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Volumn 276, Issue 5 39-5, 1999, Pages

Primary active transport of organic anions on bile canalicular membrane in humans

Author keywords

Canalicular membrane vesicles; Canalicular multispecific organic anion transporter; Glucuronides; Glutathione conjugates; Species difference

Indexed keywords

2,4 DINITROPHENOL; 6 HYDROXY 5,7 DIMETHYL 2 METHYLAMINO 4 (3 PYRIDYLMETHYL)BENZOTHIAZOLE; ACIVICIN; ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; ANION; BROMSULFOPHTHALEIN; CARRIER PROTEIN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYTOSOL AMINOPEPTIDASE; ESTRADIOL 17 GLUCURONIDE; GAMMA GLUTAMYLTRANSFERASE; GLUCURONIDE; GLUTATHIONE DERIVATIVE; GREPAFLOXACIN; LEUKOTRIENE C4; METHOTREXATE; ORGANIC COMPOUND; PRAVASTATIN; TAUROCHOLIC ACID; XENOBIOTIC AGENT;

EID: 0032974409     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.5.g1153     Document Type: Article
Times cited : (67)

References (55)
  • 2
    • 0020541036 scopus 로고
    • Ethanol effects in a rat hepatoma cell line: Induction of γ-glutamyltransferase
    • Barouki, R., M. Chobert, J. Finidori, M. Aggerbeck, B. Nalpas, and J. Hanoune. Ethanol effects in a rat hepatoma cell line: induction of γ-glutamyltransferase. Hepatology 3: 323-329, 1983.
    • (1983) Hepatology , vol.3 , pp. 323-329
    • Barouki, R.1    Chobert, M.2    Finidori, J.3    Aggerbeck, M.4    Nalpas, B.5    Hanoune, J.6
  • 3
    • 0027935348 scopus 로고
    • Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes
    • Bissig, M., B. Hagenbuch, B. Stieger, T. Koller, and P. J. Meier. Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J. Biol. Chem. 269: 3017-3021, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3017-3021
    • Bissig, M.1    Hagenbuch, B.2    Stieger, B.3    Koller, T.4    Meier, P.J.5
  • 4
    • 0028284238 scopus 로고
    • Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver
    • Bohme, M., M. Muller., I. Leier., G. Jedlitschky., and D. Keppler. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107: 255-265, 1994.
    • (1994) Gastroenterology , vol.107 , pp. 255-265
    • Bohme, M.1    Muller, M.2    Leier, I.3    Jedlitschky, G.4    Keppler, D.5
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microsomal quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. A rapid and sensitive method for the quantitation of microsomal quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 0040761368 scopus 로고    scopus 로고
    • cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • Buchler, M., J. Konig, M. Brom, J. Kartenbeck, H. Spring, T. Horie, and D. Keppler. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 271: 15091-15098, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 15091-15098
    • Buchler, M.1    Konig, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5    Horie, T.6    Keppler, D.7
  • 8
    • 0030959378 scopus 로고    scopus 로고
    • Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
    • Chu, X., Y. Kato, K. Niinuma, K. Sudo, H. Hakusui, and Y. Sugiyama. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J. Pharmacol. Exp. Ther. 281: 304-314, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 304-314
    • Chu, X.1    Kato, Y.2    Niinuma, K.3    Sudo, K.4    Hakusui, H.5    Sugiyama, Y.6
  • 9
    • 0030906434 scopus 로고    scopus 로고
    • Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats
    • Chu, X., Y. Kato, and Y. Sugiyama. Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res. 57: 1934-1938, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 1934-1938
    • Chu, X.1    Kato, Y.2    Sugiyama, Y.3
  • 13
    • 0026511550 scopus 로고
    • Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats
    • Fernandez-Checa, J. C., H. Takikawa, T. Horie, M. Ookhtens, and N. Kaplowitz. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J. Biol. Chem. 267: 1667-1673, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1667-1673
    • Fernandez-Checa, J.C.1    Takikawa, H.2    Horie, T.3    Ookhtens, M.4    Kaplowitz, N.5
  • 14
    • 84858843788 scopus 로고
    • Structual, functional, and clinical aspects of γ-glutamyl transferase
    • Goldberg, D. M. Structual, functional, and clinical aspects of γ-glutamyl transferase. Crit. Rev. Clin. Lab. Sci. 12: 1-58, 1980.
    • (1980) Crit. Rev. Clin. Lab. Sci. , vol.12 , pp. 1-58
    • Goldberg, D.M.1
  • 15
    • 0031866357 scopus 로고    scopus 로고
    • Hepatic expression of multidrug resistance-associated protein (MRP)-like proteins maintained in Eisai hyperbilirubinemic rats (EHBR)
    • Hirohashi, T., H. Suzuki, K. Ito, K. Ogawa, K. Kume, T. Shimizu, and Y. Sugiyama. Hepatic expression of multidrug resistance-associated protein (MRP)-like proteins maintained in Eisai hyperbilirubinemic rats (EHBR). Mol. Pharmacol. 53: 1068-1075, 1998.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 1068-1075
    • Hirohashi, T.1    Suzuki, H.2    Ito, K.3    Ogawa, K.4    Kume, K.5    Shimizu, T.6    Sugiyama, Y.7
  • 16
    • 0025132673 scopus 로고
    • ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane
    • Ishikawa, T., M. Muller, C. Klunemann, T. Schaub, and D. Keppler. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. J. Biol. Chem. 265: 19279-19286, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19279-19286
    • Ishikawa, T.1    Muller, M.2    Klunemann, C.3    Schaub, T.4    Keppler, D.5
  • 17
    • 0030951558 scopus 로고    scopus 로고
    • Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR)
    • Ishizuka, H., K. Konno, H. Naganuma, K. Sasahara, Y. Kawahara, K. Niinuma, H. Suzuki, and Y. Sugiyama. Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR). J. Pharmacol. Exp. Ther. 280: 1304-1311, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 1304-1311
    • Ishizuka, H.1    Konno, K.2    Naganuma, H.3    Sasahara, K.4    Kawahara, Y.5    Niinuma, K.6    Suzuki, H.7    Sugiyama, Y.8
  • 18
    • 0031031247 scopus 로고    scopus 로고
    • Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
    • Gastrointest. Liver Physiol. 35
    • Ito, K., H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu, and Y. Sugiyama. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G16-G22, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 19
    • 0031916830 scopus 로고    scopus 로고
    • Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
    • Ito, K., H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu, and Y. Sugiyama. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J. Biol. Chem. 273: 1684-1688, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1684-1688
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 21
    • 0029950964 scopus 로고    scopus 로고
    • Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics
    • Iwatsubo, T., N. Hirota, T. Ooie, H. Suzuki, and Y. Sugiyama. Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics. Biopharm. Drug Dispos. 17: 273-310, 1996.
    • (1996) Biopharm. Drug Dispos. , vol.17 , pp. 273-310
    • Iwatsubo, T.1    Hirota, N.2    Ooie, T.3    Suzuki, H.4    Sugiyama, Y.5
  • 22
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
    • Jansen, P. L. M., W. H. M. Peters, and W. H. Lamers. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology 5: 573-579, 1985.
    • (1985) Hepatology , vol.5 , pp. 573-579
    • Jansen, P.L.M.1    Peters, W.H.M.2    Lamers, W.H.3
  • 23
    • 0028001416 scopus 로고
    • ATP-dependent transport of glutathione S-conjugates by the multidrug resistance associated protein
    • Jedlitschky, G., I. Leier, U. Buchholz, M. Center, and D. Keppler. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance associated protein. Cancer Res. 54: 4833-4836, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 4833-4836
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Center, M.4    Keppler, D.5
  • 24
    • 0021741806 scopus 로고
    • Evaluation of cytosolic aminopeptidase in human sera, evaluation in hepatic disorders
    • Kanno, T., M. Maekawa, S. Kanda, H. Kohno, and K. Sudo. Evaluation of cytosolic aminopeptidase in human sera, evaluation in hepatic disorders. Am. J. Clin. Pathol. 82: 700-705, 1984.
    • (1984) Am. J. Clin. Pathol. , vol.82 , pp. 700-705
    • Kanno, T.1    Maekawa, M.2    Kanda, S.3    Kohno, H.4    Sudo, K.5
  • 25
    • 0025343017 scopus 로고
    • Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
    • Kobayashi, K., Y. Sogame, H. Hara, and K. Hayashi. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem. 265: 7737-7741, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7737-7741
    • Kobayashi, K.1    Sogame, Y.2    Hara, H.3    Hayashi, K.4
  • 26
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • Kool, M., M. de Haas, G. L. Scheffer, R. J. Scheper, M. J. van Eijk, J. A. Juijn, F. Baas, and P. Borst. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57: 3537-3547, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 3537-3547
    • Kool, M.1    De Haas, M.2    Scheffer, G.L.3    Scheper, R.J.4    Van Eijk, M.J.5    Juijn, J.A.6    Baas, F.7    Borst, P.8
  • 27
    • 0029912351 scopus 로고    scopus 로고
    • ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
    • Leier, I., G. Jedlitschky, U. Buchholz, M. Center, S. P. Cole, R. G. Deeley, and D. Keppler. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem. J. 314: 433-437, 1996.
    • (1996) Biochem. J. , vol.314 , pp. 433-437
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Center, M.4    Cole, S.P.5    Deeley, R.G.6    Keppler, D.7
  • 29
    • 0030978107 scopus 로고    scopus 로고
    • Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein
    • Madon, J., U. Eckhardt, T. Gerloff, B. Stieger, and P. J. Meier. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett. 406: 75-78, 1997.
    • (1997) FEBS Lett. , vol.406 , pp. 75-78
    • Madon, J.1    Eckhardt, U.2    Gerloff, T.3    Stieger, B.4    Meier, P.J.5
  • 30
    • 0029133131 scopus 로고
    • Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
    • Mayer, R., J. Kartenbeck, M. Buchler, G. Jedlitschky, I. Leier, and D. Keppler. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J. Cell Biol. 131: 137-150, 1995.
    • (1995) J. Cell Biol. , vol.131 , pp. 137-150
    • Mayer, R.1    Kartenbeck, J.2    Buchler, M.3    Jedlitschky, G.4    Leier, I.5    Keppler, D.6
  • 33
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
    • Muller, M., C. Meijer, G. J. Zaman, P. Borst, R. J. Scheper, N. H. Mulder, E. G. de Vries, and P. L. Jansen. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA 91: 13033-13037, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 13033-13037
    • Muller, M.1    Meijer, C.2    Zaman, G.J.3    Borst, P.4    Scheper, R.J.5    Mulder, N.H.6    De Vries, E.G.7    Jansen, P.L.8
  • 34
    • 0029937429 scopus 로고    scopus 로고
    • Secretion of organic anions by hepatocytes: Involvement of homologues of the multidrug resistance protein
    • Muller, M., H. Roelofsen, and P. L. Jansen. Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein. Semin. Liver Dis. 16: 211-219, 1996.
    • (1996) Semin. Liver Dis. , vol.16 , pp. 211-219
    • Muller, M.1    Roelofsen, H.2    Jansen, P.L.3
  • 36
    • 0030818770 scopus 로고    scopus 로고
    • Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide
    • Niinuma, K., O. Takenaka, T. Horie, K. Kobayashi, Y. Kato, H. Suzuki, and Y. Sugiyama. Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide. J. Pharmacol. Exp. Ther. 282: 866-872, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 866-872
    • Niinuma, K.1    Takenaka, O.2    Horie, T.3    Kobayashi, K.4    Kato, Y.5    Suzuki, H.6    Sugiyama, Y.7
  • 39
    • 0001454265 scopus 로고
    • Studies on dipeptidases and aminopeptidases. I. Distinction between leucine aminopeptidase and enzymes that hydrolyze L-leucyl-β-naphthylamide
    • Patterson, E. K., S. Hsiao, and A. Keppel. Studies on dipeptidases and aminopeptidases. I. Distinction between leucine aminopeptidase and enzymes that hydrolyze L-leucyl-β-naphthylamide. J. Biol. Chem. 238: 3611-3620, 1963.
    • (1963) J. Biol. Chem. , vol.238 , pp. 3611-3620
    • Patterson, E.K.1    Hsiao, S.2    Keppel, A.3
  • 41
    • 0031911625 scopus 로고    scopus 로고
    • Carrier-mediated mechanism for the biliary excretion of a quinolone antibiotic, grepafloxacin and its glucuronide in rats
    • Sasabe, H., A. Tsuji, and Y. Sugiyama. Carrier-mediated mechanism for the biliary excretion of a quinolone antibiotic, grepafloxacin and its glucuronide in rats. J. Pharmacol. Exp. Ther. 284: 1033-1039, 1998.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 1033-1039
    • Sasabe, H.1    Tsuji, A.2    Sugiyama, Y.3
  • 42
    • 0028939884 scopus 로고
    • ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione
    • Saxena, M., and G. B. Henderson. ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione. J. Biol. Chem. 270: 5312-5319, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5312-5319
    • Saxena, M.1    Henderson, G.B.2
  • 43
    • 0030957234 scopus 로고    scopus 로고
    • Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123
    • Gastrointest. Liver Physiol. 35
    • Shin, H., Y. Kato, T. Yamada, K. Niinuma, A. Hisaka, and Y. Sugiyama. Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G979-G986, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Shin, H.1    Kato, Y.2    Yamada, T.3    Niinuma, K.4    Hisaka, A.5    Sugiyama, Y.6
  • 44
    • 0030977084 scopus 로고    scopus 로고
    • Characterization of the hepatic canalicular membrane transport of a model oligopeptide: Ditekiren
    • Takahashi, H., R. B. Kim, P. R. Perry, and G. R. Wilkinson. Characterization of the hepatic canalicular membrane transport of a model oligopeptide: ditekiren. J. Pharmacol. Exp. Ther. 281: 297-303, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 297-303
    • Takahashi, H.1    Kim, R.B.2    Perry, P.R.3    Wilkinson, G.R.4
  • 45
    • 0029582975 scopus 로고
    • Kinetic analysis of hepatobiliary transport for conjugative metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugative hyperbilirubinemia
    • Takenaka, O., T. Horie, H. Suzuki, K. Kobayashi, and Y. Sugiyama. Kinetic analysis of hepatobiliary transport for conjugative metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugative hyperbilirubinemia. Pharm. Res. 12: 1746-1755, 1995.
    • (1995) Pharm. Res. , vol.12 , pp. 1746-1755
    • Takenaka, O.1    Horie, T.2    Suzuki, H.3    Kobayashi, K.4    Sugiyama, Y.5
  • 47
    • 0029870301 scopus 로고    scopus 로고
    • Biliary excretion of estradiol-17-glucuronide in the rat
    • Takikawa, H., R. Yamazaki, N. Sano, and M. Yamanaka. Biliary excretion of estradiol-17-glucuronide in the rat. Hepatology 23: 607-613, 1996.
    • (1996) Hepatology , vol.23 , pp. 607-613
    • Takikawa, H.1    Yamazaki, R.2    Sano, N.3    Yamanaka, M.4
  • 48
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi, K., M. Wada, K. Kohno, T. Nakamura, T. Kawabe, M. Kawakami, K. Kagotani, K. Okumura, S. Akiyama, and M. Kuwano. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 56: 4124-4129, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5    Kawakami, M.6    Kagotani, K.7    Okumura, K.8    Akiyama, S.9    Kuwano, M.10
  • 49
    • 0027081369 scopus 로고
    • Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes
    • Wolters, H., F. Kuipers, M. J. H. Slooff, and R. J. Vonk. Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes. J. Clin. Invest. 90: 2321-2326, 1992.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2321-2326
    • Wolters, H.1    Kuipers, F.2    Slooff, M.J.H.3    Vonk, R.J.4
  • 51
    • 0024492557 scopus 로고
    • Characterization of rose bengal binding to sinusoidal and canalicular plasma membrane from rat liver
    • Yachi, K., Y. Sugiyama, Y. Sawada, T. Iga, Y. Ikeda, G. Toda, and M. Hanano. Characterization of rose bengal binding to sinusoidal and canalicular plasma membrane from rat liver. Biochim. Biophys. Acta 978: 1-7, 1989.
    • (1989) Biochim. Biophys. Acta , vol.978 , pp. 1-7
    • Yachi, K.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Ikeda, Y.5    Toda, G.6    Hanano, M.7
  • 52
    • 0019854279 scopus 로고
    • A pharmacokinetic analysis program (MULTI) for microcomputer
    • Yamaoka, K., Y. Tanigawara, Y. Nakagawa, and T. Uno. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4: 879-885, 1981.
    • (1981) J. Pharmacobio-Dyn. , vol.4 , pp. 879-885
    • Yamaoka, K.1    Tanigawara, Y.2    Nakagawa, Y.3    Uno, T.4
  • 53
    • 0029782268 scopus 로고    scopus 로고
    • Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats
    • Yamazaki, M., K. Kobayashi, and Y. Sugiyama. Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats. Biopharm. Drug Dispos. 17: 607-621, 1996.
    • (1996) Biopharm. Drug Dispos. , vol.17 , pp. 607-621
    • Yamazaki, M.1    Kobayashi, K.2    Sugiyama, Y.3
  • 54
    • 0029926676 scopus 로고    scopus 로고
    • Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
    • Yamazaki, M., H. Suzuki, and Y. Sugiyama. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res. 13: 497-513, 1996.
    • (1996) Pharm. Res. , vol.13 , pp. 497-513
    • Yamazaki, M.1    Suzuki, H.2    Sugiyama, Y.3
  • 55
    • 0028606064 scopus 로고
    • ATP-dependent transport of the linear renin-inhibiting peptide EMD-51921 by canalicular plasma membrane vesicles of rat liver: Evidence of drug-stimulatable ATP-hydrolysis
    • Ziegler, K., C. Kolac, and W. Ising. ATP-dependent transport of the linear renin-inhibiting peptide EMD-51921 by canalicular plasma membrane vesicles of rat liver: evidence of drug-stimulatable ATP-hydrolysis. Biochim. Biophys. Acta 1196: 209-217, 1994.
    • (1994) Biochim. Biophys. Acta , vol.1196 , pp. 209-217
    • Ziegler, K.1    Kolac, C.2    Ising, W.3


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