A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation

Cancer Research

Volumn 56, Issue 18, 1996, Pages 4124-4129

  Taniguchi, Ken ^a   Wada, Morimasa ^a   Kohno, Kimitoshi ^b   Nakamura, Takanori ^a   Kawabe, Takeshi ^a   Kawakami, Mina ^a   Kagotani, Kazuhiro ^c   Okumura, Katsuzumi ^c   Akiyama, Shin Ichi ^d   Kuwano, Michihiko ^a,e  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c MIE UNIVERSITY   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

^e KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CISPLATIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANION TRANSPORT; ARTICLE; CANCER RESISTANCE; CHROMOSOME; CHROMOSOME 10Q; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ANION TRANSPORT PROTEINS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; CISPLATIN; CONSERVED SEQUENCE; DNA PRIMERS; DNA, COMPLEMENTARY; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KB CELLS; MALE; MOLECULAR SEQUENCE DATA; PROSTATIC NEOPLASMS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; URINARY BLADDER NEOPLASMS;

EID: 9544233652     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Gottesman, M. M., and Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev. Biochem., 62: 385-427, 1993
2. Endicott, J A., and Ling, V. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem., 58: 137-171, 1989.
3. Loe, D W., Deeley, R. G , and Cole, S. P. C. Biology of the multidrug resistance protein, MRP. Eur J Cancer, 32A: 945-957, 1996.
4. Cole, S. P., Bhardwaj, G., Gerlach, J. H., Mackie, J E , Grant, C. E., Almquist, K. C., Stewart, A J., Kurz, E. U., Duncan, A. M , and Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line Science (Washington DC), 258: 1650-1654, 1992.
5. Cole, S P., Sparks, K. E., Fraser, K., Loe, D. W., Grant, C E., Wilson, G. M., and Deeley, R G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res., 54: 5902-5910, 1994
6. Kruh, G. D., Chan, A., Myers, K., Gaughan, K., Miki, T., and Aaronson, S. A. Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene Cancer Res., 54: 1649-1652, 1994.
7. Muller, M. Meijer, C , Zaman, G. J., Borst, P., Scheper, R. J., Mulder, N. H., de Vries, E G . and Jausen, P. L Overexpression of the gene encoding the multidrug 78 resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci USA, 91 13033-13037, 1994
8. Zaman, G. J , Lankelma, J., van Tellingen, O , Beijnen, J., Dekker, H , Paulusma, C , Oude Elferink, R P., Baas, F , and Borst, P. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc. Natl. Acad Sci USA, 92: 7690-7694, 1995.
9. Leier, I , Jedlitschky, G , Buchholz, U., Cole, S. P., Deeley, R. G., and Keppler, D The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J. Biol. Chem., 269 27807-27810, 1994.
10. Tew, K. D. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res., 54 4313-4320, 1994.
11. Chu, G. Cellular response to cisplatin J. Biol Chem., 269: 787-790, 1994.
12. Nakagawa, M., Nomura, Y., Kohno, K., Ono, M., Mizoguchi, H., Ogata, J., and Kuwano, M. Reduction of drug accumulation in cisplatin-resistant variants of human prostatic cancer PC-3 cell line J. Urol., 150 1970-1973, 1993
13. Kotoh, S., Naito, S., Yokomizo, A., Kumazawa, J., Asakuno, K., Kohno, K., and Kuwano, M. Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells. Cancer Res., 54: 3248-3252, 1994.
14. Fujii, R., Mutoh, M., Niwa, K., Yamada, K , Atkou, T., Nakagawa, M., Kuwano, M., and Akiyama, S. Active efflux system for cisplatin in cisplatin-resistant human KB cells. Jpn. J. Cancer Res., 85: 426-433, 1994
15. Ueda, K., Cardarelli, C., Gottesman, M M., and Pastan, I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl. Acad. Sci. USA, 84: 3004-3008, 1987
16. Paulusma, C. C., Bosma, P. J , Zaman, G. J R , Bakker, C T M., Borst, P., and Oude Elferink, R. P. J. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Washington DC), 271, 1126-1128, 1996
17. Fujii, R., Mutoh, M., Sumizawa, T., Chen, Z., Yoshimura, A , and Akiyama, S. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermotd carcinoma tumor cells. J. Natl. Cancer Inst., 86: 1781-1784, 1994.
18. Koike, K , Abe, T., Hisano, T., Kubo, T , Wada, M., Kohno, K., and Kuwano, M Overexpression of multidrug resistance protein gene in human cancer cell lines selected for drug resistance to epipodophyllotoxins. Jpn. J. Cancer Res., 87: 765-772, 1996.
19. Kohno, K., Sato, S., Uchiumi, T., Takano, H , Kato, S., and Kuwano, M. Tissue-specific enhancer of the human multidrug resistance (MDR1) gene. J Biol. Chem , 265, 19690-19696, 1990.
20. Kohno, K , Tanimura, H , Sato, S , Nakayama, Y , Makino, Y., Wada, M , Fojo, A. T., and Kuwano, M. Cellular control of human multidrug resistance I (nidr-1) gene expression in absence and presence of gene amplification in human cancer cells J. Biol. Chem., 269: 20503-20508, 1994.
21. Kusaba, H., Kohno, K., Asakuno, K , Kuwano, M , Okumura, K , Green, E D., Schlessinger, D., and Wada, M. Functional expression of yeast artificial chromosome-human multidrug resistance genes in mouse cells. Genome Res., 5: 245-258, 1996.
22. Higgins, C. F., and Gottesman, M M Is the multidrug transporter a flippase? Trends Biochem Sci , 17 18-21, 1992.
23. White, R., Woodward, S., Leppert, M , O'Connell, P., Hoff, M , Herbst, J , Lalouel, J. M , Dean, M., and Vande, W. G A closely linked genetic marker for cystic fibrosis. Nature (Lond.), 318: 382-384, 1985
24. Fojo, A , Lebo, R., Shimizu, N , Chin, J E., Rononson, I B , Merlino, G T , Gottesman, M M., and Pastan, I Localization of multidrug resistance-associated DNA sequences to human chromosome 7 Somatic Cell Mol. Genet., 12: 415-420, 1986.
25. Mayer, R., Kartenbeck, J., Buchler, M., Jedlitschky, G., Leier, I., and Keppler, D. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J. Cell Biol , 131: 137-150, 1995.
26. Ishikawa, T , Muller, M., Klunemann, C., Schaub, T., and Keppler, D ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J. Biol. Chem, 265: 19279-19286, 1990
27. Ishikawa, T., and Ali-Osman, F. Glutathione-associated cis- diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells Molecular characterization of glutathione-platinum complex and its biological significance. J Biol. Chem., 268: 20116-20125, 1993.
28. Goto, S., Yoshida, K., Morikawa, T., Urata, Y., Suzuki, K , and Kondo, T. Augmentation of transport for cisplatin-glutathione adduct in cisplatin-resistant cancer cells. Cancer Res , 55: 4297-4301, 1995.
29. Jedlitschky, G., Leier, I., Buchholz, U., Barnouin, K., Kurz, G., and Keppler, D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res , 56: 988-994, 1996.