Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney

Journal of Biological Chemistry

Volumn 271, Issue 34, 1996, Pages 20719-20725

  Salto, Hideyuki ^a   Masuda, Satohiro ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; BROMSULFOPHTHALEIN; CARRIER PROTEIN; FOLIC ACID; LEUKOTRIENE C4; METHOTREXATE; ORGANIC ANION TRANSPORTER PROTEIN; PROSTAGLANDIN E2; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; DRUG UPTAKE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MALE; MICHAELIS CONSTANT; MOLECULAR WEIGHT; NONHUMAN; NORTHERN BLOTTING; OPEN READING FRAME; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; ANION TRANSPORT PROTEINS; ANIONS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL POLARITY; CLONING, MOLECULAR; DNA PRIMERS; DNA, COMPLEMENTARY; GENE EXPRESSION; KIDNEY CORTEX; MEMBRANE PROTEINS; METHOTREXATE; MOLECULAR SEQUENCE DATA; ORGANIC ANION TRANSPORTERS; RATS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SOLUBILITY; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0029786681     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.34.20719     Document Type: Article

References (28)

1. Frimmer, M., and Ziegler, K. (1988) Biochim. Biophys. Acta 947, 75-99
2. Oude Elferink, P. J., Meijer, D. K. F., Kuipers, F., Jansen, P. L. M., Groen, A. K., and Groothuis, G. M. M. (1995) Biochim. Biophys. Acta 1241, 215-268
3. Hagenbuch, B., Stieger, B., Foguet, M., Lübbert, H., and Meier, P. J. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 10629-10633
4. Jacquemin, E., Hagenbuch, B., Stieger, B., Wolkoff, A. W., and Meier, P. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 133-137
5. Ullrich, K. J. (1994) Biochim. Biophys. Acta 1197, 45-62
6. Shimada, H., Moewes, B., and Burckhardt, G. (1987) Am. J. Physiol. 253, F795-F801
7. Saito, H., Okuda, M., Terada, T., Sasaki, S., and Inui, K. (1995) J. Pharmacol. Exp. Ther. 275, 1631-1631
8. Uchida, S., Sasaki, S., Furukawa, T., Hiraoka, M., Imai, T., Hirata, Y., and Marumo, F. (1993) J. Biol. Chem. 288, 3821-3824
9. Saito, H., Yamamoto, M., Inui, K., and Hori, R. (1992) Am. J. Physiol. 262, C59-C66
10. Brewer, C. B. (1994) Methods Cell Biol. 43, 233-245
11. Gu, H., Wall, S. C., and Rudnick, G. (1994) J. Biol. Chem. 269, 7124-7130
12. Sippel, C. J., McCollum, M. J., and Perlmutter, D. H. (1994) J. Biol. Chem. 269, 2820-2826
13. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
14. Kozak, M. (1987) Nucleic Acids Res. 15, 8125-8148
15. Hakes, D. J., and Berezney, R. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 6186-6190
16. Kanai, N., Lu, R., Satriano, J. A., Bao, Y., Wolkoff, A. W., and Schuster, V. L. (1995) Science 268, 866-869
17. Kyte, J., and Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132
18. Kennelly, P. J., and Krebs, E. G. (1991) J. Biol. Chem. 266, 15555-15558
19. Yamaoka, K., Tanigawara, Y., Nakagawa, T., and Uno, T. (1981) J. Pharmacobio-Dyn. 4, 879-885
20. Jackson, R. C. (1984) Pharmacol. & Ther. 25, 61-82
21. He, Y., Tanigawara, Y., Yasuhara, M., and Hori, R. (1991) Drug Metab. Dispos. 19, 729-734
22. Bourke, R. S., Chheda, G., Bremer, A., Watanabe, O., and Tower, D. B. (1975) Cancer Res. 35, 110-116
23. Nierenberg, D. W. (1987) J. Pharmacol. Exp. Ther. 240, 712-716
24. Mayer, R., Kartenbeck, J., Büchler, M., Jedlitschky, G., Leier, I., and Keppler, D. (1995) J. Cell Biol. 131, 137-150
25. Horne, D. W., and Reed, K. A. (1992) Arch. Biochem. Biophys. 298, 121-128
26. Said, H. M., and Redha, R. (1987) Biochem. J. 247, 141-146
27. Williams, F. M. R., Murray, R. C., Underhill, T. M., and Flintoff, W. F. (1994) J. Biol. Chem. 269, 5810-5816
28. Williams, F. M. R., and Flintoff, W. F. (1995) J. Biol. Chem. 270, 2987-2992