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Volumn 87, Issue 9, 1998, Pages 1025-1040

The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CENTRAL NERVOUS SYSTEM AGENTS; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; DEXAMETHASONE; DIGOXIN; DOMPERIDONE; DOXORUBICIN; EPIPODOPHYLLOTOXIN; ETOPOSIDE; GLYCOPROTEIN P; HYDROCORTISONE; IVERMECTIN; LOPERAMIDE; METHOTREXATE; MITOXANTRONE; MORPHINE; ONDANSETRON; PACLITAXEL; PHENYTOIN; QUINIDINE; STEROID; TACROLIMUS; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE; VINCRISTINE;

EID: 0031691234     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js970100b     Document Type: Article
Times cited : (124)

References (191)
  • 1
    • 0015893137 scopus 로고
    • Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells
    • Dano, K. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. Biochim. Biophys. Acta 1973, 323, 466-483.
    • (1973) Biochim. Biophys. Acta , vol.323 , pp. 466-483
    • Dano, K.1
  • 2
    • 0018200435 scopus 로고
    • Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells
    • Skovsgaard, T. Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells. Cancer Res. 1978, 38, 1785-1791.
    • (1978) Cancer Res. , vol.38 , pp. 1785-1791
    • Skovsgaard, T.1
  • 3
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins, C. F. ABC transporters: From microorganisms to man. Annu. Rev. Cell Biol. 1992, 8, 67-113.
    • (1992) Annu. Rev. Cell Biol. , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 4
    • 0030001378 scopus 로고    scopus 로고
    • P-glycoproteins and multidrug resistance
    • Bellamy, W. T. P-glycoproteins and multidrug resistance. Annu. Rev. Pharmacol. Toxicol. 1996, 36, 161-183.
    • (1996) Annu. Rev. Pharmacol. Toxicol. , vol.36 , pp. 161-183
    • Bellamy, W.T.1
  • 5
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman, M. M.; Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 1993, 62, 385-427.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 9
  • 10
    • 0029954845 scopus 로고    scopus 로고
    • Biology of the multidrug resistance-associated protein, MRP
    • Loe, D. W.; Deeley, R. G.; Cole, S. P. C. Biology of the multidrug resistance-associated protein, MRP. Eur. J. Cancer 1996, 32A, 945-957.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 945-957
    • Loe, D.W.1    Deeley, R.G.2    Cole, S.P.C.3
  • 11
    • 0029821995 scopus 로고    scopus 로고
    • Multidrug resistance mediated by the multidrug resistance protein (MRP) gene
    • Lautier, D.; Canitrot, Y.; Deeley, R. G.; Cole, S. P. Multidrug resistance mediated by the multidrug resistance protein (MRP) gene. Biochem. Pharmacol. 1996, 52, 967-977.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 967-977
    • Lautier, D.1    Canitrot, Y.2    Deeley, R.G.3    Cole, S.P.4
  • 12
    • 0026487058 scopus 로고
    • Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone
    • Ueda, K.; Okamura, N.; Hirai, M.; Tanigawara, Y.; Saeki, T.; Kioka, N.; Komano, T.; Hori, R. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 1992, 267, 24248-24252.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24248-24252
    • Ueda, K.1    Okamura, N.2    Hirai, M.3    Tanigawara, Y.4    Saeki, T.5    Kioka, N.6    Komano, T.7    Hori, R.8
  • 16
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel, A. H.; Wagenaar, E.; van Deemter, L.; Mol, C. A. A. M.; Borst, P. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 1995, 96, 1698-1705.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3    Mol, C.A.A.M.4    Borst, P.5
  • 17
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    • Schinkel, A. H.; Wagenaar, E.; Mol, C. A. A. M.; van Deemter, L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 1996, 97, 2517-2524.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1    Wagenaar, E.2    Mol, C.A.A.M.3    Van Deemter, L.4
  • 19
    • 0029860174 scopus 로고    scopus 로고
    • Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein
    • Mayer, U.; Wagenaar, E.; Beijnen, J. H.; Smit, J. W.; Meijer, D. K.; van Asperen, J.; Borst, P.; Schinkel, A. H. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. Br. J. Pharmacol. 1996, 119, 1038-1044.
    • (1996) Br. J. Pharmacol. , vol.119 , pp. 1038-1044
    • Mayer, U.1    Wagenaar, E.2    Beijnen, J.H.3    Smit, J.W.4    Meijer, D.K.5    Van Asperen, J.6    Borst, P.7    Schinkel, A.H.8
  • 21
    • 0027997698 scopus 로고
    • Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein
    • Loo, T. W.; Clarke, D. M. Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein. Biochemistry 1994, 33, 14049-14057.
    • (1994) Biochemistry , vol.33 , pp. 14049-14057
    • Loo, T.W.1    Clarke, D.M.2
  • 22
    • 0025051429 scopus 로고
    • Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185- - - -Val-185 substitution in P-glycoprotein
    • Safa, A. R.; Stern, R. K.; Choi, K.; Agresti, M.; Tamai, I.; Mehta, N. D.; Roninson, I. B. Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185- - - -Val-185 substitution in P-glycoprotein. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 7225-7229.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 7225-7229
    • Safa, A.R.1    Stern, R.K.2    Choi, K.3    Agresti, M.4    Tamai, I.5    Mehta, N.D.6    Roninson, I.B.7
  • 23
    • 0028899422 scopus 로고
    • Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells
    • Rao, U. S. Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells. J. Biol. Chem. 1995, 270, 6686-6690.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6686-6690
    • Rao, U.S.1
  • 24
    • 0030796990 scopus 로고    scopus 로고
    • Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity
    • Taguchi, Y.; Morishima, M.; Komano, T.; Ueda, K. Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity. FEBS Lett. 1997, 413, 142-146.
    • (1997) FEBS Lett. , vol.413 , pp. 142-146
    • Taguchi, Y.1    Morishima, M.2    Komano, T.3    Ueda, K.4
  • 26
    • 0030052748 scopus 로고    scopus 로고
    • P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake
    • de Graaf, D.; Sharma, R. C.; Mechetner, E. B.; Schimke, R. T.; Roninson, I. B. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 1238-1242.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1238-1242
    • De Graaf, D.1    Sharma, R.C.2    Mechetner, E.B.3    Schimke, R.T.4    Roninson, I.B.5
  • 27
    • 0029845053 scopus 로고    scopus 로고
    • ATP-dependent transport of beta-estradiol 17-(beta-D-glucuronide) in rat canalicular membrane vesicles
    • Vore, M.; Hoffman, T.; Gosland, M. ATP-dependent transport of beta-estradiol 17-(beta-D-glucuronide) in rat canalicular membrane vesicles. Am. J. Physiol. 1996, 277, G791-G798.
    • (1996) Am. J. Physiol. , vol.277
    • Vore, M.1    Hoffman, T.2    Gosland, M.3
  • 30
    • 0025074116 scopus 로고
    • Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord
    • Sugawara, I.; Hamada, H.; Tsuruo, T.; Mon, S. Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord. Jpn. J. Cancer Res. 1990, 81, 727-730.
    • (1990) Jpn. J. Cancer Res. , vol.81 , pp. 727-730
    • Sugawara, I.1    Hamada, H.2    Tsuruo, T.3    Mon, S.4
  • 32
    • 0342618583 scopus 로고    scopus 로고
    • Renal secretion of xenobiotics mediated by P-glycoprotein: Importance to renal function in health and exploitation for targeted drug delivery to epithelial cysts in polycystic kidney disease
    • Simons, N. L.; Hunter, J.; Jepson, M. A. Renal secretion of xenobiotics mediated by P-glycoprotein: Importance to renal function in health and exploitation for targeted drug delivery to epithelial cysts in polycystic kidney disease. Adv. Drug Deliv. Rev. 1997, 25, 243-256.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 243-256
    • Simons, N.L.1    Hunter, J.2    Jepson, M.A.3
  • 33
    • 0343488673 scopus 로고    scopus 로고
    • Intestinalsecretion of drugs. The role of P-glycoprotein and related drug efflux sstems in limiting oral drug absorption
    • Hunter, J.; Hirst, B. H. Intestinalsecretion of drugs. The role of P-glycoprotein and related drug efflux sstems in limiting oral drug absorption. Adv. Drug Deliv. Rev. 1997, 25, 129-157.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 34
    • 0343247810 scopus 로고    scopus 로고
    • Blood-brain barrier function of P-glycoprotein
    • Tsuji, A.; Tamai, I. Blood-brain barrier function of P-glycoprotein. Adv. Drug Deliv. Rev. 1997, 25, 285-298.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 285-298
    • Tsuji, A.1    Tamai, I.2
  • 36
  • 37
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole, S. P. C.; Sparks, K. E.; Fraser, K.; Loe, D. W.; Grant, C. E.; Wilson, G. M.; Deeley, R. G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 1994, 54, 5902-5910.
    • (1994) Cancer Res. , vol.54 , pp. 5902-5910
    • Cole, S.P.C.1    Sparks, K.E.2    Fraser, K.3    Loe, D.W.4    Grant, C.E.5    Wilson, G.M.6    Deeley, R.G.7
  • 38
    • 0028844581 scopus 로고
    • Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution
    • Breuninger, L. M.; Paul, S.; Gaughan, K.; Miki, T.; Chan, A.; Aaronson, S. A.; Kruh, G. D. Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 1995, 55, 5342-5347.
    • (1995) Cancer Res. , vol.55 , pp. 5342-5347
    • Breuninger, L.M.1    Paul, S.2    Gaughan, K.3    Miki, T.4    Chan, A.5    Aaronson, S.A.6    Kruh, G.D.7
  • 40
    • 0030063480 scopus 로고    scopus 로고
    • Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
    • Jedlitschky, G.; Leier, I.; Buchholz, U.; Barnouin, K.; Kurz, G.; Keppler, D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 1996, 56, 988-994.
    • (1996) Cancer Res. , vol.56 , pp. 988-994
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Barnouin, K.4    Kurz, G.5    Keppler, D.6
  • 41
    • 0024415437 scopus 로고
    • Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression
    • McGrath, T.; Latoud, C.; Arnold, S. T.; Safa, A. R.; Felsted, R. L.; Center, M. S. Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression. Biochem. Pharmacol. 1989, 38, 3611-3619.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 3611-3619
    • McGrath, T.1    Latoud, C.2    Arnold, S.T.3    Safa, A.R.4    Felsted, R.L.5    Center, M.S.6
  • 42
    • 0027249710 scopus 로고
    • The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein
    • Krishnamachary, N.; Center, M. S. The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res. 1993, 53, 3658-3661.
    • (1993) Cancer Res. , vol.53 , pp. 3658-3661
    • Krishnamachary, N.1    Center, M.S.2
  • 43
    • 0030009305 scopus 로고    scopus 로고
    • Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport
    • Loe, D. W.; Almquist, K. C.; Deeley, R. G.; Cole, S. P. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J. Biol. Chem. 1996, 271, 9675-9682.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9675-9682
    • Loe, D.W.1    Almquist, K.C.2    Deeley, R.G.3    Cole, S.P.4
  • 45
    • 0029029449 scopus 로고
    • Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein
    • Versantvoort, C. H.; Broxterman, H. J.; Bagrij, T.; Scheper, R. J.; Twentyman, P. R. Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br. J. Cancer 1995, 72, 82-89.
    • (1995) Br. J. Cancer , vol.72 , pp. 82-89
    • Versantvoort, C.H.1    Broxterman, H.J.2    Bagrij, T.3    Scheper, R.J.4    Twentyman, P.R.5
  • 46
    • 0031463255 scopus 로고    scopus 로고
    • ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter (Vol. 93, p 6929, 1996)
    • Paul, S.; Breuninger, L. M.; Tew, K. D.; Shen, H. X.; Kruh, G. D. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter (Vol. 93, p 6929, 1996). Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 14976.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 14976
    • Paul, S.1    Breuninger, L.M.2    Tew, K.D.3    Shen, H.X.4    Kruh, G.D.5
  • 48
    • 0027984511 scopus 로고
    • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
    • Leier, I.; Jedlitschky, G.; Buchholz, U.; Cole, S. P.; Deeley, R. G.; Keppler, D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J. Biol. Chem. 1994, 269, 27807-27810.
    • (1994) J. Biol. Chem. , vol.269 , pp. 27807-27810
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Cole, S.P.4    Deeley, R.G.5    Keppler, D.6
  • 49
    • 0028001416 scopus 로고
    • ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein
    • Jedlitschky, G.; Leier, I.; Buchholz, U.; Center, M.; Keppler, D. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res. 1994, 54, 4833-4836.
    • (1994) Cancer Res. , vol.54 , pp. 4833-4836
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Center, M.4    Keppler, D.5
  • 50
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
    • Muller, M.; Meijer, C.; Zaman, G. J.; Borst, P.; Scheper, R. J.; Mulder, N. H.; de Vries, E. G.; Jansen, P. L. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 13033-13037.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 13033-13037
    • Muller, M.1    Meijer, C.2    Zaman, G.J.3    Borst, P.4    Scheper, R.J.5    Mulder, N.H.6    De Vries, E.G.7    Jansen, P.L.8
  • 51
    • 15844416284 scopus 로고    scopus 로고
    • Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells
    • Ishikawa, T.; Bao, J. J.; Yamane, Y.; Akimaru, K.; Frindrich, K.; Wright, C. D.; Kuo, M. T. Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J. Biol. Chem. 1996, 271, 14981-14988.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14981-14988
    • Ishikawa, T.1    Bao, J.J.2    Yamane, Y.3    Akimaru, K.4    Frindrich, K.5    Wright, C.D.6    Kuo, M.T.7
  • 52
    • 0030570805 scopus 로고    scopus 로고
    • Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
    • Zaman, G. J.; Cnubben, N. H.; van Bladeren, P. J.; Evers, R.; Borst, P. Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP. FEBS Lett. 1996, 391, 126-130.
    • (1996) FEBS Lett. , vol.391 , pp. 126-130
    • Zaman, G.J.1    Cnubben, N.H.2    Van Bladeren, P.J.3    Evers, R.4    Borst, P.5
  • 53
    • 0030962253 scopus 로고    scopus 로고
    • ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
    • Loe, D. W.; Stewart, R. K.; Massey, T. E.; Deeley, R. G.; Cole, S. P. ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. Mol. Pharmacol. 1997, 51, 1034-1041.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 1034-1041
    • Loe, D.W.1    Stewart, R.K.2    Massey, T.E.3    Deeley, R.G.4    Cole, S.P.5
  • 54
    • 0029918142 scopus 로고    scopus 로고
    • ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids
    • Loe, D. W.; Almquist, K. C.; Cole, S. P.; Deeley, R. G. ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J. Biol. Chem. 1996, 271, 9683-9689.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9683-9689
    • Loe, D.W.1    Almquist, K.C.2    Cole, S.P.3    Deeley, R.G.4
  • 55
    • 0029983266 scopus 로고    scopus 로고
    • The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump
    • Li, Z. S.; Szczypka, M.; Lu, Y. P.; Thiele, D. J.; Rea, P. A. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J. Biol. Chem. 1996, 277, 6509-6517.
    • (1996) J. Biol. Chem. , vol.277 , pp. 6509-6517
    • Li, Z.S.1    Szczypka, M.2    Lu, Y.P.3    Thiele, D.J.4    Rea, P.A.5
  • 57
    • 0031013876 scopus 로고    scopus 로고
    • A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium
    • Li, Z. S.; Lu, Y. P.; Zhen, R. G.; Szczypka, M.; Thiele, D. J.; Rea, P. A. A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 42-47.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 42-47
    • Li, Z.S.1    Lu, Y.P.2    Zhen, R.G.3    Szczypka, M.4    Thiele, D.J.5    Rea, P.A.6
  • 58
    • 0027305406 scopus 로고
    • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance
    • Ishikawa, T.; Ali-Osman, F. Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J. Biol. Chem. 1993, 268, 20116-20125.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20116-20125
    • Ishikawa, T.1    Ali-Osman, F.2
  • 59
    • 0028006733 scopus 로고
    • GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down- Regulated by cell differentiation
    • Ishikawa, T.; Wright, C. D.; Ishizuka, H. GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J. Biol. Chem. 1994, 269, 29085-29093.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29085-29093
    • Ishikawa, T.1    Wright, C.D.2    Ishizuka, H.3
  • 60
    • 0029760088 scopus 로고    scopus 로고
    • Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers
    • Kuo, M. T.; Bao, J. J.; Curley, S. A.; Ikeguchi, M.; Johnston, D. A.; Ishikawa, T. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res. 1996, 56, 3642-3644.
    • (1996) Cancer Res. , vol.56 , pp. 3642-3644
    • Kuo, M.T.1    Bao, J.J.2    Curley, S.A.3    Ikeguchi, M.4    Johnston, D.A.5    Ishikawa, T.6
  • 61
    • 0026459859 scopus 로고
    • The ATP-dependent glutathione S-conjugate export pump
    • Ishikawa, T. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem. Sci. 1992, 17, 463-468.
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 463-468
    • Ishikawa, T.1
  • 64
    • 0029939542 scopus 로고    scopus 로고
    • Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter
    • Stride, B. D.; Valdimarsson, G.; Gerlach, J. H.; Wilson, G. M.; Cole, S. P.; Deeley, R. G. Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol. Pharmacol. 1996, 49, 962-971.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 962-971
    • Stride, B.D.1    Valdimarsson, G.2    Gerlach, J.H.3    Wilson, G.M.4    Cole, S.P.5    Deeley, R.G.6
  • 66
    • 0342872090 scopus 로고    scopus 로고
    • Hepatobiliary elimination of cationic drugs: The role of P-glycoproteins and other ATP-dependent transporters
    • Meijer, D. K. F.; Smit, J. W.; Muller, M. Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters. Adv. Drug Deliv. Rev. 1997, 25, 159-200.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 159-200
    • Meijer, D.K.F.1    Smit, J.W.2    Muller, M.3
  • 67
    • 0030939088 scopus 로고    scopus 로고
    • Hepatic canalicular membrane 4: Expression of the multidrug resistance genes in the liver
    • Silverman, J. A.; Schrenk, D. Hepatic canalicular membrane 4: expression of the multidrug resistance genes in the liver. FASEB J. 1997, 11, 308-313.
    • (1997) FASEB J. , vol.11 , pp. 308-313
    • Silverman, J.A.1    Schrenk, D.2
  • 68
    • 0024371025 scopus 로고
    • The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
    • Kamimoto, Y.; Gatmaitan, Z.; Hsu, J.; Arias, I. M. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J. Biol. Chem. 1989, 264, 11693-11698.
    • (1989) J. Biol. Chem. , vol.264 , pp. 11693-11698
    • Kamimoto, Y.1    Gatmaitan, Z.2    Hsu, J.3    Arias, I.M.4
  • 69
    • 0026683912 scopus 로고
    • Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine
    • Watanabe, T.; Miyauchi, S.; Sawada, Y.; Iga, T.; Hanano, M.; Inaba, M.; Sugiyama, Y. Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine. J. Hepatol. 1992, 16, 77-88.
    • (1992) J. Hepatol. , vol.16 , pp. 77-88
    • Watanabe, T.1    Miyauchi, S.2    Sawada, Y.3    Iga, T.4    Hanano, M.5    Inaba, M.6    Sugiyama, Y.7
  • 72
    • 0027538652 scopus 로고
    • Molecular targets in oncology: Implications of the multidrug resistance gene
    • Lum, B. L.; Gosland, M. P.; Kaubisch, S.; Sikic, B. I. Molecular targets in oncology: implications of the multidrug resistance gene. Pharmacother. 1993, 13, 88-109.
    • (1993) Pharmacother. , vol.13 , pp. 88-109
    • Lum, B.L.1    Gosland, M.P.2    Kaubisch, S.3    Sikic, B.I.4
  • 75
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • Ford, J. M.; Hait, W. N. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 1990, 42, 155-199.
    • (1990) Pharmacol. Rev. , vol.42 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 76
    • 0028935166 scopus 로고
    • Modulators of multidrug resistance. Preclinical studies
    • Ford, J. M. Modulators of multidrug resistance. Preclinical studies. Hematol. Oncol. Clin. North America 1995, 9, 337-361.
    • (1995) Hematol. Oncol. Clin. North America , vol.9 , pp. 337-361
    • Ford, J.M.1
  • 77
    • 0028711167 scopus 로고
    • In vivo models of P-glycoprotein-mediated multidrug resistance
    • Gottesman, M. M.; Mickisch, G. H.; Pastan, I. In vivo models of P-glycoprotein-mediated multidrug resistance. Cancer Treat. Res. 1994, 73, 107-128.
    • (1994) Cancer Treat. Res. , vol.73 , pp. 107-128
    • Gottesman, M.M.1    Mickisch, G.H.2    Pastan, I.3
  • 78
    • 0026611746 scopus 로고
    • Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity
    • Keller, R. P.; Altermatt, H. J.; Donatsch, P.; Zihlmann, H.; Laissue, J. A.; Hiestand, P. C. Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int. Natl. Cancer 1992, 51, 433-438.
    • (1992) Int. Natl. Cancer , vol.51 , pp. 433-438
    • Keller, R.P.1    Altermatt, H.J.2    Donatsch, P.3    Zihlmann, H.4    Laissue, J.A.5    Hiestand, P.C.6
  • 79
    • 0028941366 scopus 로고
    • Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo
    • Watanabe, T.; Tsuge, H.; Oh-Hara, T.; Naito, M.; Tsuruo, T. Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo. Acta Oncologica 1995, 34, 235-241.
    • (1995) Acta Oncologica , vol.34 , pp. 235-241
    • Watanabe, T.1    Tsuge, H.2    Oh-Hara, T.3    Naito, M.4    Tsuruo, T.5
  • 80
    • 0027136660 scopus 로고
    • Clinical trials of agents that reverse multidrug resistance. A literature review
    • Raderer, M.; Scheithauer, W. Clinical trials of agents that reverse multidrug resistance. A literature review. Cancer 1993, 72, 3553-3563.
    • (1993) Cancer , vol.72 , pp. 3553-3563
    • Raderer, M.1    Scheithauer, W.2
  • 83
    • 0024339994 scopus 로고
    • Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts
    • Horton, J. K.; Thimmaiah, K. N.; Houghton, J. A.; Horowitz, M. E.; Houghton, P. J. Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts. Biochem. Pharmacol. 1989, 38, 1727-1736.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1727-1736
    • Horton, J.K.1    Thimmaiah, K.N.2    Houghton, J.A.3    Horowitz, M.E.4    Houghton, P.J.5
  • 84
    • 0029921377 scopus 로고    scopus 로고
    • Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia
    • Colombo, T.; Gonzalez Paz, O.; D'Incalci, M. Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia. Br. J. Cancer 1996, 73, 866-871.
    • (1996) Br. J. Cancer , vol.73 , pp. 866-871
    • Colombo, T.1    Gonzalez Paz, O.2    D'Incalci, M.3
  • 85
    • 0028951303 scopus 로고
    • MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors
    • Lum, B. L.; Gosland, M. P. MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors. Hematol. Oncol. Clin. North America 1995, 9, 319-336.
    • (1995) Hematol. Oncol. Clin. North America , vol.9 , pp. 319-336
    • Lum, B.L.1    Gosland, M.P.2
  • 86
    • 0029013159 scopus 로고
    • P-glycoprotein and pharmacokinetics
    • Leveque, D.; Jehl, F. P-glycoprotein and pharmacokinetics. Anticancer Res. 1995, 15, 331-336.
    • (1995) Anticancer Res. , vol.15 , pp. 331-336
    • Leveque, D.1    Jehl, F.2
  • 87
    • 0028283471 scopus 로고
    • Effect of the nonimmunosuppressive cyclosporin analogue SDZ PSC-833 on colchicine and doxorubicin biliary secretion by the rat in vivo
    • Speeg, K. V.; Maldonado, A. L. Effect of the nonimmunosuppressive cyclosporin analogue SDZ PSC-833 on colchicine and doxorubicin biliary secretion by the rat in vivo. Cancer Chemother. Pharmacol. 1994, 34, 133-136.
    • (1994) Cancer Chemother. Pharmacol. , vol.34 , pp. 133-136
    • Speeg, K.V.1    Maldonado, A.L.2
  • 88
    • 0030067042 scopus 로고    scopus 로고
    • Effect of modulators of the multidrug resistance pump on the distribution of vinblastine in tissues of the mouse
    • Lyubimov, E.; Lan, L. B.; Pashinsky, I.; Stein, W. D. Effect of modulators of the multidrug resistance pump on the distribution of vinblastine in tissues of the mouse. Anti-Cancer Drugs 1996, 7, 60-69.
    • (1996) Anti-Cancer Drugs , vol.7 , pp. 60-69
    • Lyubimov, E.1    Lan, L.B.2    Pashinsky, I.3    Stein, W.D.4
  • 89
    • 0030922974 scopus 로고    scopus 로고
    • Multidrug resistance reversing agents increase vinblastine distribution in normal tissues expressing the p glycoprotein but do not enhance drug penetration in brain and testis
    • Arboix, M.; Paz, O. G.; Colombo, T.; Dincalci, M. Multidrug resistance reversing agents increase vinblastine distribution in normal tissues expressing the p glycoprotein but do not enhance drug penetration in brain and testis. J. Pharmacol. Exp. Ther. 1997, 281, 1226-1230.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 1226-1230
    • Arboix, M.1    Paz, O.G.2    Colombo, T.3    Dincalci, M.4
  • 91
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada, T.; Yamazaki, H.; Mimura, M.; Inui, Y.; Guengerich, F. P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 1994, 270, 414-423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 92
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher, V. J.; Wu, C. Y.; Benet, L. Z. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol. Carcinog. 1995, 13, 129-134.
    • (1995) Mol. Carcinog. , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 93
    • 0030059953 scopus 로고    scopus 로고
    • Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
    • Schuetz, E. G.; Beck, W. T.; Schuetz, J. D. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol. Pharmacol. 1996, 49, 311-318.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 311-318
    • Schuetz, E.G.1    Beck, W.T.2    Schuetz, J.D.3
  • 94
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503a in mice and humans
    • Schuetz, E. G.; Schinkel, A. H.; Relling, M. V.; Schuetz, J. D. P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 4001-4005.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 97
    • 0028132031 scopus 로고
    • Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver
    • Vollrath, V.; Wielandt, A. M.; Acuna, C.; Duarte, I.; Andrade, L.; Chianale, J. Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver. J. Hepatol. 1994, 21, 754-763.
    • (1994) J. Hepatol. , vol.21 , pp. 754-763
    • Vollrath, V.1    Wielandt, A.M.2    Acuna, C.3    Duarte, I.4    Andrade, L.5    Chianale, J.6
  • 98
    • 0023689651 scopus 로고
    • Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics
    • Burt, R. K.; Thorgeirsson, S. S. Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics. J. Natl. Cancer Inst. 1988, 80, 1383-1386.
    • (1988) J. Natl. Cancer Inst. , vol.80 , pp. 1383-1386
    • Burt, R.K.1    Thorgeirsson, S.S.2
  • 99
    • 0026327875 scopus 로고
    • Regulation of 2-acetylaminofluorene- and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver
    • Gant, T. W.; Silverman, J. A.; Bisgaard, H. C.; Burt, R. K.; Marino, P. A.; Thorgeirsson, S. S. Regulation of 2-acetylaminofluorene- and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Mol. Carcinog. 1991, 4, 499-509.
    • (1991) Mol. Carcinog. , vol.4 , pp. 499-509
    • Gant, T.W.1    Silverman, J.A.2    Bisgaard, H.C.3    Burt, R.K.4    Marino, P.A.5    Thorgeirsson, S.S.6
  • 100
    • 0029915184 scopus 로고    scopus 로고
    • Regulation of mdr1b gene expression in Fischer, Wistar and Sprague-Dawley rats in vivo and in vitro
    • Hill, B. A.; Brown, P. C.; Preisegger, K. H.; Silverman, J. A. Regulation of mdr1b gene expression in Fischer, Wistar and Sprague-Dawley rats in vivo and in vitro. Carcinogenesis 1996, 17, 451-457.
    • (1996) Carcinogenesis , vol.17 , pp. 451-457
    • Hill, B.A.1    Brown, P.C.2    Preisegger, K.H.3    Silverman, J.A.4
  • 101
    • 0023179571 scopus 로고
    • Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver
    • Thorgeirsson, S. S.; Huber, B. E.; Sorrell, S.; Fojo, A.; Pastan, I.; Gottesman, M. M. Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Science 1987, 236, 1120-1122.
    • (1987) Science , vol.236 , pp. 1120-1122
    • Thorgeirsson, S.S.1    Huber, B.E.2    Sorrell, S.3    Fojo, A.4    Pastan, I.5    Gottesman, M.M.6
  • 102
    • 0027377964 scopus 로고
    • Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis
    • Teeter, L. D.; Estes, M.; Chan, J. Y.; Atassi, H.; Sell, S.; Becker, F. F.; Kuo, M. T. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol. Carcinog. 1993, 8, 67-73.
    • (1993) Mol. Carcinog. , vol.8 , pp. 67-73
    • Teeter, L.D.1    Estes, M.2    Chan, J.Y.3    Atassi, H.4    Sell, S.5    Becker, F.F.6    Kuo, M.T.7
  • 103
    • 0027445209 scopus 로고
    • Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication
    • Nakatsukasa, H.; Silverman, J. A.; Gant, T. W.; Evarts, R. P.; Thorgeirsson, S. S. Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication. Hepatology (St. Louis) 1993, 18, 1202-1207.
    • (1993) Hepatology (St. Louis) , vol.18 , pp. 1202-1207
    • Nakatsukasa, H.1    Silverman, J.A.2    Gant, T.W.3    Evarts, R.P.4    Thorgeirsson, S.S.5
  • 105
    • 0025386379 scopus 로고
    • Regulation of the multidrug resistance gene in regenerating rat liver. Cell
    • Marino, P. A.; Gottesman, M. M.; Pastan, I. Regulation of the multidrug resistance gene in regenerating rat liver. Cell Growth Different. 1990, 1, 57-62.
    • (1990) Growth Different. , vol.1 , pp. 57-62
    • Marino, P.A.1    Gottesman, M.M.2    Pastan, I.3
  • 106
    • 0027362087 scopus 로고
    • Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites
    • Orr, G. A.; Han, E. K.; Browne, P. C.; Nieves, E.; O'Connor, B. M.; Yang, C. P.; Horwitz, S. B. Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. J. Biol. Chem. 1993, 268, 25054-25062.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25054-25062
    • Orr, G.A.1    Han, E.K.2    Browne, P.C.3    Nieves, E.4    O'Connor, B.M.5    Yang, C.P.6    Horwitz, S.B.7
  • 107
    • 0027460274 scopus 로고
    • Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C
    • Chambers, T. C.; Pohl, J.; Raynor, R. L.; Kuo, J. F. Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C. J. Biol. Chem. 1993, 268, 4592-4595.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4592-4595
    • Chambers, T.C.1    Pohl, J.2    Raynor, R.L.3    Kuo, J.F.4
  • 108
    • 0027076780 scopus 로고
    • Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells
    • Chambers, T. C.; Zheng, B.; Kuo, J. F. Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells. Mol. Pharmacol. 1992, 41, 1008-1015.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 1008-1015
    • Chambers, T.C.1    Zheng, B.2    Kuo, J.F.3
  • 109
    • 0027256373 scopus 로고
    • Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells
    • Ahmad, S.; Glazer, R. I. Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells. Mol. Pharmacol. 1993, 43, 858-862.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 858-862
    • Ahmad, S.1    Glazer, R.I.2
  • 110
    • 0027853682 scopus 로고
    • Differential modulation of P-glycoprotein transport by protein kinase inhibition
    • Bates, S. E.; Lee, J. S.; Dickstein, B.; Spolyar, M.; Fojo, A. T. Differential modulation of P-glycoprotein transport by protein kinase inhibition. Biochemistry 1993, 32, 9156-9164.
    • (1993) Biochemistry , vol.32 , pp. 9156-9164
    • Bates, S.E.1    Lee, J.S.2    Dickstein, B.3    Spolyar, M.4    Fojo, A.T.5
  • 111
    • 0027005480 scopus 로고
    • Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists
    • Chaudhary, P. M.; Roninson, I. B. Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol. Res. 1992, 4, 281-290.
    • (1992) Oncol. Res. , vol.4 , pp. 281-290
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 112
    • 0025565954 scopus 로고
    • Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells
    • Sato, W.; Yusa, K.; Naito, M.; Tsuruo, T. Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells. Biochem. Biophys. Res. Commun. 1990, 173, 1252-1257.
    • (1990) Biochem. Biophys. Res. Commun. , vol.173 , pp. 1252-1257
    • Sato, W.1    Yusa, K.2    Naito, M.3    Tsuruo, T.4
  • 116
    • 0028307550 scopus 로고
    • Phosphatidylcholine translocase: A physiological role for the mdr2 gene
    • Ruetz, S.; Gros, P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 1994, 77, 1071-1081.
    • (1994) Cell , vol.77 , pp. 1071-1081
    • Ruetz, S.1    Gros, P.2
  • 117
    • 0007544439 scopus 로고    scopus 로고
    • MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
    • van Helvoort, A.; Smith, A. J.; Sprong, H.; Fritzsche, I.; Schinkel, A. H.; Borst, P.; van Meer, G. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 1996, 87, 507-517.
    • (1996) Cell , vol.87 , pp. 507-517
    • Van Helvoort, A.1    Smith, A.J.2    Sprong, H.3    Fritzsche, I.4    Schinkel, A.H.5    Borst, P.6    Van Meer, G.7
  • 118
    • 0028850221 scopus 로고
    • The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology
    • Oude Elferink, R. P.; Groen, A. K. The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology. J. Hepatol. 1995, 23, 617-625.
    • (1995) J. Hepatol. , vol.23 , pp. 617-625
    • Oude Elferink, R.P.1    Groen, A.K.2
  • 119
    • 0343488668 scopus 로고    scopus 로고
    • MDR2 P-glycoprotein-mediated lipid secretion and its relevance to biliary drug transport
    • Frijters, C. M. G.; Groen, A. K.; Oude Elferink, R. P. J. MDR2 P-glycoprotein-mediated lipid secretion and its relevance to biliary drug transport. Adv. Drug Deliv. Rev. 1997, 25, 201-215.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 201-215
    • Frijters, C.M.G.1    Groen, A.K.2    Oude Elferink, R.P.J.3
  • 120
    • 0024517937 scopus 로고
    • Retrograde intrabiliary injection of amphipathic materials causes phospholipid secretion into bile. Taurocholate causes phosphatidylcholine secretion, 3-[(3-cholamidopropyl)dimethylammonio]-propane-1-sulphonate (CHAPS) causes mixed phospholipid secretion
    • Coleman, R.; Rahman, K.; Kan, K. S.; Parslow, R. A. Retrograde intrabiliary injection of amphipathic materials causes phospholipid secretion into bile. Taurocholate causes phosphatidylcholine secretion, 3-[(3-cholamidopropyl)dimethylammonio]-propane-1-sulphonate (CHAPS) causes mixed phospholipid secretion. Biochem. J. 1989, 258, 17-22.
    • (1989) Biochem. J. , vol.258 , pp. 17-22
    • Coleman, R.1    Rahman, K.2    Kan, K.S.3    Parslow, R.A.4
  • 121
    • 0028820769 scopus 로고
    • Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate. Implications for hepatic bile formation
    • Ruetz, S.; Gros, P. Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate. Implications for hepatic bile formation. J. Biol. Chem. 1995, 270, 25388-25395.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25388-25395
    • Ruetz, S.1    Gros, P.2
  • 122
    • 0029926676 scopus 로고    scopus 로고
    • Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
    • Yamazaki, M.; Suzuki, H.; Sugiyama, Y. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res. 1996, 13, 497-513.
    • (1996) Pharm. Res. , vol.13 , pp. 497-513
    • Yamazaki, M.1    Suzuki, H.2    Sugiyama, Y.3
  • 123
    • 0029849789 scopus 로고    scopus 로고
    • The canalicular conjugate export pump encoded by the cmrp/cmoat gene
    • Keppler, D.; Kartenbeck, J. The canalicular conjugate export pump encoded by the cmrp/cmoat gene. Progr. Liver Dis. 1996, 14, 55-67.
    • (1996) Progr. Liver Dis. , vol.14 , pp. 55-67
    • Keppler, D.1    Kartenbeck, J.2
  • 124
    • 0029937429 scopus 로고    scopus 로고
    • Secretion of organic anions by hepatocytes: Involvement of homologues of the multidrug resistance protein
    • Muller, M.; Roelofsen, H.; Jansen, P. L. Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein. Semin. Liver Dis. 1996, 16, 211-220.
    • (1996) Semin. Liver Dis. , vol.16 , pp. 211-220
    • Muller, M.1    Roelofsen, H.2    Jansen, P.L.3
  • 126
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
    • Jansen, P. L.; Peters, W. H.; Lamers, W. H. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology (St. Louis) 1985, 5, 573-579.
    • (1985) Hepatology (St. Louis) , vol.5 , pp. 573-579
    • Jansen, P.L.1    Peters, W.H.2    Lamers, W.H.3
  • 129
    • 0000552161 scopus 로고
    • Chronic idiopathic jaundice with unidentified pigment in liver cells: A new clinicopathologic entity with a report of 12 cases
    • Dubin, I. N.; Johnson, F. B. Chronic idiopathic jaundice with unidentified pigment in liver cells: a new clinicopathologic entity with a report of 12 cases. Medicine 1954, 33, 155-172.
    • (1954) Medicine , vol.33 , pp. 155-172
    • Dubin, I.N.1    Johnson, F.B.2
  • 130
    • 0030638506 scopus 로고    scopus 로고
    • Hepatic canalicular membrane. Introduction: Transport across the hepatocyte canalicular membrane
    • Keppler, D.; Arias, I. M. Hepatic canalicular membrane. Introduction: transport across the hepatocyte canalicular membrane. FASEB J. 1997, 11, 15-18.
    • (1997) FASEB J. , vol.11 , pp. 15-18
    • Keppler, D.1    Arias, I.M.2
  • 131
    • 0030752006 scopus 로고    scopus 로고
    • Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2
    • Keppler, D.; Leier, I.; Jedlitschky, G. Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol. Chem. 1997, 378, 787-791.
    • (1997) Biol. Chem. , vol.378 , pp. 787-791
    • Keppler, D.1    Leier, I.2    Jedlitschky, G.3
  • 132
    • 0030753125 scopus 로고    scopus 로고
    • Molecular aspects of hepatobiliary transport
    • Muller, M.; Jansen, P. L. Molecular aspects of hepatobiliary transport. Am. J. Physiol. 1997, 272, G1285-G1303.
    • (1997) Am. J. Physiol. , vol.272
    • Muller, M.1    Jansen, P.L.2
  • 133
    • 0025343017 scopus 로고
    • Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
    • Kobayashi, K.; Sogame, Y.; Hara, H.; Hayashi, K. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem. 1990, 265, 7737-7741.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7737-7741
    • Kobayashi, K.1    Sogame, Y.2    Hara, H.3    Hayashi, K.4
  • 134
    • 0025132673 scopus 로고
    • ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates
    • Ishikawa, T.; Muller, M.; Klunemann, C.; Schaub, T.; Keppler, D. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J. Biol. Chem. 1990, 265, 19279-19286.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19279-19286
    • Ishikawa, T.1    Muller, M.2    Klunemann, C.3    Schaub, T.4    Keppler, D.5
  • 135
    • 0031058993 scopus 로고    scopus 로고
    • Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells
    • Roelofsen, H.; Vos, T. A.; Schippers, I. J.; Kuipers, F.; Koning, H.; Moshage, H.; Jansen, P. L.; Muller, M. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology 1997, 112, 511-521.
    • (1997) Gastroenterology , vol.112 , pp. 511-521
    • Roelofsen, H.1    Vos, T.A.2    Schippers, I.J.3    Kuipers, F.4    Koning, H.5    Moshage, H.6    Jansen, P.L.7    Muller, M.8
  • 136
    • 0030814774 scopus 로고    scopus 로고
    • The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man
    • Paulusma, C. C.; Oude Elferink, R. P. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man. J. Mol. Med. 1997, 75, 420-428.
    • (1997) J. Mol. Med. , vol.75 , pp. 420-428
    • Paulusma, C.C.1    Oude Elferink, R.P.2
  • 138
    • 0029940766 scopus 로고    scopus 로고
    • Role of multidrug resistance protein (MRP) in glutathione S-conjugate transport in mammalian cells
    • Muller, M.; de Vries, E. G.; Jansen, P. L. Role of multidrug resistance protein (MRP) in glutathione S-conjugate transport in mammalian cells. J. Hepatol. 1996, 24, 100-108.
    • (1996) J. Hepatol. , vol.24 , pp. 100-108
    • Muller, M.1    De Vries, E.G.2    Jansen, P.L.3
  • 139
    • 0029582975 scopus 로고
    • Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia
    • Takenaka, O.; Horie, T.; Kobayashi, K.; Suzuki, H.; Sugiyama, Y. Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia. Pharm. Res. 1995, 12, 1746-1755.
    • (1995) Pharm. Res. , vol.12 , pp. 1746-1755
    • Takenaka, O.1    Horie, T.2    Kobayashi, K.3    Suzuki, H.4    Sugiyama, Y.5
  • 140
    • 0030959378 scopus 로고    scopus 로고
    • Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
    • Chu, X. Y.; Kato, Y.; Niinuma, K.; Sudo, K. I.; Hakusui, H.; Sugiyama, Y. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J. Pharmacol. Exp. Ther. 1997, 281, 304-314.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 304-314
    • Chu, X.Y.1    Kato, Y.2    Niinuma, K.3    Sudo, K.I.4    Hakusui, H.5    Sugiyama, Y.6
  • 141
    • 0030906434 scopus 로고    scopus 로고
    • Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats
    • Chu, X. Y.; Kato, Y.; Sugiyama, Y. Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res. 1997, 57, 1934-1938.
    • (1997) Cancer Res. , vol.57 , pp. 1934-1938
    • Chu, X.Y.1    Kato, Y.2    Sugiyama, Y.3
  • 142
    • 0029026940 scopus 로고
    • Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats
    • Takenaka, O.; Horie, T.; Suzuki, H.; Sugiyama, Y. Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats. J. Pharmacol. Exp. Ther. 1995, 274, 1362-1369.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1362-1369
    • Takenaka, O.1    Horie, T.2    Suzuki, H.3    Sugiyama, Y.4
  • 143
    • 0028027840 scopus 로고
    • Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds
    • Shimamura, H.; Suzuki, H.; Hanano, M.; Suzuki, A.; Tagaya, O.; Horie, T.; Sugiyama, Y. Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds. J. Pharmacol. Exp. Ther. 1994, 271, 370-378.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 370-378
    • Shimamura, H.1    Suzuki, H.2    Hanano, M.3    Suzuki, A.4    Tagaya, O.5    Horie, T.6    Sugiyama, Y.7
  • 144
    • 0030444592 scopus 로고    scopus 로고
    • Biliary excretion of glycyrrhizin in rats: Kinetic basis for multiplicity in bile canalicular transport of organic anions
    • Shimamura, H.; Suzuki, H.; Tagaya, O.; Horie, T.; Sugiyama, Y. Biliary excretion of glycyrrhizin in rats: kinetic basis for multiplicity in bile canalicular transport of organic anions. Pharm. Res. 1996, 13, 1833-1837.
    • (1996) Pharm. Res. , vol.13 , pp. 1833-1837
    • Shimamura, H.1    Suzuki, H.2    Tagaya, O.3    Horie, T.4    Sugiyama, Y.5
  • 145
    • 0024844257 scopus 로고
    • Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia
    • Kuipers, F.; Radominska, A.; Zimniak, P.; Little, J. M.; Havinga, R.; Vonk, R. J.; Lester, R. Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia. J. Lipid Res. 1989, 30, 1835-1845.
    • (1989) J. Lipid Res. , vol.30 , pp. 1835-1845
    • Kuipers, F.1    Radominska, A.2    Zimniak, P.3    Little, J.M.4    Havinga, R.5    Vonk, R.J.6    Lester, R.7
  • 146
  • 147
  • 148
    • 0029848514 scopus 로고    scopus 로고
    • Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats
    • Yamazaki, M.; Kobayashi, K.; Sugiyama, Y. Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats. Biopharm. Drug Disp. 1996, 17, 645-659.
    • (1996) Biopharm. Drug Disp. , vol.17 , pp. 645-659
    • Yamazaki, M.1    Kobayashi, K.2    Sugiyama, Y.3
  • 149
    • 0030951558 scopus 로고    scopus 로고
    • Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR)
    • Ishizuka, H.; Konno, K.; Naganuma, H.; Sasahara, K.; Kawahara, Y.; Niinuma, K.; Suzuki, H.; Sugiyama, Y. Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR). J. Pharmacol. Exp. Ther. 1997, 280, 1304-1311.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 1304-1311
    • Ishizuka, H.1    Konno, K.2    Naganuma, H.3    Sasahara, K.4    Kawahara, Y.5    Niinuma, K.6    Suzuki, H.7    Sugiyama, Y.8
  • 150
  • 151
    • 0030957234 scopus 로고    scopus 로고
    • Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123
    • Shin, H. C.; Kato, Y.; Yamada, T.; Niinuma, K.; Hisaka, A.; Sugiyama, Y. Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123. Am. J. Physiol. 1997, 272, G979-G986.
    • (1997) Am. J. Physiol. , vol.272
    • Shin, H.C.1    Kato, Y.2    Yamada, T.3    Niinuma, K.4    Hisaka, A.5    Sugiyama, Y.6
  • 152
    • 0030432375 scopus 로고    scopus 로고
    • Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide
    • Yamada, T.; Niinuma, K.; Lemaire, M.; Terasaki, T.; Sugiyama, Y. Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide. J. Pharmacol. Exp. Ther. 1996, 279, 1357-1364.
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 1357-1364
    • Yamada, T.1    Niinuma, K.2    Lemaire, M.3    Terasaki, T.4    Sugiyama, Y.5
  • 153
    • 0030668526 scopus 로고    scopus 로고
    • ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
    • Jedlitschky, G.; Leier, I.; Buchholz, U.; Hummel-Eisenbeiss, J.; Burchell, B.; Keppler, D. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem. J. 1997, 327, 305-310.
    • (1997) Biochem. J. , vol.327 , pp. 305-310
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Hummel-Eisenbeiss, J.4    Burchell, B.5    Keppler, D.6
  • 155
    • 0029615982 scopus 로고
    • Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile
    • Meier, P. J. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. 1995, 269, G801-G812.
    • (1995) Am. J. Physiol. , vol.269
    • Meier, P.J.1
  • 157
    • 0031031247 scopus 로고    scopus 로고
    • Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
    • Ito, K.; Suzuki, H.; Hirohashi, T.; Kume, K.; Shimizu, T.; Sugiyama, Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 1997, 272, G16-G22.
    • (1997) Am. J. Physiol. , vol.272
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 158
    • 0029880973 scopus 로고    scopus 로고
    • Expression of the putative ATP-binding cassette region, homologous to that in multidrug resistance associated protein (MRP), is hereditarily defective in Eisai hyperbirilubinemic rats (EHBR)
    • Ito, K.; Suzuki, H.; Hirohashi, T.; Kume, K.; Shimizu, T.; Sugiyama, Y. Expression of the putative ATP-binding cassette region, homologous to that in multidrug resistance associated protein (MRP), is hereditarily defective in Eisai hyperbirilubinemic rats (EHBR). Int. Hepatol. Commun. 1996, 4, 292-299.
    • (1996) Int. Hepatol. Commun. , vol.4 , pp. 292-299
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 159
    • 0040761368 scopus 로고    scopus 로고
    • cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • Buchler, M.; Konig, J.; Brom, M.; Kartenbeck, J.; Spring, H.; Horie, T.; Keppler, D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 1996, 271, 15091-15098.
    • (1996) J. Biol. Chem. , vol.271 , pp. 15091-15098
    • Buchler, M.1    Konig, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5    Horie, T.6    Keppler, D.7
  • 160
    • 0026734708 scopus 로고
    • Defective biliary excretion of epinephrine metabolites in mutant (TR-) rats: Relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and Corriedale sheep with an analogous excretory defect
    • Kitamura, T.; Alroy, J.; Gatmaitan, Z.; Inoue, M.; Mikami, T.; Jansen, P.; Arias, I. M. Defective biliary excretion of epinephrine metabolites in mutant (TR-) rats: relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and Corriedale sheep with an analogous excretory defect. Hepatology (St. Louis) 1992, 15, 1154-1159.
    • (1992) Hepatology (St. Louis) , vol.15 , pp. 1154-1159
    • Kitamura, T.1    Alroy, J.2    Gatmaitan, Z.3    Inoue, M.4    Mikami, T.5    Jansen, P.6    Arias, I.M.7
  • 161
    • 0031916830 scopus 로고    scopus 로고
    • Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
    • Ito, K.; Suzuki, H.; Hirohashi, T.; Kume, K.; Shimizu, T.; Sugiyama, Y. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J. Biol. Chem. 1998, 273, 1684-1688.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1684-1688
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 162
    • 0030978107 scopus 로고    scopus 로고
    • Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein
    • Madon, J.; Eckhardt, U.; Gerloff, T.; Stieger, B.; Meier, P. J. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett. 1997, 406, 75-78.
    • (1997) FEBS Lett. , vol.406 , pp. 75-78
    • Madon, J.1    Eckhardt, U.2    Gerloff, T.3    Stieger, B.4    Meier, P.J.5
  • 163
    • 0025769498 scopus 로고
    • Hepatocanalicular organic-anion transport is regulated by protein kinase C
    • Roelofsen, H.; Ottenhoff, R.; Oude Elferink, R. P.; Jansen, P. L. Hepatocanalicular organic-anion transport is regulated by protein kinase C. Biochem. J. 1991, 278, 637-641.
    • (1991) Biochem. J. , vol.278 , pp. 637-641
    • Roelofsen, H.1    Ottenhoff, R.2    Oude Elferink, R.P.3    Jansen, P.L.4
  • 164
    • 0027480216 scopus 로고
    • Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter
    • Oude Elferink, R. P.; Bakker, C. T.; Roelofsen, H.; Middelkoop, E.; Ottenhoff, R.; Heijn, M.; Jansen, P. L. Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter. Hepatology (St. Louis) 1993, 17, 434-444.
    • (1993) Hepatology (St. Louis) , vol.17 , pp. 434-444
    • Oude Elferink, R.P.1    Bakker, C.T.2    Roelofsen, H.3    Middelkoop, E.4    Ottenhoff, R.5    Heijn, M.6    Jansen, P.L.7
  • 166
    • 0030817669 scopus 로고    scopus 로고
    • Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes
    • Kauffmann, H. M.; Keppler, D.; Kartenbeck, J.; Schrenk, D. Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes. Hepatology (St. Louis) 1997, 26, 980-985.
    • (1997) Hepatology (St. Louis) , vol.26 , pp. 980-985
    • Kauffmann, H.M.1    Keppler, D.2    Kartenbeck, J.3    Schrenk, D.4
  • 167
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi, K.; Wada, M.; Kohno, K.; Nakamura, T.; Kawabe, T.; Kawakami, M.; Kagotani, K.; Okumura, K.; Akiyama, S.; Kuwano, M. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 1996, 56, 4124-4129.
    • (1996) Cancer Res. , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5    Kawakami, M.6    Kagotani, K.7    Okumura, K.8    Akiyama, S.9    Kuwano, M.10
  • 168
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • Kool, M.; de Haas, M.; Scheffer, G. L.; Scheper, R. J.; van Eijk, M. J.; Juijn, J. A.; Baas, F.; Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 1997, 57, 3537-3547.
    • (1997) Cancer Res. , vol.57 , pp. 3537-3547
    • Kool, M.1    De Haas, M.2    Scheffer, G.L.3    Scheper, R.J.4    Van Eijk, M.J.5    Juijn, J.A.6    Baas, F.7    Borst, P.8
  • 169
    • 0001168550 scopus 로고    scopus 로고
    • Vermeulen, N. P. E., Mulder, G. J., Nieuwenhuyse, H., Peters, W. H. M., van Bladeren, P. J., Eds.; Taylor and Francis: London
    • Ishikawa, T.; Akimaru, K. In In glutathione S-transferases: structure, function, and clinical implications; Vermeulen, N. P. E., Mulder, G. J., Nieuwenhuyse, H., Peters, W. H. M., van Bladeren, P. J., Eds.; Taylor and Francis: London, 1996; pp 199-211.
    • (1996) In Glutathione S-transferases: Structure, Function, and Clinical Implications , pp. 199-211
    • Ishikawa, T.1    Akimaru, K.2
  • 170
    • 0031468814 scopus 로고    scopus 로고
    • A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells
    • Koike, K.; Kawabe, T.; Tanaka, T.; Toh, S.; Uchiumi, T.; Wada, M.; Akiyama, S.; Ono, M.; Kuwano, M. A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res. 1997, 57, 5475-5479.
    • (1997) Cancer Res. , vol.57 , pp. 5475-5479
    • Koike, K.1    Kawabe, T.2    Tanaka, T.3    Toh, S.4    Uchiumi, T.5    Wada, M.6    Akiyama, S.7    Ono, M.8    Kuwano, M.9
  • 171
    • 0029986408 scopus 로고    scopus 로고
    • Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • Kartenbeck, J.; Leuschner, U.; Mayer, R.; Keppler, D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology (St. Louis) 1996, 23, 1061-1066.
    • (1996) Hepatology (St. Louis) , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3    Keppler, D.4
  • 172
    • 6844250107 scopus 로고    scopus 로고
    • Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
    • Wada, M.; Toh, S.; Taniguchi, K.; Nakamura, T.; Uchiumi, T.; Kohno, K.; Yoshida, I.; Kimura, A.; Sakisaka, S.; Adachi, Y.; Kuwano, M. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum. Mol. Genet. 1998, 7, 203-207.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 203-207
    • Wada, M.1    Toh, S.2    Taniguchi, K.3    Nakamura, T.4    Uchiumi, T.5    Kohno, K.6    Yoshida, I.7    Kimura, A.8    Sakisaka, S.9    Adachi, Y.10    Kuwano, M.11
  • 173
    • 0030818770 scopus 로고    scopus 로고
    • Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazoleglucuronide
    • Niinuma, K.; Takenaka, O.; Horie, T.; Kobayashi, K.; Kato, Y.; Suzuki, H.; Sugiyama, Y. Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazoleglucuronide. J. Pharmacol. Exp. Ther. 1997, 282, 866-872.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 866-872
    • Niinuma, K.1    Takenaka, O.2    Horie, T.3    Kobayashi, K.4    Kato, Y.5    Suzuki, H.6    Sugiyama, Y.7
  • 175
    • 15444339505 scopus 로고    scopus 로고
    • Characterization of ATP-dependent organic anion transport system on rat canalicular membrane maintained in EHBR
    • Hirohashi, T.; Niinuma, K.; Ito, K.; Suzuki, H.; Kume, K.; Shimizu, T.; Sugiyama, Y. Characterization of ATP-dependent organic anion transport system on rat canalicular membrane maintained in EHBR. Hepatology (St. Louis) 1996, 24, 203A.
    • (1996) Hepatology (St. Louis) , vol.24
    • Hirohashi, T.1    Niinuma, K.2    Ito, K.3    Suzuki, H.4    Kume, K.5    Shimizu, T.6    Sugiyama, Y.7
  • 176
    • 0031866357 scopus 로고    scopus 로고
    • Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai Hyperbilirubinemic rats
    • Hirohashi, T.; Suzuki, H.; Ito, K.; Ogawa, K.; Kume, K.; Shimizu, T.; Sugiyama, Y. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai Hyperbilirubinemic rats. Mol. Pharmacol. 1998, 53, 1068-1075.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 1068-1075
    • Hirohashi, T.1    Suzuki, H.2    Ito, K.3    Ogawa, K.4    Kume, K.5    Shimizu, T.6    Sugiyama, Y.7
  • 177
    • 15444338789 scopus 로고    scopus 로고
    • Molecular characterization of canalicular multispecific organic anion transporter and its related proteins expressed in rat liver
    • Ogawa, K.; Suzuki, H.; Ito, K.; Kume, K.; Shimizu, T.; Sugiyama, Y. Molecular characterization of canalicular multispecific organic anion transporter and its related proteins expressed in rat liver. Pharm. Res. 1997, 14, S-458.
    • (1997) Pharm. Res. , vol.14
    • Ogawa, K.1    Suzuki, H.2    Ito, K.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 178
    • 0001130357 scopus 로고
    • Hereditary acholuric jaundice in a new mutant strain of rats
    • Gunn, C. K. Hereditary acholuric jaundice in a new mutant strain of rats. J. Hered. 1938, 29, 137-139.
    • (1938) J. Hered. , vol.29 , pp. 137-139
    • Gunn, C.K.1
  • 179
    • 0027480292 scopus 로고
    • Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)
    • Oude Elferink, R. P.; Bakker, C. T.; Jansen, P. L. Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells). Biochem. J. 1993, 290, 759-764.
    • (1993) Biochem. J. , vol.290 , pp. 759-764
    • Oude Elferink, R.P.1    Bakker, C.T.2    Jansen, P.L.3
  • 180
    • 0024854291 scopus 로고
    • Evidence for leukotriene C4 transport mediated by an ATP-dependent glutathione S-conjugate carrier in rat heart and liver plasma membranes
    • Ishikawa, T.; Kobayashi, K.; Sogame, Y.; Hayashi, K. Evidence for leukotriene C4 transport mediated by an ATP-dependent glutathione S-conjugate carrier in rat heart and liver plasma membranes. FEBS Lett. 1989, 259, 95-98.
    • (1989) FEBS Lett. , vol.259 , pp. 95-98
    • Ishikawa, T.1    Kobayashi, K.2    Sogame, Y.3    Hayashi, K.4
  • 181
    • 0024472768 scopus 로고
    • ATP/Mg2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles
    • Ishikawa, T. ATP/Mg2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles. J. Biol. Chem. 1989, 264, 17343-17348.
    • (1989) J. Biol. Chem. , vol.264 , pp. 17343-17348
    • Ishikawa, T.1
  • 182
  • 183
    • 0019464615 scopus 로고
    • Transport of glutathione S-conjugate from human erythrocytes
    • Board, P. G. Transport of glutathione S-conjugate from human erythrocytes. FEBS Lett. 1981, 124, 163-165.
    • (1981) FEBS Lett. , vol.124 , pp. 163-165
    • Board, P.G.1
  • 184
    • 0026563648 scopus 로고
    • Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the Dubin-Johnson syndrome and in rats with hereditary hyperbilirubinemia
    • Board, P.; Nishida, T.; Gatmaitan, Z.; Che, M.; Arias, I. M. Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the Dubin-Johnson syndrome and in rats with hereditary hyperbilirubinemia. Hepatology (St. Louis) 1992, 15, 722-725.
    • (1992) Hepatology (St. Louis) , vol.15 , pp. 722-725
    • Board, P.1    Nishida, T.2    Gatmaitan, Z.3    Che, M.4    Arias, I.M.5
  • 185
    • 0029806319 scopus 로고    scopus 로고
    • Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homologue of the multidrug-resistance protein
    • Leier, I.; Jedlitschky, G.; Buchler, M.; Buchholz, U.; Brom, M.; Keppler, D. Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homologue of the multidrug-resistance protein. Eur. J. Biochem. 1996, 242, 201-205.
    • (1996) Eur. J. Biochem. , vol.242 , pp. 201-205
    • Leier, I.1    Jedlitschky, G.2    Buchler, M.3    Buchholz, U.4    Brom, M.5    Keppler, D.6
  • 186
    • 0031809205 scopus 로고    scopus 로고
    • Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line (MBEC4)
    • Kusuhara, H.; Suzuki, H.; Naito, M.; Tsuruo, T.; Sugiyama, Y. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line (MBEC4). J. Pharmacol. Exp. Ther. 1998, 285, 1260-1265.
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 1260-1265
    • Kusuhara, H.1    Suzuki, H.2    Naito, M.3    Tsuruo, T.4    Sugiyama, Y.5
  • 187
    • 0343554785 scopus 로고    scopus 로고
    • Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system
    • Suzuki, H.; Terasaki, T.; Sugiyama, Y. Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv. Drug Deliv. Rev. 1997, 25, 257-285.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 257-285
    • Suzuki, H.1    Terasaki, T.2    Sugiyama, Y.3
  • 188
    • 0030582637 scopus 로고    scopus 로고
    • Calcein is excreted from the intestinal mucosal cell membrane by the active transport system
    • Fujita, T.; Yamada, H.; Fukuzumi, M.; Nishimaki, A.; Yamamoto, A.; Muranishi, S. Calcein is excreted from the intestinal mucosal cell membrane by the active transport system. Life Sci. 1997, 60, 307-313.
    • (1997) Life Sci. , vol.60 , pp. 307-313
    • Fujita, T.1    Yamada, H.2    Fukuzumi, M.3    Nishimaki, A.4    Yamamoto, A.5    Muranishi, S.6
  • 189
    • 0029950964 scopus 로고    scopus 로고
    • Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics
    • Iwatsubo, T.; Hirota, N.; Ooie, T.; Suzuki, H.; Sugiyama, Y. Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics. Biopharm. Drug Disp. 1996, 17, 273-310.
    • (1996) Biopharm. Drug Disp. , vol.17 , pp. 273-310
    • Iwatsubo, T.1    Hirota, N.2    Ooie, T.3    Suzuki, H.4    Sugiyama, Y.5


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