LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers

Gastroenterology

Volumn 120, Issue 7, 2001, Pages 1689-1699

  Abe, Takaaki ^a   Unno, Michiaki ^b   Onogawa, Tohru ^b   Tokui, Taro ^e   Noriko Kondo, Tohru ^b   Nakagomi, Rie ^e   Adachi, Hisanobu ^a,b   Fujiwara, Koh ^a,b   Okabe, Mitsunori ^a,b   Suzuki, Takehiro ^a   Nunoki, Kazuo ^c   Sato, Eiichi ^c   Kakyo, Masayuki ^b   Nishio, Toshiyuki ^c   Sugita, Junichi ^b   Asano, Naoki ^a,c,d   Tanemoto, Masayuki ^f   Seki, Makoto ^a,g   Ono, Katsuhiko ^c   Kondo, Yoshiaki ^c   Shiiba, Kenichi ^b   Suzuki, Masanori ^b   Ohtani, Haruo ^c   Shimosegawa, Tooru ^d   Iinuma, Kazuie ^c   Nagura, Hiroshi ^c   Ito, Sadayoshi ^a   Matsuno, Seiki ^b   more..

^a Division of Nephrology Endocrinology and Vascular Medicine   (Japan)

^b Departments of Surgery II   (Japan)

^c Department of Molecular Pharmacology ^*  (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e DAIICHI SANKYO CO   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g Research Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; GENE PRODUCT; LIVER SPECIFIC TRANSPORTER; METHOTREXATE; PROTEIN LST 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; CANCER CHEMOTHERAPY; CELL KILLING; CELL STRAIN; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DNA LIBRARY; DRUG SENSITIVITY; DRUG TARGETING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; XENOPUS;

EID: 0035006408     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.24804     Document Type: Article

References (38)

1. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin)
2. The pharmacology and clinical use of methotrexate
3. Poten bile salt and organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte
4. Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell
5. Carrier-mediated membrane transport of folates in mammalian cells
6. Transport of 5-methyltetrahydrofolic acid and folic acid in freshly isolated hepatocytes
7. Molecular cloning of the human placental folate transporter
8. 2+ signal transduction
9. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
10. Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
11. TreeView: An application to display phylogenetic trees on personal computers
12. A novel cDNA restores reduce folate carrier activity and methotrexate sensitivity to transport deficient cells
13. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
14. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2
15. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1
16. Aminopeptidase M from human liver. I. Solubilization, purification, and some properties of the enzyme
17. Expression of costimulatory molecules B7-1 and B7-2 by macrophages along invasive margin of colon cancer: A possible antitumor immunity?
18. A simple method for displaying the hydropathic character of a protein
19. Protein kinase recognition sequence motifs
20. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
21. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
22. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
23. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
24. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
25. +-independent organic anion transporter
26. Isolation of a multispecific organic anion and cardiac glucoside transporter from rat brain
27. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
28. Cloning, in vitro expression and tissue distribution of a human prostaglandin transporter cDNA (hPGT)
29. Identification and characterization of a prostaglandin transporter
30. Oxygen sensing and molecular adaptation to hypoxia
31. Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: Biological significance and implications for improved therapy of human cancer
32. Perturbation of methotrexate transport by verapamil, vinblastine, taurocholate and bromosulfophthalein in rat hepatocytes
33. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
34. Intestinal folate transport: Identification of a cDNA involved in folate transport and the functional expression and distribution of mRNA
35. Angiogenesis and tumor metastasis