Inhibition of biliary excretion of methotrexate by probenecid in rats: Quantitative prediction of interaction from in vitro data

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 3, 2001, Pages 1036-1043

  Ueda, Kaoru ^a   Kato, Yukio ^a   Komatsu, Kanji ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMETOPTERIN; METHOTREXATE; PROBENECID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CLEARANCE; DRUG EXCRETION; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INTRAHEPATIC BILE DUCT; LIVER SINUSOID; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE;

ANIMALS; BILE; BILIARY TRACT; BIOLOGICAL TRANSPORT, ACTIVE; CYTOPLASMIC VESICLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HEPATOCYTES; LIVER; MALE; METABOLIC CLEARANCE RATE; METHOTREXATE; MODELS, BIOLOGICAL; PROBENECID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035012079     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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