclovir and AZT, are absorbed by the intestinal PEPT1 peptide transporter
    • in press
    • Han, H-k.; de Vrueh, R. L. A.; Rhie, J. K.; Covitz, K.-M. Y.; Smith, P. L.; Lee, C.-P.; Oh, D.-M.; Sadée, W.; Amidon, G. L. 5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir and AZT, Are Absorbed by the Intestinal PEPT1 Peptide Transporter. Pharm. Res. 1998, 15(8), in press.
    • (1998) Pharm. Res. , vol.15 , Issue.8
    • Han, H.-K.1    De Vrueh, R.L.A.2    Rhie, J.K.3    Covitz, K.-M.Y.4    Smith, P.L.5    Lee, C.-P.6    Oh, D.-M.7    Sadée, W.8    Amidon, G.L.9
  • 25
    • 0019796746 scopus 로고
    • Neutral amino acid transport systems in Chinese hamster ovary cells
    • Shotwell, M. A.; Jayme, D. W.; Kilberg, M. S.; Oxender, D. L. Neutral amino acid transport systems in Chinese hamster ovary cells. J. Biol. Chem. 1981, 256, 5422-5427.
    • (1981) J. Biol. Chem. , vol.256 , pp. 5422-5427
    • Shotwell, M.A.1    Jayme, D.W.2    Kilberg, M.S.3    Oxender, D.L.4
  • 26
    • 0024891564 scopus 로고
    • Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: Enalapril and fosinopril
    • Friedman, D. I.; Amidon, G. L. Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril. Pharm. Res. 1989, 6, 1043-1047.
    • (1989) Pharm. Res. , vol.6 , pp. 1043-1047
    • Friedman, D.I.1    Amidon, G.L.2
  • 27
    • 0023807777 scopus 로고
    • Characterization of the oral absorption of β-lactam antibiotics. I. Cephalosporins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ
    • Sinko, P. J.; Amidon, G. L. Characterization of the oral absorption of β-lactam antibiotics. I. Cephalosporins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ. Pharm. Res. 1988, 5, 645-650.
    • (1988) Pharm. Res. , vol.5 , pp. 645-650
    • Sinko, P.J.1    Amidon, G.L.2
  • 28
    • 0026672499 scopus 로고
    • Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ
    • Oh, D.-M.; Sinko, P. J.; and Amidon, G. L., Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ. Int. J. Pharm. 1992, 85, 181-187.
    • (1992) Int. J. Pharm. , vol.85 , pp. 181-187
    • Oh, D.-M.1    Sinko, P.J.2    Amidon, G.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.