메뉴 건너뛰기




Volumn 440, Issue 3, 2000, Pages 337-350

The multispecific organic anion transporter (OAT) family

Author keywords

Multispecific organic anion transporter; Organic anion; p Aminohippurate; Pharmacokinetics; Tubular secretion; Xenobiotics

Indexed keywords

ANION; CARNITINE; CARRIER PROTEIN; MEMBRANE PROTEIN; ORGANIC ANION TRANSPORTER PROTEIN; UNCLASSIFIED DRUG;

EID: 0033938669     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240000297     Document Type: Review
Times cited : (303)

References (115)
  • 1
    • 15444342300 scopus 로고    scopus 로고
    • Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
    • 1. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Matsuno S, Kondo H, Yawo H (1998) Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401
    • (1998) J Biol Chem , vol.273 , pp. 22395-22401
    • Abe, T.1    Kakyo, M.2    Sakagami, H.3    Tokui, T.4    Nishio, T.5    Tanemoto, M.6    Nomura, H.7    Hebert, S.C.8    Matsuno, S.9    Kondo, H.10    Yawo, H.11
  • 4
    • 0032931612 scopus 로고    scopus 로고
    • Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
    • 4. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H (1999) Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol 55:847-854
    • (1999) Mol Pharmacol , vol.55 , pp. 847-854
    • Apiwattanakul, N.1    Sekine, T.2    Chairoungdua, A.3    Kanai, Y.4    Nakajima, N.5    Sophasan, S.6    Endou, H.7
  • 5
    • 0024536228 scopus 로고
    • The renal proximal tubule: A model for diversity of anion exchangers and stilbene-sensitive anion transporters
    • 5. Aronson PS (1989) The renal proximal tubule: a model for diversity of anion exchangers and stilbene-sensitive anion transporters. Annu Rev Physiol 51:419-441
    • (1989) Annu Rev Physiol , vol.51 , pp. 419-441
    • Aronson, P.S.1
  • 6
    • 0000599907 scopus 로고
    • Tubulointerstitial disease and toxic nephropathy
    • Brenner BM, Rector FC (eds). Saunders, Philadelphia
    • 6. Bennett WM, Elzinga LW, Porter GA (1991) Tubulointerstitial disease and toxic nephropathy. In: Brenner BM, Rector FC (eds) The kidney, 4th edn. Saunders, Philadelphia, pp 1430-1496
    • (1991) The Kidney, 4th Edn. , pp. 1430-1496
    • Bennett, W.M.1    Elzinga, L.W.2    Porter, G.A.3
  • 8
    • 0027935348 scopus 로고
    • Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes
    • 8. Bissig M, Hagenbuch B, Stieger B, Koller T, Meier PJ (1994) Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J Biol Chem 269:3017-3021
    • (1994) J Biol Chem , vol.269 , pp. 3017-3021
    • Bissig, M.1    Hagenbuch, B.2    Stieger, B.3    Koller, T.4    Meier, P.J.5
  • 9
    • 0018840360 scopus 로고
    • pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles
    • 9. Blomstedt JW, Aronson PS (1980) pH Gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles. J Clin Invest 65:931-934
    • (1980) J Clin Invest , vol.65 , pp. 931-934
    • Blomstedt, J.W.1    Aronson, P.S.2
  • 10
    • 0030098277 scopus 로고    scopus 로고
    • Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver
    • 10. Bossuyt X, Müller M, Hagenbuch B, Meier PJ (1996) Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther 276:891-896
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 891-896
    • Bossuyt, X.1    Müller, M.2    Hagenbuch, B.3    Meier, P.J.4
  • 11
    • 0016413786 scopus 로고
    • Inhibition of renal tubular transport of methotrexate by probenecid
    • 11. Bourke RS, Chheda G, Bremer A, Watanabe O, Tower DB (1975) Inhibition of renal tubular transport of methotrexate by probenecid. Cancer Res 35:110-116
    • (1975) Cancer Res , vol.35 , pp. 110-116
    • Bourke, R.S.1    Chheda, G.2    Bremer, A.3    Watanabe, O.4    Tower, D.B.5
  • 12
    • 0021024932 scopus 로고
    • Carnitine-metabolism and functions
    • 12. Bremer J (1983) Carnitine-metabolism and functions. Physiol Rev 63:1420-1480
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 13
    • 0040761368 scopus 로고    scopus 로고
    • cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • 13. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T, Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271:15091-15098
    • (1996) J Biol Chem , vol.271 , pp. 15091-15098
    • Büchler, M.1    König, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5    Horie, T.6    Keppler, D.7
  • 14
    • 0033985338 scopus 로고    scopus 로고
    • Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT)
    • 14. Burckhardt BC, Wolff NA, Burckhardt G (2000) Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT). J Am Soc Nephrol 11: 9-17
    • (2000) J Am Soc Nephrol , vol.11 , pp. 9-17
    • Burckhardt, B.C.1    Wolff, N.A.2    Burckhardt, G.3
  • 15
    • 0021254084 scopus 로고
    • Sodium-dependent dicarboxylate transport in rat renal basolateral membrane vesicles
    • 15. Burckhardt G (1984) Sodium-dependent dicarboxylate transport in rat renal basolateral membrane vesicles. Pflügers Arch 401:254-261
    • (1984) Pflügers Arch , vol.401 , pp. 254-261
    • Burckhardt, G.1
  • 16
    • 0014588917 scopus 로고
    • p-Aminohippurate uptake and exchange by separated renal tubules
    • 16. Burg MB, Orloff J (1969) p-Aminohippurate uptake and exchange by separated renal tubules. Am J Physiol 217:1064-1068
    • (1969) Am J Physiol , vol.217 , pp. 1064-1068
    • Burg, M.B.1    Orloff, J.2
  • 17
    • 0033517087 scopus 로고    scopus 로고
    • Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: A novel Arg169G1n mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality
    • 17. Burwinkel B, Kreuder J, Schweitzer S, Vorgerd M, Gempel K, Gerbitz KD, Kilimann MW (1999) Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: a novel Arg169G1n mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality. Biochem Biophys Res Commun 261:484-487
    • (1999) Biochem Biophys Res Commun , vol.261 , pp. 484-487
    • Burwinkel, B.1    Kreuder, J.2    Schweitzer, S.3    Vorgerd, M.4    Gempel, K.5    Gerbitz, K.D.6    Kilimann, M.W.7
  • 18
    • 0000518648 scopus 로고    scopus 로고
    • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    • 18. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275:4507-4512
    • (2000) J Biol Chem , vol.275 , pp. 4507-4512
    • Cha, S.H.1    Sekine, T.2    Kusuhara, H.3    Yu, E.4    Kim, J.Y.5    Kim, D.K.6    Sugiyama, Y.7    Kanai, Y.8    Endou, H.9
  • 20
    • 0032856603 scopus 로고    scopus 로고
    • The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
    • 20. Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH (1999) The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 56:570-580
    • (1999) Mol Pharmacol , vol.56 , pp. 570-580
    • Cihlar, T.1    Lin, D.C.2    Pritchard, J.B.3    Fuller, M.D.4    Mendel, D.B.5    Sweet, D.H.6
  • 22
    • 0031849799 scopus 로고    scopus 로고
    • Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: The nephrotoxin can be reabsorbed in all nephron segments by different mechanisms
    • 22. Dahlmann A, Dantzler WH, Silbernagl S, Gekle M (1998) Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms. J Pharmacol Exp Ther 286:157-162
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 157-162
    • Dahlmann, A.1    Dantzler, W.H.2    Silbernagl, S.3    Gekle, M.4
  • 23
    • 0032436410 scopus 로고    scopus 로고
    • Recent advances in molecular mechanisms of nephrotoxicity
    • 23. Endou H (1998) Recent advances in molecular mechanisms of nephrotoxicity. Toxicol Lett 102-103:29-33
    • (1998) Toxicol Lett , vol.102-103 , pp. 29-33
    • Endou, H.1
  • 24
    • 0032723798 scopus 로고    scopus 로고
    • Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate
    • 24. Gorboulev V, Volk C, Arndt P, Akhoundova A, Koepsell H (1999) Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate. Mol Pharmacol 56:1254-1261
    • (1999) Mol Pharmacol , vol.56 , pp. 1254-1261
    • Gorboulev, V.1    Volk, C.2    Arndt, P.3    Akhoundova, A.4    Koepsell, H.5
  • 26
    • 0031935556 scopus 로고    scopus 로고
    • Peritubular transport of ochratoxin A in rabbit renal proximal tubules
    • 26. Groves CE, Morales M, Wright SH (1998) Peritubular transport of ochratoxin A in rabbit renal proximal tubules. J Pharmacol Exp Ther 284:943-948
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 943-948
    • Groves, C.E.1    Morales, M.2    Wright, S.H.3
  • 27
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • 27. Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549-552
    • (1994) Nature , vol.372 , pp. 549-552
    • Gründemann, D.1    Gorboulev, V.2    Gambaryan, S.3    Veyhl, M.4    Koepsell, H.5
  • 30
    • 0020775343 scopus 로고
    • Specificity and modes of the anion exchanger in dog renal microvillus membranes
    • 30. Guggino SE, Martin GJ, Aronson PS (1983) Specificity and modes of the anion exchanger in dog renal microvillus membranes. Am J Physiol 244:F612-F621
    • (1983) Am J Physiol , vol.244
    • Guggino, S.E.1    Martin, G.J.2    Aronson, P.S.3
  • 31
    • 0029902410 scopus 로고    scopus 로고
    • Renal organic anion secretion: Evidence for dopaminergic and adrenergic regulation
    • 31. Halpin PA, Renfro JL (1996) Renal organic anion secretion: evidence for dopaminergic and adrenergic regulation. Am J Physiol 271:R1372-R1379
    • (1996) Am J Physiol , vol.271
    • Halpin, P.A.1    Renfro, J.L.2
  • 32
    • 0028290638 scopus 로고
    • The renal basolateral transport system for organic anions: Properties of the regulation mechanism
    • 32. Hohage H, Löhr M, Querl U, Greven J (1994) The renal basolateral transport system for organic anions: properties of the regulation mechanism. J Pharmacol Exp Ther 269:659-664
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 659-664
    • Hohage, H.1    Löhr, M.2    Querl, U.3    Greven, J.4
  • 33
    • 0032919287 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    • 33. Hosoyamada M, Sekine T, Kanai Y, Endou H (1999) Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276: F122-F128
    • (1999) Am J Physiol , vol.276
    • Hosoyamada, M.1    Sekine, T.2    Kanai, Y.3    Endou, H.4
  • 34
    • 0031031247 scopus 로고    scopus 로고
    • Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
    • 34. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272: G16-G22
    • (1997) Am J Physiol , vol.272
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 37
    • 0020674617 scopus 로고
    • Urate transport via anion exchange in dog renal microvillus membrane vesicles
    • 37. Kahn AM, Aronson PS (1983) Urate transport via anion exchange in dog renal microvillus membrane vesicles. Am J Physiol 244:F56-F63
    • (1983) Am J Physiol , vol.244
    • Kahn, A.M.1    Aronson, P.S.2
  • 38
    • 0020805432 scopus 로고
    • Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles
    • 38. Kahn AM, Branham S, Weinman EJ (1983) Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles. Am J Physiol 245:F151-F158
    • (1983) Am J Physiol , vol.245
    • Kahn, A.M.1    Branham, S.2    Weinman, E.J.3
  • 39
    • 0031456590 scopus 로고    scopus 로고
    • Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: In vivo evidence by use of the brain efflux index method
    • 39. Kakee A, Terasaki T, Sugiyama Y (1997) Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method. J Pharmacol Exp Ther 283:1018-1025
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1018-1025
    • Kakee, A.1    Terasaki, T.2    Sugiyama, Y.3
  • 41
    • 0032569029 scopus 로고    scopus 로고
    • Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
    • 41. Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971-15979
    • (1998) J Biol Chem , vol.273 , pp. 15971-15979
    • Kekuda, R.1    Prasad, P.D.2    Wu, X.3    Wang, H.4    Fei, Y.J.5    Leibach, F.H.6    Ganapathy, V.7
  • 42
    • 0033524933 scopus 로고    scopus 로고
    • Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter
    • 42. Kekuda R, Wang H, Huang W, Pajor AM, Leibach FH, Devoe LD, Prasad PD, Ganapathy V (1999) Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J Biol Chem 274:3422-3429
    • (1999) J Biol Chem , vol.274 , pp. 3422-3429
    • Kekuda, R.1    Wang, H.2    Huang, W.3    Pajor, A.M.4    Leibach, F.H.5    Devoe, L.D.6    Prasad, P.D.7    Ganapathy, V.8
  • 43
    • 0001369645 scopus 로고
    • Urinary and biliary excretions of various phenol red derivatives in the anethetized dog
    • 43. Kim JH, Hong SK (1962) Urinary and biliary excretions of various phenol red derivatives in the anethetized dog. Am J Physiol 202:174-178
    • (1962) Am J Physiol , vol.202 , pp. 174-178
    • Kim, J.H.1    Hong, S.K.2
  • 44
    • 0031893146 scopus 로고    scopus 로고
    • Organic cation transporters in intestine, kidney, liver, and brain
    • 44. Koepsell H (1998) Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 60:243-266
    • (1998) Annu Rev Physiol , vol.60 , pp. 243-266
    • Koepsell, H.1
  • 45
    • 0032942525 scopus 로고    scopus 로고
    • Molecular pharmacology of organic cation transporters in kidney
    • 45. Koepsell H, Gorboulev V, Arndt P (1999) Molecular pharmacology of organic cation transporters in kidney. J Membr Biol 167:103-117
    • (1999) J Membr Biol , vol.167 , pp. 103-117
    • Koepsell, H.1    Gorboulev, V.2    Arndt, P.3
  • 46
    • 0030437929 scopus 로고    scopus 로고
    • Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide
    • 46. Kontaxi M, Echkardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E (1996) Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J Pharmacol Exp Ther 279:1507-1513
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1507-1513
    • Kontaxi, M.1    Echkardt, U.2    Hagenbuch, B.3    Stieger, B.4    Meier, P.J.5    Petzinger, E.6
  • 49
    • 0033555578 scopus 로고    scopus 로고
    • Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells
    • 49. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G (1999) Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem 274:1519-1524
    • (1999) J Biol Chem , vol.274 , pp. 1519-1524
    • Kuze, K.1    Graves, P.2    Leahy, A.3    Wilson, P.4    Stuhlmann, H.5    You, G.6
  • 50
    • 0032923725 scopus 로고    scopus 로고
    • Functional analysis and molecular modeling of a cloned urate transporter/channel
    • 50. Leal-Pinto E, Cohen BE, Abramson RG (1999) Functional analysis and molecular modeling of a cloned urate transporter/channel. J Membr Biol 169:13-27
    • (1999) J Membr Biol , vol.169 , pp. 13-27
    • Leal-Pinto, E.1    Cohen, B.E.2    Abramson, R.G.3
  • 51
    • 0032568838 scopus 로고    scopus 로고
    • 4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
    • 4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem 273:16184-16191
    • (1998) J Biol Chem , vol.273 , pp. 16184-16191
    • Li, L.1    Lee, T.K.2    Meier, P.J.3    Ballatori, N.4
  • 52
    • 0030940999 scopus 로고    scopus 로고
    • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    • 52. Lopez-Nieto CE, You G, Bush KT, Barros EJG, Beier DR, Nigam SK (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478
    • (1997) J Biol Chem , vol.272 , pp. 6471-6478
    • Lopez-Nieto, C.E.1    You, G.2    Bush, K.T.3    Barros, E.J.G.4    Beier, D.R.5    Nigam, S.K.6
  • 53
    • 0032995116 scopus 로고    scopus 로고
    • Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C
    • 53. Lu R, Chan BS, Schuster VL (1999) Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol 276:F295-F303
    • (1999) Am J Physiol , vol.276
    • Lu, R.1    Chan, B.S.2    Schuster, V.L.3
  • 54
    • 0027507306 scopus 로고
    • A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
    • 54. Marger MD, Saier MH Jr (1993) A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem Sci 18:13-20
    • (1993) Trends Biochem Sci , vol.18 , pp. 13-20
    • Marger, M.D.1    Saier M.H., Jr.2
  • 55
    • 0027981987 scopus 로고
    • Expression of rat renal sulfate transport systems in Xenopus laevis oocytes. Functional characterization and molecular identification
    • 55. Markovich D, Bissig M, Sorribas V, Hagenbuch B, Meier PJ, Murer H (1994) Expression of rat renal sulfate transport systems in Xenopus laevis oocytes. Functional characterization and molecular identification. J Biol Chem 269:3022-3026
    • (1994) J Biol Chem , vol.269 , pp. 3022-3026
    • Markovich, D.1    Bissig, M.2    Sorribas, V.3    Hagenbuch, B.4    Meier, P.J.5    Murer, H.6
  • 57
    • 0031589135 scopus 로고    scopus 로고
    • mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules
    • 57. Masuda S, Saito H, Nonoguchi H, Tomita K, Inui K (1997) mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett 407:127-131
    • (1997) FEBS Lett , vol.407 , pp. 127-131
    • Masuda, S.1    Saito, H.2    Nonoguchi, H.3    Tomita, K.4    Inui, K.5
  • 58
    • 0032943652 scopus 로고    scopus 로고
    • Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney
    • 58. Masuda S, Ibaramoto K, Takeuchi A, Saito H, Hashimoto Y, Inui K (1999) Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Mol Pharmacol 55:743-752
    • (1999) Mol Pharmacol , vol.55 , pp. 743-752
    • Masuda, S.1    Ibaramoto, K.2    Takeuchi, A.3    Saito, H.4    Hashimoto, Y.5    Inui, K.6
  • 59
    • 0030725999 scopus 로고    scopus 로고
    • Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    • 59. Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B (1997) Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26:1667-1677
    • (1997) Hepatology , vol.26 , pp. 1667-1677
    • Meier, P.J.1    Eckhardt, U.2    Schroeder, A.3    Hagenbuch, B.4    Stieger, B.5
  • 60
    • 0031939970 scopus 로고    scopus 로고
    • Protein kinase C regulation of organic anion transport in renal proximal tubule
    • 60. Miller DS (1998) Protein kinase C regulation of organic anion transport in renal proximal tubule. Am J Physiol 274:F156-F164
    • (1998) Am J Physiol , vol.274
    • Miller, D.S.1
  • 61
    • 0020273461 scopus 로고
    • Renal organic anion transport system: Pharmacological, physiological, and biochemical aspects
    • 61. Møller JV, Sheikh MI (1983) Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol Rev 34:315-358
    • (1983) Pharmacol Rev , vol.34 , pp. 315-358
    • Møller, J.V.1    Sheikh, M.I.2
  • 63
  • 65
    • 0032967070 scopus 로고    scopus 로고
    • Transepithelial transport of organic anions across the choroid plexus: Possible involvement of organic anion transporter and multidrug resistance-associated protein
    • 65. Nishino J, Suzuki H, Sugiyama D, Kitazawa T, Ito K, Hanano M, Sugiyama Y (1999) Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein. J Pharmacol Exp Ther 290:289-294
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 289-294
    • Nishino, J.1    Suzuki, H.2    Sugiyama, D.3    Kitazawa, T.4    Ito, K.5    Hanano, M.6    Sugiyama, Y.7
  • 66
    • 0030886124 scopus 로고    scopus 로고
    • Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    • 66. Noé B, Hagenbuch B, Stieger B, Meier PJ (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94:10346-10350
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10346-10350
    • Noé, B.1    Hagenbuch, B.2    Stieger, B.3    Meier, P.J.4
  • 67
    • 0030590117 scopus 로고    scopus 로고
    • cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
    • 67. Okuda M, Saito H, Urakami Y, Takano M, Inui K (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 224:500-507
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 500-507
    • Okuda, M.1    Saito, H.2    Urakami, Y.3    Takano, M.4    Inui, K.5
  • 68
    • 0028957041 scopus 로고
    • Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter
    • 68. Pajor AM (1995) Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J Biol Chem 270: 5779-5785
    • (1995) J Biol Chem , vol.270 , pp. 5779-5785
    • Pajor, A.M.1
  • 69
    • 0029968824 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney
    • 69. Pajor AM (1996) Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol 270:F642-F648
    • (1996) Am J Physiol , vol.270
    • Pajor, A.M.1
  • 72
    • 0023765854 scopus 로고
    • Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles
    • 72. Pritchard JB (1988) Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles. Am J Physiol 255:F597-F604
    • (1988) Am J Physiol , vol.255
    • Pritchard, J.B.1
  • 73
    • 0027133590 scopus 로고
    • Mechanisms mediating renal secretion of organic anions and cations
    • 73. Pritchard JB, Miller DS (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73: 765-796
    • (1993) Physiol Rev , vol.73 , pp. 765-796
    • Pritchard, J.B.1    Miller, D.S.2
  • 74
    • 0033574034 scopus 로고    scopus 로고
    • Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
    • 74. Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999) Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun 255:508-514
    • (1999) Biochem Biophys Res Commun , vol.255 , pp. 508-514
    • Race, J.E.1    Grassl, S.M.2    Williams, W.J.3    Holtzman, E.J.4
  • 77
    • 0029786681 scopus 로고    scopus 로고
    • Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
    • 77. Saito H, Masuda S, Inui K (1996) Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem 271:20719-20725
    • (1996) J Biol Chem , vol.271 , pp. 20719-20725
    • Saito, H.1    Masuda, S.2    Inui, K.3
  • 78
    • 0030832802 scopus 로고    scopus 로고
    • Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
    • 78. Schaub TP, Kartenbeck J, König J, Vogel O, Witzgall R, Kriz W, Keppler D (1997) Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol 8:1213-1221
    • (1997) J Am Soc Nephrol , vol.8 , pp. 1213-1221
    • Schaub, T.P.1    Kartenbeck, J.2    König, J.3    Vogel, O.4    Witzgall, R.5    Kriz, W.6    Keppler, D.7
  • 80
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • 80. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272: 18526-18529
    • (1997) J Biol Chem , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 82
    • 17144449057 scopus 로고    scopus 로고
    • Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    • 82. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182
    • (1998) FEBS Lett , vol.429 , pp. 179-182
    • Sekine, T.1    Cha, S.H.2    Tsuda, M.3    Apiwattanakul, N.4    Nakajima, N.5    Kanai, Y.6    Endou, H.7
  • 84
    • 0033401711 scopus 로고    scopus 로고
    • Molecular biology of multispecific organic anion transporter family (OAT family)
    • 84. Sekine T, Cha SH, Kanai Y, Endou H (1999) Molecular biology of multispecific organic anion transporter family (OAT family). Clin Exp Nephrol 3:237-243
    • (1999) Clin Exp Nephrol , vol.3 , pp. 237-243
    • Sekine, T.1    Cha, S.H.2    Kanai, Y.3    Endou, H.4
  • 85
    • 0020589006 scopus 로고
    • Reabsorption of dicarboxylic acids from the proximal convolution of rat kidney
    • 85. Sheridan E, Rumrich G, Ullrich KJ (1983) Reabsorption of dicarboxylic acids from the proximal convolution of rat kidney. Pflügers Arch 399:18-28
    • (1983) Pflügers Arch , vol.399 , pp. 18-28
    • Sheridan, E.1    Rumrich, G.2    Ullrich, K.J.3
  • 86
    • 0023514358 scopus 로고
    • + of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles
    • + of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles. Am J Physiol 253:F795-F801
    • (1987) Am J Physiol , vol.253
    • Shimada, H.1    Moewes, B.2    Burckhardt, G.3
  • 87
    • 0019571976 scopus 로고
    • Basis for heterogeneity of para-aminohippurate secretion in rabbit proximal tubules
    • 87. Shimomura A, Chonko AM, Grantham JJ (1981) Basis for heterogeneity of para-aminohippurate secretion in rabbit proximal tubules. Am J Physiol 240:F430-F436
    • (1981) Am J Physiol , vol.240
    • Shimomura, A.1    Chonko, A.M.2    Grantham, J.J.3
  • 88
    • 0003122021 scopus 로고    scopus 로고
    • Renal handling of organic anions and cations: Excretion of uric acid
    • Brenner BM (ed). Saunders, Philadelphia
    • 88. Sica DA, Schoolwerth AC (2000) Renal handling of organic anions and cations: excretion of uric acid. In: Brenner BM (ed) The kidney, 6th edn. Saunders, Philadelphia, pp 680-700
    • (2000) The Kidney, 6th Edn. , pp. 680-700
    • Sica, D.A.1    Schoolwerth, A.C.2
  • 89
    • 0028285029 scopus 로고
    • Molecular cloning and characterization of a novel liver-specific transport protein
    • 89. Simonson GD, Vincent AC, Roberg KJ, Huang Y, Iwanij V (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 107:1065-1072
    • (1994) J Cell Sci , vol.107 , pp. 1065-1072
    • Simonson, G.D.1    Vincent, A.C.2    Roberg, K.J.3    Huang, Y.4    Iwanij, V.5
  • 90
    • 0030781076 scopus 로고    scopus 로고
    • Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney
    • 90. Sweet DH, Wolff NA, Pritchard JB (1997) Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272:30088-30095
    • (1997) J Biol Chem , vol.272 , pp. 30088-30095
    • Sweet, D.H.1    Wolff, N.A.2    Pritchard, J.B.3
  • 91
    • 0029737131 scopus 로고    scopus 로고
    • Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells
    • 91. Takano M, Nagai J, Yasuhara M, Inui K (1996) Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells. Am J Physiol 271:F469-F475
    • (1996) Am J Physiol , vol.271
    • Takano, M.1    Nagai, J.2    Yasuhara, M.3    Inui, K.4
  • 92
    • 0033458777 scopus 로고    scopus 로고
    • Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity
    • 92. Takeda M, Tojo A, Sekine T, Makoto H, Kanai Y, Endou H (1999) Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int 56:2128-2136
    • (1999) Kidney Int , vol.56 , pp. 2128-2136
    • Takeda, M.1    Tojo, A.2    Sekine, T.3    Makoto, H.4    Kanai, Y.5    Endou, H.6
  • 93
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • 93. Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, Tsuji A (1997) Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419:107-111
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3    Sai, Y.4    Oku, A.5    Shimane, M.6    Tsuji, A.7
  • 94
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • 94. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378-20382
    • (1998) J Biol Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3    Yabuuchi, H.4    Oku, A.5    Shimane, M.6    Sai, Y.7    Tsuji, A.8
  • 95
    • 0032979273 scopus 로고    scopus 로고
    • Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney
    • 95. Tojo A, Sekine T, Nakajinia N, Hosoyamada M, Kanai Y, Kimura K, Endou H (1999) Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10:464-471
    • (1999) J Am Soc Nephrol , vol.10 , pp. 464-471
    • Tojo, A.1    Sekine, T.2    Nakajima, N.3    Hosoyamada, M.4    Kanai, Y.5    Kimura, K.6    Endou, H.7
  • 98
    • 0030726054 scopus 로고    scopus 로고
    • Nephrotoxicity of beta-lactam antibiotics: Mechanisms and strategies for prevention
    • 98. Tune BM (1997) Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention. Pediatr Nephrol 11:768-772
    • (1997) Pediatr Nephrol , vol.11 , pp. 768-772
    • Tune, B.M.1
  • 99
    • 0030850803 scopus 로고    scopus 로고
    • Renal transporters for organic anions and organic cations. Structural requirements for substrates
    • 99. Ullrich KJ (1997) Renal transporters for organic anions and organic cations. Structural requirements for substrates. J Membr Biol 158:95-107
    • (1997) J Membr Biol , vol.158 , pp. 95-107
    • Ullrich, K.J.1
  • 100
    • 0033250793 scopus 로고    scopus 로고
    • Affinity of drugs to the different renal transporters for organic anions and organic cations
    • Amidon GL, Sadée W (eds). Kluwer/Plenum, New York
    • 100. Ullrich KJ (1999) Affinity of drugs to the different renal transporters for organic anions and organic cations. In: Amidon GL, Sadée W (eds) Membrane transporters as drug targets. Kluwer/Plenum, New York, pp 159-179
    • (1999) Membrane Transporters as Drug Targets , pp. 159-179
    • Ullrich, K.J.1
  • 101
    • 0023916963 scopus 로고
    • Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions
    • 101. Ullrich KJ, Rumrich G (1988) Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions. Am J Physiol 254:F453-F462
    • (1988) Am J Physiol , vol.254
    • Ullrich, K.J.1    Rumrich, G.2
  • 102
    • 0026671402 scopus 로고
    • 1-methyl-nicotinamide, NMeN) do not see the degree of substrate ionization
    • 1-methyl-nicotinamide, NMeN) do not see the degree of substrate ionization. Pflügers Arch 421:286-288
    • (1992) Pflügers Arch , vol.421 , pp. 286-288
    • Ullrich, K.J.1    Rumrich, G.2
  • 103
    • 0030890801 scopus 로고    scopus 로고
    • Luminal transport step of para-aminohippurate (PAH): Transport from PAH-loaded proximal tubular cells into the tubular lumen of the rat kidney in vivo
    • 103. Ullrich KJ, Rumrich G (1997) Luminal transport step of para-aminohippurate (PAH): transport from PAH-loaded proximal tubular cells into the tubular lumen of the rat kidney in vivo. Pflügers Arch 433:735-743
    • (1997) Pflügers Arch , vol.433 , pp. 735-743
    • Ullrich, K.J.1    Rumrich, G.2
  • 104
    • 0027373329 scopus 로고
    • Bisubstrates: Substances that interact with both renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: Dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: Steroid hormones and cyclophosphamides
    • 104. Ullrich KJ, Rumrich G, David C, Fritzsch G (1993) Bisubstrates: substances that interact with both renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides. Pflügers Arch 425:300-312
    • (1993) Pflügers Arch , vol.425 , pp. 300-312
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 105
    • 0027378438 scopus 로고
    • Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines
    • 105. Ullrich KJ, Rumrich G, David C, Fritzsch G (1993) Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflügers Arch 425:280-299
    • (1993) Pflügers Arch , vol.425 , pp. 280-299
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 106
    • 0031768564 scopus 로고    scopus 로고
    • Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney
    • 106. Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K (1998) Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett 438:321-324
    • (1998) FEBS Lett , vol.438 , pp. 321-324
    • Uwai, Y.1    Okuda, M.2    Takami, K.3    Hashimoto, Y.4    Inui, K.5
  • 107
    • 0031841605 scopus 로고    scopus 로고
    • Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells
    • 107. Van Aubel RAMH, Kuijck MA van, Koenderink JB, Deen PMT, Os CH van, Russel FGM (1998) Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. Mol Pharmacol 53:1062-1067
    • (1998) Mol Pharmacol , vol.53 , pp. 1062-1067
    • Van Aubel, R.A.M.H.1    Kuijck, M.A.V.2    Koenderink, J.B.3    Deen, P.M.T.4    Os, C.H.V.5    Russel, F.G.M.6
  • 109
    • 0033515017 scopus 로고    scopus 로고
    • Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency
    • 109. Wang Y, Ye J, Ganapathy V, Longo N (1999) Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency. Proc Natl Acad Sci USA 96:2356-2360
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2356-2360
    • Wang, Y.1    Ye, J.2    Ganapathy, V.3    Longo, N.4
  • 110
    • 0025267318 scopus 로고
    • Urate and p-aminohippurate transport in the brush border membrane of the pig kidney
    • 110. Werner D, Martinez F, Roch-Ramel F (1990) Urate and p-aminohippurate transport in the brush border membrane of the pig kidney. J Pharmacol Exp Ther 252:792-799
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 792-799
    • Werner, D.1    Martinez, F.2    Roch-Ramel, F.3
  • 111
    • 0030777903 scopus 로고    scopus 로고
    • Expression cloning and characterization of a renal organic anion transporter from winter flounder
    • 111. Wolff NA, Werner A, Burkhardt S, Burckhardt G (1997) Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett 417:287-291
    • (1997) FEBS Lett , vol.417 , pp. 287-291
    • Wolff, N.A.1    Werner, A.2    Burkhardt, S.3    Burckhardt, G.4
  • 112
    • 0028039878 scopus 로고
    • Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter
    • 112. Wong MH, Oelkers P, Craddock AL, Dawson PA (1994) Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J Biol Chem 269:1340-1347
    • (1994) J Biol Chem , vol.269 , pp. 1340-1347
    • Wong, M.H.1    Oelkers, P.2    Craddock, A.L.3    Dawson, P.A.4
  • 113
    • 0018085540 scopus 로고
    • Relationship between para-aminohippurate secretion and cellular morphology in rabbit proximal tubules
    • 113. Woodhall PB, Tisher CC, Simonton CA, Robinson RR (1978) Relationship between para-aminohippurate secretion and cellular morphology in rabbit proximal tubules. J Clin Invest 61:1320-1329
    • (1978) J Clin Invest , vol.61 , pp. 1320-1329
    • Woodhall, P.B.1    Tisher, C.C.2    Simonton, C.A.3    Robinson, R.R.4
  • 115
    • 0032577202 scopus 로고    scopus 로고
    • cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • 115. Wu X, Prasad PD, Leibach FH, Ganapathy V (1998) cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 246:589-595
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.